ZNTL Zentalis Pharmaceuticals Inc.

46.4
-0.08  -0%
Previous Close 46.48
Open 46.95
52 Week Low 22
52 Week High 59.32
Market Cap $1,884,482,965
Shares 40,613,857
Float 16,136,645
Enterprise Value $1,501,672,422
Volume 322,945
Av. Daily Volume 197,533
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Upcoming Catalysts

Drug Stage Catalyst Date
ZN-e4
Non-small cell lung cancer
Phase 1
Phase 1
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ZN-c3
Solid tumors
Phase 1
Phase 1
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Drug Pipeline

Drug Stage Notes
ZN-c5
ER+/HER2- breast cancer
Phase 1/2
Phase 1/2
Phase 2 monotherapy trial to be initiated in the first half of 2021.

Latest News

  1. NEW YORK and SAN DIEGO, Nov. 12, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced that Anthony Sun, MD, Chairman and Chief Executive Officer of Zentalis, will participate in two upcoming virtual investor conferences.

    Presentation Details:

    Event: Jefferies Virtual London Healthcare Conference
    Format: Fireside chat
    Date: Thursday, November 19, 2020
    Time: 5:00 p.m. GMT/12:00 p.m. EST

    Event
    : SVB Leerink Oncology 1x1 Day
    Format: One-on-one meetings
    Date: Thursday, November 19, 2020

    A live webcast of the Jefferies fireside chat will be accessible through…

    NEW YORK and SAN DIEGO, Nov. 12, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced that Anthony Sun, MD, Chairman and Chief Executive Officer of Zentalis, will participate in two upcoming virtual investor conferences.

    Presentation Details:

    Event: Jefferies Virtual London Healthcare Conference

    Format: Fireside chat

    Date: Thursday, November 19, 2020

    Time: 5:00 p.m. GMT/12:00 p.m. EST



    Event
    : SVB Leerink Oncology 1x1 Day

    Format: One-on-one meetings

    Date: Thursday, November 19, 2020

    A live webcast of the Jefferies fireside chat will be accessible through the Investors section of the Company's website at www.zentalis.com. Following the event, an archived webcast will be available on the Zentalis website.

    About Zentalis

    Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is developing a broad pipeline of potentially best-in-class oncology candidates, including ZN-c5, an oral selective estrogen receptor degrader (SERD) for ER+/HER2- breast cancer, ZN-c3, a WEE1 inhibitor, ZN-d5, a BCL-2 inhibitor and ZN-e4, an EGFR inhibitor. Zentalis has operations in both New York and San Diego.

    For more information, please visit www.zentalis.com. Follow Zentalis on Twitter at @ZentalisP and on LinkedIn at www.linkedin.com/company/zentalis-pharmaceuticals.

    Investor Contact:

    Thomas Hoffmann

    Solebury Trout

    1.646.378.2931

    Media Contact:

    Julia Deutsch

    Solebury Trout

    1.646.378.2967

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  2. Announced topline data from the Phase 1 monotherapy dose escalation trial of ZN-c5, its investigational oral SERD, in patients with ER+/HER2- advanced breast cancer; Phase 2 trial expected to initiate in H1 2021

    Entered into a clinical collaboration with Eli Lilly to evaluate ZN-c5 in combination with abemaciclib, a CDK4 and 6 inhibitor

    Raised an additional ~$166.0 million in gross proceeds from recent follow-on offering

    NEW YORK and SAN DIEGO, Nov. 09, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced financial results for the third quarter…

    Announced topline data from the Phase 1 monotherapy dose escalation trial of ZN-c5, its investigational oral SERD, in patients with ER+/HER2- advanced breast cancer; Phase 2 trial expected to initiate in H1 2021

    Entered into a clinical collaboration with Eli Lilly to evaluate ZN-c5 in combination with abemaciclib, a CDK4 and 6 inhibitor

    Raised an additional ~$166.0 million in gross proceeds from recent follow-on offering

    NEW YORK and SAN DIEGO, Nov. 09, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced financial results for the third quarter ended September 30, 2020, and highlighted recent corporate accomplishments.

