BPC January 05 update

Longeveron LGVN Phase 2a trial; AlloVir ALVR Regenerative Medicine Advanced Therapy designation

Pre-Market Updates

Longeveron, Inc. (NASDAQ: LGVN) initiated its Phase 2a clinical trial evaluating Lomecel-B for Alzheimer’s disease (AD). The first patient has consented to participate in the trial, and patient screening has begun.

AlloVir, Inc. (NASDAQ: ALVR) announced that the FDA granted Regenerative Medicine Advanced Therapy (RMAT) designation to posoleucel (Viralym-M, ALVR105) to treat adenovirus (AdV) infection following allogeneic hematopoietic stem cell transplant (allo-HCT).

Connect Biopharma Holdings Limited (NASDAQ: CNTB) reported data from its Phase 2b trial of CBP-201 to treat atopic dermatitis. Patients across all treatment groups had significantly lower disease severity at baseline.

NRx Pharmaceuticals (NASDAQ: NRXP) announced that it has submitted an application for Emergency Use Authorization (EUA) to the FDA for the use of ZYESAMI (aviptadil) in patients with critical COVID-19 who are at immediate risk of death from respiratory failure.

Annexon, Inc. (NASDAQ: ANNX) posted interim data from its Phase 2 trial of ANX005 in patients with Huntington's disease (HD). Results showed improvement in mean Composite Unified Huntington's Disease Rating Scale (cUHDRS) in more than half of all evaluable patients.

Pfizer Inc. (NYSE: PFE) and BioNTech SE (NASDAQ: BNTX) announced a new collaboration deal to develop a mRNA-based vaccine for shingles. This is the third collaboration between Pfizer and BioNTech in the infectious diseases field, following the influenza vaccine collaboration initiated in 2018 and the COVID-19 vaccine collaboration initiated in 2020.

Pre-Market Advancers

CompanyPriceChange
CGTX
Cognition Therapeutics Inc.
$4.30+0.8  +22.86%
HOOK
HOOKIPA Pharma Inc.
$1.79+0.29  +19.33%
MRKR
Marker Therapeutics Inc.
$0.71+0.11  +18.33%
IMMX
Immix Biopharma Inc.
$5.31+0.8  +17.74%
BSGM
BioSig Technologies Inc.
$2.10+0.3  +16.67%
CALA
Calithera Biosciences Inc.
$0.52+0.0678  +14.99%
PALI
Palisade Bio Inc.
$1.21+0.155  +14.69%
RMTI
Rockwell Medical Inc.
$0.45+0.0568  +14.45%
VRPX
Virpax Pharmaceuticals Inc.
$2.63+0.3301  +14.35%
NRBO
NeuroBo Pharmaceuticals Inc.
$1.28+0.16  +14.29%

Pre-Market Decliners

CompanyPriceChange
ARDS
Aridis Pharmaceuticals Inc.
$1.32-0.28  -17.50%
HILS
Hillstream BioPharma Inc.
$2.89-0.47  -13.99%
CINC
CinCor Pharma Inc.
$15.66-2.54  -13.96%
RUBY
Rubius Therapeutics Inc.
$6.54-0.7615  -10.43%
GMDA
Gamida Cell Ltd.
$2.95-0.29  -8.95%
KPTI
Karyopharm Therapeutics Inc.
$7.63-0.65  -7.85%
BDSI
BioDelivery Sciences International Inc.
$3.10-0.26  -7.74%
ITCI
Intra-Cellular Therapies Inc.
$39.57-3.09  -7.24%
BNTC
Benitec Biopharma Inc.
$2.31-0.18  -7.23%
VAXX
Vaxxinity Inc.
$7.57-0.59  -7.23%