SNSE Sensei Biotherapeutics Inc.

4.8
-0.31  -6%
Previous Close 5.11
Open 5.05
52 Week Low 4.7
52 Week High 26.5
Market Cap $146,864,774
Shares 30,596,828
Float 21,010,138
Enterprise Value $-15,066,226
Volume 78,027
Av. Daily Volume 93,685
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Drug Pipeline

Drug Stage Notes
SNS-301 and KEYTRUDA (pembrolizumab)
Squamous Cell Carcinoma of the Head and Neck
Phase 1/2
Phase 1/2
Development has been discontinued - noted August 4, 2021.

Latest News

  1. BOSTON, Jan. 06, 2022 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced two key promotions within the company's senior management team. Erin Colgan, formerly senior vice president of finance and administration, has been appointed to chief financial officer. Robert Pierce, M.D., formerly chief scientific officer, has been appointed chief research & development officer and will have additional responsibility for drug discovery, translational medicine, and clinical development of Sensei's pipeline programs.

    "Both Erin and Rob have made substantial contributions to Sensei, including critical roles in our…

    BOSTON, Jan. 06, 2022 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced two key promotions within the company's senior management team. Erin Colgan, formerly senior vice president of finance and administration, has been appointed to chief financial officer. Robert Pierce, M.D., formerly chief scientific officer, has been appointed chief research & development officer and will have additional responsibility for drug discovery, translational medicine, and clinical development of Sensei's pipeline programs.

    "Both Erin and Rob have made substantial contributions to Sensei, including critical roles in our initial public offering and pipeline expansion, respectively," said John Celebi, chief executive officer of Sensei Biotherapeutics. "They have each built strong teams and helped Sensei navigate a high level of growth within a complex environment. Their promotions reflect not only their accomplishments to this point, but our confidence in their respective abilities to help lead the Company into the future"

    Erin Colgan joined Sensei Biotherapeutics in 2020 and has been responsible for all accounting, finance, and business functions. Previously, Ms. Colgan was the vice president of financial and commercial planning and analysis at Intarcia Therapeutics, running the annual budgeting process as well as helping the company to prepare for a potential launch of their Type II diabetes product. She also held various accounting and finance roles of increasing responsibility over a nine-year career at Vertex Pharmaceuticals, including European Controller supporting the launch of their global cystic fibrosis franchise, overseeing the company-wide annual budgeting process, and several years leading the global commercial planning process.  Ms. Colgan began her career in public accounting at PwC where she worked in both audit and business development. She holds a Bachelor's degree in Accounting from the University of Massachusetts, Amherst.

    Dr. Pierce has more than two decades of scientific leadership and experience managing large teams dedicated to translational medicine platforms in academia and industry, particularly in immuno-oncology. His research has focused on the mechanisms of tumor-induced immune tolerance and he has longstanding expertise in the development of biomarkers to predict responses to immuno-oncology treatments. Prior to Sensei, he was the scientific director of the Immunopathology Lab in the Clinical Research Division at the Fred Hutchinson Cancer Research Center. Previously at Merck, Dr. Pierce led a team focused on the development of tissue-based biomarkers for Merck's anti-PD- 1 therapeutic antibody (pembrolizumab; KEYTRUDA®) and was the medical lead responsible for initiating the clinical trials of pembrolizumab in merkel cell carcinoma (MCC) and cutaneous T cell lymphoma (CTCL). He was also previously the chief medical officer and, subsequently, chief scientific officer of OncoSec Medical. Dr. Pierce is a board-certified Anatomic Pathologist with a strong academic and industry background in immuno-oncology. Dr. Pierce received his B.A in philosophy from Yale College and his M.D. from Brown University and residency training at the University of Washington.

    About Sensei Biotherapeutics

    Sensei Biotherapeutics is a biopharmaceutical company engaged in discovery, development, and delivery of next generation immunotherapies with an initial focus on treatments for cancer. Sensei has developed two unique approaches – its TMAb™ (Tumor Microenvironment Activated biologics) platform, comprising unique human monoclonal antibodies and alpaca derived nanobodies that are selectively active in the tumor microenvironment, and its ImmunoPhage™ platform that leverages bacteriophage to drive potent anti-tumor immune responses. Using its TMAb platform, the company has developed SNS-101, an antibody-based therapeutic in lead generation targeting an immune checkpoint gene that inhibits anti-tumor immune responses called V-domain Ig suppressor of T cell activation (VISTA). Using the ImmunoPhage platform, Sensei is developing a library of ImmunoPhage, called Phortress™, with multiple tumor-associated antigens to create a personalized, yet off-the-shelf cocktail approach for treating cancer patients. The platform is designed to enable efficient, scalable and cost-effective manufacturing to support all of Sensei's clinical programs. SNS-401-NG is an ImmunoPhage cocktail in preclinical development for the treatment of Merkel Cell Carcinoma. For more information, please visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.