    "We are proud of the clinical progress we have made this quarter, making meaningful strides in the advancement of our broad oncology pipeline," commented Dr. Anthony Sun, Chairman and Chief Executive Officer of Zentalis. "In July, we announced positive topline results from the Phase 1 monotherapy dose escalation trial of our lead candidate, ZN-c5, with a clinical benefit rate of 40%. Based on this candidate's favorable tolerability and encouraging anti-tumor activity, we are preparing to initiate the Phase 2 trial in patients with ER+/HER2- advanced breast cancer in the first half of 2021."

    Continued Dr. Sun, "In addition to our multiple ongoing studies, we remain on track to initiate a Phase 1b trial of ZN-c5 and Verzenio® (abemaciclib) in collaboration with Eli Lilly, as well as a Phase 1 combination trial with ZN-c3 and a chemotherapy agent before year-end. Supported by our recent financing, we maintain a strong position for sustained clinical and strategic growth and look forward to expanding the breadth of our pipeline with the hopes of bringing transformative cancer treatments to patients."

    Program Highlights:

    • In July 2020, Zentalis announced positive topline results from the Phase 1 monotherapy dose escalation trial of ZN-c5 in patients with ER+/HER2- advanced breast cancer. ZN-c5 was well tolerated and showed preliminary efficacy, with a clinical benefit rate of 40%. The Company expects to initiate the Phase 2 monotherapy trial in the first half of 2021.

       
    • In July 2020, the Company entered into a clinical collaboration with Eli Lilly to evaluate the combination of ZN-c5, the Company's oral selective estrogen receptor degrader (SERD) product candidate, and Verzenio® (abemaciclib), Eli Lilly's CDK4 and 6 inhibitor. Zentalis plans to initiate a Phase 1b open label, multicenter trial in patients with ER+/HER2- advanced breast cancer before year-end.



    • In September 2020, Zentalis hosted a virtual meeting with Key Opinion Leaders on its investigational WEE1 inhibitor, ZN-c3, and its potential for the treatment of advanced solid tumors. Currently, the Company is conducting a Phase 1/2 clinical trial of ZN-c3 in patients with advanced solid tumors and expects to report topline results from the Phase 1 portion of this trial in 2021.

    Corporate Highlights:

    • In August 2020, Zentalis closed a follow-on offering of common stock resulting in gross proceeds of approximately $166.0 million.

       
    • In July 2020, the Company appointed Kimberly Blackwell, M.D., to the Board of Directors. Dr. Blackwell is the current Chief Medical Officer of Tempus, as well as a renowned breast cancer researcher who has made significant contributions to the biopharmaceutical industry for more than two decades.

       
    • In September 2020, Zentalis appointed Alexis Pinto, J.D., as Chief Legal Officer. Ms. Pinto joins Zentalis with over 20 years of legal and strategic business development experience in the healthcare industry, most recently at Celgene Corporation.

    Third Quarter 2020 Financial Results

    • Cash and Marketable Securities Position: As of September 30, 2020, Zentalis had cash, cash equivalents and marketable securities of $367.4 million. Zentalis expects that its existing cash, cash equivalents and marketable securities, which includes the net proceeds of approximately $155.2 million from the follow-on offering, will enable the Company to fund its operating expenses and capital expenditure requirements into 2023.

       
    • Research and Development Expenses: Research and development expenses were $24.7 million in the third quarter of 2020, compared to $10.7 million for the same period in 2019. This increase of $14.0 million was primarily due to increases in external research and development expenses related to Zentalis' lead product candidates, as the Company advanced its Phase 1/2 clinical trials for ZN-c5 and ZN-c3 and prepared for ZN-d5 development. In addition, in the three months ended September 30, 2020, the Company conducted additional preclinical studies, incurred additional manufacturing costs, and incurred increased costs for study and lab materials.

       
    • General and Administrative Expenses: General and administrative expenses were $10.1 million in the third quarter of 2020, compared to $1.8 million for the same period in 2019. This increase of $8.3 million was primarily attributable to an increase of $6.5 million in employee-related costs of which $5.0 million was driven by non-cash, stock-based compensation from incentive grants issued during the quarter and increased headcount to support growth. Professional service fees for legal, accounting and consulting services increased by $1.1 million to support the increased operations of the organization, and insurance costs increased by $0.7 million related to operating as a public company.

       
    • Net Loss: The Company's net loss for the third quarter of 2020 was $34.7 million, compared to the net loss of $12.6 million for the same period in 2019.

