SQZ SQZ Biotechnologies Company

29.31
+1.69  (+6%)
Previous Close 27.62
Open 28.81
52 Week Low 12.98
52 Week High 36.49
Market Cap $702,625,504
Shares 23,972,211
Float 17,547,817
Enterprise Value $675,036,139
Volume 100,883
Av. Daily Volume 0
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Latest News

  1. SQZ Biotechnologies (NYSE:SQZ), a cell therapy company developing novel treatments for multiple therapeutic areas, today announced that Armon Sharei, PhD, chief executive officer of SQZ, will be participating in a fireside chat at the Evercore ISI Virtual HealthCONx Conference on Wednesday, December 2, 2020 at 10:55 am EST.

    To access the live webcast, please visit the "Events & Presentations" page within the Investors & Media section of the SQZ website. Replays of the webcast will be available on the SQZ website for 90 days following the event.

    About SQZ Biotech
    SQZ Biotech is a clinical-stage biotechnology company developing transformative cell therapies for patients with cancer, infectious diseases, and other serious conditions. Using its…

    SQZ Biotechnologies (NYSE:SQZ), a cell therapy company developing novel treatments for multiple therapeutic areas, today announced that Armon Sharei, PhD, chief executive officer of SQZ, will be participating in a fireside chat at the Evercore ISI Virtual HealthCONx Conference on Wednesday, December 2, 2020 at 10:55 am EST.

    To access the live webcast, please visit the "Events & Presentations" page within the Investors & Media section of the SQZ website. Replays of the webcast will be available on the SQZ website for 90 days following the event.

    About SQZ Biotech

    SQZ Biotech is a clinical-stage biotechnology company developing transformative cell therapies for patients with cancer, infectious diseases, and other serious conditions. Using its proprietary technology, SQZ has the unique ability to deliver multiple materials into many patient cell types to engineer what we believe to be an unprecedented range of potential therapeutics for a range of diseases. SQZ has the potential to create well-tolerated cell therapies that can provide therapeutic benefit for patients and potentially improve the patient experience over existing cell therapy approaches, with accelerated production timelines under 24 hours and the elimination of preconditioning and lengthy hospital stays. Our goal is to use the SQZ approach to establish a new paradigm for cell therapies. The first therapeutic applications leverage SQZ's ability to generate target-specific immune responses, both in activation for the treatment of solid tumors and immune tolerance for the treatment of unwanted immune reactions and autoimmune diseases. For more information please visit www.sqzbiotech.com.

    Forward Looking Statement

    This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained that do not relate to matters of historical fact should be considered forward-looking statements, including statements relating to upcoming events and presentations, our product candidates, preclinical or clinical trial timing, and preclinical or clinical data or results. These forward-looking statements are based on management's current expectations. The words "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "estimate," "believe," "predict," "potential" or "continue" or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words.

    These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.

    These and other important factors discussed under the caption "Risk Factors" in our Form S-1 filed with the U.S. Securities and Exchange Commission (SEC) on October 26, 2020 and our other filings with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements. Any forward-looking statements represent management's estimates as of this date. New risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. While we may elect to update forward-looking statements in the future, except as required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. Although we believe the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct.

    Certain information contained in this press release relates to or is based on studies, publications, surveys and other data obtained from third-party sources and our own internal estimates and research. While we believe these third-party sources to be reliable as of the date of this press release, we have not independently verified, and we make no representation as to the adequacy, fairness, accuracy or completeness of any information obtained from third-party sources.

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  2. SQZ Biotechnologies (NYSE:SQZ), a cell therapy company developing novel treatments for multiple therapeutic areas, today announced that Armon Sharei, PhD, chief executive officer of SQZ, and additional management will participate in the following upcoming virtual investor conferences:

    Stifel 2020 Virtual Healthcare Conference
    Tuesday, November 17, 2020
    Presentation Time: 1:20 pm EST
    Webcast available

    Jefferies Virtual London Healthcare Conference
    Thursday, November 19, 2020
    Presentation Time: 7:55 am EST/12:55 pm GMT
    Webcast available

    The live webcast of SQZ's presentations can also be accessed through the "Events & Presentations" page within the Investors & Media section of the SQZ website. Replays of the webcast will be available on the…

    SQZ Biotechnologies (NYSE:SQZ), a cell therapy company developing novel treatments for multiple therapeutic areas, today announced that Armon Sharei, PhD, chief executive officer of SQZ, and additional management will participate in the following upcoming virtual investor conferences:

    Stifel 2020 Virtual Healthcare Conference

    Tuesday, November 17, 2020

    Presentation Time: 1:20 pm EST

    Webcast available

    Jefferies Virtual London Healthcare Conference

    Thursday, November 19, 2020

    Presentation Time: 7:55 am EST/12:55 pm GMT

    Webcast available

    The live webcast of SQZ's presentations can also be accessed through the "Events & Presentations" page within the Investors & Media section of the SQZ website. Replays of the webcast will be available on the SQZ website for 90 days following the event.

    About SQZ Biotech

    SQZ Biotech is a clinical-stage biotechnology company developing transformative cell therapies for patients with cancer, infectious diseases, and other serious conditions. Using its proprietary technology, SQZ has the unique ability to deliver multiple materials into many patient cell types to engineer what we believe to be an unprecedented range of potential therapeutics for a range of diseases. SQZ has the potential to create well-tolerated cell therapies that can provide therapeutic benefit for patients and potentially improve the patient experience over existing cell therapy approaches, with accelerated production timelines under 24 hours and the elimination of preconditioning and lengthy hospital stays. Our goal is to use the SQZ approach to establish a new paradigm for cell therapies. The first therapeutic applications leverage SQZ's ability to generate target-specific immune responses, both in activation for the treatment of solid tumors and immune tolerance for the treatment of unwanted immune reactions and autoimmune diseases. For more information please visit www.sqzbiotech.com.

    Forward Looking Statement

    This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained that do not relate to matters of historical fact should be considered forward-looking statements, including statements relating to upcoming events and presentations, our product candidates, preclinical or clinical trial timing, and preclinical or clinical data or results. These forward-looking statements are based on management's current expectations. The words "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "estimate," "believe," "predict," "potential" or "continue" or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words.

    These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.

    These and other important factors discussed under the caption "Risk Factors" in our Form S-1 filed with the U.S. Securities and Exchange Commission (SEC) on October 26, 2020 and our other filings with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements. Any forward-looking statements represent management's estimates as of this date. New risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. While we may elect to update forward-looking statements in the future, except as required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. Although we believe the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct.

    Certain information contained in this press release relates to or is based on studies, publications, surveys and other data obtained from third-party sources and our own internal estimates and research. While we believe these third-party sources to be reliable as of the date of this press release, we have not independently verified, and we make no representation as to the adequacy, fairness, accuracy or completeness of any information obtained from third-party sources.

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  3. SQZ presents five posters, including Phase 1 SQZ-PBMC-HPV-101 Trial-in-Progress poster

    SQZ Biotechnologies (NYSE:SQZ), a cell therapy company developing novel treatments for multiple therapeutic areas, today announced the presentation of first-time preclinical data for SQZ Antigen Presenting Cells (APCs) in combination with immune-oncology compounds in a poster at the 35th Annual Meeting of The Society for Immunotherapy of Cancer (SITC 2020) virtual poster sessions. A trial-in-progress poster for SQZ-PBMC-HPV-101 and additional posters of preclinical data from two proprietary cell therapy platforms, SQZ APCs and SQZ Activating Antigen Carriers (AACs), will also be presented. The presented data for both SQZ APCs and SQZ AACs summarize the robust…

    SQZ presents five posters, including Phase 1 SQZ-PBMC-HPV-101 Trial-in-Progress poster

    SQZ Biotechnologies (NYSE:SQZ), a cell therapy company developing novel treatments for multiple therapeutic areas, today announced the presentation of first-time preclinical data for SQZ Antigen Presenting Cells (APCs) in combination with immune-oncology compounds in a poster at the 35th Annual Meeting of The Society for Immunotherapy of Cancer (SITC 2020) virtual poster sessions. A trial-in-progress poster for SQZ-PBMC-HPV-101 and additional posters of preclinical data from two proprietary cell therapy platforms, SQZ APCs and SQZ Activating Antigen Carriers (AACs), will also be presented. The presented data for both SQZ APCs and SQZ AACs summarize the robust CD8 T cell activation observed in the pre-clinical studies, supporting their potential as promising cellular vaccine platforms.

    SQZ Posters at SITC 2020 on SQZ APCs

    Abstract #140

    Session: Cellular Therapies

    PBMC-based Cancer Vaccines Generated with Microfluidics Squeezing Demonstrate Synergistic and Durable Tumor Reduction in Combination With PD-1 Checkpoint and FAP Targeted IL-2 Variants

    Findings showed that monotherapy with SQZ-PBMC based cancer vaccines drove anti-tumor responses in a mouse model. These responses were enhanced when combined with targeted immunocytokines. In the TC-1 tumor model the following were observed:

    • Weekly administration of PD1-IL2v or FAP-IL2v in combination with mouse-derived SQZ-PBMC-HPV resulted in enhanced anti-tumor activity
    • Re-challenge of tumor-free mice treated with these combination protocols showed protective immunity without any tumor regrowth
    • E7-specifc CD8 TILs were driven by mouse-derived SQZ-PBMC-HPV and further augmented in combination with PD1-IL2v

    Abstract #169

    Session: Cellular Therapies

    Microfluidic Cell Squeezing Enables Human PBMCs as Drivers of Antigen-specific

    CD8 T Cell Responses Across a Broad Range of Antigens for Diverse Clinical Applications

    Data showed efficient generation of APCs via Cell Squeeze® technology using non-traditional human cell types that are abundant in patient leukaphereses and with multiple material types

    • Findings showed delivery of antigen and engineering of peripheral blood mononuclear cells (PBMCs) as a population as well as their individual cell subtypes, T cells, B cells, monocytes and NKs cells, as APCs
    • Antigen specific CD8 T cell responses observed in vitro using synthetic long peptides as cargo, as well as mRNA-encoding antigen as cargo

    Abstract #170

    Session: Cellular Therapies

    Microfluidics Cell Squeezing Enables Potent Cellular Vaccines in Murine Models Through Direct Cytosolic Loading and Direct CD8 T Cell Priming

    Results showed robust generation of T cells responses and tumor reduction in murine models

    • Data showed rapid kinetics of mouse splenocytes processing and presentation of antigen
    • Dosing and adjuvating processes explored to determine boosting effects and adjuvant optimization in mice
    • Data highlighting that SQZ APCs elicited more efficient CD8 tumor infiltrating lymphocyte (TIL) responses as compared to peptide vaccines in mice

    Abstract #418

    Session: In-Progress: Clinical Trials

    Clinical Trial in Progress: A Phase 1 Dose Escalation and Dose Expansion Study of SQZ-PBMC-HPV as Monotherapy and in Combination with Atezolizumab in HLA-A*02+ Patients with HPV16+ Recurrent or Metastatic Solid Tumors.

    In this ongoing clinical study, researchers are evaluating the safety and tolerability of SQZ-PBMC-HPV in patients with human papillomavirus 16 positive (HPV16+) recurrent, locally advanced or metastatic solid tumors. The poster highlights:

    • Supporting preclinical data
      • Highlighting that SQZ APCs elicited more efficient CD8 TIL responses as compared to peptide vaccines
    • Clinical trial design
      • Dose escalation and expansion cohorts for monotherapy
      • Expansion cohorts exploring SQZ-PBMC-HPV in combination with other immune oncology agents, including atezolizumab.
      • Patient eligibility across all HLA A*02+ patients with HPV16+ tumors
    • Treatment cycles, study assessments, and endpoints
    • Rapid manufacturing without pre-conditioning
      • Patient cells processed in less than 24 hours
      • Vein-to-vein time of approximately 1 week

    SQZ Poster at SITC 2020 on SQZ AACs

    Abstract #165

    Session: Cellular Therapies

    Activating Antigen Carriers Generated with Microfluidic Cell Squeezing Drive Effective Anti-Tumor Responses

    The Cell Squeeze® technology is used to generate SQZ AACs from red blood cells (RBCs) by delivering tumor-specific antigens and adjuvant. The preclinical results showed that SQZ AACs drove antigen-specific CD8 T cell responses and anti-tumor effects, supporting its potential as a cellular vaccine. Data includes:

    • Rapid SQZ AAC uptake by endogenous professional antigen presenting cells
    • SQZ AACs drove tumor regression in mice which correlates with significant increases in antigen specific CD8 TILs

    About SQZ Biotech

    SQZ Biotech is a clinical-stage biotechnology company developing transformative cell therapies for patients with cancer, infectious diseases, and other serious conditions. Using its proprietary technology, SQZ has the unique ability to deliver multiple materials into many patient cell types to engineer what we believe to be an unprecedented range of potential therapeutics for a range of diseases. SQZ has the potential to create well-tolerated cell therapies that can provide therapeutic benefit for patients and potentially improve the patient experience over existing cell therapy approaches, with accelerated production timelines under 24 hours and the elimination of preconditioning and lengthy hospital stays. Our goal is to use the SQZ approach to establish a new paradigm for cell therapies. The first therapeutic applications leverage SQZ's ability to generate target-specific immune responses, both in activation for the treatment of solid tumors and immune tolerance for the treatment of unwanted immune reactions and autoimmune diseases. For more information please visit www.sqzbiotech.com.

    Forward Looking Statement

    This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained that do not relate to matters of historical fact should be considered forward-looking statements, including statements relating to upcoming events and presentations, our product candidates, preclinical or clinical trial timing, and preclinical or clinical data or results. These forward-looking statements are based on management's current expectations. The words "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "estimate," "believe," "predict," "potential" or "continue" or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words.

