MRSN Mersana Therapeutics Inc.

5.11
-0.22  -4%
Previous Close 5.33
Open 5.25
52 Week Low 4.84
52 Week High 24.38
Market Cap $367,469,467
Shares 71,911,833
Float 63,107,243
Enterprise Value $194,980,466
Volume 947,819
Av. Daily Volume 1,054,791
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Upcoming Catalysts

Drug Stage Catalyst Date
Upifitamab rilsodotin (XMT-1536) - (UPGRADE)
Platinum-Sensitive Ovarian Cancer
Phase 1/2
Phase 1/2
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Drug Pipeline

Drug Stage Notes
XMT-2056
HER2-expressing tumors
Phase 1
Phase 1
Phase 1 trial to commence in mid-2022.
XMT-1660
Phase 1
Phase 1
Phase 1 trial to commence in mid-2022.
XMT-1592
Non-small cell lung cancer (NSCLC) adenocarcinoma and ovarian cancer
Phase 1
Phase 1
Phase 1 dose exploration to be complete in 2H 2022.
Upifitamab Rilsodotin (UpRi) - (UP-NEXT)
Ovarian Cancer
Phase 3
Phase 3
Phase 3 trial to be initiated in 2Q 2022.
Upifitamab Rilsodotin (XMT-1536) - (UPLIFT)
Ovarian Cancer, Non Small Cell Lung Cancer
Phase 1
Phase 1
Phase 1 initial data released September 10, 2021. Complete response rate 2.6% (2/75); overall response rate 23% (17/75) in all patients. 22 patients not evaluable. Enrollment to be completed by 3Q 2022.
XMT1522
HER2 - breast cancer
Phase 1
Phase 1
Development to be discontinued - noted January 4, 2019.

Latest News

  1. UPLIFT, a single-arm registrational trial of UpRi in platinum-resistant ovarian cancer, expected to complete enrollment in Q3 2022

    UP-NEXT, a Phase 3 trial of UpRi monotherapy maintenance in platinum-sensitive ovarian cancer, expected to initiate in Q2 2022

    Interim data from UPGRADE dose escalation umbrella trial of UpRi in combination with platinum planned for 2H 2022

    Phase 1 dose escalation studies for two first-in-class candidates, XMT-1660, a Dolasynthen B7-H4 targeted ADC and XMT-2056, an Immunosynthen STING-agonist ADC targeting HER2, both expected to initiate in mid-2022

    CAMBRIDGE, Mass., Jan. 07, 2022 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering…

    UPLIFT, a single-arm registrational trial of UpRi in platinum-resistant ovarian cancer, expected to complete enrollment in Q3 2022

    UP-NEXT, a Phase 3 trial of UpRi monotherapy maintenance in platinum-sensitive ovarian cancer, expected to initiate in Q2 2022

    Interim data from UPGRADE dose escalation umbrella trial of UpRi in combination with platinum planned for 2H 2022

    Phase 1 dose escalation studies for two first-in-class candidates, XMT-1660, a Dolasynthen B7-H4 targeted ADC and XMT-2056, an Immunosynthen STING-agonist ADC targeting HER2, both expected to initiate in mid-2022

    CAMBRIDGE, Mass., Jan. 07, 2022 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today provided its strategic priorities and anticipated milestones for 2022. Anna Protopapas, President and CEO of Mersana Therapeutics, Inc. will provide a business update at the upcoming virtual 40th Annual J.P. Morgan Healthcare Conference on Wednesday, January 12, 2022.

    "During 2021, we have made substantial progress in executing on the four strategic pillars that underlie our vision of building Mersana into an ADC leader: building UpRi into a foundational medicine in ovarian cancer, advancing a diverse pipeline of first-in-class ADCs addressing areas of high unmet medical need, driving ADC innovation and building Mersana into an organization with world-class talent," said Anna Protopapas. "With UPLIFT and UPGRADE ongoing and UP-NEXT expected to initiate in Q2 2022, we have established a highly differentiated development strategy with the goal of bringing UpRi to a broad population of ovarian cancer patients with limited options. With XMT-1660 and XMT-2056, two first-in-class candidates initiating Phase I dose escalation in mid-2022 and two additional candidates that will be disclosed during the course of year, we are expanding and diversifying our pipeline by leveraging our three innovative product engines: Dolasynthen, Dolaflexin, and Immunosynthen."

    Ms. Protopapas continued: "Our selection as a Top Place to Work by the Boston Globe is validation of the talent we have attracted to Mersana and the mission-focused culture we have built."

    Corporate Updates and 2022 Anticipated Goals and Milestones

    Build Upifitamab Rilsodotin (UpRi), a first-in-class Dolaflexin ADC targeting NaPi2b, as a foundational medicine in ovarian cancer:

    • UPLIFT, a single-arm registrational trial in platinum-resistant ovarian cancer, is expected to complete enrollment in the third quarter of 2022. UPLIFT is enrolling a broader population of patients with platinum-resistant ovarian cancer than other studies in this space through more flexible inclusion criteria with respect to lines of therapy, prior therapies, and underlying comorbidities. The primary endpoint is based on objective response rate in NaPi2b high patients, which represent approximately two-thirds of the patients as determined by a robust diagnostic assay, with a secondary endpoint in the overall population. The Company plans to enroll approximately 100 patients with high NaPi2b expression and up to 180 patients overall.



    • UP-NEXT, a Phase 3 monotherapy maintenance trial in platinum-sensitive recurrent ovarian cancer, is expected to initiate in the second quarter of 2022. The design of UP-NEXT was informed by discussions with the FDA and CHMP and could serve as a confirmatory trial that expands UpRi into earlier lines of therapy. UP-NEXT will enroll platinum-sensitive patients who have achieved a response or stable disease after platinum therapy. Prior PARP therapy is required only for BRCA mutant patients. NaPi2b high patients, which represent approximately two-thirds of the ovarian cancer population, will be enrolled. In recognition of the unmet medical need and the lack of a standard of care for these patients, the trial will be randomized against placebo.



    • UPGRADE, a Phase 1/2 combination umbrella trial in platinum-sensitive ovarian cancer, continues to enroll with interim data expected in the second half of 2022. UPGRADE is currently in a Phase 1 dose escalation trial evaluating the combination of carboplatin with UpRi for up to six cycles followed by UpRi continuation as a single-agent. The dose escalation portion of the trial is intended to determine the recommended Phase 2 dose in combination with carboplatin. The expansion portion of the trial is intended to provide proof of concept for a potential new standard of care for platinum-sensitive ovarian cancer earlier in the disease by demonstrating that the combination of platinum and UpRi followed by UpRi continuation as a single-agent could result in improved efficacy and tolerability with the ultimate goal of improved clinical benefit for patients. The trial will inform further development of UpRi in this broader and earlier line patient population.

    Build out a pipeline of highly impactful cancer medicines:

    • XMT-1592, a first Dolasynthen ADC targeting NaPi2b, is currently in a Phase 1 trial, with dose exploration expected to be complete in the second half of 2022. XMT-1592 was designed to provide Mersana with a second shot on goal in NSCLC adenocarcinoma based on the increased preclinical activity shown in this indication. The Company is continuing dose exploration to determine the recommended Phase 2 dose and plans to provide an update on next steps for this program in the second half of 2022.



    • XMT-1660, a first-in-class Dolasynthen ADC targeting B7-H4, is expected to initiate a Phase 1 dose escalation trial in mid-2022. XMT-1660 targets B7-H4, a target selectively expressed on tumors in areas of high unmet medical need including breast, endometrial and ovarian cancers. XMT-1660 is a Dolasynthen ADC that utilizes the Company's unique DolaLock payload with controlled bystander effect. Clinical experience to date with ADCs carrying the DolaLock payload has demonstrated no association with severe neutropenia, peripheral neuropathy or ocular toxicity.



    • XMT-2056, a first-in-class HER2-targeted Immunosynthen STING-agonist ADC, is expected to initiate a Phase 1 dose escalation trial in mid-2022. XMT-2056 is the Company's first ADC candidate developed using Immunosynthen, its novel STING-agonist immunostimulatory ADC platform. XMT-2056 is designed to offer a differentiated and complementary therapeutic approach to the treatment of HER2-expressing tumors. XMT-2056 targets a novel HER2 epitope with differentiated binding from trastuzumab and pertuzumab, providing an opportunity for development as a single-agent as well as in combination with well-established and investigational anti-HER2 agents. Across multiple preclinical models, XMT-2056 monotherapy demonstrated increased efficacy in comparison to benchmark agents such as a trastuzumab-TLR7/8 agonist ADC as well as a small molecule systemically-administered STING agonist. XMT-2056 also demonstrated efficacy in both high and low HER2 expression models. In addition, in preclinical models, XMT-2056 showed increased efficacy in combination with trastuzumab. XMT-2056 was generally well-tolerated in non-human primate studies with no clinical signs and no adverse findings in clinical pathology or histopathology after single and repeat IV doses.

