PSTX Poseida Therapeutics Inc.

11.1
-0.12  -1%
Previous Close 11.22
Open 11.22
52 Week Low 7.63
52 Week High 17.62
Market Cap $686,202,111
Shares 61,820,010
Float 61,413,869
Enterprise Value $399,290,710
Volume 64,009
Av. Daily Volume 159,033
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Upcoming Catalysts

Drug Stage Catalyst Date
P-PSMA-101
Castrate-resistant prostate cancer (CRPC)
Phase 1
Phase 1
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Drug Pipeline

Drug Stage Notes
P-BCMA-101
Multiple myeloma
Phase 1/2
Phase 1/2
Phase 1/2 trial enrolling at a slower pace than planned. Phase 2 dosing decision due early 2021.

Latest News

  1. SAN DIEGO, Nov. 12, 2020 /PRNewswire/ -- Poseida Therapeutics, Inc. (NASDAQ:PSTX), a clinical-stage biopharmaceutical company utilizing proprietary gene engineering platform technologies to create cell and gene therapeutics with the capacity to cure, today announced an operational update and financial results for the quarter ended September 30, 2020.

    "During our first quarter as a publicly traded company, we continued to maintain our focus on research innovation and advancement of our clinical programs, while also building new strategic collaborations," said Eric Ostertag, M.D., Ph.D., Chief Executive Officer of Poseida. "In early September, we released data demonstrating new manufacturing technology that has the potential to create more efficacious cell therapies and have now implemented that technology across our entire CAR-T pipeline. In October, we announced a research collaboration with TScan Therapeutics to evaluate the feasibility of producing a novel cell-based therapeutic for the treatment of COVID-19. This collaboration will expand our platforms to include T cell receptor-engineered T cell (TCR-T) therapies and further expand the indications we can potentially treat beyond oncology."

    Program Updates

    P-PSMA-101

    P-PSMA-101 is a solid tumor autologous CAR-T product candidate being developed to treat patients with metastatic castrate resistant prostate cancer. The program started enrollment in May 2020. On November 2, 2020, the Company announced that a clinical hold placed on the trial was lifted by the FDA.  The trial has now resumed with minor protocol modifications to increase patient compliance and safety. The protocol changes are specific to the P-PSMA-101 program and do not affect the ongoing P-BCMA-101 clinical trial. The Company now expects to provide an initial data update in mid-2021.

    P-BCMA-101

    P-BCMA-101 is an autologous CAR-T product candidate for the treatment of patients with relapsed/refractory multiple myeloma.  The program is currently enrolling in an expanded Phase 1 clinical trial to inform the potentially registrational Phase 2 clinical trial.  Phase 1 dose expansion enrollment continues, although at a slower pace than planned due in part to the COVID-19 pandemic.  Further, the Company expects to make a Phase 2 dosing decision on P-BCMA-101 by early 2021. 

    At the CAR-TCR Digital Week meeting on September 16, 2020, the Company presented data related to CAR-T manufacturing optimizations and also illustrated the impact of these optimizations with preliminary clinical analysis of the first patients dosed in the P-BCMA-101 Phase 1 expansion trial.

    P-BCMA-ALLO1

    The Company's first allogeneic CAR-T product candidate, P-BCMA-ALLO1, is in development for the treatment of relapsed/refractory multiple myeloma and is designed to be fully allogeneic, with genetic edits designed to reduce or eliminate both host-vs-graft and graft-vs-host alloreactivity. The program is proceeding toward an IND filing which is expected in the first half 2021.

    P-MUC1C-ALLO1

    This allogeneic CAR-T product candidate is in preclinical development with the potential to treat a wide range of solid tumors, including breast and ovarian cancers. The program is proceeding with an expected IND filing in 2021.

    P-OTC-101 Gene Therapy Program

    P-OTC-101 is the Company's first liver-directed gene therapy program for in vivo treatment of urea cycle disease caused by congenital mutations in the OTC gene, a condition characterized by high unmet medical need. The Company now expects to submit an IND in 2022 due to pandemic related factors, including longer timelines due to COVID-19 vaccine-related capacity constraints at certain vendors.

