KRON Kronos Bio Inc.

12.29
-0.81  -6%
Previous Close 13.1
Open 12.6
52 Week Low 12.64
52 Week High 39.605
Market Cap $692,508,145
Shares 56,347,286
Float 40,248,246
Enterprise Value $373,821,446
Volume 213,815
Av. Daily Volume 210,663
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Upcoming Catalysts

Drug Stage Catalyst Date
KB-0742
Solid tumors
Phase 1/2
Phase 1/2
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Entospletinib
FLT3-mutated Acute myeloid leukemia (AML)
Phase 1/2
Phase 1/2
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Entospletinib
Acute myeloid leukemia (AML)
Phase 3
Phase 3
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Drug Pipeline

Drug Stage Notes
Lanraplenib
Relaped or Refractory FLT3-mutated AML
Phase 1/2
Phase 1/2
Phase 1b/2 patient dosing expected to commence 1Q 2022.
Lanraplenib + Venetoclax/Azacitidine
NPM1-mutated AML, FLT3-mutated AML
Phase 1/2
Phase 1/2
Phase 1b/2 trial to be initiated 1H 2022.

Latest News

  1. SAN MATEO, Calif. and CAMBRIDGE, Mass., Nov. 24, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that members of the management team will participate in fireside chats at the following investor conferences:

    • Piper Sandler's 33rd Annual Virtual Healthcare Conference on Tuesday, November 30, 2021 at 11 a.m. Eastern Time; and
    • Evercore ISI's 4th Annual HealthCONx on Thursday, December 2, 2021 at 1 p.m. Eastern Time.

    The fireside chats will be available on the Investors & Media section of the company's website at www.kronosbio.com. A replay of the webcasts will be archived and available for one month following each event.

    About Kronos Bio, Inc.

    SAN MATEO, Calif. and CAMBRIDGE, Mass., Nov. 24, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that members of the management team will participate in fireside chats at the following investor conferences:

    • Piper Sandler's 33rd Annual Virtual Healthcare Conference on Tuesday, November 30, 2021 at 11 a.m. Eastern Time; and

    • Evercore ISI's 4th Annual HealthCONx on Thursday, December 2, 2021 at 1 p.m. Eastern Time.

    The fireside chats will be available on the Investors & Media section of the company's website at www.kronosbio.com. A replay of the webcasts will be archived and available for one month following each event.

    About Kronos Bio, Inc.

    Kronos Bio is a clinical-stage biopharmaceutical company dedicated to discovering and developing therapies that seek to transform the lives of those affected by cancer. The company focuses on targeting dysregulated transcription factors and the regulatory networks within cells that drive cancerous growth. Kronos Bio's lead investigational therapy is entospletinib, a selective inhibitor targeting spleen tyrosine kinase (SYK) in development for the frontline treatment of NPM1-mutated acute myeloid leukemia (AML). The company is also developing KB-0742, an oral inhibitor of cyclin dependent kinase 9 (CDK9), for the treatment of MYC-amplified solid tumors.

    Kronos Bio is based in San Mateo, Calif., and has a research facility in Cambridge, Mass. For more information, visit www.kronosbio.com or follow the company on LinkedIn.

    Company contact:

    Marni Kottle

    Kronos Bio

    650-900-3450

    Investors:

    Claudia Styslinger

    Argot Partners

    212-600-1902

    Media:

    Sheryl Seapy

    Real Chemistry

    949-903-4750



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  2. SAN MATEO, Calif. and CAMBRIDGE, Mass., Nov. 11, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced the appointment of Roshawn Blunt to the company's Board of Directors.

    Ms. Blunt has more than 25 years of experience in the biopharmaceutical and medical device industries. She founded and currently is managing director of 1798, LLC, a national health care consulting firm. She began her pharmaceutical career at The Boston Consulting Group, working primarily in the health care industry. Prior to that, Ms. Blunt held a variety of strategic reimbursement and commercialization positions at Amgen, Inc. She was also the first global director of health…

    SAN MATEO, Calif. and CAMBRIDGE, Mass., Nov. 11, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced the appointment of Roshawn Blunt to the company's Board of Directors.