       
    • Impact from COVID-19 Pandemic: The Company is continuing to monitor how the spread of the COVID-19 pandemic is affecting its employees, business, preclinical studies and clinical trials. The COVID-19 pandemic has caused disruptions to the Company's development plans and research-stage programs, including delayed initiations, suspended enrollment at some clinical sites for new patients, and limited operations at its laboratory facilities. As a result, this pandemic may continue to impact Zentalis' business, revenues, results of operations and financial condition.

    About Zentalis Pharmaceuticals

    Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is developing a broad pipeline of potentially best-in-class oncology candidates, including ZN-c5, an oral selective estrogen receptor degrader for ER+/HER2- breast cancer, ZN-c3, a WEE1 inhibitor, ZN-d5, a BCL-2 inhibitor and ZN-e4, an EGFR inhibitor. Zentalis has operations in both New York and San Diego.

    For more information, please visit www.zentalis.com. Follow Zentalis on Twitter at @ZentalisP and on LinkedIn at www.linkedin.com/company/zentalis-pharmaceuticals.

    Forward-Looking Statements

    This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding our expectations surrounding the development, potential, safety, efficacy, and regulatory and clinical progress of our product candidates in the Unites States and globally, plans and timing for the initiation of and the release of data from our clinical trials and our ability to meet other key milestones, activities in connection with our collaborations with Eli Lilly, the anticipated direct and indirect impact of COVID-19 on our business and operations, and the sufficiency of our cash and cash equivalents. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: the outbreak of the novel coronavirus disease, COVID-19, has adversely impacted and may continue to adversely impact our business, including our preclinical studies and clinical trials; our limited operating history, which may make it difficult to evaluate our current business and predict our future success and viability; we have and expect to continue to incur significant losses; our need for additional funding, which may not be available; our substantial dependence on the success of our lead product candidate; failure to identify additional product candidates and develop or commercialize marketable products; the early stage of our development efforts; potential unforeseen events during clinical trials could cause delays or other adverse consequences; risks relating to the regulatory approval process or ongoing regulatory obligations; failure to obtain U.S. or international marketing approval; our product candidates may cause serious adverse side effects; inability to maintain our collaborations, or the failure of these collaborations; our reliance on third parties; effects of significant competition; the possibility of system failures or security breaches; risks relating to intellectual property; our ability to attract, retain and motivate qualified personnel; and significant costs as a result of operating as a public company. These and other important factors discussed under the caption "Risk Factors" in our Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2020 filed with the U.S. Securities and Exchange Commission (SEC) and our other filings with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management's estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change.



    Investor Contact:

    Thomas Hoffmann

    Solebury Trout

    1.646.378.2931



    Media Contact:

    Julia Deutsch

    Solebury Trout

    1.646.378.2967





    Zentalis Pharmaceuticals, Inc. (Successor to Zentalis Pharmaceuticals, LLC)

    Condensed Consolidated Statements of Operations

    (Unaudited)

    (In thousands, except per unit and per share amounts)

     Three Months Ended

    September 30,
     Nine Months Ended

    September 30,
     2020 2019 2020 2019
    Operating Expenses       
    Research and development$24,670  $10,739  $55,380  $26,517 
    General and administrative10,097  1,844  23,162  5,423 
    Total operating expenses34,767  12,583  78,542  31,940 
    Operating loss(34,767) (12,583) (78,542) (31,940)
    Other Income (Expense)       
    Investment and other income, net120  12  368  123 
    Net loss before income taxes(34,647) (12,571) (78,174) (31,817)
    Income tax expense18  1  18  15 
    Net loss(34,665) (12,572) (78,192) (31,832)
    Net loss attributable to noncontrolling interests(110) (228) (654) (675)
    Net loss attributable to Zentalis$(34,555) $(12,344) $(77,538) $(31,157)
    Net loss per common share outstanding, basic and diluted$(0.91) $  $(3.21) $ 
    Net loss per Class A common unit outstanding, basic and diluted$  $(2.20) $  $(5.56)
    Common shares/units used in computing net loss per share/Class A common unit, basic and diluted37,959  5,601  24,143  5,601 





    Zentalis Pharmaceuticals, Inc. (Successor to Zentalis Pharmaceuticals, LLC)

    Selected Condensed Consolidated Balance Sheet Data

    (Unaudited)

    (In thousands)

     As of As of
     September 30, December 31,
     2020 2019
        
    Cash, cash equivalents and marketable securities$367,436  $67,246 
    Working capital (1)348,830  53,994 
    Total assets393,233  87,481 
    Total liabilities27,400  19,060 
    Convertible preferred units  141,706 
    Total Zentalis equity (deficit)365,833  (73,285)
        
    (1) The Company defines working capital as current assets less current liabilities.
     