    Early Stage Development Programs

    For programs in early development, including the fully allogeneic Dual CAR programs, P-PSMA-ALLO1 and P-MMUT-101, the Company expects to update specific guidance at a later date, as it gains further clarity on the timelines and any impacts of the COVID-19 pandemic.

    Other Operational Updates and Upcoming Events

    Collaboration agreement with TScan Therapeutics to explore developing allogeneic T cell receptor therapies for the treatment of COVID-19

    In October, the Company and TScan Therapeutics announced a research collaboration and license agreement to explore the use of the Company's fully allogeneic stem cell memory T cell platform in combination with TScan's proprietary TCR platform and findings related to SARS-CoV-2. The collaboration will allow the Company to explore platform and T cell technology utilizing one or more TCRs in allogeneic cell therapy applications.

    Piper Sandler 32nd Annual Virtual Healthcare Conference

    The Company is participating in a virtual conference that will be made available at 10 am ET on November 23, 2020, ahead of the conference start scheduled for December 1, 2020. The audio recording of the presentation, formatted as a fireside chat, will be available through the conference coordinators and posted on the Company's website.

    62nd American Society of Hematology (ASH) Annual Meeting and Exposition

    The Company plans to provide an update on the P-BCMA-101 Phase 1 expansion trial in early December with an oral presentation at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition scheduled for Saturday, December 5, 2020.

    Financial Results

    Research and Development Expenses

    Research and development expenses were $27.0 million for the three months ended September 30, 2020, compared to $15.7 million for the same period in 2019. For the nine months ended September 30, 2020, research and development expenses were $75.6 million, compared to $41.2 million for the same period in 2019. The increase in both periods was primarily due to increased headcount, external costs related to preclinical programs and clinical stage programs, including the ongoing P-BCMA-101 and P-PSMA-101 clinical trials, and internal costs related to facilities development.

    General and Administrative Expenses

    General and administrative expenses were $6.5 million for the three months ended September 30, 2020, compared to $4.0 million for the same period in 2019.  General and administrative expenses were $15.6 million for the nine months ended September 30, 2020, compared to $14.4 million for the same period in 2019. The increase in both periods was primarily due to increased headcount and professional fees associated with becoming a publicly traded company.

    Net Losses

    Net losses were $34.4 million and $93.6 million for the three and nine months ended September 30, 2020, respectively, and $21.0 million and $62.9 million for the three and nine months ended September 30, 2019, respectively. 

    Cash Position

    As of September 30, 2020, cash, cash equivalents and marketable securities were $341.5 million. Net proceeds from the Company's initial public offering, which closed in July 2020, were $205.7 million.

    About Poseida Therapeutics, Inc.

    Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing our proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure. We have discovered and are developing a broad portfolio of product candidates in a variety of indications based on our core proprietary platforms, including our non-viral piggyBac® DNA Modification System, Cas-CLOVER™ site-specific gene editing system and nanoparticle- and AAV-based gene delivery technologies. Our core platform technologies have utility, either alone or in combination, across many cell and gene therapeutic modalities and enable us to engineer our wholly-owned portfolio of product candidates that are designed to overcome the primary limitations of current generation cell and gene therapeutics.

    Forward-Looking Statements

    Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding, among other things, the potential benefits of Poseida's technology platforms and product candidates, Poseida's plans and strategy with respect to developing its technologies and product candidates and anticipated timelines and milestones with respect to Poseida's development programs. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon Poseida's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with development and regulatory approval of novel product candidates in the biopharmaceutical industry and the other risks described in Poseida's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Poseida undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

    Poseida Therapeutics, Inc.

    Selected Financial Data

    (Unaudited) 

     (In thousands, except share amounts)



    STATEMENTS OF OPERATIONS







    Three Months Ended September 30,



    Nine Months Ended September 30,





    2020



    2019



    2020



    2019

    Operating expenses:

















    Research and development



    $         27,016



    $         15,696



    $        75,636



    $        41,189

    General and administrative



    6,458



    4,007



    15,553



    14,449

    Increase in contingent consideration





    1,060





    6,683

    Total operating expenses



    33,474



    20,763



    91,189



    62,321

    Loss from operations



    (33,474)



    (20,763)



    (91,189)



    (62,321)

    Other income (expense):

















    Interest expense



    (848)



    (935)



    (2,654)



    (2,633)

    Other income (expense), net



    (92)



    744



    216



    2,040

    Net loss before income tax



    (34,414)



    (20,954)



    (93,627)



    (62,914)

    Income tax benefit









    Net loss



    $       (34,414)



    $       (20,954)



    $      (93,627)



    $      (62,914)

    Net loss per share attributable to common stockholders, basic and diluted



    $           (0.63)



    $           (1.65)



    $          (3.43)



    $          (5.06)

    Weighted-average shares of common stock, basic and diluted



    54,973,788



    12,665,834



    27,324,297



    12,427,367





































    SELECTED BALANCE SHEET DATA











    September 30,

    2020



    December 31,

    2019



    Cash, cash equivalents and short-term investments



    $              341,457



    $              125,318



    Total assets



    405,171



    146,996



    Total liabilities



    109,335



    74,334



    Convertible preferred stock



    -



    222,173



    Total stockholders' equity (deficit)



    295,836



    (149,511)



























     

    Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/poseida-therapeutics-reports-operational-update-and-financial-results-for-third-quarter-2020-301172363.html

    SOURCE Poseida Therapeutics, Inc.

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  2. SAN DIEGO, Nov. 2, 2020 /PRNewswire/ -- Poseida Therapeutics, Inc., (NASDAQ:PSTX), a clinical-stage biopharmaceutical company dedicated to utilizing its proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure, today announced the U.S. Food and Drug Administration (FDA) has lifted a clinical hold on the Company's Phase 1 study of P-PSMA-101 in metastatic castration-resistant prostate cancer (mCRPC) and plans to resume the trial immediately. P-PSMA-101 is the company's first solid tumor autologous CAR-T therapeutic candidate.

    The Company has agreed to implement protocol amendments intended to increase patient compliance and safety that include modified inclusion and exclusion criteria and frequency of monitoring and laboratory testing.

    About P-PSMA-101

    P-PSMA-101 is an autologous CAR-T therapeutic candidate in metastatic castration-resistant prostate cancer (mCRPC). It is designed to target prostate-specific membrane antigen (PSMA), which is expressed on mCRPC cells. It was developed using Poseida's proprietary piggyBac DNA Modification System, which produces product candidates with a high percentage of stem cell memory T (TSCM) cells. A Phase 1 trial of P-PSMA-101 in mCRPC was initiated in May 2020.

    About Poseida Therapeutics, Inc.

    Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing our proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure. We have discovered and are developing a broad portfolio of product candidates in a variety of indications based on our core proprietary platforms, including our non-viral piggyBac® DNA Modification System, Cas-CLOVER™ site-specific gene editing system and nanoparticle- and AAV-based gene delivery technologies. Our core platform technologies have utility, either alone or in combination, across many cell and gene therapeutic modalities and enable us to engineer our wholly-owned portfolio of product candidates that are designed to overcome the primary limitations of current generation cell and gene therapeutics.

    Forward-Looking Statements

    Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon Poseida's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with development and regulatory approval of novel product candidates in the biopharmaceutical industry and the other risks described in Poseida's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Poseida undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

    Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/poseida-therapeutics-announces-clinical-hold-lifted-on-phase-i-autologous-car-t-study-in-prostate-cancer-301164397.html

    SOURCE Poseida Therapeutics, Inc.

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  3. SAN DIEGO and WALTHAM, Mass., Oct. 21, 2020 /PRNewswire/ -- Poseida Therapeutics, Inc. (NASDAQ:PSTX), a clinical-stage biopharmaceutical company utilizing proprietary gene engineering platform technologies to create cell and gene therapeutics with the capacity to cure, and TScan Therapeutics, Inc., a biopharmaceutical company focused on the development of T cell receptor (TCR)-engineered T cell therapies in oncology, today announced a research collaboration and license agreement to explore developing TCR-T cell therapies for the treatment of COVID-19.  Poseida's allogeneic T cell platform will be used in combination with TScan's discovered immunodominant epitopes and TCR sequences for the development and commercialization of allogeneic TCR-T…