    Investor Contact:

    Erin Colgan

    Chief Financial Officer

    Sensei Biotherapeutics



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  2. BOSTON, Dec. 16, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced that it has won a Comparably award for 2021 "Best CEOs."

    "What makes Comparably awards so meaningful is that they are based exclusively on employee feedback," said Elisabeth Colunio, Vice President of Human Resources. "We are thrilled but not surprised to see John recognized as a 2021 Best CEO. John is an emotionally intelligent, driven, and experienced leader focused on progressing scientific accomplishments within a collaborative and respectful culture."

    A leading workplace culture and compensation monitoring site, Comparably evaluates…

    BOSTON, Dec. 16, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced that it has won a Comparably award for 2021 "Best CEOs."

    "What makes Comparably awards so meaningful is that they are based exclusively on employee feedback," said Elisabeth Colunio, Vice President of Human Resources. "We are thrilled but not surprised to see John recognized as a 2021 Best CEO. John is an emotionally intelligent, driven, and experienced leader focused on progressing scientific accomplishments within a collaborative and respectful culture."

    A leading workplace culture and compensation monitoring site, Comparably evaluates companies based on sentiment ratings anonymously provided by employees about their workplaces. 70,000 companies were considered for inclusion in Comparably's annual rankings.

    The Best CEO Awards are derived from nationwide sentiment ratings provided by employees who anonymously rated their CEOs on during a 12-month period (November 26, 2020-November 26, 2021). The award is based on verified employee reviews and compares CEOs managing companies of the same size across the United States. Sensei's ranking places it in the top 5% of all 70,000 companies on Comparably.

    About Sensei Biotherapeutics

    Sensei Biotherapeutics is a biopharmaceutical company engaged in discovery, development, and delivery of next generation immunotherapies with an initial focus on treatments for cancer. Sensei has developed two unique approaches – its TMAb™ (Tumor Microenvironment Activated biologics) platform, comprising unique human monoclonal antibodies and alpaca derived nanobodies that are selectively active in the tumor microenvironment, and its ImmunoPhage™ platform that leverages bacteriophage to fully engage the immune system. Using its TMAb platform, the company has developed SNS-101, an antibody-based therapeutic in lead generation targeting an immune checkpoint gene that inhibits anti-tumor immune responses called V-domain Ig suppressor of T cell activation (VISTA). Using the ImmunoPhage platform, Sensei is developing a library of ImmunoPhage, called Phortress™, with multiple tumor-associated antigens to create a personalized, yet off-the-shelf cocktail approach for treating cancer patients. The platform is designed to enable efficient, scalable and cost-effective manufacturing to support all of Sensei's clinical programs. SNS-401-NG is an ImmunoPhage cocktail in preclinical development for the treatment of Merkel Cell Carcinoma. For more information, please visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.

    Investor Contact:

    Erin Colgan

    SVP, Finance and Administration

    Sensei Biotherapeutics



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  3. BOSTON, Dec. 13, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced it was added to the NASDAQ Biotechnology Index (NASDAQ:NBI), effective prior to market open on Monday, December 20, 2021.

    The NBI was launched in 1993 and includes securities of NASDAQ-listed companies that are classified according to the Industry Classification Benchmark as either biotechnology or pharmaceutical companies. Companies in the NBI must meet eligibility requirements, including average daily trading volume, minimum market capitalization, and other criteria. The index is evaluated annually in December and serves as the…

    BOSTON, Dec. 13, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced it was added to the NASDAQ Biotechnology Index (NASDAQ:NBI), effective prior to market open on Monday, December 20, 2021.

    The NBI was launched in 1993 and includes securities of NASDAQ-listed companies that are classified according to the Industry Classification Benchmark as either biotechnology or pharmaceutical companies. Companies in the NBI must meet eligibility requirements, including average daily trading volume, minimum market capitalization, and other criteria. The index is evaluated annually in December and serves as the basis for the iShares NASDAQ Biotechnology Index Fund.

    For more information about the NASDAQ Biotechnology Index, please visit nasdaqomx.com.

    About Sensei Biotherapeutics

    Sensei Biotherapeutics is a biopharmaceutical company engaged in discovery, development, and delivery of next generation immunotherapies with an initial focus on treatments for cancer. Sensei has developed two unique approaches – its TMAb™ (Tumor Microenvironment Activated biologics) platform, comprising unique human monoclonal antibodies and alpaca derived nanobodies that are selectively active in the tumor microenvironment, and its ImmunoPhage™ platform that leverages bacteriophage to fully engage the immune system. Using its TMAb platform, the company has developed SNS-101, an antibody-based therapeutic in lead generation targeting an immune checkpoint gene that inhibits anti-tumor immune responses called V-domain Ig suppressor of T cell activation (VISTA). Using the ImmunoPhage platform, Sensei is developing a library of ImmunoPhage, called Phortress™, with multiple tumor-associated antigens to create a personalized, yet off-the-shelf cocktail approach for treating cancer patients. The platform is designed to enable efficient, scalable and cost-effective manufacturing to support all of Sensei's clinical programs. SNS-401-NG is an ImmunoPhage cocktail in preclinical development for the treatment of Merkel Cell Carcinoma. For more information, please visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.

    Cautionary Note Regarding Forward-Looking Statements

    Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as "believe", "expect", "may", "plan", "potential", "will", and similar expressions, and are based on Sensei's current beliefs and expectations. These forward-looking statements include expectations regarding the development of Sensei's product candidates and platforms. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the development of therapeutic product candidates, such as preclinical discovery and development, conduct of clinical trials and related regulatory requirements, Sensei's reliance on third parties over which it may not always have full control, and other risks and uncertainties that are described in Sensei's Annual Report on Form 10-K filed with the U.S. Securities and Exchange Commission (SEC) on March 30, 2021 and Sensei's other Periodic Reports filed with the SEC. Any forward-looking statements speak only as of the date of this press release and are based on information available to Sensei as of the date of this release, and Sensei assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise.

    Investor Contact:

    Erin Colgan

    SVP, Finance and Administration

    Sensei Biotherapeutics



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  4. BOSTON, Nov. 19, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced its participation in a fireside chat during the Piper Sandler 33rd Annual Virtual Healthcare conference being held from November 29 to December 2, 2021.

    John Celebi, president and chief executive officer and Erin Colgan, senior vice president of finance and administration of Sensei Biotherapeutics, participated in a pre-recorded fireside chat. The webcast will be made available beginning 10:00 am ET on Monday, November 22, 2021, on the Events & Presentations section of Sensei's website at www.senseibio.com. A replay of the webcast…

    BOSTON, Nov. 19, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced its participation in a fireside chat during the Piper Sandler 33rd Annual Virtual Healthcare conference being held from November 29 to December 2, 2021.

    John Celebi, president and chief executive officer and Erin Colgan, senior vice president of finance and administration of Sensei Biotherapeutics, participated in a pre-recorded fireside chat. The webcast will be made available beginning 10:00 am ET on Monday, November 22, 2021, on the Events & Presentations section of Sensei's website at www.senseibio.com. A replay of the webcast will be on the website for approximately 90 days following the event.

    About Sensei Biotherapeutics

    Sensei Biotherapeutics is a biopharmaceutical company engaged in discovery, development, and delivery of next generation immunotherapies with an initial focus on treatments for cancer. Sensei has developed two unique approaches – its TMAb™ (Tumor Microenvironment Activated biologics) platform, comprising unique human monoclonal antibodies and alpaca derived nanobodies that are selectively active in the tumor microenvironment, and its ImmunoPhage™ platform that leverages bacteriophage to drive the generation of tumor antigen-specific immune responses. Using its TMAb platform, the company has developed SNS-101, an antibody-based therapeutic targeting an immune checkpoint gene that inhibits anti-tumor immune responses called V-domain Ig suppressor of T cell activation (VISTA). Using the ImmunoPhage platform, Sensei is developing a library of ImmunoPhage, called Phortress™, with multiple tumor-associated antigens to create a personalized, yet off-the-shelf cocktail approach for treating cancer patients. The platform is designed to enable efficient, scalable and cost-effective manufacturing to support all of Sensei's clinical programs. SNS-401-NG is an ImmunoPhage cocktail in preclinical development for the treatment of Merkel Cell Carcinoma. For more information, please visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.