     

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  3. NEW YORK and SAN DIEGO, Sept. 11, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced that it will host a Key Opinion Leader (KOL) virtual meeting on its clinical candidate ZN-c3, the Company's WEE1 inhibitor, and its potential in the treatment of advanced solid tumors on Thursday, September 24, 2020 from 12:00 p.m. to 1:30 p.m. EDT.

    The virtual event will feature presentations by KOL Kwok-Kin Wong, MD, PhD, Professor of Oncology, Department of Medicine at the NYU Grossman School of Medicine and Director of the Division of Hematology and Medical…

    NEW YORK and SAN DIEGO, Sept. 11, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced that it will host a Key Opinion Leader (KOL) virtual meeting on its clinical candidate ZN-c3, the Company's WEE1 inhibitor, and its potential in the treatment of advanced solid tumors on Thursday, September 24, 2020 from 12:00 p.m. to 1:30 p.m. EDT.

    The virtual event will feature presentations by KOL Kwok-Kin Wong, MD, PhD, Professor of Oncology, Department of Medicine at the NYU Grossman School of Medicine and Director of the Division of Hematology and Medical Oncology Chief at The Perlmutter Cancer Center at NYU Langone Medical Center and KOL Gordon Mills, MD, PhD, Professor of Cell, Developmental and Cancer Biology, School of Medicine and Director of Precision Oncology and SMMART Trials, Knight Cancer Institute at Oregon Health & Science University. The Zentalis management team will also provide an overview of the ongoing clinical development strategy of ZN-c3.

    The inhibition of WEE1 aims to generate sufficient DNA damage to cancer cells, resulting in programmed cell death and prevention of tumor growth. ZN-c3 is designed to have a best-in-class product profile with significant advantages over other investigational WEE1 inhibitor therapies, including good solubility, target selectivity and pharmacokinetic properties. The Company is currently conducting a Phase 1/2 trial in patients with advanced solid tumors.

    Dr. Wong's research, teaching and clinical activities focus on understanding the genetic alterations driving lung tumor formation and the testing of new targeted and immune lung cancer therapies. The unique models used in Dr. Wong's laboratory allow scientists to investigate the efficacy of new targeted therapeutics and immunotherapeutics. Dr. Wong and his team continue to lead the search for curative treatments for patients with advanced lung cancer.

    Dr. Mills is responsible for the implementation of an integrated program of tumor analysis, decision-making and implementation of novel precision oncology trials. His key goal is to use serial tumor and liquid biopsies to evaluate and target adaptive responses in real time to interdict cancer evolution. Dr. Mills has published more than 1,000 papers and holds more than 20 patents.

    The live webcast of the event will be accessible from the Investors page of Zentalis' website, www.zentalis.com. The archived webcast and presentation will be available on the Company's website after the event.

    About ZN-c3

    ZN-c3 is an oral inhibitor of WEE1 in development for the treatment of advanced solid tumors. The inhibition of WEE1, a DNA damage response protein, aims to generate sufficient DNA damage in cancer cells, causing cell death, thereby preventing tumor growth and potentially causing tumor regression. Zentalis is currently conducting a Phase 1/2 clinical trial of ZN-c3, and expects to initiate a Phase 1b clinical trial evaluating ZN-c3 in combination with chemotherapy in patients with advanced ovarian cancer in the second half of 2020.

    About Zentalis

    Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is developing a broad pipeline of potentially best-in-class oncology candidates, including ZN-c5, an oral selective estrogen receptor degrader (SERD) for ER+/HER2- breast cancer, ZN-c3, a WEE1 inhibitor, ZN-d5, a BCL-2 inhibitor and ZN-e4, an EGFR inhibitor. Zentalis has operations in both New York and San Diego.