    SAN DIEGO and WALTHAM, Mass., Oct. 21, 2020 /PRNewswire/ -- Poseida Therapeutics, Inc. (NASDAQ:PSTX), a clinical-stage biopharmaceutical company utilizing proprietary gene engineering platform technologies to create cell and gene therapeutics with the capacity to cure, and TScan Therapeutics, Inc., a biopharmaceutical company focused on the development of T cell receptor (TCR)-engineered T cell therapies in oncology, today announced a research collaboration and license agreement to explore developing TCR-T cell therapies for the treatment of COVID-19.  Poseida's allogeneic T cell platform will be used in combination with TScan's discovered immunodominant epitopes and TCR sequences for the development and commercialization of allogeneic TCR-T cell therapies.

    "The TScan relationship will allow us to expand our platform and T cell experience, utilizing one or more TCRs in allogeneic cell therapy applications," said Devon Shedlock, Ph.D., Senior Vice President of Research and Development for Poseida. "We are impressed by TScan's novel platform for the discovery of TCRs. This, coupled with the opportunity to explore our allogeneic T cell platform's potential for also treating diseases outside of oncology, including COVID-19 and eventually other infectious diseases, represents an exciting and differentiated approach."

    "Therapeutic strategies to treat COVID-19 have largely focused on neutralizing antibodies that block viral infection or small molecule drugs that inhibit viral replication," said Gavin MacBeath, Ph.D., Chief Scientific Officer at TScan. "We are excited about the possibility of combining our SARS-CoV-2 TCR findings with Poseida's allogeneic T Cell approach to explore a potential cellular therapy for patients with COVID-19. We look forward to collaborating with the Poseida team on this approach."

    Emerging studies suggest that patients who fail to mount effective T cell responses often end up with more severe and life-threatening disease. Administering virus-specific engineered T cells may provide a rapid and effective way to address this deficiency. Results from TScan demonstrate that generating a memory T cell response targeting specific proteins may be important for fighting the virus and for long-term immunity. Combining these findings with Poseida's off-the-shelf allogeneic T cell product approach, which has generated a very high percentage of stem cell memory T cells (Tscm) and has the potential to yield hundreds of doses from a single manufacturing run using proprietary booster molecule technology, may provide both an immediate therapeutic effect, as well as longer-term immunity.

    TScan recently announced data generated by their TCR/Target Discovery platform identifying the precise targets of T cells isolated from COVID-19 convalescent patients, along with the TCRs that recognize them. A core set of targets were shared among patients with the same human leukocyte antigen (HLA) type and were primarily located outside the spike protein. A paper describing this work is currently in press at Immunity, a Cell Press journal. TScan worked with clinical partner Atlantic Health Systems to recruit recovering COVID-19 patients for this work.  Combining these findings with Poseida's off-the-shelf allogeneic T cell product platform may provide an accessible cell-based therapy for patients with insufficient T cell responses.

    Under the terms of the Agreement, Poseida will gain access to TScan's data and IP related to TCR sequences and targets potentially valuable in treating COVID-19, and TScan will provide TCR expertise and counsel to the research collaboration.  Detailed financial terms of the collaboration were not disclosed. 

    About Poseida Therapeutics, Inc.

    Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing our proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure. We have discovered and are developing a broad portfolio of product candidates in a variety of indications based on our core proprietary platforms, including our non-viral piggyBac® DNA Modification System, Cas-CLOVER™ site-specific gene editing system and nanoparticle- and AAV-based gene delivery technologies. Our core platform technologies have utility, either alone or in combination, across many cell and gene therapeutic modalities and enable us to engineer our wholly-owned portfolio of product candidates that are designed to overcome the primary limitations of current generation cell and gene therapeutics.