    Build innovation and scientific leadership in ADCs

    • The Company plans to disclose two new development candidates, XMT-2068 and XMT-2175, during the first half of 2022. Both candidates were created utilizing the Company's Immunosynthen platform and are STING-agonist ADCs targeting tumor-associated antigens in the tumor microenvironment with broad expression across indications.

    Upcoming Events

    • The Company will review these corporate updates and milestones during its upcoming presentation at the upcoming virtual 40th Annual J.P. Morgan Healthcare Conference on Wednesday, January 12, 2022 at 3:00 pm ET.

    About Mersana Therapeutics

    Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to rapidly develop novel ADCs with optimal efficacy, safety and tolerability to meaningfully improve the lives of people fighting cancer. Mersana's lead product candidate, upifitamab rilsodotin (UpRi), is a Dolaflexin ADC targeting NaPi2b and is being studied in UPLIFT, a single-arm registrational trial in patients with platinum-resistant ovarian cancer, as well as in UPGRADE, a Phase 1/2 umbrella trial of UpRi in combination with other ovarian cancer therapies. XMT-1592, Mersana's second ADC product candidate targeting NaPi2b-expressing tumors, was created using Mersana's customizable and homogeneous Dolasynthen platform and is in the dose escalation portion of a Phase 1 proof-of-concept clinical trial. The Company's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, as well as XMT-2056, a STING-agonist ADC developed using the Company's Immunosynthen platform and targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). In addition, multiple partners are using Mersana's platforms to advance their ADC pipelines. Mersana was recently named among the 2021 Top Places to Work in Massachusetts by the Boston Globe. The Company routinely posts information that may be useful to investors on the "Investors and Media" section of our website at www.mersana.com.

    Forward-Looking Statements

    This press release contains "forward-looking" statements within the meaning of federal securities laws. These forward-looking statements are not statements of historical facts and are based on management's beliefs and assumptions and on information currently available to management. Forward-looking statements include information concerning the Company's business strategy, the design, progression and timing of its clinical trials, including the Company's UPLIFT, UP-NEXT and UPGRADE clinical trials, the ability of its current and planned clinical trials to generate registration enabling and/or supportive data, the potential benefits of our product candidates, and expectations regarding future clinical trial results based on data achieved to date, and activities and prospects pursuant to collaboration agreements with third parties. Forward-looking statements generally can be identified by terms such as "aims," "anticipates," "believes," "contemplates," "continues," "could," "estimates," "expects," "goal," "intends," "may," "on track," "opportunity," "plans," "poised for," "possible," "potential," "predicts," "projects," "promises to be," "seeks," "should," "target," "will," "would" or similar expressions and the negatives of those terms. Forward-looking statements represent management's beliefs and assumptions only as of the date of this press release. The Company's operations involve risks and uncertainties, many of which are outside its control, and any one of which, or combination of which, could materially affect its results of operations and whether the forward-looking statements ultimately prove to be correct. Factors that may materially affect the Company's results of operations and whether these forward-looking statements prove to be correct include, among other things, that research, development or commercialization activities conducted by the Company or its collaboration partners prove to be unsuccessful, that we may not meet clinical endpoints with statistical significance or there may be safety concerns or adverse events associated with our product candidates, that preclinical testing or early clinical results may not be predictive of the results or success of ongoing or later preclinical or clinical trials, that we may not meet our goals for the timing of, or our ability to obtain and maintain, regulatory approvals for our product candidates, that the identification, development and testing of the Company's or its partners' product candidates and new platforms will take longer and/or cost more than planned, and that our clinical studies may not be initiated or completed on schedule, if at all, as well as those listed in the Company's Quarterly Report on Form 10-Q filed on November 9, 2021, with the Securities and Exchange Commission ("SEC"), and subsequent SEC filings. In addition, while we expect that the COVID-19 pandemic might adversely affect the Company's preclinical and clinical development efforts, business operations and financial results, the extent of the impact on the Company's operations and the value of and market for the Company's common stock will depend on future developments that are highly uncertain and cannot be predicted with confidence at this time, such as the ultimate duration of the pandemic, the spread of variants of COVID-19, travel restrictions, quarantines, physical distancing and business closure requirements in the U.S. and in other countries, and the effectiveness of actions taken globally to contain and treat the disease. Except as required by law, the Company assumes no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future.

    Copies of the Company's Quarterly Report on Form 10-Q and our other SEC filings are available by visiting EDGAR on the SEC website at http://www.sec.gov.​

    Contact:

    Investor & Media Contact

    James Salierno, 617-498-0020



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  2. CAMBRIDGE, Mass., Jan. 05, 2022 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc., (NASDAQ:MRSN) a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that Anna Protopapas, President and Chief Executive Officer, will present a company overview at the 40th Annual J.P. Morgan Healthcare Conference on Wednesday, January 12, 2022 at 3:00 p.m. ET.  

    A live webcast of the presentation will be available on the Investors & Media section of Mersana's website at www.mersana.com. Archived replays will be available for approximately 30 days following the presentation.

    About Mersana Therapeutics
    Mersana Therapeutics…

    CAMBRIDGE, Mass., Jan. 05, 2022 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc., (NASDAQ:MRSN) a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that Anna Protopapas, President and Chief Executive Officer, will present a company overview at the 40th Annual J.P. Morgan Healthcare Conference on Wednesday, January 12, 2022 at 3:00 p.m. ET.  

    A live webcast of the presentation will be available on the Investors & Media section of Mersana's website at www.mersana.com. Archived replays will be available for approximately 30 days following the presentation.

    About Mersana Therapeutics

    Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to rapidly develop novel ADCs with optimal efficacy, safety and tolerability to meaningfully improve the lives of people fighting cancer. Mersana's lead product candidate, upifitamab rilsodotin (UpRi), is a Dolaflexin ADC targeting NaPi2b and is being studied in UPLIFT, a single-arm registration strategy in patients with platinum-resistant ovarian cancer, as well as in UPGRADE, a Phase 1 umbrella study in combination with other ovarian cancer therapies. XMT-1592, Mersana's second ADC product candidate targeting NaPi2b-expressing tumors, was created using Mersana's customizable and homogeneous Dolasynthen platform and is in the dose escalation portion of a Phase 1 proof-of-concept clinical study. The Company's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, as well as XMT-2056, a STING-agonist ADC developed using the Company's Immunosynthen platform and targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). In addition, multiple partners are using Mersana's Dolaflexin platform to advance their ADC pipelines. Mersana Therapeutics was recently named among the 2021 Top Places to Work in Massachusetts by the Boston Globe. The Company routinely posts information that may be useful to investors on the "Investors and Media" section of our website at www.mersana.com.

    Contact:

    Investor & Media Contact

    James Salierno, 617-498-0020

     



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  3. CAMBRIDGE, Mass., Dec. 02, 2021 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that the Boston Globe has named the company among its annual "Top Places to Work 2021" list in the midsize employer category.

    "We are honored to have received this recognition and believe it speaks to our strong culture and driven team members who demonstrate their dedication to our mission and core values every single day. Mersana is a diverse, science-driven team where we achieve results with agility, innovation, camaraderie and passion," said Anna Protopapas…

    CAMBRIDGE, Mass., Dec. 02, 2021 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that the Boston Globe has named the company among its annual "Top Places to Work 2021" list in the midsize employer category.

    "We are honored to have received this recognition and believe it speaks to our strong culture and driven team members who demonstrate their dedication to our mission and core values every single day. Mersana is a diverse, science-driven team where we achieve results with agility, innovation, camaraderie and passion," said Anna Protopapas, President and Chief Executive Officer of Mersana. "Despite the unprecedented challenges presented to employees and their families during the COVID-19 pandemic, our team has continued to thrive through collaboration and our shared commitment to bring new therapeutic options to patients living with cancer."

    The rankings in the Boston Globe's Top Places to Work in Massachusetts are based on a survey collected by Energage, an employee research and consulting firm. Employers around the state were invited to have their employees take an anonymous survey covering factors such as company direction, execution, connection, management, work, pay and benefits and engagement. Any employer with at least 50 employees in Massachusetts was eligible. Companies also provided supplemental information about responses to the global pandemic and changes implemented in how teams work.

    Mersana is fully dedicated to hiring and expanding its workforce to advance therapies that make a significant impact in the lives of people living with cancer. The Company strives to cultivate a highly collaborative and welcoming workplace that shares a strong commitment to scientific excellence and patient care. Interested candidates are encouraged to explore employment opportunities by visiting https://www.mersana.com/careers/culture/.

