LABP Landos Biopharma Inc.

12.9
-2.34  -15%
Previous Close 15.24
Open 14.99
52 Week Low 10.77
52 Week High 15.35
Market Cap $505,204,945
Shares 39,163,174
Float 8,957,823
Enterprise Value $601,462,209
Volume 309,179
Av. Daily Volume 0
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Drug Pipeline

Drug Stage Notes
NX-13
Ulcerative Colitis
Phase 1b
Phase 1b
Phase 1b trial to commence in 2021.
NX-13
Crohn’s Disease
Phase 2
Phase 2
Phase 2 trial to commence 1H 2022.
BT 11
Crohn’s Disease
Phase 2
Phase 2
Phase 2 trial to commence 1H 2021.
BT-11
Ulcerative Colitis
Phase 3
Phase 3
Phase 3 trial to commence 1H 2021.

Latest News

  1. NX-13 was well tolerated with no reported serious adverse events

    All primary and secondary endpoints in the Phase 1 study of NX-13 were met

    Landos expects to initiate a Phase 1b trial of NX-13 in patients with ulcerative colitis (UC) later this year

    BLACKSBURG, Va., March 04, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma (NASDAQ:LABP), a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced NX-13, the Company's first-in-class novel, orally administered therapeutic candidate for the treatment of inflammatory bowel disease (IBD), has successfully met all primary and secondary endpoints in a Phase 1 study. The data showed that NX-13 was well tolerated…

    NX-13 was well tolerated with no reported serious adverse events

    All primary and secondary endpoints in the Phase 1 study of NX-13 were met

    Landos expects to initiate a Phase 1b trial of NX-13 in patients with ulcerative colitis (UC) later this year

    BLACKSBURG, Va., March 04, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma (NASDAQ:LABP), a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced NX-13, the Company's first-in-class novel, orally administered therapeutic candidate for the treatment of inflammatory bowel disease (IBD), has successfully met all primary and secondary endpoints in a Phase 1 study. The data showed that NX-13 was well tolerated following evaluation of multiple doses over one and seven days compared with placebo.

    "The favorable results from this trial underscore the promise of NX-13's novel multimodal mechanism of action, targeting the NLRX1 pathway locally in the GI tract, and its potential to bring a new approach to treating patients with IBD," commented Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer of Landos. "As a part of our growing franchise of gut-restricted, oral therapeutics for ulcerative colitis (UC) and Crohn's disease (CD) with novel immunometabolic mechanisms, we are excited that NX-13 met all primary and secondary endpoints in this first-in-humans study."

    "By using Landos' powerful LANCE discovery and development platform, we have identified three novel mechanisms of therapeutic efficacy (LANCL2, NLRX1 and PLXDC2) and developed seven novel product candidates around those targets. Our lead product candidates (BT-11 and NX-13) are in clinical testing and our development pipeline currently targets up to 14 autoimmune disease indications. We are pleased that it took only 18 months for NX-13 to advance from discovery to Phase 1 clinical testing and we are looking forward to initiating a Phase 1b trial in patients with UC later this year," commented Raquel Hontecillas, PhD, Chief Scientific Officer of Landos.

    The Phase 1 trial was a randomized, double-blind, placebo-controlled single and multiple ascending dose study designed to evaluate the safety, tolerability and pharmacokinetics of NX-13, which was orally administered. The single ascending dose arm consisted of 35 healthy volunteers in a total of five cohorts (250 to 4,000 mg). The multiple ascending dose arm consisted of 21 healthy volunteers enrolled in a total of three cohorts (1,000 to 4,000 mg). Within each cohort in both dose arms, five participants received NX-13 and two participants received placebo. Across the eight cohorts, no SAEs were reported. The maximum tolerated dose was identified to be 10-fold greater than the anticipated therapeutic dose.

    Following the positive results from the Phase 1 study, Landos plans to initiate a Phase 1b trial of NX-13 in patients with ulcerative colitis in 2021. Additionally, building on the success of the LANCE computational platform in BT-11 and NX-13, Landos anticipates filing at least three new INDs in 2021.

    About NX-13

    NX-13 is a first-in-class, orally active, gut-restricted, small molecule therapeutic candidate for the treatment of inflammatory bowel disease. NX-13 targets NLRX1, a mitochondria-associated receptor with the ability to modulate immune responses. By activating the NLRX1 pathway, NX-13 is designed to increase oxidative phosphorylation in immune cells, reduces differentiation of effector CD4-positive T cells, and decrease production of inflammatory cytokines.

    About Landos Biopharma

    Landos Biopharma is a clinical-stage biopharmaceutical company focused on the discovery and development of oral therapeutics for patients with autoimmune diseases that are the first to target new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 immunometabolic pathways. Landos Biopharma's core expertise is in the development of therapeutic candidates targeting novel pathways at the interface of immunity and metabolism. Lead asset BT-11 is a novel, oral, gut-restricted small molecule therapeutic candidate for the treatment of ulcerative colitis and Crohn's disease that targets the LANCL2 pathway. NX-13 is a novel, oral, gut-restricted compound for the treatment of inflammatory bowel disease, which targets the NLRX1 pathway. Additional candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, multiple sclerosis, and diabetes.

    Contacts:

    Thomas Hoffmann (investors)

    Solebury Trout

    646-378-2931

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943

     



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  2. BLACKSBURG, Va., Feb. 23, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma (NASDAQ:LABP), a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced that Dr. Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer, will participate in a fireside chat at the upcoming virtual SVB Leerink 10th Annual Global Healthcare Conference on Wednesday, February 24, 2021 at 12:00 PM EST.

    A live webcast of the fireside chat will be accessible through the Investors/Media section of the Company's website at www.landosbiopharma.com. Following the event, the webcast will be archived on the Landos website.

    About Landos Biopharma

    Landos Biopharma is…

    BLACKSBURG, Va., Feb. 23, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma (NASDAQ:LABP), a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced that Dr. Josep Bassaganya-Riera, Chairman, President and Chief Executive Officer, will participate in a fireside chat at the upcoming virtual SVB Leerink 10th Annual Global Healthcare Conference on Wednesday, February 24, 2021 at 12:00 PM EST.

    A live webcast of the fireside chat will be accessible through the Investors/Media section of the Company's website at www.landosbiopharma.com. Following the event, the webcast will be archived on the Landos website.

    About Landos Biopharma

    Landos Biopharma is a clinical-stage biopharmaceutical company focused on the discovery and development of oral therapeutics for patients with autoimmune diseases that are the first to target new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 immunometabolic pathways. Landos Biopharma's core expertise is in the development of therapeutic candidates targeting novel pathways at the interface of immunity and metabolism. Lead asset BT-11 is a novel, oral, gut-restricted small molecule therapeutic candidate for the treatment of ulcerative colitis and Crohn's disease that targets the LANCL2 pathway. NX-13 is a novel, oral, gut-restricted compound for the treatment of inflammatory bowel disease, which targets the NLRX1 pathway. Additional candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, multiple sclerosis, and diabetes.

    Contacts:

    Thomas Hoffmann (investors)

    Solebury Trout

    646-378-2931

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943



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  3. BLACKSBURG, Va., Feb. 03, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced the pricing of its initial public offering of 6,250,000 shares of common stock at the public offering price of $16.00 per share, for total gross proceeds of $100 million, before deducting underwriting discounts and commissions and offering expenses payable by Landos Biopharma. All of the shares of the common stock are being offered by Landos Biopharma.

    The shares are expected to begin trading on the Nasdaq Global Select Market on February 4, 2021 under the trading symbol of "LABP." The offering is expected to close on…

    BLACKSBURG, Va., Feb. 03, 2021 (GLOBE NEWSWIRE) -- Landos Biopharma, a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutics for patients with autoimmune diseases, today announced the pricing of its initial public offering of 6,250,000 shares of common stock at the public offering price of $16.00 per share, for total gross proceeds of $100 million, before deducting underwriting discounts and commissions and offering expenses payable by Landos Biopharma. All of the shares of the common stock are being offered by Landos Biopharma.

    The shares are expected to begin trading on the Nasdaq Global Select Market on February 4, 2021 under the trading symbol of "LABP." The offering is expected to close on February 8, 2021, subject to customary closing conditions. In addition, Landos Biopharma has granted the underwriters a 30-day option to purchase up to an additional 937,500 shares of its common stock at the initial public offering price less the underwriting discounts and commissions.

    J.P. Morgan, Jefferies and SVB Leerink are acting as joint book-running mangers for the offering. Raymond James is acting as lead manager for the offering.

    A registration statement relating to the securities being sold in the offering was declared effective by the Securities and Exchange Commission on February 3, 2021. This offering is being made only by means of a prospectus. Copies of the final prospectus relating to this offering may be obtained, when available, by contacting: J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, New York 11717, via telephone: +1 (866) 803-9204, or by emailing ; Jefferies, LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022 or by emailing ; and SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, Massachusetts 02120, telephone: 1-800-808-7525, ext. 6105, or by email at .

    This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the security laws of such state or jurisdiction.

    About Landos Biopharma

    Landos Biopharma is a clinical-stage biopharmaceutical company focused on the discovery and development of oral therapeutics for patients with autoimmune diseases that are the first to target new mechanisms of action, including the LANCL2, NLRX1 and PLXDC2 immunometabolic pathways. Landos Biopharma's core expertise is in the development of therapeutic candidates targeting novel pathways at the interface of immunity and metabolism. Lead asset BT-11 is a novel, oral, gut-restricted small molecule therapeutic candidate for the treatment of ulcerative colitis and Crohn's disease that targets the LANCL2 pathway. NX-13 is a novel, oral, gut-restricted compound for the treatment of inflammatory bowel disease, which targets the NLRX1 pathway. Additional candidates are in development for the treatment of lupus nephritis, rheumatoid arthritis, multiple sclerosis, and diabetes.

    Contacts:

    Thomas Hoffmann (investors)

    Solebury Trout

    646-378-2931

    Hannah Gendel (media)

    Solebury Trout

    646-378-2943



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