    About TScan Therapeutics

    TScan discovers and develops transformative T cell therapies (TCR-T) to treat liquid cancers, solid tumors, and other serious diseases. Our proprietary, high-throughput platform identifies previously uncharacterized, clinically-derived shared T cell antigens and all off-target TCR interactions, to enable the development of highly efficacious TCR-Ts with minimal off-target effects. Lead program TSC-100 is expected to enter clinical development for liquid cancers in 2021, and the Company is advancing additional TCR-Ts for solid cancers. TScan was co-founded by Chair Christoph Westphal (Partner, Longwood Fund) based on pioneering research from the Elledge Lab at Brigham and Women's Hospital. The Company has raised over $80 million to date from leading strategic collaborators and investors including Longwood Fund, Novartis Institutes for Biomedical Research, Astellas Venture Management, Novartis Venture Fund, Bessemer Venture Partners, GV, 6 Dimensions Capital, and Pitango Venture Capital.

    Forward-Looking Statements

    Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon Poseida's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with development and regulatory approval of novel product candidates in the biopharmaceutical industry and the other risks described in Poseida's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Poseida undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

    Cision View original content to download multimedia:http://www.prnewswire.com/news-releases/poseida-therapeutics-and-tscan-therapeutics-announce-research-collaboration-and-license-agreement-to-explore-developing-allogeneic-t-cell-receptor-therapies-for-the-treatment-of-covid-19-301156338.html

    SOURCE Poseida Therapeutics, Inc.

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  4. - Longitude Venture Partners IV will build on the Firm's commitment to improve clinical outcomes, enhance patient quality of life, and drive efficiency in healthcare delivery -

    - In 2020 to date, Longitude portfolio companies announced 4 IPOs and 3 M&A transactions -

    MENLO PARK, Calif. and GREENWICH, Conn. and BOSTON, Sept. 23, 2020 (GLOBE NEWSWIRE) -- Longitude Capital, a leading healthcare venture capital firm, today announced the closing of Longitude Venture Partners IV, L.P. ("LVP4"), with $585 million in capital commitments. LVP4, the largest fund that Longitude Capital has raised to date, will build on the proven strategy of its predecessor funds by investing in biotechnology, medical technology, and health solutions companies that…

    - Longitude Venture Partners IV will build on the Firm's commitment to improve clinical outcomes, enhance patient quality of life, and drive efficiency in healthcare delivery -

    - In 2020 to date, Longitude portfolio companies announced 4 IPOs and 3 M&A transactions -

    MENLO PARK, Calif. and GREENWICH, Conn. and BOSTON, Sept. 23, 2020 (GLOBE NEWSWIRE) -- Longitude Capital, a leading healthcare venture capital firm, today announced the closing of Longitude Venture Partners IV, L.P. ("LVP4"), with $585 million in capital commitments. LVP4, the largest fund that Longitude Capital has raised to date, will build on the proven strategy of its predecessor funds by investing in biotechnology, medical technology, and health solutions companies that seek to transform the healthcare industry.

    "We are in the golden era of medical and biological innovation. The significant unmet clinical needs and the inefficiencies of our current healthcare system are driving meaningful scientific breakthroughs and creative solutions," said Patrick Enright, co-founder and Managing Director of Longitude Capital. Since inception in 2006, Longitude Capital has raised nearly $2 billion in cumulative capital commitments and managed over 30 company exits. "We are fortunate to have helped build many successful healthcare companies and look forward to working alongside the next wave of entrepreneurs and scientists to advance critical medicines, devices, and health solutions to the marketplace."

    Juliet Bakker, co-founder and Managing Director of Longitude Capital, added, "We are thankful for the continued support of, and partnerships with, our investors who value our differentiated venture growth investing approach, experienced team, and passion for forging new frontiers in healthcare."

    LVP4 will invest opportunistically across all stages of a company's development through a variety of approaches that include traditional venture capital investing and special situations such as spin-outs, equity-linked transactions, and private investments in public equities. Many of these investments stem from Longitude's proprietary research of targeted healthcare sectors, therapeutic areas, and technologies of interest.

    Longitude Capital's recent Initial Public Offerings (IPOs) and exits include 89bio (NASDAQ:ETNB), Aimmune (NASDAQ:AIMT, recently agreed to be acquired by Nestlé Health Science))), Axonics Modulation Technologies (NASDAQ:AXNX), Checkmate Pharmaceuticals (NASDAQ:CMPI), Inflazome (acquired by Roche), Inozyme Pharma (NASDAQ:INZY), KaNDy Therapeutics (acquired by Bayer), Molecular Templates (NASDAQ:MTEM), Poseida Therapeutics (NASDAQ:PSTX), and Vaxcyte (NASDAQ:PCVX).

    About Longitude Capital

    Longitude Capital is a leading healthcare venture capital firm, that invests in transformative biotechnology, medical technology, and health solutions companies seeking to improve clinical outcomes, enhance quality of life, and drive efficiency of healthcare delivery. Founded in 2006, Longitude Capital invests in both privately held and publicly traded companies through a variety of investment approaches. Longitude Capital has offices in Menlo Park, CA, Greenwich, CT, and Boston, MA. For more information, including a complete listing of investments, please visit www.longitudecapital.com.

    About Longitude Capital Recent IPOs and Exits

    • 89bio is a biopharmaceutical company developing and commercializing innovative therapies for the treatment of liver and cardio-metabolic diseases. 89bio was originally spun out of Teva Pharmaceuticals in 2018 by founding investors Longitude Capital and OrbiMed, and completed its IPO in November 2019. www.89bio.com.



    • Aimmune is a biopharmaceutical company developing and commercializing treatments for potentially life-threatening food allergies. Aimmune's PALFORZIA® is the world's first approved treatment for peanut allergy. Longitude Capital was the founding institutional investor of Aimmune. In 2020, Aimmune agreed to be acquired by Nestlé Health Science for $34.50 per share in cash, representing a total equity value of $2.6 billion. www.aimmune.com.



    • Axonics Modulation Technologies is a medical technology company developing and commercializing novel implantable rechargeable sacral neuromodulation (SNM) devices for patients with urinary and bowel dysfunction. In 2018, Longitude Capital led a $40 million financing that preceded the company's IPO later that year. www.axonics.com.



    • Checkmate Pharmaceuticals is a clinical-stage biopharmaceutical company developing proprietary technology to harness the power of the immune system to combat cancer. In 2020, Longitude Capital and Novo Holdings led the company's $85 million Series C financing that preceded the company's IPO later in the year. www.checkmatepharma.com.



    • Inflazome is a biotechnology company developing small molecules that block harmful inflammation by targeting inflammasomes, protein complexes that generate signals in order to activate an immune response. In 2020, Inflazome announced its acquisition by Roche for an upfront payment of €380 million, and potential predetermined milestone payments. www.inflazome.com.



    • Inozyme Pharma is a rare disease pharmaceutical company developing novel therapeutics for the treatment of diseases of abnormal mineralization. Longitude Capital led Inozyme's $49 million Series A financing in 2017, and was joined by New Enterprise Associates, Novo Holdings, and Sanofi Ventures. Inozyme completed its initial public offering in 2020. www.inozyme.com.



    • KaNDy Therapeutics was a UK-based clinical-stage company focused on optimizing the potential of its unique NK-1,3 receptor antagonist NT-814 to treat common, chronic debilitating conditions related to menopause. In 2020, KaNDy Therapeutics was acquired by Bayer Pharmaceuticals for an upfront payment of $425 million, and a potential $450 million in R&D, regulatory milestones and additional commercial milestones.



    • Molecular Templates is a clinical-stage company focused on the discovery and development of targeted biologic therapeutics. In 2017, Longitude Capital led Molecular Template's $40 million PIPE (private investment into public equity) financing. Molecular Templates now has strategic collaborations with Takeda Pharmaceuticals and Vertex Pharmaceuticals. www.mtem.com.



    • Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing its proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure various cancers. Longitude Capital led Poseida's $30 million Series B financing in 2018. Poseida completed its IPO in 2020. www.poseida.com.



    • Vaxcyte is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. Longitude Capital invested in Vaxcyte's $22 million Series A financing and served on the Board of the company through its IPO in 2020. www.vaxcyte.com.

    About Longitude Capital Recent Investments

    • Eargo is a medical device company dedicated to improving the quality of life of people with hearing loss. Longitude Capital and Gilde Healthcare led Eargo's $81 million Series E financing in 2020. www.eargo.com.



    • Epirium Bio is a clinical-stage biopharmaceutical company that uses insights related to the biology of mitochondrial function and tissue regeneration to pursue novel and clinically significant therapeutic approaches for neuromuscular, neurodegenerative, and mitochondrial disorders. Longitude Capital and ARCH Venture Partners led Epirium's $85 million Series A financing in 2019. www.epirium.com.



    • Polares Medical is a clinical-stage medical technology company focused on the development of a unique trans-catheter mitral valve hemi-replacement system to treat patients suffering from mitral regurgitation (MR). Longitude Capital led Polares Medical's $40 million Series B financing in 2020. www.polaresmedical.com.



    • WelbeHealth is a services company dedicated to unlocking the full potential of vulnerable seniors through PACE (Program of All-Inclusive Care for the Elderly), a comprehensive medical and social care model. Longitude Capital and .406 Ventures led WelbeHealth's $30 million Series C in 2020. www.welbehealth.com.

    Source: Longitude Capital

    Contact Information
    
    Maggie Jamison
    Longitude Capital
    650-854-5700 
    

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  5. SAN DIEGO, Sept. 18, 2020 /PRNewswire/ -- Poseida Therapeutics, Inc., (NASDAQ:PSTX), a clinical-stage biopharmaceutical company dedicated to utilizing its proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure, today announced its addition as a member of the US small-cap Russell 2000® Index, effective September 18, 2020, as part of the index's quarterly initial public offering (IPO) additions.

    "We are pleased to be added to the US small-cap Russell 2000 Index, which will help increase investor exposure to our Company's mission of providing cell and gene therapies for patients with high unmet medical need," said Eric Ostertag, M.D., Ph.D., Chief Executive Officer of Poseida. "We look forward to the opportunity to expand awareness around our pipeline of differentiated product candidates for the treatment of a variety of oncology indications and orphan genetic diseases."

    Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. Approximately $9 trillion in assets are benchmarked against Russell's US indexes. Russell indexes are part of FTSE Russell, a leading global index provider.

    For more information on the Russell 2000® Index and the Russell indexes IPO additions, please visit the "Russell U.S. Index IPO Additions" section on the FTSE Russell website.

    About Poseida Therapeutics, Inc.

    Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing our proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure. We have discovered and are developing a broad portfolio of product candidates in a variety of indications based on our core proprietary platforms, including our non-viral piggyBac® DNA Modification System, Cas-CLOVER™ site-specific gene editing system and nanoparticle- and AAV-based gene delivery technologies. Our core platform technologies have utility, either alone or in combination, across many cell and gene therapeutic modalities and enable us to engineer our wholly-owned portfolio of product candidates that are designed to overcome the primary limitations of current generation cell and gene therapeutics.

    About FTSE Russell

    FTSE Russell is a leading global index provider creating and managing a wide range of indexes, data and analytic solutions to meet client needs across asset classes, style and strategies. Covering 98% of the investable market, FTSE Russell indexes offer a true picture of global markets, combined with the specialist knowledge gained from developing local benchmarks around the world.

    FTSE Russell index expertise and products are used extensively by institutional and retail investors globally. Approximately $16 trillion is currently benchmarked to FTSE Russell indexes. For over 30 years, leading asset owners, asset managers, ETF providers and investment banks have chosen FTSE Russell indexes to benchmark their investment performance and create investment funds, ETFs, structured products and index-based derivatives. FTSE Russell indexes also provide clients with tools for asset allocation, investment strategy analysis and risk management.

    A core set of universal principles guides FTSE Russell index design and management: a transparent rules-based methodology is informed by independent committees of leading market participants. FTSE Russell is focused on index innovation and customer partnership applying the highest industry standards and embracing the IOSCO Principles. FTSE Russell is wholly owned by London Stock Exchange Group.

    For more information, visit www.ftserussell.com 

    Forward-Looking Statements

    Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding the impact of Poseida's addition to the US small-cap Russell 2000® Index, the potential benefits of Poseida's technology platforms and product candidates and Poseida's plans and strategy with respect to developing its technologies and product candidates. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon Poseida's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with development and regulatory approval of novel product candidates in the biopharmaceutical industry and the other risks described in Poseida's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Poseida undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

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    SOURCE Poseida Therapeutics, Inc.

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