    About Mersana Therapeutics

    Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to rapidly develop novel ADCs with optimal efficacy, safety and tolerability to meaningfully improve the lives of people fighting cancer. Mersana's lead product candidate, upifitamab rilsodotin (UpRi), is a Dolaflexin ADC targeting NaPi2b and is being studied in UPLIFT, a single-arm registration strategy in patients with platinum-resistant ovarian cancer, as well as in UPGRADE, a Phase 1 umbrella study in combination with other ovarian cancer therapies. XMT-1592, Mersana's second ADC product candidate targeting NaPi2b-expressing tumors, was created using Mersana's customizable and homogeneous Dolasynthen platform and is in the dose escalation portion of a Phase 1 proof-of-concept clinical study. The Company's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, as well as XMT-2056, a STING-agonist ADC developed using the Company's Immunosynthen platform and targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). In addition, multiple partners are using Mersana's Dolaflexin platform to advance their ADC pipelines. Mersana Therapeutics was recently named among the 2021 Top Places to Work in Massachusetts by the Boston Globe. The Company routinely posts information that may be useful to investors on the "Investors and Media" section of our website at www.mersana.com.

    Contact:

    Investor & Media Contact

    Sarah Carmody, 617-844-8577



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  4. AMSTERDAM, Nov. 30, 2021 /PRNewswire/ -- Synaffix B.V., a biotechnology company focused on commercializing its clinical-stage platform technology for the development of antibody-drug conjugates (ADCs) with best-in-class therapeutic index, today announces the expansion of its license agreement with Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need.

    Under the expanded license agreement, Mersana will expand its access to Synaffix's GlycoConnect™ site-specific ADC bioconjugation technology for six additional ADC targets. The license rights granted to Mersana are tied to specific…

    AMSTERDAM, Nov. 30, 2021 /PRNewswire/ -- Synaffix B.V., a biotechnology company focused on commercializing its clinical-stage platform technology for the development of antibody-drug conjugates (ADCs) with best-in-class therapeutic index, today announces the expansion of its license agreement with Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need.

    Under the expanded license agreement, Mersana will expand its access to Synaffix's GlycoConnect™ site-specific ADC bioconjugation technology for six additional ADC targets. The license rights granted to Mersana are tied to specific ADC targets to be selected and provide non-exclusive access to deploy GlycoConnect™ site-specific ADC bioconjugation technology against the specified targets. Under the expanded deal, Synaffix is eligible to receive upfront and milestone payments on a per-target basis with a total potential deal value exceeding $1 billion plus royalties. This builds on the long-term relationship between the two companies announced in 2019.

    Anna Protopapas, President and Chief Executive Officer of Mersana Therapeutics, said: "Our collaboration with Synaffix and use of the GlycoConnect™ site-specific ADC bioconjugation technology has yielded highly innovative ADC products with superior characteristics. Based on the data that we generated to date across multiple programs, we have gained the confidence to significantly expand our collaboration with Synaffix and elect GlycoConnect™ as our preferred site-specific ADC bioconjugation technology."

    Peter van de Sande, Chief Executive Officer of Synaffix, said: "We are delighted to expand our collaboration with Mersana, a leader in ADC innovation, who will be utilizing our GlycoConnect™ platform to build out their pipeline with innovative ADC cancer therapeutics. We are honored to see the confidence that Mersana has placed in our platform, demonstrating once again the added value GlycoConnect™ can bring to innovative ADCs."

    Mersana will continue to be responsible for the research, development, manufacturing and commercialization of any resulting ADC products.

    This licensing agreement expansion follows three recent ADC technology out-licensing agreements with Kyowa Kirin, a global specialty pharmaceutical company; ProfoundBio, an emerging oncology biotherapeutics company; and Innovent Biologics, a leading biopharmaceutical company developing innovative medicines for the treatment of major diseases. Other collaborators include ADC Therapeutics and Shanghai Miracogen. Twelve ADCs using Synaffix's technology are currently in development of which three are in clinical development.

    About Synaffix B.V.

    Synaffix B.V. is a biotechnology company that enables best-in-class ADCs using its clinical-stage technology platform that allows any company with an antibody to develop proprietary ADC products under a single license from Synaffix.

    The Synaffix platform allows a rapid timeline to clinic due to the established supply chain of technology components. Granted patents covering Synaffix' technology provide end-to-end protection of the manufacturing technology as well as the resulting products through at least 2035. The business model of Synaffix is target-specific technology out-licensing, as exemplified through its existing deals with ADC Therapeutics, Mersana Therapeutics, Shanghai Miracogen, Innovent Biologics, ProfoundBio and Kyowa Kirin.

    Synaffix is backed by a top tier, life science-focused investor syndicate that includes Aravis, BioGeneration Ventures, BOM Capital and M Ventures. 

    For more information, please visit the website at www.synaffix.com.

    About The Synaffix ADC Platform Technology

    Synaffix' proprietary ADC platform consists of GlycoConnect™, HydraSpace™ and toxSYN™ technologies.  Both GlycoConnect™ and HydraSpace™ are clinical-stage technologies that enable best-in-class ADCs with significantly enhanced efficacy and tolerability. 

    GlycoConnect™ is a conjugation technology that exploits the native antibody glycan for site-specific and stable payload attachment and is tunable to DAR1, DAR2 or DAR4 formats. 

    HydraSpace™ is a compact and highly polar spacer technology that is designed to further enhance therapeutic index, particularly with hydrophobic payloads. toxSYN™ is a linker-payload platform that spans key, validated MOAs for ADC product development, including SYNtecan E™ and SYNeamicin G™, among other linker-payloads.

    The combination of these three technologies provides developers with a "one stop" and easy-to-use ADC technology platform, allowing any antibody developer to develop its own proprietary ADC and any ADC developer to expand its pipeline further and increase its competitive position.

    About Mersana Therapeutics

    Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to rapidly develop novel ADCs with optimal efficacy, safety and tolerability to meaningfully improve the lives of people fighting cancer. Mersana's lead product candidate, upifitamab rilsodotin (UpRi), is a Dolaflexin ADC targeting NaPi2b and is being studied in UPLIFT, a single-arm registration strategy in patients with platinum-resistant ovarian cancer, as well as in UPGRADE, a Phase 1 umbrella study in combination with other ovarian cancer therapies. XMT-1592, Mersana's second ADC product candidate targeting NaPi2b-expressing tumors, was created using Mersana's customizable and homogeneous Dolasynthen platform and is in the dose escalation portion of a Phase 1 proof-of-concept clinical study. The Company's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, as well as XMT-2056, a STING-agonist ADC developed using the Company's Immunosynthen platform and targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). In addition, multiple partners are using Mersana's Dolaflexin platform to advance their ADC pipelines. The Company routinely posts information that may be useful to investors on the "Investors and Media" section of our website at www.mersana.com.

    Cision View original content:https://www.prnewswire.com/news-releases/synaffix-announces-expansion-of-mersana-license-deal-to-a-total-potential-value-exceeding-1-billion-301433019.html

    SOURCE Synaffix

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  5. CAMBRIDGE, Mass., Nov. 23, 2021 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that the Company's management team will participate in a fireside chat at the 4th Annual Evercore ISI HealthCONx Conference on Wednesday, December 1, 2021, at 2:40 p.m. ET.

    A live webcast of the presentation will be available on the Investors & Media section of Mersana's website at www.mersana.com. An archived replay will be available for approximately 90 days following the event.

    About Mersana Therapeutics

    Mersana Therapeutics is a clinical-stage biopharmaceutical…

    CAMBRIDGE, Mass., Nov. 23, 2021 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that the Company's management team will participate in a fireside chat at the 4th Annual Evercore ISI HealthCONx Conference on Wednesday, December 1, 2021, at 2:40 p.m. ET.

    A live webcast of the presentation will be available on the Investors & Media section of Mersana's website at www.mersana.com. An archived replay will be available for approximately 90 days following the event.

    About Mersana Therapeutics

    Mersana Therapeutics is a clinical-stage biopharmaceutical company using its differentiated and proprietary ADC platforms to rapidly develop novel ADCs with optimal efficacy, safety and tolerability to meaningfully improve the lives of people fighting cancer. Mersana's lead product candidate, upifitamab rilsodotin (UpRi), is a Dolaflexin ADC targeting NaPi2b and is being studied in UPLIFT, a single-arm registration strategy in patients with platinum-resistant ovarian cancer, as well as in UPGRADE, a Phase 1 umbrella study in combination with other ovarian cancer therapies. XMT-1592, Mersana's second ADC product candidate targeting NaPi2b-expressing tumors, was created using Mersana's customizable and homogeneous Dolasynthen platform and is in the dose escalation portion of a Phase 1 proof-of-concept clinical study. The Company's early-stage programs include XMT-1660, a Dolasynthen ADC targeting B7-H4, as well as XMT-2056, a STING-agonist ADC developed using the Company's Immunosynthen platform and targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). In addition, multiple partners are using Mersana's Dolaflexin platform to advance their ADC pipelines. The Company routinely posts information that may be useful to investors on the "Investors and Media" section of our website at www.mersana.com.

    Contact:

    Investor & Media Contact

    Sarah Carmody

    617-844-8577



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