    Ms. Blunt has more than 25 years of experience in the biopharmaceutical and medical device industries. She founded and currently is managing director of 1798, LLC, a national health care consulting firm. She began her pharmaceutical career at The Boston Consulting Group, working primarily in the health care industry. Prior to that, Ms. Blunt held a variety of strategic reimbursement and commercialization positions at Amgen, Inc. She was also the first global director of health economics and reimbursement for Biosense Webster, Inc., a Johnson & Johnson company. Prior to starting 1798 Consultants, Ms. Blunt was vice president of strategy, planning, and communication at Long Beach Memorial Center and Miller Children's Hospital.

    "We are very pleased to welcome Roshawn to our Board of Directors," said Norbert Bischofberger, Ph.D., president and chief executive officer of Kronos Bio. "Roshawn brings to our Board decades of experience in the commercialization of new therapeutics, including oncology medicines. Her expertise, particularly in enabling patient access, reimbursement and health policy, will be invaluable as we plan for and work toward our first potential product launches."

    "I am excited to join Kronos Bio's Board," said Ms. Blunt. "Throughout my career in the biopharmaceutical industry, I've worked to help companies commercialize important new therapies and to help payors understand the value innovative medicines can bring. I am looking forward to working with the team at Kronos Bio as the company advances its investigational products toward potential market approval."

    Ms. Blunt graduated from Princeton University, where she earned her A.B. from the Princeton School of Public and International Affairs and she holds an MBA from Kellogg School of Management at Northwestern University.

    About Kronos Bio, Inc.

    Kronos Bio is a clinical-stage biopharmaceutical company dedicated to discovering and developing therapies that seek to transform the lives of those affected by cancer. The company focuses on targeting dysregulated transcription factors and the regulatory networks within cells that drive cancerous growth. Kronos Bio's lead investigational therapy is entospletinib, a selective inhibitor targeting spleen tyrosine kinase (SYK) in development for the frontline treatment of NPM1-mutated acute myeloid leukemia (AML). The company is also developing KB-0742, an oral inhibitor of cyclin dependent kinase 9 (CDK9), for the treatment of MYC-amplified solid tumors.

    Kronos Bio is based in San Mateo, Calif., and has a research facility in Cambridge, Mass. For more information, visit www.kronosbio.com or follow the company on LinkedIn.

    Company Contact:

    Marni Kottle

    Kronos Bio

    650-900-3450

    Investors:

    Claudia Styslinger

    Argot Partners

    212-600-1902

    Media:

    Sheryl Seapy

    Real Chemistry

    949-903-4750



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  3. Company today announces progression of two discovery programs within its pipeline

    Highlights from the quarter include presentation of preclinical data on the company's CDK9 inhibitor KB-0742 at AACR-NCI-EORTC meeting in October; Kronos Bio remains on track to report interim data from ongoing Phase 1/2 trial of KB-0742 by year end

    $398.4 million in cash, cash equivalents and investments as of September 30, 2021

    SAN MATEO, Calif. and CAMBRIDGE, Mass., Nov. 09, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today reported recent business progress and third-quarter financial results.

    "As we approach the end of the year, we look forward to reporting interim…

    Company today announces progression of two discovery programs within its pipeline

    Highlights from the quarter include presentation of preclinical data on the company's CDK9 inhibitor KB-0742 at AACR-NCI-EORTC meeting in October; Kronos Bio remains on track to report interim data from ongoing Phase 1/2 trial of KB-0742 by year end

    $398.4 million in cash, cash equivalents and investments as of September 30, 2021

    SAN MATEO, Calif. and CAMBRIDGE, Mass., Nov. 09, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today reported recent business progress and third-quarter financial results.

    "As we approach the end of the year, we look forward to reporting interim data from the ongoing Phase 1/2 study of our internally discovered CDK9 inhibitor, KB-0742, capping off a year of significant progress," said Norbert Bischofberger, Ph.D., president and chief executive officer of Kronos Bio. "In addition to continued execution across our clinical stage programs, I am also pleased with the progress we are making with our pipeline – particularly the addition of two new discovery programs, which underscore the capabilities of our product engine."

