Imara Inc. (NASDAQ:IMRA) shares closed down 38% to $14.72 following the release of data from its Phase 2a trial of IMR-687 in adult patients with sickle cell disease (SCD). While the monotherapy arm showed a 25% lower rate of vaso-occlusive crises/sickle cell-related pain crises (VOCs/SCPCs), it recorded decreases in fetal hemoglobin (HbF) levels of 1.1.% compared with baseline. The combination arm of IMR-687 and hydroxyurea saw no meaningful differences in VOCs/SCPCs.
Clearside Biomedical, Inc. (NASDAQ:CLSD) announced a registered direct offering for the sale of 4,209,050 shares at a price of $2.851 per share for gross proceeds of approximately $12m. Shares closed down 11% to $3.45.
Atossa Therapeutics, Inc. (NASDAQ:ATOS) shares fell 19% to $0.92 on news of a registered direct offering of 23,850,000 shares and warrants to purchase 17,887,500 shares at a combined purchase price for one share and .75 warrants to purchase one share of common stock of $1.055.
Aileron Therapeutics, Inc. (NASDAQ:ALRN) also announced a registered direct offering for the sale of 32,630,983 of its shares of common stock at a purchase price of $1.10 per share for gross proceeds of $35.9m. Shares closed down 5% to $1.23.
EyeGate Pharmaceuticals, Inc. (NASDAQ:EYEG) announced a private placement of shares and warrants at a combined price of $5.225 per share and warrant for gross proceeds of $8m. Shares closed up 5% to $5.34.
Harpoon Therapeutics, Inc. (NASDAQ:HARP) shares are trading down 6% to $17.35 after hours on news it has commenced an underwritten public offering of its common stock.
REGENXBIO Inc. (NASDAQ:RGNX) also announced after hours that it intends to offer $175m of its common stock in an underwritten public offering. Shares have pulled back 3% to $47.00 after hours after closing normal trading hours up 8%.
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Major price movers (stocks priced > $1.00, volume > 50k listed on NASDAQ/NYSE):
Refer to the BioPharmCatalyst Biotech Stocks page for Top 10 Gainers/Losers/Unusual Volume:
ADVANCERS:
Orchard Therapeutics plc (ORTX): $6.50; +33%.
9 Meters Biopharma, Inc. (NMTR): $1.37; +28%.
DBV Technologies S.A. (DBVT): $3.62; +27%.
NeuroBo Pharmaceuticals, Inc. (NRBO): $6.68; +20%.
Radius Health, Inc. (RDUS): $21.60; +16%.
DECLINERS:
Brickell Biotech, Inc. (BBI): $1.08; -11%.
Sigilon Therapeutics, Inc. (SGTX): $33.60; -11%.
Lumos Pharma, Inc. (LUMO): $21.29; -9%.
Pandion Therapeutics, Inc. (PAND): $18.88; -8%.
Genocea Biosciences, Inc. (GNCA): $2.45; -8%.
Pipeline updates below: