LABP Landos Biopharma Inc.

15.43
-0.34  -2%
Previous Close 15.77
Open 15.6
52 Week Low 8.82
52 Week High 16.989
Market Cap $619,014,537
Shares 40,117,598
Float 4,639,108
Enterprise Value $508,300,472
Volume 60,855
Av. Daily Volume 46,529
Stock charts supplied by TradingView

Upcoming Catalysts

Drug Stage Catalyst Date
Omilancor (BT-11)
Ulcerative Colitis
Phase 2
Phase 2
Premium membership is required to view catalyst dates, analyst ratings, earnings dates and cash burn data. Click here to unlock and sign up to a 14-day FREE TRIAL.
Omilancor (BT-11)
Crohn’s Disease
Phase 2
Phase 2
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque sapien.
NX-13
Ulcerative Colitis
Phase 1b
Phase 1b
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque sapien.

Drug Pipeline

Drug Stage Notes
LABP-104
Systemic Lupus Erythematosus (SLE)
Phase 1
Phase 1
Phase 1 clinical trial anticipated to commence 4Q 2021. Preclinical data to be presented at the American College of Rheumatology (ACR) Convergence 2021, November 3-10, 2021.
NX-13
Crohn’s Disease
Phase 2
Phase 2
Phase 2 trial to commence 1H 2022.

Latest News

  1. Second Phase 2 trial of omilancor in Crohn's disease (CD), expected to initiate in 2021

    Awarded a $3 million NIH R01 grant from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases to fund this study

    BLACKSBURG, Va., Sept. 20, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral small-molecule therapeutics for patients with autoimmune diseases, today announced a research collaboration with the Icahn School of Medicine at Mount Sinai to conduct a Phase 2 trial of omilancor, Landos' novel, orally administered, gut-restricted LANCL2 agonist, in patients with moderate-to-severe Crohn's disease (CD…

    Second Phase 2 trial of omilancor in Crohn's disease (CD), expected to initiate in 2021

    Awarded a $3 million NIH R01 grant from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases to fund this study

    BLACKSBURG, Va., Sept. 20, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral small-molecule therapeutics for patients with autoimmune diseases, today announced a research collaboration with the Icahn School of Medicine at Mount Sinai to conduct a Phase 2 trial of omilancor, Landos' novel, orally administered, gut-restricted LANCL2 agonist, in patients with moderate-to-severe Crohn's disease (CD).

    "Entering this partnership with the Icahn School of Medicine at Mount Sinai highlights our ability to pursue innovative clinical and translational studies that build on our pioneering immunometabolism franchise in autoimmune diseases," said Dr. Josep Bassaganya-Riera, Chairman, President, and CEO of Landos. "We are excited to expand the investigation of our Phase-3 ready product candidate, omilancor, in this mechanistic Phase 2 study in CD to further validate how activation of the LANCL2 pathway by omilancor enhances regulatory T cell (Treg) function in the gastrointestinal tract. Rescuing Treg function in biologic failure patients is a critical step for inducing durable remission given the impaired regulatory compartment in this hard to treat patient population. We thank the U.S. National Institutes of Health (NIH) for recognizing the promise of omilancor as a potential oral treatment for inflammatory bowel disease (IBD) and the value of its novel LANCL2 mechanism of action with this competitive grant that provides further independent validation and de-risking for omilancor and our broader inflammation and immunology pipeline."

    This Phase 2 trial is a randomized, double-blind study designed to evaluate the efficacy, safety and mechanisms of omilancor in patients with moderate-to-severe CD. Approximately 40 patients will be randomized to receive either 880 mg of omilancor or adalimumab (Humira), the standard of care, once daily for 12 weeks. Over the course of the induction period, patients will be monitored at baseline, 2, 6 and 12 weeks for an assessment of symptoms, disease-associated biomarkers and patient-reported outcomes. Intestinal biopsy specimens, stool and peripheral blood will be comprehensively analyzed at the Laboratory of Mucosal Immunology at Mount Sinai Hospital. This trial is funded by a $3 million grant awarded to Landos by the National Institute of Diabetes and Digestive and Kidney Diseases at the NIH.

    "Patients with CD need safer and more effective oral therapeutic options, especially those who have previously failed on biologics," said Jean-Frederic Colombel, MD, Director, Susan and Leonard Feinstein IBD Clinical Center at the Icahn School of Medicine at Mount Sinai in New York City. Dr. Colombel is also a member of the Landos Clinical Advisory Board and a paid consultant. "By looking at the underlying cellular and molecular multi-pronged mechanisms of omilancor in CD patients that failed biologics, we can better understand how it provides clinical benefit. Based on the promise of previous studies, I am excited by its potential to fill a clear treatment gap for patients with moderate-to-severe CD."

    "We are excited to launch immunometabolism studies in IBD as part of this mechanistic Phase 2 study," said Saurabh Mehandru, MD, Associate Professor and Principal Investigator of the Laboratory of Mucosal Immunology at Mount Sinai Hospital where the mechanistic studies will be performed. "Immunometabolism is a relatively novel frontier in IBD pioneered by the Landos team. Through these studies, we aim to learn more about the metabolic underpinnings of cellular immune responses in IBD and their targeting with omilancor and LANCL2 engagement. Further, by studying patients longitudinally, we may be able to determine early predictors of therapeutic response to omilancor which could pave the way to better patient stratification in future. Therefore, I am very excited at the prospect of this well-designed, mechanism-focused study in patients with CD."

    Prescription therapeutics used to treat CD in the United States generated approximately $10.7 billion in sales in 2020 and are anticipated to grow at over 4.1% per annum over the coming years. Humira comprises nearly 33% of the market, with an estimated sales forecast of $2.3 billion by patient growth.

    About Crohn's Disease (CD)

    CD is a chronic, autoimmune disease of the gastrointestinal tract that causes inflammation, irritation and ulcers in any segment of the gastrointestinal tract. CD impacts the end of the small bowel and beginning of the colon most commonly, which in turn can lead to symptoms of abdominal pain, increased abdominal sounds, rectal pain and bleeding, bloody stools, diarrhea, fever, weight loss and malnutrition. Current therapeutic options for severe CD are limited primarily to biologics, which have limitations, including but not limited to safety risks for malignancies, infections or even death, limited efficacy and lack of long-term maintenance options. There is an unmet clinical need for novel first-in-class therapeutics for CD and improvement upon the existing constraints in administration, tolerability and efficacy.

    About Omilancor

    Discovered using Landos' proprietary LANCE® Advanced A.I. platform, omilancor is a novel, oral, gut-restricted, small-molecule investigational drug that targets the Lanthionine Synthetase C-Like 2 (LANCL2) pathway impacting the gastrointestinal tract. LANCL2 plays an important role in the immunoregulatory process. By activating the LANCL2 pathway and modulating the interactions between immunological and metabolic signals in immune cells, omilancor is designed to create a favorable regulatory microenvironment in the gut, decreasing the production of key inflammatory mediators and enhancing regulatory T cells (Treg) function within the site of inflammation. Landos reported continued positive Phase 2 results of omilancor evaluating patients with ulcerative colitis (UC) in 2021 and following a positive End-of-Phase 2 meeting has initiated site feasibility studies for its global pivotal Phase 3 clinical program (PACIFY I and PACIFY II trials) in patients with mild-to-moderately active UC. Additionally, Landos initiated a Phase 2 trial of omilancor in 150 patients with Crohn's disease in the first half of 2021 with topline results expected in the first half of 2022 and anticipates initiation of Phase 1 studies in eosinophilic esophagitis. Omilancor is also being studied in a topical formulation for psoriasis and atopic dermatitis.

    About Landos Biopharma

    Landos Biopharma is a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to discover and develop novel oral therapeutics for patients with autoimmune diseases. Using the LANCE® platform, the Company has discovered new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 immunometabolic pathways. Landos Biopharma has 17 active development programs targeting these novel pathways at the interface of immunity and metabolism. Its lead product candidate, omilancor targets the LANCL2 pathway and is a novel oral, gut-restricted, small-molecule potentially first-in-class therapeutic currently being prepared for global pivotal Phase 3 trials for the treatment of ulcerative colitis, in an active Phase 2 trial in Crohn's disease, and is anticipated to initiate Phase 1 studies in eosinophilic esophagitis in 2022. Omilancor is also being studied in a topical formulation for psoriasis and atopic dermatitis. Landos has another novel, oral, gut-restricted small-molecule drug candidate, NX-13, that is being investigated in an active Phase 1b trial in ulcerative colitis. NX-13 targets the NLRX1 pathway. Additional product candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, non-alcoholic steatohepatitis (NASH), asthma, chronic obstructive pulmonary disease (COPD), diabetes, and diabetic nephropathy. For more information, please visit www.landosbiopharma.com.

    Cautionary Note on Forward-Looking Statements

    Statements in this press release about future expectations, plans and prospects for Landos Biopharma, Inc. (the "Company"), including statements about the Company's strategy, clinical development and regulatory plans for its product candidates, the Company's anticipated milestones and future expectations and plans and prospects for the Company and other statements containing the words "anticipate", "plan", "expect", "may", "will", "could", the negatives thereof, variations thereon and similar expressions, or any discussions of strategy constitute forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties inherent in the initiation and enrollment of future clinical trials, expectations of expanding ongoing clinical trials, availability and timing of data from ongoing clinical trials, expectations for regulatory approvals, other matters that could affect the availability or commercial potential of the Company's product candidates and other similar risks. Risks regarding our business are described in detail in our Securities and Exchange Commission ("SEC") filings, including in our Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, which are available on the SEC's website at www.sec.gov. Additional information will be made available in other filings that we make from time to time with the SEC. Such risks may be amplified by the impacts of the COVID-19 pandemic. In addition, the forward-looking statements included in this press release represent the Company's views only as of the date hereof. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so, except as may be required by law. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date hereof.

    Contacts:

    Marek Ciszewski, J.D.

    Landos Biopharma

    562-373-5787

    IR@LandosBiopharma.com

    Michael K. Levitan (investors)

    Solebury Trout

    646-378-2920

    mlevitan@soleburytrout.com

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943

    hgendel@soleburytrout.com



    Primary Logo

    View Full Article Hide Full Article
  2. Oral treatment with LABP-104 in preclinical models of Systemic Lupus Erythematosus (SLE) resulted in enhanced Treg function, decreased kidney inflammation and reduced interferon gamma signaling

    Phase 1 clinical trial anticipated to begin during Q4 2021

    BLACKSBURG, Va., Sept. 15, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to discover and develop novel oral therapeutics for patients with autoimmune diseases, today announced that it will present preclinical data of LABP-104, an oral, small-molecule LANCL2 agonist, in Systemic Lupus Erythematosus (SLE or Lupus) as an oral presentation at the upcoming American College of Rheumatology…

    Oral treatment with LABP-104 in preclinical models of Systemic Lupus Erythematosus (SLE) resulted in enhanced Treg function, decreased kidney inflammation and reduced interferon gamma signaling

    Phase 1 clinical trial anticipated to begin during Q4 2021

    BLACKSBURG, Va., Sept. 15, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to discover and develop novel oral therapeutics for patients with autoimmune diseases, today announced that it will present preclinical data of LABP-104, an oral, small-molecule LANCL2 agonist, in Systemic Lupus Erythematosus (SLE or Lupus) as an oral presentation at the upcoming American College of Rheumatology (ACR) Convergence 2021. The meeting will be held virtually from November 3-10, 2021.

    "These novel findings support the potential therapeutic efficacy of LABP-104 in SLE, along with the power of our LANCE platform to discover and validate novel targets at the intersection of immunity and metabolism. Altogether, they highlight the breadth and depth of our expansible inflammation and immunology pipeline," said Dr. Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer of Landos. "Our Phase 2 trial with omilancor in ulcerative colitis illustrated the important immunoregulatory mechanisms of the Lanthionine Synthetase C-Like 2 (LANCL2) pathway including enhancing regulatory T cell (Treg) function. With these new data in lupus, we have further validation of LABP-104's therapeutic potential to activate this pathway's ability to intercept and possibly reverse the complex cascade of immunological events that lead to disease and pathology in lupus patients. We plan to pursue development of LABP-104 in lupus in addition to other debilitating autoimmune diseases with unmet clinical needs, where enhancement of Treg function plays an important therapeutic role."

    Landos expects to enter Phase 1 clinical testing of LABP-104 as an oral therapeutic candidate for lupus during the fourth quarter of 2021, further expanding the company's deep inflammation and immunology pipeline.

    ACR 2021 Presentation Details

    Title: Therapeutic Efficacy of LABP-104, an Oral LANCL2 Agonist, for the Treatment of Systemic Lupus Erythematosus

    Presentation ID: 1815680

    Session: Abstracts: SLE – Animal Models

    Date/Time: Saturday, November 6, 2021, from 11:15 to 11:30 a.m. EDT

    Highlights Include:

    • Oral treatment with LABP-104 protected against worsening from baseline in proteinuria grade in greater than 90% of mice, improved proteinuria grade in roughly 50% of mice and reduced anti-nuclear antibody levels by three-fold.
    • Reduced overall histological score in the kidneys, including improvement in interstitial inflammation, glomerular proliferation and cellular crescents as well as significantly reduced effector IL-17+ and IL-21+ CD4+ T cells in the spleen while significantly increasing CD25+ FOXP3+ regulatory CD4+ T cells (Treg).
    • Significantly reduced the production of interferon alpha in human peripheral blood mononuclear cells (PBMCs) from SLE patients in response to general, TLR7 and CpG oligonucleotide stimuli.

    The presentation will be available under the "Publications" section of the Company's website at www.landosbiopharma.com concurrent with the live presentation on November 6, 2021.

    About Systemic Lupus Erythematosus (SLE)

    Systemic lupus erythematosus (SLE) is the most common type of the autoimmune disease lupus. In SLE, the immune system attacks its own tissues, causing widespread inflammation and tissue damage. SLE can affect multiple organs and systems including skin, joints, kidneys, brain, blood cells, lungs and heart. SLE is commonly treated with corticosteroids and antimalarials that aim to lower the interferon alpha response, which elicit strong antiviral activities in target cells. However, current therapeutic options for SLE can cause serious side effects, including the potential for cardiovascular damage, increased risk of infections, sepsis and pneumonia. As such, there is a high unmet medical need for an alternative frontline therapy for the estimated 1.5 million SLE patients in the US and approximately 5 million patients globally, with an estimated market value of approximately $1.6 billion by 2028 and a growth rate of 5.6%.

    About LABP-104

    LABP-104 is an oral, systemically distributed, small-molecule therapeutic candidate which activates LANCL2, a surface membrane-associated receptor that is responsible for modulating key cellular and molecular changes tied to autoimmune diseases. By activating the LANCL2 pathway, LABP-104 increases the anti-inflammatory capacity and stability of regulatory CD4+ T cells while also supporting the metabolic demands of autophagy in phagocytes. To date, treatment with LABP-104 has reduced the production of interferon alpha in human PBMCs from SLE patients and provided protection from clinical disease and tissue pathology in mouse models of lupus. Landos expects to enter Phase 1 clinical testing in healthy volunteers in Q4 2021.

    About Landos Biopharma

    Landos Biopharma is a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to discover and develop novel oral therapeutics for patients with autoimmune diseases. Using the LANCE® platform, the Company has discovered new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 immunometabolic pathways. Landos Biopharma has 17 active development programs targeting these novel pathways at the interface of immunity and metabolism. Its lead product candidate, omilancor targets the LANCL2 pathway and is a novel oral, gut-restricted, small-molecule potentially first-in-class therapeutic currently being prepared for global pivotal Phase 3 trials for the treatment of ulcerative colitis, in an active Phase 2 trial in Crohn's disease, and is anticipated to initiate Phase 1 studies in eosinophilic esophagitis in 2022. Omilancor is also being studied in a topical formulation for psoriasis and atopic dermatitis. Landos has another novel, oral, gut-restricted small-molecule drug candidate, NX-13, that is being investigated in an active Phase 1b trial in ulcerative colitis. NX-13 targets the NLRX1 pathway. Additional product candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, non-alcoholic steatohepatitis (NASH), asthma, chronic obstructive pulmonary disease (COPD), diabetes, and diabetic nephropathy. For more information, please visit www.landosbiopharma.com.

    Cautionary Note on Forward-Looking Statements

    Statements in this press release about future expectations, plans and prospects for Landos Biopharma, Inc. (the "Company"), including statements about the Company's strategy, clinical development and regulatory plans for its product candidates, the Company's anticipated milestones and future expectations and plans and prospects for the Company and other statements containing the words "anticipate", "plan", "expect", "may", "will", "could", the negatives thereof, variations thereon and similar expressions, or any discussions of strategy constitute forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties inherent in the initiation and enrollment of future clinical trials, expectations of expanding ongoing clinical trials, availability and timing of data from ongoing clinical trials, expectations for regulatory approvals, other matters that could affect the availability or commercial potential of the Company's product candidates and other similar risks. Risks regarding the Company's business are described in detail in its Securities and Exchange Commission ("SEC") filings, including in its Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, which are available on the SEC's website at www.sec.gov. Additional information will be made available in other filings that the Company makes from time to time with the SEC. Such risks may be amplified by the impacts of the COVID-19 pandemic. In addition, the forward-looking statements included in this press release represent the Company's views only as of the date hereof. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so, except as may be required by law. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date hereof.

    Contacts:

    Marek Ciszewski, J.D.

    Landos Biopharma

    562-373-5787

    IR@LandosBiopharma.com

    Michael K. Levitan (investors)

    Solebury Trout

    646-378-2920

    mlevitan@soleburytrout.com

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943

    hgendel@soleburytrout.com 



    Primary Logo

    View Full Article Hide Full Article
  3. BLACKSBURG, Va., Sept. 01, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral therapeutics for patients with autoimmune diseases, today announced that Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer of Landos will participate in two upcoming virtual investor conferences in September.

    Presentation Details:
    Event: Citi's 16th Annual BioPharma Conference
    Date: September 8-10, 2021
    Format: 1x1 meetings

    Event: H.C. Wainwright 23rd Annual Global Investment Conference
    Date: September 13, 2021
    Format: Presentation
    Time: On-demand beginning at 7:00 a.m. ET

    A live webcast and subsequent archive…

    BLACKSBURG, Va., Sept. 01, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral therapeutics for patients with autoimmune diseases, today announced that Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer of Landos will participate in two upcoming virtual investor conferences in September.

    Presentation Details:

    Event: Citi's 16th Annual BioPharma Conference

    Date: September 8-10, 2021

    Format: 1x1 meetings

    Event: H.C. Wainwright 23rd Annual Global Investment Conference

    Date: September 13, 2021

    Format: Presentation

    Time: On-demand beginning at 7:00 a.m. ET

    A live webcast and subsequent archive of the H.C. Wainwright presentation will be accessible through the Investors/Media section of the Company's website at www.landosbiopharma.com.

    About Landos Biopharma

    Landos Biopharma is a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to discover and develop novel oral therapeutics for patients with autoimmune diseases. LANCE has discovered new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 plus several additional undisclosed immunometabolic pathways. Landos has 17 active development programs targeting these novel pathways at the interface of immunity and metabolism across 14 indications. Lead asset omilancor targets the LANCL2 pathway and is a novel oral, gut-restricted small molecule drug candidate currently being prepared for global pivotal Phase 3 trials for the treatment of ulcerative colitis, in an active Phase 2 trial in Crohn's disease and, is anticipated to initiate Phase 1b studies in Eosinophilic Esophagitis and, in topical cream formulation, for psoriasis and atopic dermatitis. NX-13 targets the NLRX1 pathway and is a novel oral, gut-restricted small molecule drug candidate currently in an active Phase 1b trial in ulcerative colitis. Additional candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, Multiple Sclerosis, and diabetes. For more information, please visit www.landosbiopharma.com.

    Cautionary Note on Forward-Looking Statements

    Any statements in this press release about future expectations, plans and prospects for Landos Biopharma, Inc. (the "Company"), including statements about the Company's strategy, clinical development and regulatory plans for its product candidates, the Company's anticipated milestones and future expectations and plans and prospects for the Company and other statements containing the words "anticipate", "plan", "expect", "may", "will", "could", the negatives thereof, variations thereon and similar expressions, or by discussions of strategy constitute forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties inherent in the initiation and enrollment of future clinical trials, expectations of expanding ongoing clinical trials, availability and timing of data from ongoing clinical trials, expectations for regulatory approvals, other matters that could affect the availability or commercial potential of the Company's product candidates and other similar risks. Risks regarding our business are described in detail in our Securities and Exchange Commission ("SEC") filings, including in our Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, which are available on the SEC's website at www.sec.gov. Additional information will be made available in other filings that we make from time to time with the SEC. Such risks may be amplified by the impacts of the COVID-19 pandemic.  In addition, the forward-looking statements included in this press release represent the Company's views only as of the date hereof. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so, except as may be required by law. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date hereof.

    Contacts:

    Marek Ciszewski, J.D.

    Landos Biopharma

    562.373.5787

    IR@LandosBiopharma.com



    Michael K. Levitan (investors)

    Solebury Trout

    646-378-2920

    mlevitan@soleburytrout.com

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943

    hgendel@soleburytrout.com



    Primary Logo

    View Full Article Hide Full Article
  4. BLACKSBURG, Va., Aug. 26, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral therapeutics for patients with autoimmune diseases, today announced that it has entered into a research collaboration with Peter Calabresi, M.D., Director of the Multiple Sclerosis Center and Professor of Neurology at Johns Hopkins University (JHU) School of Medicine. This research funded by the National Institutes of Health (NIH) will focus on further validating the NLRX1 immunometabolic pathway in Multiple Sclerosis (MS).

    "We are honored to collaborate with Dr. Calabresi to continue research on the NLRX1 pathway with the goal to develop…

    BLACKSBURG, Va., Aug. 26, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral therapeutics for patients with autoimmune diseases, today announced that it has entered into a research collaboration with Peter Calabresi, M.D., Director of the Multiple Sclerosis Center and Professor of Neurology at Johns Hopkins University (JHU) School of Medicine. This research funded by the National Institutes of Health (NIH) will focus on further validating the NLRX1 immunometabolic pathway in Multiple Sclerosis (MS).

