Marker Therapeutics, Inc. (Nasdaq:MRKR) announced that the FDA lifted the partial clinical hold on its Phase 2 trial investigating MT-401 for the treatment of post-transplant acute myeloid leukemia (AML). Shares closed up 18% to $1.73.
Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) announced that it has sold its Rare Pediatric Disease Priority Review Voucher (PRV) for $100m. Shares closed up 4% to $31.52.
Hoth Therapeutics, Inc. (NASDAQ:HOTH) shares closed down 8% to $2.30 following news of a private placement of 2,475,248 shares and accompanying warrants to purchase up to 1,237,624 shares, at a purchase price of $2.02 per share and accompanying warrant to purchase 0.5 of a share, for gross proceeds of approximately $5m.
Millendo Therapeutics, Inc. (Nasdaq: MLND) shares fell 18% to $1.69 following its announcement it will discontinue development of its lead pipeline candidate, MLE-301, following data from the ongoing single ascending dose portion of its Phase 1 trial being conducted in healthy male volunteers.
Mersana Therapeutics, Inc. (NASDAQ:MRSN) shares closed down 29% to $18.70 following an update from its Phase 1 trial of XMT-1536 in patients with ovarian cancer. Among all 47 patients evaluable for response, the company noted an overall response rate (ORR) of 28% (13/47), compared with an ORR of 34% recorded in September.
Aerpio Pharmaceuticals, Inc. (Nasdaq: ARPO) shares are trading up 11% to $1.19 after hours on news it will be reviewing a range of strategic alternatives, which might include options such as partnerships, sale of assets, merger of the company or license agreements.
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Major price movers (stocks priced > $1.00, volume > 50k listed on NASDAQ/NYSE):
Refer to the BioPharmCatalyst Biotech Stocks page for Top 10 Gainers/Losers/Unusual Volume:
ADVANCERS:
Synthetic Biologics, Inc. (SYN): $1.00; +100%.
Brickell Biotech, Inc. (BBI): $1.22; +49%.
Gritstone Oncology, Inc. (GRTS): $5.55; +36%.
9 Meters Biopharma, Inc. (NMTR): $1.07; +28%.
Aileron Therapeutics, Inc. (ALRN): $1.30; +24%.
DECLINERS:
Lumos Pharma, Inc. (LUMO): $23.50; -24%.
Generation Bio Co. (GBIO): $24.90; -17%.
Precigen, Inc. (PGEN): $9.57; -13%.
Prelude Therapeutics Incorporated (PRLD): $59.81; -11%.
Celldex Therapeutics, Inc. (CLDX): $17.06; -11%.
Pipeline updates below: