IMRX Immuneering Corporation

12.06
-0.42  -3%
Previous Close 12.48
Open 12.1
52 Week Low 11.03
52 Week High 33.99
Market Cap $317,421,600
Shares 26,320,199
Float 21,570,561
Enterprise Value $168,508,389
Volume 69,719
Av. Daily Volume 70,763
Stock charts supplied by TradingView

Drug Pipeline

Drug Stage Notes
IMM-1-104
Solid tumors
Phase 1
Phase 1
Phase 1 trial planned for 1H 2022. IND planned for 1Q 2022.

Latest News

  1. BOSTON, Jan. 19, 2022 (GLOBE NEWSWIRE) -- PepGen, Inc., a company advancing next-generation oligonucleotide therapies for neuromuscular and neurologic diseases, today announced that it has appointed Laurie Keating as Chair of the company's Board of Directors.

    "We are very pleased that Laurie has agreed to join as Chair of our Board of Directors – she is a seasoned executive and Board member who has been a key member of the executive teams of two Boston biotechs that have transitioned from preclinical to successful commercial companies. We look forward to her strategic contributions and guidance as we continue to grow and build PepGen into a leading oligonucleotide therapies company focused on serious genetic disorders," said James McArthur…

    BOSTON, Jan. 19, 2022 (GLOBE NEWSWIRE) -- PepGen, Inc., a company advancing next-generation oligonucleotide therapies for neuromuscular and neurologic diseases, today announced that it has appointed Laurie Keating as Chair of the company's Board of Directors.

    "We are very pleased that Laurie has agreed to join as Chair of our Board of Directors – she is a seasoned executive and Board member who has been a key member of the executive teams of two Boston biotechs that have transitioned from preclinical to successful commercial companies. We look forward to her strategic contributions and guidance as we continue to grow and build PepGen into a leading oligonucleotide therapies company focused on serious genetic disorders," said James McArthur, Ph.D., President and Chief Executive Officer of PepGen.

    Dr. McArthur continued, "Laurie replaces Ramin Farzaneh-Far, M.D., who served as PepGen's Board Chair from November 2020 and will continue in his current role as acting Chief Medical Officer. We are very grateful to Ramin for his critical service in advancing the company, and for his support during our Series A and B fundraising rounds."

    In addition to her role on the PepGen Board of Directors, Laurie also serves as a Director of Immuneering Corp (NASDAQ:IMRX) and Imago Biosciences (NASDAQ:IMGO), and has served for more than ten years on the Board of MassBio. Laurie previously served as the Executive Vice President, General Counsel and Corporate Secretary of Alnylam Pharmaceuticals. In this role she led global government affairs, legal, IP, litigation and compliance, and advised the Board on financing and strategic collaborations, governance, and corporate strategy. Prior to Alnylam, she served as SVP, General Counsel and Corporate Secretary of Millennium Pharmaceuticals, a commercial stage company that was later acquired by Takeda. At Millennium, Laurie led the global Legal, Intellectual Property, Corporate Quality and Compliance groups. Prior to Millennium, Laurie was founding CEO and a director of Hydra Biosciences. Her contributions and executive leadership at public high technology companies earlier in her career led to her being named one of the 45 most influential in-house lawyers in the U.S. under the age of 45. Laurie earned her bachelor's degree in Economics from the University of California at Berkeley, and her JD from the University of California, Hastings College of the Law.

    "I am thrilled to be joining PepGen as the new Chair of the Board of Directors. I look forward to guiding the company's development and supporting the leadership team as they seek to transform the lives of patients with innovative new treatment options for severe neuromuscular and neurologic diseases," Keating said.

    About PepGen 



    PepGen, Inc. is a biotechnology company advancing next-generation oligonucleotide therapies for neuromuscular and neurologic diseases. PepGen's proprietary Enhanced Delivery Oligonucleotides (EDOs) are designed to target the underlying causes of rare diseases safely and effectively such as Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1). In preclinical studies, PepGen's enhanced delivery peptides demonstrated success in cell penetration and delivery of therapeutic candidates to multiple tissue types, including cardiac tissue. PepGen was founded by leading neurology researchers in Oxford, UK and is backed by a strong syndicate of investors including RA Capital Management, Oxford Science Enterprises, and others. The company is headquartered in Boston, Mass. For more information, visit www.pepgen.com or follow PepGen on Twitter and LinkedIn.