    Pipeline Progress

    Kronos Bio today announced it has initiated two new discovery programs, each focused on a distinct target or node identified through the company's research and mapping of the MYC and AR transcriptional regulatory networks (TRNs).

    • Target 1: MYC TRN. Dysregulation of the MYC TRN is a hallmark of cancer and occurs in a large percentage of cancers. The company's existing development candidate, KB-0742, targets CDK9 and is being evaluated in a Phase 1/2 clinical study. KB-0742 is intended to target MYC dysregulation in the context of MYC genomic amplification, which occurs in 30% of all solid tumors. The new Target 1 program is aimed at modulating a protein-protein interaction in the MYC TRN with the objective of treating additional MYC-dysregulated cancers beyond those targeted by KB-0742.
    • Target 2: AR TRN. Dysregulation of the AR (androgen receptor) TRN is a primary driver of prostate cancer. Although therapies that directly inhibit the androgen receptor already exist, many patients with prostate cancer ultimately develop resistance to these therapies and patients with castration-resistant prostate cancer (CRPC) have a particularly poor prognosis. This new program aims to overcome resistance to current therapies by targeting an AR cofactor that selectively modulates the AR TRN in the context of CRPC.
    • The company anticipates identifying a lead candidate and submitting an Investigational New Drug (IND) application out of one of its discovery programs in 2023.

    Additionally, Kronos Bio yesterday announced a multi-year collaboration with Tempus, a leader in artificial intelligence and precision medicine. The agreement will provide Kronos Bio with access to real-world patient genomic and transcriptomic data and data analytics tools, with the goal of accelerating the development of the company's current and future clinical portfolio.

    Third-Quarter Company Highlights

    • Kronos Bio presented preclinical data characterizing the pharmacokinetic (PK) and pharmacodynamic (PD) profile of KB-0742 in a poster at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics in October 2021. These data build on results first shared at the American Association for Cancer Research meeting earlier this year. The new data demonstrated a favorable preclinical PK profile and human PK projection that support the intermittent dosing schedule for patients in the Phase 1/2 study.
    • The U.S. Food and Drug Administration cleared the company's IND for lanraplenib, a next-generation spleen tyrosine kinase (SYK) inhibitor. This allows Kronos Bio to proceed with its planned Phase 1b/2 clinical trial of the compound in patients with relapsed or refractory FLT3-mutated acute myeloid leukemia (AML) in combination with gilteritinib.

    Upcoming Milestones

    • The company plans to report interim safety, PK and PD data in Q4 2021 from the ongoing dose escalation phase of its Phase 1/2 clinical trial of KB-0742, which is being developed to treat MYC-amplified or over-expressing solid tumors.
    • Kronos Bio remains on track to dose the first patient in its planned Phase 3 clinical trial of entospletinib before the end of the year, with a data readout expected in the second half of 2023. This trial will assess measurable residual disease (MRD) negative complete response as the primary endpoint to support potential accelerated approval in patients newly diagnosed with NPM1-mutated AML and eligible for intensive induction chemotherapy.
    • The company expects to dose the first patient in the first of two planned Phase 1b/2 clinical trials of lanraplenib in the first quarter of 2022. This first trial will evaluate lanraplenib in patients with relapsed or refractory FLT3-mutated AML.
    • Kronos Bio plans to initiate a second Phase 1b/2 clinical trial of lanraplenib, in combination with venetoclax/azacitidine in patients newly diagnosed with NPM1-mutated and/or FLT3-mutated AML who are older than age 75 or not eligible for intensive induction chemotherapy in the first half of 2022.

    Third Quarter Financial Highlights

    • Cash, Cash Equivalents and Investments: As of September 30, 2021, cash, cash equivalents and investments totaled $398.4 million.



    • R&D Expenses: Research and development expenses were $24.7 million for the third quarter of 2021, which includes non-cash stock-based compensation expense of $3.5 million.



    • G&A Expenses: General and administrative expenses were $9.0 million for the third quarter of 2021, which includes non-cash stock-based compensation expense of $3.6 million.



    • Net Loss: Net loss for the third quarter of 2021 was $33.6 million, or $0.61 per share, including non-cash stock-based compensation expense of $7.1 million.

    About Kronos Bio, Inc.

    Kronos Bio is a clinical-stage biopharmaceutical company dedicated to discovering and developing therapies that seek to transform the lives of those affected by cancer. The company focuses on targeting dysregulated transcription factors and the regulatory networks within cells that drive cancerous growth. Kronos Bio's lead investigational therapy is entospletinib, a selective inhibitor targeting spleen tyrosine kinase (SYK) in development for the frontline treatment of NPM1-mutated acute myeloid leukemia (AML). The company is also developing KB-0742, an oral inhibitor of cyclin dependent kinase 9 (CDK9), for the treatment of MYC-amplified or overexpressing solid tumors.

    Kronos Bio is based in San Mateo, Calif., and has a research facility in Cambridge, Mass. For more information, visit www.kronosbio.com or follow the company on LinkedIn.

    Forward-Looking Statements

    Statements in this press release that are not statements of historical fact are forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release, in some cases, uses terms such as "look forward," "intend," "aim," "anticipate," "goal," "future," "will," "plan," "expect," or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding Kronos Bio's intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the potential of KB-0742 to target MYC dysregulation in the context of MYC genomic amplification; the potential of the Target 1 program to treat MYC-dysregulated cancers; the potential of the Target 2 program to treat patients with CRPC; Kronos Bio's plans to submit an IND application out of one of its discovery programs in 2023; the potential benefits to Kronos Bio from its collaboration agreement with Tempus, including the acceleration of Kronos Bio's current and future clinical portfolio; Kronos Bio's plans to initiate a registrational Phase 3 trial of entospletinib later this year and the ability of the trial to support potential accelerated approval of entospletinib in patients newly diagnosed with NPM1-mutated AML and eligible for intensive induction chemotherapy; Kronos Bio's plans to begin a Phase 1b/2 clinical trial of lanraplenib in the first quarter of 2022 and another Phase 1b/2 clinical trial of lanraplenib in the first half of 2022; the design of such planned Phase 1b/2 clinical trials of lanraplenib; the expected timing for reporting data; anticipated inflection points in the coming months; and other statements that are not historical fact. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, including, without limitation: whether Kronos Bio will be able to initiate or complete the current and planned clinical trials of entospletinib, lanraplenib and KB-0742 on the timeline expected, if at all, including due to risks associated with the COVID-19 pandemic and risks inherent in the clinical development of novel therapeutics; risks related to using MRD negative complete response as the primary endpoint to support potential accelerated approval in patients newly diagnosed with NPM1-mutated AML and eligible for intensive induction chemotherapy, including the fact that so far there have not been any regulatory approvals on the basis of MRD status in AML; risks related to Kronos Bio's lack of experience as a company in conducting clinical trials; the risk that results of preclinical studies and early clinical trials are not necessarily predictive of future results; and risks associated with the sufficiency of Kronos Bio's cash resources and need for additional capital. These and other risks are described in greater detail in Kronos Bio's filings with the Securities and Exchange Commission (SEC), including under the heading "Risk Factors" in its Quarterly Report on Form 10-Q for the quarter ended June 30, 2021, filed with the SEC on August 12, 2021. Any forward-looking statements that are made in this press release speak only as of the date of this press release and are based on management's assumptions and estimates as of such date. Except as required by law, Kronos Bio assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.



    Kronos Bio, Inc.
    Statements of Operations and Comprehensive Loss
    (in thousands, except share and per share amounts)
    (Unaudited)
     
      Three months ended

    September 30,
     Nine months ended

    September 30,
      2021 2020 2021 2020
    Operating expenses:        
    Research and development $24,688  $16,755  $62,084  $30,125 
    General and administrative 8,985  4,054  26,908  6,831 
    Total operating expenses 33,673  20,809  88,992  36,956 
    Loss from operations (33,673) (20,809) (88,992) (36,956)
    Other income (expense), net:        
    Change in fair value of convertible notes payable   (15,215)   (15,215)
    Interest expense   (3,889)   (3,890)
    Interest and other income, net 70  200  248  774 
    Total other income (expense), net 70  (18,904) 248  (18,331)
    Net loss (33,603) (39,713) (88,744) (55,287)
    Other comprehensive income (loss):        
    Net unrealized gain (loss) on available-for-sale securities 1  (117) 26  65 
    Net comprehensive loss $(33,602) $(39,830) $(88,718) $(55,222)
    Net loss per share, basic and diluted $(0.61) $(6.48) $(1.63) $(9.39)
    Weighted-average shares of common stock, basic and diluted 54,977,085  6,127,146  54,549,747  5,886,191 



    Kronos Bio, Inc.
    Selected Balance Sheet Data
    (in thousands, except share and per share amounts)
    (Unaudited)
     
      September 30, 2021 December 31, 2020
    Cash, cash equivalents and investments $398,382  $462,062 
    Total assets 447,529  511,964 
    Total liabilities 48,506  46,445 
    Total stockholders' equity 399,023  465,519 

    Company Contact:

    Marni Kottle

    Kronos Bio

    415-218-7111

    Investors:

    Claudia Styslinger

    Argot Partners

    212-600-1902

    Media:

    Sheryl Seapy

    Real Chemistry

    949-903-4750



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  4. SAN MATEO, Calif., and CAMBRIDGE, Mass., Nov. 04, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that Charles Lin, Ph.D., Senior Vice President, Biology, will participate in the Emerging Trends and Therapeutics in Oncology panel at the BMO Biopharma Spotlight Series on Monday, November 8 at 3:25 p.m. Eastern Time.

    A replay of the panel will be posted to the Investors & Media section of the company's website at www.kronosbio.com and will be available for one month following the event. 

    About Kronos Bio, Inc.
    Kronos Bio is a clinical-stage biopharmaceutical company dedicated to discovering and developing therapies that seek to transform the…

    SAN MATEO, Calif., and CAMBRIDGE, Mass., Nov. 04, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that Charles Lin, Ph.D., Senior Vice President, Biology, will participate in the Emerging Trends and Therapeutics in Oncology panel at the BMO Biopharma Spotlight Series on Monday, November 8 at 3:25 p.m. Eastern Time.

    A replay of the panel will be posted to the Investors & Media section of the company's website at www.kronosbio.com and will be available for one month following the event. 

    About Kronos Bio, Inc.

    Kronos Bio is a clinical-stage biopharmaceutical company dedicated to discovering and developing therapies that seek to transform the lives of those affected by cancer. The company focuses on targeting dysregulated transcription factors and the regulatory networks within cells that drive cancerous growth. Kronos Bio's lead investigational therapy is entospletinib, a selective inhibitor targeting spleen tyrosine kinase (SYK) in development for the frontline treatment of NPM1-mutated acute myeloid leukemia (AML). The company is also developing KB-0742, an oral inhibitor of cyclin dependent kinase 9 (CDK9), for the treatment of MYC-amplified solid tumors.

    Kronos Bio is based in San Mateo, Calif., and has a research facility in Cambridge, Mass. For more information, visit www.kronosbio.com or follow the company on LinkedIn.

    Company Contact:

    Marni Kottle

    Kronos Bio

    650-900-3450

    Investors: 

    Claudia Styslinger 

    Argot Partners 

    212-600-1902 

      

    Media: 

    Sheryl Seapy 

    Real Chemistry 

    949-903-4750 

      



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  5. SAN MATEO, Calif. and CAMBRIDGE, Mass., Sept. 30, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that it will present preclinical data in a poster at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics. The meeting will be held from Oct. 7-10, 2021.

    The poster will include preclinical data on the pharmacokinetics and pharmacodynamics of KB-0742, Kronos Bio's internally discovered oral CDK9 inhibitor. The data build on results first shared at the American Association for Cancer Research (AACR) meeting earlier this year.

    The investigational compound, which is being developed for the treatment of…

    SAN MATEO, Calif. and CAMBRIDGE, Mass., Sept. 30, 2021 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (NASDAQ:KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that it will present preclinical data in a poster at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics. The meeting will be held from Oct. 7-10, 2021.

    The poster will include preclinical data on the pharmacokinetics and pharmacodynamics of KB-0742, Kronos Bio's internally discovered oral CDK9 inhibitor. The data build on results first shared at the American Association for Cancer Research (AACR) meeting earlier this year.

    The investigational compound, which is being developed for the treatment of MYC-amplified solid tumors, is currently being assessed as part of an ongoing Phase 1/2 study, and Kronos Bio remains on track to announce preliminary results from the clinical study in the fourth quarter.

    The abstract title is now available on the conference website. Details of the poster presentation are as follows:

    Poster Title: Preclinical pharmacokinetics and pharmacodynamics of KB-0742, a selective, oral CDK9 inhibitor

    Abstract Number: P228

    Date and Time: Oct. 7 at 9 a.m. ET

    About KB-0742

    KB-0742 is a highly selective, orally bioavailable inhibitor of cyclin dependent kinase 9 (CDK9) in development for the treatment of MYC-amplified solid tumors. CDK9 is a global regulator of transcription and plays an essential role in both the expression and function of MYC, a well-characterized transcription factor and a long-recognized driver of cancer that is amplified in approximately 30% of solid tumors, including those affecting the lungs, ovaries, esophagus, breast, stomach, pancreas and liver. KB-0742 was generated and optimized from a compound that was identified using the company's proprietary small molecule microarray (SMM) screening platform.

    About Kronos Bio, Inc.

    Kronos Bio is a clinical-stage biopharmaceutical company dedicated to discovering, developing and commercializing therapies that seek to transform the lives of those affected by cancer. The company focuses on targeting dysregulated transcription factors and the regulatory networks within cells that drive cancerous growth. Kronos Bio's lead investigational therapy is entospletinib, a selective inhibitor targeting spleen tyrosine kinase (SYK) in development for the frontline treatment of NPM1-mutated acute myeloid leukemia (AML). The company is also developing KB-0742, an oral inhibitor of cyclin dependent kinase 9 (CDK9), for the treatment of MYC-amplified solid tumors.

    Kronos Bio is based in San Mateo, Calif., and has a research facility in Cambridge, Mass. For more information, visit www.kronosbio.com or follow the company on LinkedIn.



    Forward-Looking Statements

    Statements in this press release that are not statements of historical fact are forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release, in some cases, uses terms such as "will," "present," "anticipated," "ongoing," "to announce" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding Kronos Bio's intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the design of the KB-0742 Phase 1/2 clinical trial, including to establish clinical proof of concept to enable potential further development, the timing of and results from the KB-0742 clinical trial, and other statements that are not historical fact. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, including, without limitation: whether Kronos Bio will be able to complete the Phase 1/2 clinical trial of KB-0742, including due to risks associated with the COVID-19 pandemic and risks inherent in the clinical development of novel therapeutics; risks related to Kronos Bio's lack of experience as a company in conducting clinical trials; the risk that results of preclinical studies and early clinical trials are not necessarily predictive of future results; the risk that due to the relatively small number of patients that Kronos Bio plans to dose in the planned Phase 1/2 KB-0742 clinical trial, the results from such trial, once completed, may be less reliable than results achieved in larger clinical trials, which may hinder Kronos Bio's efforts to further develop and obtain regulatory approval for KB-0742; and risks associated with the sufficiency of Kronos Bio's cash resources and need for additional capital. These and other risks are described in greater detail in Kronos Bio's filings with the Securities and Exchange Commission (SEC), including under the heading "Risk Factors" in its Quarterly Report on Form 10-Q for the quarter ended June 30, 2021, filed with the SEC on August 12, 2021. Any forward-looking statements that are made in this press release speak only as of the date of this press release and are based on management's assumptions and estimates as of such date. Except as required by law, Kronos Bio assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.

    Company Contact:

    Marni Kottle

    Senior Vice President, Corporate Communications & Investor Relations

    415-218-7111

    Investors:

    Claudia Styslinger

    Argot Partners

    212-600-1902

    Media:

    Sheryl Seapy

    Real Chemistry

    949-903-4750



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