    These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.

    These and other important factors discussed under the caption "Risk Factors" in our Form S-1 filed with the U.S. Securities and Exchange Commission (SEC) on October 26, 2020 and our other filings with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements. Any forward-looking statements represent management's estimates as of this date. New risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. While we may elect to update forward-looking statements in the future, except as required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. Although we believe the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct.

    Certain information contained in this press release relates to or is based on studies, publications, surveys and other data obtained from third-party sources and our own internal estimates and research. While we believe these third-party sources to be reliable as of the date of this press release, we have not independently verified, and we make no representation as to the adequacy, fairness, accuracy or completeness of any information obtained from third-party sources.

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  4. VANCOUVER, British Columbia, Nov. 09, 2020 (GLOBE NEWSWIRE) -- Quark Venture LP (Quark) and GF Securities are pleased to announce the successful listing of portfolio company, SQZ Biotechnologies (NYSE:SQZ) ("SQZ") on the New York Stock Exchange (NYSE) as of October 30, 2020. This announcement marks Global Health Sciences (GHS) Fund's third portfolio company to successfully go public after Eloxx Pharmaceuticals, Inc., (NASDAQ:ELOX) in April 2018 and Keros Therapeutics, Inc. (NASDAQ:KROS) in April 2020.

    As one of the early investors in SQZ in 2016, alongside Polaris Partners, NanoDimension and GV (formerly Google Ventures), Quark has continued to support the growth of the company to advance its proprietary CellSqueeze® technology and its application…

    VANCOUVER, British Columbia, Nov. 09, 2020 (GLOBE NEWSWIRE) -- Quark Venture LP (Quark) and GF Securities are pleased to announce the successful listing of portfolio company, SQZ Biotechnologies (NYSE:SQZ) ("SQZ") on the New York Stock Exchange (NYSE) as of October 30, 2020. This announcement marks Global Health Sciences (GHS) Fund's third portfolio company to successfully go public after Eloxx Pharmaceuticals, Inc., (NASDAQ:ELOX) in April 2018 and Keros Therapeutics, Inc. (NASDAQ:KROS) in April 2020.

    As one of the early investors in SQZ in 2016, alongside Polaris Partners, NanoDimension and GV (formerly Google Ventures), Quark has continued to support the growth of the company to advance its proprietary CellSqueeze® technology and its application in developing impactful cell therapies for patients. The SQZ technology was invented by company founder and CEO Armon Sharei based on the research of his team in the laboratories of Klavs Jensen and Robert Langer at the Massachusetts Institute of Technology (MIT) in Boston. The company focuses on developing transformative cell therapies for patients with cancer, infectious diseases, and other serious conditions. Using its proprietary technology, SQZ has the unique ability to engineer almost any cell type and deliver multiple materials, potentially resulting in powerful, multifunctional cell therapies for a range of diseases. In 2018 Roche expanded on its existing partnership with SQZ to develop SQZ APC in oncology and SQZ is currently enrolling patients in their Phase I trial for SQZ-PBMC-HPV for patients with HPV16+ tumors.

    "We were always confident about the company's ground-breaking work to enable the development of innovative cell therapies. By physically squeezing cells, effectively opening the cell membrane and allowing desired cargo to diffuse inside, SQZ's proprietary technology overcomes the limitations of current cell therapies. SQZ's news coupled with our portfolio company Keros Therapeutics' recent IPO, marks another milestone for our GHS Fund this year, especially during this challenging time of pandemic and economic volatility," said Karimah Es Sabar, CEO & Partner, Quark Venture and Director of the GHS Fund.

    About Quark Venture LP

    Quark Venture LP is a global venture capital company, headquartered in Vancouver, British Columbia, Canada, with a health investment portfolio. Focused on equity financing of innovative life science companies with breakthrough discovery and innovation, led by outstanding scientific and business teams, our strategic goal is to identify early stage companies and support their growth and development of innovative health solutions.

    For information about Quark Venture and its innovative health enterprise portfolio, please visit www.quarkventure.com.

    About Global Health Sciences Fund 

    Global Health Sciences [GHS] Fund is a joint venture between Quark Venture LP and GF Securities established in 2016. The Fund is a diversified health sciences focused fund investing globally in innovative biotechnology and health technology companies addressing unmet medical needs through innovations in drug development, medical devices, digital health, big data/AI in health and emerging convergent technologies.

    For Media Interest Please Contact:

    Kamran Shaikh, 778-846-5406

    Primary Logo

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