    Media Contact 

    Gwendolyn Schanker 

    LifeSci Communications 



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  2. CAMBRIDGE, Mass., Jan. 18, 2022 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced the appointment of Diana F. Hausman, M.D., Chief Medical Officer of Lengo Therapeutics (a wholly-owned subsidiary of Blueprint Medicines Corporation), to its Board of Directors. This appointment brings Immuneering's Board to six members.

    "Diana has dedicated her career to creating new and better possibilities for cancer patients, as a Board certified oncologist with more than 20 years of clinical drug development experience at both privately held and publicly traded…

    CAMBRIDGE, Mass., Jan. 18, 2022 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced the appointment of Diana F. Hausman, M.D., Chief Medical Officer of Lengo Therapeutics (a wholly-owned subsidiary of Blueprint Medicines Corporation), to its Board of Directors. This appointment brings Immuneering's Board to six members.

    "Diana has dedicated her career to creating new and better possibilities for cancer patients, as a Board certified oncologist with more than 20 years of clinical drug development experience at both privately held and publicly traded companies. She brings an important depth of expertise which will be invaluable as we continue to advance our pipeline including our lead candidate, IMM-1-104, a dual-MEK inhibitor for the treatment of RAS mutant solid tumors," stated Ben Zeskind, Ph.D., Co-Founder and Chief Executive Officer of Immuneering. "She will fit right in with our phenomenal, world-class board and her strengths will be highly complementary. We look forward to Diana's many contributions."

    "The preclinical data for IMM-1-104 is highly compelling, and supports Immuneering's unique deep-cyclic inhibition approach for treating the many tumors that are driven by MAPK pathway activation," noted Dr. Hausman. "The earlier stage pipeline is also very exciting, along with the translational bioinformatics platform that yielded many of the counterintuitive, data-driven insights underlying these programs. The Immuneering team is terrific. I am honored to be working with them, and am eager to bring my specific skills, insights and industry relationships to bear in order to help the company achieve its goals."

    Dr. Hausman's broad pharmaceutical industry experience includes work with biologics, antibody-drug conjugates and targeted small molecules in the fields of oncology (including immunotherapy), hemostasis, hepatitis C, and Crohn's disease. Additionally, she is well versed in all aspects of drug development, including development and implementation of clinical strategy.

    Since June 2021, Dr. Hausman has been the Chief Medical Officer of Lengo Therapeutics, a biopharmaceutical company developing novel precision medicines targeting driver mutations in oncology and now a wholly-owned subsidiary of Blueprint Medicines Corporation. From 2016 to 2021, Dr. Hausman was Chief Medical Officer at Zymeworks Inc., responsible for the development and implementation of global clinical strategy for the company's preclinical and clinical stage products. Earlier, from 2009 to 2016, Dr. Hausman held various positions at Oncothyreon Inc. (acquired by Seattle Genetics, Inc.), most recently serving as Chief Medical Officer, overseeing the Phase 1b and early Phase 2 clinical program for the HER2-targeted small molecule, tucatinib. During her career, she has also held positions of increasing responsibility at ZymoGenetics, Inc. (acquired by Bristol Myers Squibb), Berlex, Inc. and Immunex Corporation (acquired by Amgen Inc.).

    Dr. Hausman received her internal medicine and specialty training in hematology and medical oncology at the University of Washington. She received her M.D. degree from the University of Pennsylvania, Philadelphia, PA, and a Bachelor of Arts degree in biology from Princeton University. She is an active member of both the American Society of Hematology and American Society of Clinical Oncology and is co-author of numerous papers, abstract and posters which have been published in peer reviewed journals.

    About Immuneering Corporation                                        

    Immuneering is a biopharmaceutical company with an emerging pipeline focused on improving patient outcomes across a spectrum of debilitating oncologic and neurologic diseases by applying its deep knowledge of translational bioinformatics to every stage of the drug development process. Immuneering has more than a decade of experience in translational bioinformatics and generating insights into drug mechanisms of action and patient treatment responses. Building on this experience, Immuneering has developed a disease-agnostic platform that enables the company to utilize human data, novel biology and chemistry, and translational planning to create and advance its wholly owned pipeline. Immuneering's current development programs in oncology are focused on providing potential treatments for patients with solid tumors caused by mutations of oncologic signaling pathways, including the MAPK pathway. Immuneering's lead product candidate, IMM-1-104, is designed to be a highly selective dual-MEK inhibitor that further disrupts KSR for the treatment of advanced solid tumors in patients harboring RAS mutant tumors. Additionally, Immuneering has six other oncology programs in the discovery stage that are designed to target either the MAPK or mTOR pathway, and two neuroscience programs in the discovery stage.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements," including, without limitation, statements regarding Immuneering's progress toward drugs targeting cancers driven by alterations that activate the RAS/MAPK pathway, the treatment potential of IMM-1-104, including in comparison to existing treatments, the timing of regulatory filings for IMM-1-104 with the FDA and commencement of clinical trials for IMM-1-104. Forward-looking statements are based on Immuneering's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the risks inherent in oncology and neuroscience drug development, including target discovery, target validation, lead compound identification, lead compound optimization, preclinical studies and clinical trials. These and other risks and uncertainties are described more fully in the section titled "Risk Factors" in the Company's most recent Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) as well as in Immuneering's subsequent filings it makes with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immuneering undertakes no duty to update such information except as required under applicable law.

