NVS Novartis AG

88.15
-0.17  -0%
Previous Close 88.32
Open 88.57
Price To Book 2.61
Market Cap 203626500000
Shares 2,310,000,000
Volume 1,933,315
Short Ratio 0.6
Av. Daily Volume 2,633,414

Drug Information

Drug catalyst information is displayed when you hover over the stage bar graph.

Head-to-head trial versus proposed biosimilar adalimumab initiated. Expected completion 2022.
Cosentyx (secukinumab) - SURPASS
Ankylosing spondylitis (AS)
Approval announced April 30, 2018.
Tafinlar (dabrafenib) and Mekinist (trametinib)
Melanoma with BRAF V600E or V600K mutations
Approval announced May 11, 2018.
Fingolimod
Multiple Sclerosis (MS)
Phase 1 initiation of dosing announced January 16, 2018.
AVXS-101 STRONG
Spinal muscular atrophy (SMA) Type 2
FDA Approval announced June 22, 2017.
Tafinlar (dabrafenib) and Mekinist (trametinib)
Non-small cell lung cancer (NSCLC) with BRAF V600E mutation
Approval announced May 1, 2018.
Kymriah (CTL019 )- JULIET
Cancer - Diffuse Large B-Cell Lymphoma (DLBCL)
Phase 3 updated data at ASCO June 4, 2017.
Ribociclib + Letrozole - MONALEESA-2
Breast cancer
CRL issued May 2, 2018.
Biosimilar rituximab
Various blood cancers, rheumatoid arthritis.
Priority review granted February 22, 2017. Approval announced May 26, 2017.
Zykadia
First-line use in patients with ALK+ metastatic NSCLC
Phase 3 trial commenced June 2017.Expected completion 2H 2019.
Ruxolitinib - REACH 3
Steroid-refractory chronic GVHD (Graft versus host disease)
Phase 3 trial to be completed 2H 2019.
Ruxolitinib - REACH 2
Steroid-refractory acute GVHD (Graft versus host disease)
Phase 2 complete. Regulatory filing due 2018.
SEG101
Sickle Cell Disease Pain Crises (SCPC)
CRL announced October 18, 2018.
ACZ885 (canakinumab)
CV risk reduction
Phase 3 data released March 22, 2017 - primary endpoints not met.
RELAX-AHF-2 (RLX030)
Acute heart failure
Phase 3 data released June 20, 2017 - primary and key secondary endpoints met. Additional data presented at ARVO conference April 30, 2018.
RTH258 (brolucizumab)
Neovascular AMD
Phase 3 trial to be completed 2H 2019.
QVM149
Asthma
Phase 3 data due 2020.
QAW039 (fevipiprant)
Asthma
Phase 3 trial met primary endpoint - November 8, 2017.
LEE011: MONALEESA-7
Breast cancer - (pre-menopausal)
Phase 3 data due 2H 2019.
OMB157 (ofatumumab)
Relapsing multiple sclerosis
Phase 3 data presented at ASCO 2018 - PFS 20.5 months v 12.8 months
Kisqali plus fulvestrant: MONALEESA-3
Breast cancer - (post-menopausal)
Phase 3 data due mid-2019.
Entresto - PARAGON
HF-pEF (heart failure with preserved ejection fraction)
Phase 3 trial completion due 2020.
Entresto - PARADISE
AMI (acute myocardial infarction)
Approval announced early - August 30, 2017.
Kymriah (CTL019)
Relapsed/Refractory B-Cell Acute lymphoblastic leukemia
Phase 3 trial to be completed 2Q 2019.
AIN457 (Cosentyx)
Psoriatic arthritis
Approval announced May 17, 2018.
Erenumab
Migraine
Phase 3 ongoing. Expected completion 2024.
CNP 520
Alzheimer’s Disease
Priority review granted November 14, 2016. Approval announced April 28, 2017.
Rydapt (Midostaurin - PKC412)
Acute myeloid leukemia (AML)
Priority review granted November 1, 2016. Approval announced March 13, 2017.
LEE011
HR+/HER2- advanced breast cancer
FDA approval announced October 31, 2018.
Adalimumab
Rheumatoid Arthritis
Approved January 26, 2018. Acquired from Advanced Accelerator Applications (NASDAQ: AAAP).
Lutathera
Inoperable progressive midgut NETs
PDUFA date under priority review May 2019. Exact date not released.
AVXS-101
Spinal muscular atrophy (SMA) Type 1
PDUFA date under priority review February 24, 2019.
Ruxolitinib
Graft versus host disease
Pivotal trial initiated 2Q 2018 (Europe). To be completed in 2020.
AVXS-101 STR1VE EU
Spinal muscular atrophy (SMA) Type 1
Phase 2 interim analysis 1H 2018.
LJN452
Non-alcoholic steatohepatitis (NASH)
Phase 2 released October 19, 2018. ORR 72% in treatment-naive patients, 39% in previously treated patients.
INC280
Non-small cell lung cancer
Program discontinued - noted July 18, 2018.
LIK066
Obesity
Phase 3 trial met primary endpoint - August 23, 2018. PFS 11 months v 5.7 months for fulvestrant alone.
BYL719 + fulvestrant
HR + Metastatic breast cancer (MBC)
FDA approval announced February 8, 2018.
Cosentyx
Psoriasis
Phase 3 trial to be initiated 1Q 2019.
AVXS-101 REACH
Pediatric SMA Types 1, 2, 3
sNDA approval announced November 16, 2018.
Promacta (eltrombopag)
Severe aplastic anemia (SAA)
PDUFA date under priority review set for March 2019. Exact date not noted.
BAF312
Secondary progressive multiple sclerosis
Phase 3 data due 2H 2019.
PDR001
BRAFV600 mutant metastatic melanoma
Phase 3 data noted 46% reduction in serious clinical outcomes endpoint.
Entresto - PIONEER
Heart failure
Regulatory filing due 1H 2019.
Crizanlizumab
Sickle cell disease

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