    For more information, please visit www.zentalis.com. Follow Zentalis on Twitter at @ZentalisP and on LinkedIn at www.linkedin.com/company/zentalis-pharmaceuticals.

    Forward-Looking Statements

    This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding our clinical development strategy and goals, the potential of our product candidates, including without limitation ZN-c3 and upcoming meetings and presentations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: the outbreak of the novel coronavirus disease, COVID-19, has adversely impacted and may continue to adversely impact our business, including our preclinical studies and clinical trials; our limited operating history, which may make it difficult to evaluate our current business and predict our future success and viability; we have and expect to continue to incur significant losses; our need for additional funding, which may not be available; our substantial dependence on the success of our lead product candidate; failure to identify additional product candidates and develop or commercialize marketable products; the early stage of our development efforts; potential unforeseen events during clinical trials could cause delays or other adverse consequences; risks relating to the regulatory approval process or ongoing regulatory obligations; failure to obtain U.S. or international marketing approval; our product candidates may cause serious adverse side effects; inability to maintain our collaborations, or the failure of these collaborations; our reliance on third parties; effects of significant competition; the possibility of system failures or security breaches; risks relating to intellectual property; our ability to attract, retain and motivate qualified personnel; and significant costs as a result of operating as a public company. These and other important factors discussed under the caption "Risk Factors" in our Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2020 filed with the U.S. Securities and Exchange Commission (SEC) and our other filings with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management's estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change.

    Investor Contact:

    Thomas Hoffmann

    Solebury Trout

    1.646.378.2931

    Media Contact:

    Julia Deutsch

    Solebury Trout

    1.646.378.2967

    Primary Logo

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  4. NEW YORK and SAN DIEGO, Sept. 10, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced that Anthony Sun, MD, Chairman and Chief Executive Officer of Zentalis, will participate in two upcoming virtual investor conferences.

    Presentation Details:

    Event: Morgan Stanley 18th Annual Global Healthcare Conference
    Date: Thursday, September 17, 2020
    Time: 8:45 a.m. ET

    Event: Cantor Fitzgerald Virtual Global Healthcare Conference
    Date: Thursday, September 17, 2020
    Time: 10:00 a.m. ET

    Live webcasts from the Morgan Stanley and Cantor fireside chats will be accessible…

    NEW YORK and SAN DIEGO, Sept. 10, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced that Anthony Sun, MD, Chairman and Chief Executive Officer of Zentalis, will participate in two upcoming virtual investor conferences.

    Presentation Details:

    Event: Morgan Stanley 18th Annual Global Healthcare Conference

    Date: Thursday, September 17, 2020

    Time: 8:45 a.m. ET

    Event: Cantor Fitzgerald Virtual Global Healthcare Conference

    Date: Thursday, September 17, 2020

    Time: 10:00 a.m. ET

    Live webcasts from the Morgan Stanley and Cantor fireside chats will be accessible through the Investors section of the Company's website at www.zentalis.com. Following the events, archived webcasts will be available on the Zentalis website.

    About Zentalis  

    Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is developing a broad pipeline of potentially best-in-class oncology candidates, including  ZN-c5, an oral selective estrogen receptor degrader (SERD) for ER+/HER2- breast cancer, ZN-c3, a WEE1 inhibitor, ZN-d5, a BCL-2 inhibitor and ZN-e4, an EGFR inhibitor. Zentalis has operations in both New York and San Diego.

    For more information, please visit www.zentalis.com. Follow Zentalis on Twitter at @ZentalisP and on LinkedIn at www.linkedin.com/company/zentalis-pharmaceuticals.

    Investor Contact:

    Thomas Hoffmann

    Solebury Trout

    1.646.378.2931

    Media Contact:

    Julia Deutsch

    Solebury Trout

    1.646.378.2967

    Primary Logo

    View Full Article Hide Full Article
  5. NEW YORK and SAN DIEGO, Sept. 01, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced the appointment of Alexis Pinto as Chief Legal Officer. Ms. Pinto joins Zentalis with over 20 years of legal and strategic business development experience in the healthcare industry, most recently at Celgene Corporation.

