BPC January 13 update

Adagio ADGI Covid-19 data; VYNE Deal

Pre-Market Updates

Notable JPM presentation for Thursday, January 13, 2022: AUPH

Adagio Therapeutics, Inc. (NASDAQ: ADGI) released summarized preclinical studies that reported that ADG20 retains neutralizing activity against variants of concern of the SARS-CoV-2 virus, including Omicron, Alpha, Beta, Delta, and Gamma, and a diverse panel of circulating variants, including the Lambda, Mu and Delta plus variants.

VYNE Therapeutics Inc. (NASDAQ: VYNE) sold its Molecule Stabilizing Technology franchise, including AMZEEQ, for cash payments of $25 million and potential milestones of up to $450 million.

Denali Therapeutics Inc. (NASDAQ: DNLI) announced that the FDA placed a clinical hold on its DNL919 Investigational New Drug (IND) application. The FDA indicated they will provide an official clinical hold letter to Denali in approximately 30 days.

Puma Biotechnology, Inc. (NASDAQ: PBYI) announced that the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology for the treatment of breast cancer have been updated. Guidelines now include NERLYNX for the treatment of adjuvant HER2-positive Breast Cancer (BINV-L) and added dose escalation as an approach to improve the tolerability of neratinib in the treatment of adjuvant HER2-positive Breast Cancer (BINV-L).

First Wave BioPharma, Inc. (NASDAQ: FWBI) provided an update on its adrulipase (FW-EPI) clinical program noting that it has filed two new provisional patent applications with the U.S. Patent and Trademark Office (USPTO) and will commence a Phase 2b trial of adrulipase as a monotherapy.

Pre-Market Advancers

CompanyPriceChange
CGTX
Cognition Therapeutics Inc.
$4.30+0.8  +22.86%
HOOK
HOOKIPA Pharma Inc.
$1.79+0.29  +19.33%
MRKR
Marker Therapeutics Inc.
$0.71+0.11  +18.33%
IMMX
Immix Biopharma Inc.
$5.31+0.8  +17.74%
BSGM
BioSig Technologies Inc.
$2.10+0.3  +16.67%
CALA
Calithera Biosciences Inc.
$0.52+0.0678  +14.99%
PALI
Palisade Bio Inc.
$1.21+0.155  +14.69%
RMTI
Rockwell Medical Inc.
$0.45+0.0568  +14.45%
VRPX
Virpax Pharmaceuticals Inc.
$2.63+0.3301  +14.35%
NRBO
NeuroBo Pharmaceuticals Inc.
$1.28+0.16  +14.29%

Pre-Market Decliners

CompanyPriceChange
ARDS
Aridis Pharmaceuticals Inc.
$1.32-0.28  -17.50%
HILS
Hillstream BioPharma Inc.
$2.89-0.47  -13.99%
CINC
CinCor Pharma Inc.
$15.66-2.54  -13.96%
RUBY
Rubius Therapeutics Inc.
$6.54-0.7615  -10.43%
GMDA
Gamida Cell Ltd.
$2.95-0.29  -8.95%
KPTI
Karyopharm Therapeutics Inc.
$7.63-0.65  -7.85%
BDSI
BioDelivery Sciences International Inc.
$3.10-0.26  -7.74%
ITCI
Intra-Cellular Therapies Inc.
$39.57-3.09  -7.24%
BNTC
Benitec Biopharma Inc.
$2.31-0.18  -7.23%
VAXX
Vaxxinity Inc.
$7.57-0.59  -7.23%