    Investor Contact:

    Lora Pike

    VP, Investor Relations and Communications

    Sensei Biotherapeutics



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  5. V-domain Ig-containing suppressor of T-cell activation (VISTA) is a novel immune checkpoint protein that has been recognized as an important potential immunotherapeutic target

    Preclinical data demonstrate that SNS-101 selectivity binds the active form of VISTA induced by the low pH environment of a tumor, which could overcome the challenges of rapid target-mediated drug elimination in the blood

    IND-enabling studies underway for SNS-101

    Company to webcast VISTA science symposium with a leading thought leader, Professor Robert Schreiber, Ph.D., on Tuesday, November 16 at 4:00 p.m. ET

    BOSTON, Nov. 12, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development…

    V-domain Ig-containing suppressor of T-cell activation (VISTA) is a novel immune checkpoint protein that has been recognized as an important potential immunotherapeutic target

    Preclinical data demonstrate that SNS-101 selectivity binds the active form of VISTA induced by the low pH environment of a tumor, which could overcome the challenges of rapid target-mediated drug elimination in the blood

    IND-enabling studies underway for SNS-101

    Company to webcast VISTA science symposium with a leading thought leader, Professor Robert Schreiber, Ph.D., on Tuesday, November 16 at 4:00 p.m. ET

    BOSTON, Nov. 12, 2021 (GLOBE NEWSWIRE) -- Sensei Biotherapeutics, Inc. (NASDAQ:SNSE), an immunotherapy company focused on the discovery and development of next generation therapeutics for cancer, today announced the first preclinical data for SNS-101, its anti-VISTA (V-domain Ig suppressor of T cell activation) product candidate. The data will be presented during a poster session on November 13, 2021, at the Society for Immunotherapy of Cancer's (SITC 2021) 36th Annual Meeting in Washington, D.C. and virtually.

    "VISTA has been recognized for years as an important immune checkpoint but has been difficult to drug due to its unique pH-dependent biology," said Robert Pierce, M.D. chief scientific officer of Sensei Biotherapeutics. "VISTA is primarily expressed on myeloid cells, a hub of immunosuppressive activity, and functions as a checkpoint exclusively under acidic conditions where it binds to its receptor, PSGL-1. Our scientific team has been evaluating VISTA for several years. Accordingly, we believe, the key to unlocking the power of this checkpoint lies with the development of an antibody that selectively binds the active form of VISTA that is only present within the low pH of the tumor microenvironment. At SITC, we are excited to share the preclinical data demonstrating that SNS-101 binds active VISTA with high affinity and significant selectivity (~600-fold increase at pH 6.0 versus 7.4)."

    Dr. Pierce continued, "We are also encouraged by early in vivo evidence from a human VISTA knock-in mouse model showing improved immune responses, including the anticipated combination effect with anti-PD1 in a PD1 blockade responsive tumor model. We continue to expand on this research and are looking forward to sharing more in vivo data at a future medical conference. IND-enabling studies are already underway to evaluate the potential of SNS-101 to become a novel treatment for solid cancers, as both a monotherapy and in combination, that overcomes on-target/off-tumor toxicities seen today with other I/O approaches."

    Preclinical data for SNS-101 are being presented in a poster (#228) titled: "Antagonistic pH-selective VISTA antibody SNS-101 potentiates anti-PD-1/PD-L1-induced anti-tumor immunity." A summary of data in the poster include:

    • Preclinical data demonstrated that SNS-101 successfully blocked the interaction of VISTA with its PSGL-1 receptor, demonstrating high-affinity binding to low pH-VISTA sub-nanomolar affinity with exemplary (>600-fold) pH-selectivity vs. physiologic pH-VISTA.
    • SNS-101, in combination with an anti-PD-1 inhibitor, led to superior anti-tumor activity compared to PD-1 alone.
    • SNS-101 is a fully human IgG1 and has entered IND-enabling studies.

    Sensei will host a virtual science symposium on Tuesday, November 16, 2021, at 4:00 p.m. Eastern Time to discuss the potential of the VISTA checkpoint inhibitor to address current limitations of immune checkpoint therapy. The event will be hosted by Sensei's management team and will include a presentation on VISTA biology by Robert Schreiber, Ph.D., the Andrew M. Bursky and Jane M. Bursky Distinguished Professor of Pathology and Immunology, Professor of Molecular Microbiology and co-leader of the tumor immunology program at the Siteman Comprehensive Cancer Center and Founding Director of the Center for Human Immunology and Immunotherapy Programs at the Washington University School of Medicine.