    "We are thrilled to welcome Alexis to Zentalis, as her depth of knowledge in deal-making and leading legal teams within the life science sector will be a great asset to the Company," said Dr. Anthony Sun, Chairman and Chief Executive Officer at…

    NEW YORK and SAN DIEGO, Sept. 01, 2020 (GLOBE NEWSWIRE) -- Zentalis Pharmaceuticals, Inc. (NASDAQ:ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, today announced the appointment of Alexis Pinto as Chief Legal Officer. Ms. Pinto joins Zentalis with over 20 years of legal and strategic business development experience in the healthcare industry, most recently at Celgene Corporation.

    "We are thrilled to welcome Alexis to Zentalis, as her depth of knowledge in deal-making and leading legal teams within the life science sector will be a great asset to the Company," said Dr. Anthony Sun, Chairman and Chief Executive Officer at Zentalis Pharmaceuticals. "Alexis will be responsible for the legal function across the organization, in addition to advising the Zentalis team on all legal affairs related to our growing pipeline of differentiated oncology candidates."

    Ms. Pinto most recently served as Corporate Vice President & Corporate Secretary at Celgene Corporation, where she transformed the legal support provided to the Business Development and Global Alliance Management groups, and served as lead counsel on critical, high-value transactions, including the acquisition of Celgene by Bristol Myers Squibb Company. Prior to joining Celgene, she was Managing Counsel of Corporate Transactions at Merck & Co., Inc., where she led, structured and managed complex sales, acquisitions, licensing and joint venture transactions, including the divestiture of Merck's consumer care business to Bayer AG. Over her 18-year tenure at Merck, Ms. Pinto held numerous positions of increasing responsibility and scope, starting out as a labor and employment attorney and progressing into licensing, vaccines, mergers and acquisitions and business development roles. She earned her J.D. from the University of Virginia School of Law and her B.A. from the University of Virginia.

    "I am honored to join an organization that is committed to developing best-in-class therapeutics that have the potential to revolutionize the lives of cancer patients," commented Alexis Pinto, J.D., Chief Legal Officer at Zentalis Pharmaceuticals. "Over the past year, Zentalis has made impressive strides on both the corporate and clinical fronts, and I look forward to working with the management team and board to further build the legal framework necessary to reach the Company's future milestones."

    About Zentalis

    Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is developing a broad pipeline of potentially best-in-class oncology candidates, including  ZN-c5, an oral selective estrogen receptor degrader (SERD) for ER+/HER2- breast cancer, ZN-c3, a WEE1 inhibitor, ZN-d5, a BCL-2 inhibitor and ZN-e4, an EGFR inhibitor. Zentalis has operations in both New York and San Diego.

    For more information, please visit www.zentalis.com. Follow Zentalis on Twitter at @ZentalisP and on LinkedIn at www.linkedin.com/company/zentalis-pharmaceuticals.

    Forward-Looking Statements

    This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding our expectations surrounding the development, commercialization, potential, safety, efficacy, and regulatory and clinical progress of our product candidates, and the impact of management changes. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: the outbreak of the novel coronavirus disease, COVID-19, has adversely impacted and may continue to adversely impact our business, including our preclinical studies and clinical trials; our limited operating history, which may make it difficult to evaluate our current business and predict our future success and viability; we have and expect to continue to incur significant losses; our need for additional funding, which may not be available; our substantial dependence on the success of our lead product candidate; failure to identify additional product candidates and develop or commercialize marketable products; the early stage of our development efforts; potential unforeseen events during clinical trials could cause delays or other adverse consequences; risks relating to the regulatory approval process or ongoing regulatory obligations; failure to obtain U.S. or international marketing approval; our product candidates may cause serious adverse side effects; inability to maintain our collaborations, or the failure of these collaborations; our reliance on third parties; effects of significant competition; the possibility of system failures or security breaches; risks relating to intellectual property; our ability to attract, retain and motivate qualified personnel; and significant costs as a result of operating as a public company. These and other important factors discussed under the caption "Risk Factors" in our Quarterly Report on Form 10-Q for the quarterly period ended June 30, 2020 filed with the U.S. Securities and Exchange Commission (SEC) and our other filings with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management's estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change.

    Investor Contact:

    Thomas Hoffmann

    Solebury Trout

    1.646.378.2931

    Media Contact:

    Julia Deutsch

    Solebury Trout

    1.646.378.2967

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