    "We are honored to collaborate with Dr. Calabresi to continue research on the NLRX1 pathway with the goal to develop disease-modifying precision therapies in central nervous system (CNS) disorders, including MS," said Dr. Josep Bassaganya-Riera, Chairman, President, and CEO of Landos. "Similar to our pioneering work on the NLRX1 pathway in autoimmune diseases and the recent positive, de-risking results for NX-13, our lead NLRX1 agonist for ulcerative colitis and Crohn's disease, we are excited to further investigate the translatability of these ground-breaking scientific discoveries in treating CNS diseases and look forward to advancing LABP-66 and other therapeutic candidates in our extensive inflammation and immunology portfolio into clinical testing."

    Current treatments for MS are designed to target a single cell type in the brain. In contrast, Landos' candidate LABP-66 is designed to target the NLRX1 pathway in the CNS and in turn, promote beneficial effects in CD4+ T cells, microglia and neurons. Moreover, Landos' pioneering research on the importance of the NLRX1 pathway in immunometabolic control of CD4+ T cells and other autoimmune diseases is complementary to the research Dr. Calabresi is conducting at JHU. LABP-66 has the potential to become an improved treatment option for patients with MS and Alzheimer's Disease.

    Landos' novel NLRX1 agonist, LABP-66, is an oral once-daily therapy in development for the treatment of MS, Alzheimer's Disease, and other debilitating CNS diseases. Approximately 1.0 million Americans suffer from MS, which is expected to grow to 1.2 million by 2028. The market for MS drugs is expected to increase from $18.6 billion in 2021 to $26.6 billion by the year 2028 at an average growth rate of 5.2% annually. Of note, a majority of these sales are from biologics (injectables); LABP-66 is an oral therapeutic candidate.

    About LABP-66

    LABP-66 is a once-daily, orally active, systemic small molecule therapeutic candidate which activates NLRX1, a mitochondria-associated receptor with the ability to modulate immune responses. By activating the NLRX1 pathway, LABP-66 increases autophagy and oxidative phosphorylation in immune cells while decreasing differentiation of effector CD4+ T cells, reactive oxygen species, inflammasome formation and production of inflammatory cytokines. LABP-66 recently entered IND-enabling studies and Landos expects to file for an IND in 2022. Oral treatment with LABP-66 has reduced markers of inflammation and neuronal cell stress in the CNS in addition to disease activity scores.

    About Landos Biopharma

    Landos Biopharma is a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to discover and develop novel oral therapeutics for patients with autoimmune diseases. LANCE has discovered new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 plus several additional undisclosed immunometabolic pathways. Landos has 17 active development programs targeting these novel pathways at the interface of immunity and metabolism across 14 indications. Lead asset omilancor targets the LANCL2 pathway and is a novel oral, gut-restricted small molecule drug candidate currently being prepared for global pivotal Phase 3 trials for the treatment of ulcerative colitis, in an active Phase 2 trial in Crohn's disease and, is anticipated to initiate Phase 1b studies in Eosinophilic Esophagitis and, in topical cream formulation, for psoriasis and atopic dermatitis. NX-13 targets the NLRX1 pathway and is a novel oral, gut-restricted small molecule drug candidate currently in an active Phase 1b trial in ulcerative colitis. Additional candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, Multiple Sclerosis, and diabetes. For more information, please visit www.landosbiopharma.com.

    Cautionary Note on Forward-Looking Statements

    Any statements in this press release about future expectations, plans and prospects for Landos Biopharma, Inc. (the "Company"), including statements about the Company's strategy, clinical development and regulatory plans for its product candidates, the Company's anticipated milestones and future expectations and plans and prospects for the Company and other statements containing the words "anticipate", "plan", "expect", "may", "will", "could", the negatives thereof, variations thereon and similar expressions, or by discussions of strategy constitute forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties inherent in the initiation and enrollment of future clinical trials, expectations of expanding ongoing clinical trials, availability and timing of data from ongoing clinical trials, expectations for regulatory approvals, other matters that could affect the availability or commercial potential of the Company's product candidates and other similar risks. Risks regarding our business are described in detail in our Securities and Exchange Commission ("SEC") filings, including in our Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, which are available on the SEC's website at www.sec.gov. Additional information will be made available in other filings that we make from time to time with the SEC. Such risks may be amplified by the impacts of the COVID-19 pandemic.  In addition, the forward-looking statements included in this press release represent the Company's views only as of the date hereof. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so, except as may be required by law. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date hereof.

    Contacts:

    Marek Ciszewski, J.D.

    Landos Biopharma

    562.373.5787

    IR@LandosBiopharma.com

    Michael K. Levitan (investors)

    Solebury Trout

    646-378-2920

    mlevitan@soleburytrout.com

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943

    hgendel@soleburytrout.com



    Primary Logo

    View Full Article Hide Full Article
  5. BLACKSBURG, Va., Aug. 05, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral therapeutics for patients with autoimmune diseases, today announced that Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer of Landos and additional management team members will participate in the following investor events in August.

    Event: BTIG Virtual Biotechnology Conference
    Date: August 9-10, 2021
    Format: Virtual
    Presentation: Tuesday, August 10, 2021 at 3:00 p.m. EDT

    Event: Canaccord Genuity 41st Annual Growth Conference
    Date: August 10-12, 2021
    Format: Virtual
    Presentation: Wednesday, August 11, 2021 at 10:30 a.m. ET…

    BLACKSBURG, Va., Aug. 05, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, Inc. (NASDAQ:LABP), a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to develop novel oral therapeutics for patients with autoimmune diseases, today announced that Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer of Landos and additional management team members will participate in the following investor events in August.

    Event: BTIG Virtual Biotechnology Conference

    Date: August 9-10, 2021

    Format: Virtual

    Presentation: Tuesday, August 10, 2021 at 3:00 p.m. EDT

    Event: Canaccord Genuity 41st Annual Growth Conference

    Date: August 10-12, 2021

    Format: Virtual

    Presentation: Wednesday, August 11, 2021 at 10:30 a.m. ET

    Event: BMO BioPharma Spotlight Series: Innovation in GI

    Date: August 12, 2021

    Format: Virtual

    Presentation: Thursday, August 12, 2021 at 10:50 a.m. ET

    Event: Solebury Trout Annual Hamptons CEO Roundtable

    Date: August 12, 2021

    Format: In-person

    Presentation: Thursday, August 12, 2021 at 11:30 a.m. ET

    Location: Topping Rose House, Bridgehampton, NY

    Management team will also meet with investors throughout these events. Investors interested in meeting with the Landos Biopharma management team during these events should contact their respective representatives or Marek Ciszewski, VP of Financial Strategy and Investor Relations at Landos: Marek@LandosBiopharma.com.

    Where available, a live webcast and subsequent archive of the presentations will be accessible through the Investors/Media section of the Company's website at www.landosbiopharma.com.

    About Landos Biopharma

    Landos Biopharma is a late-clinical-stage biopharmaceutical company utilizing its LANCE® Advanced A.I. platform to discover and develop novel oral therapeutics for patients with autoimmune diseases. LANCE has discovered new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 immunometabolic pathways. Landos Biopharma has 17 active development programs targeting these novel pathways at the interface of immunity and metabolism. Lead asset omilancor is a novel gut-restricted small molecule drug candidate for the treatment of ulcerative colitis, Crohn's disease, Eosinophilic Esophagitis and, in topical formulation, for psoriasis and atopic dermatitis that targets the LANCL2 pathway. NX-13 is a novel, gut-restricted small molecule drug candidate for the treatment of inflammatory bowel disease, that targets the NLRX1 pathway. Additional candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, multiple sclerosis, and diabetes. For more information, please visit www.landosbiopharma.com.

    Contacts:

    Michael K. Levitan (investors)

    Solebury Trout

    646-378-2920

    mlevitan@soleburytrout.com

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943

    hgendel@soleburytrout.com



    Primary Logo

    View Full Article Hide Full Article
View All Landos Biopharma Inc. News