    A live webcast of the symposium will be available under "Events & Presentations" in the Investors section of the company's website at www.senseibio.com. An archived replay will be available for approximately 90 days following the event.

    About VISTA (V-domain Ig suppressor of T cell activation)

    VISTA (B7-H5) is recognized as an important immune checkpoint regulator that is expressed primarily on myeloid cells, a hub of immunosuppressive activity, and acts via binding to its receptor on T-cells (PSGL-1) at sub physiologic pH. Disrupting the interaction of VISTA and its receptor on T-cells has been shown to enhance T-cell activation and tumor cell death. The VISTA-PSGL-1 T-cell checkpoint is activated under low pH conditions such as the tumor microenvironment. VISTA is found to be expressed in numerous cancer types and appears to be associated with PD-1 resistance.

    The therapeutic hypothesis that Sensei believes differentiates its VISTA program is that an effective and safe inhibitory anti-VISTA antibody must demonstrate: (1) selective binding to the active form of VISTA (protonated/low pH) in order to avoid target mediated drug disposition and on-target/off-tumor effects; (2) effective inhibition of active VISTA's interaction with PSGL-1; and (3) Fc-mediated activation of tumor resident myeloid cells to facilitate conversion from an immunosuppressive to an immune-activating phenotype.

    About SNS-101

    SNS-101 is a potent, pH-dependent fully human monoclonal antibody designed to block the interaction of VISTA, a novel immune checkpoint that is expressed primarily on myeloid cells, with its receptor, PSGL-1. Selectivity is achieved because SNS-101 targets the active (i.e., protonated) VISTA present in the low pH tumor microenvironment. SNS-101 was selected based on 1) the lack of significant binding to VISTA at physiologic pH (i.e., deprotonated VISTA in the blood), and 2) its high-affinity binding to active VISTA (pH 6.0), which yielded a > 600-fold selectivity. Based on the biochemical properties of SNS-101, Sensei anticipates tumor microenvironment selective activity for this preclinical product candidate. VISTA has been shown to be expressed in numerous tumor types, including non-small cell lung cancer (NSCLC).

    About Sensei Biotherapeutics

    Sensei Biotherapeutics is a biopharmaceutical company engaged in discovery, development, and delivery of next generation immunotherapies with an initial focus on treatments for cancer. Sensei has developed two unique approaches – its TMAb™ (Tumor Microenvironment Activated biologics) platform, comprising unique human monoclonal antibodies and alpaca derived nanobodies that are selectively active in the tumor microenvironment, and its ImmunoPhage™ platform that leverages bacteriophage to drive the generation of tumor antigen-specific immune responses. Using its TMAb platform, the company has developed SNS-101, an antibody-based therapeutic targeting an immune checkpoint gene that inhibits anti-tumor immune responses called V-domain Ig suppressor of T cell activation (VISTA). Using the ImmunoPhage platform, Sensei is developing a library of ImmunoPhage, called Phortress™, with multiple tumor-associated antigens to create a personalized, yet off-the-shelf cocktail approach for treating cancer patients. The platform is designed to enable efficient, scalable and cost-effective manufacturing to support all of Sensei's clinical programs. SNS-401-NG is an ImmunoPhage cocktail in preclinical development for the treatment of Merkel Cell Carcinoma. For more information, please visit www.senseibio.com, and follow the company on Twitter @SenseiBio and LinkedIn.

    Cautionary Note Regarding Forward-Looking Statements

    Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as "believe", "expect", "may", "plan", "potential", "will", and similar expressions, and are based on Sensei's current beliefs and expectations. These forward-looking statements include expectations regarding the development of Sensei's product candidates and platforms, and the potential attributes and benefits of Sensei's TMAb technology and SNS-101. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the development of therapeutic product candidates, such as preclinical discovery and development, conduct of clinical trials and related regulatory requirements, Sensei's reliance on third parties over which it may not always have full control, and other risks and uncertainties that are described in Sensei's Annual Report on Form 10-K filed with the U.S. Securities and Exchange Commission (SEC) on March 30, 2021 and Sensei's other Periodic Reports filed with the SEC. Any forward-looking statements speak only as of the date of this press release and are based on information available to Sensei as of the date of this release, and Sensei assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise.

    Investor Contact:

    Lora Pike

    VP, Investor Relations and Communications

    Sensei Biotherapeutics

    Media Contact:

    Mike Beyer

    Sam Brown Inc. Healthcare Communications

    312-961-2502

    sambrown.com



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