    Corporate Contact:

    Rebecca Kusko, Ph.D.

    Immuneering Corporation

    617-500-8080

    Investor Contact:

    Susan A. Noonan

    S.A. Noonan Communications

    917-513-5303



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  3. Preclinical Data Suggest IMM-1-104 May Offer Unique Therapeutic Advantage Compared with Binimetinib in NRAS Mutant Tumors

    Data to be discussed in Key External Expert event on January 6 2022, 5PM Eastern Time

    CAMBRIDGE, Mass., Jan. 06, 2022 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced preclinical data highlighting the potential of its lead product candidate, IMM-1-104, to inhibit tumor growth in NRAS mutant melanoma models. The data were submitted as a poster presentation at the recently postponed American Association for Cancer Research…

    Preclinical Data Suggest IMM-1-104 May Offer Unique Therapeutic Advantage Compared with Binimetinib in NRAS Mutant Tumors

    Data to be discussed in Key External Expert event on January 6 2022, 5PM Eastern Time

    CAMBRIDGE, Mass., Jan. 06, 2022 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced preclinical data highlighting the potential of its lead product candidate, IMM-1-104, to inhibit tumor growth in NRAS mutant melanoma models. The data were submitted as a poster presentation at the recently postponed American Association for Cancer Research (AACR) Special Conference: Targeting RAS (originally scheduled for January 7-10, 2022). Given that abstracts are not being published at this time due to postponement of the event, Immuneering is making available the data in a presentation titled "Head-to-Head Comparison of the Dual-MEK Inhibitor IMM-1-104 Versus Binimetinib in NRAS Mutant Melanoma Models," by Peter King, PhD, Vice President and Head of Discovery at Immuneering on its website (www.immuneering.com/publications/).

    IMM-1-104 is a novel, allosteric dual-MEK inhibitor that is designed to disrupt phosphorylation of both MEK and its downstream target ERK and has a short plasma drug half-life, with the aim of enabling deep cyclic inhibition with a near-zero drug trough. The Company anticipates submission of an Investigational New Drug application (IND) for IMM-1-104 to the U.S. Food and Drug Administration (FDA) in the third quarter of this year.

    "These compelling data add to the growing body of preclinical evidence in support of IMM-1-104's potential to inhibit tumors driven by the MAPK pathway including KRAS and NRAS mutant tumors. This is especially important because existing drugs targeting this pathway often are limited by toxicity or are narrowly focused on subpopulations with specific mutations," said Ben Zeskind, Ph.D., Co-Founder, President and Chief Executive Officer of Immuneering. "We look forward to evaluating IMM-1-104 in human clinical trials, with plans to enroll the first patient in the fourth quarter of this year. The preclinical data we are sharing today further support IMM-1-104's differentiation from previously developed therapies, and showcase the potential of its deep cyclic inhibition mechanism to achieve our goal of selectively impacting RAS mutant tumors with greater durability and reduced overall toxicity."

    In this preclinical study, Immuneering modeled binimetinib versus IMM-1-104 in SK-MEL-2 in vivo. SK-MEL-2 is a melanoma tumor cell line that displays a similar molecular profile to approximately half of the patients who participated in the Phase 3 NEMO study, displaying an NRAS-Q61R mutation. The NEMO study results showed binimetinib did not improve overall survival compared with dacarbazine (11.0 vs. 10.1 months, respectively) in NRAS mutant melanoma patients and, in fact, showed a 50% increase in serious adverse events (34% vs. 22%, respectively)1.

    _________________

    1 Lancet Oncol. 2017 Apr. 18(4): 435-445

    Immuneering researchers tested IMM-1-104 head-to-head compared with binimetinib across a series of preclinical experiments to better understand differential in vivo and in vitro activity of each compound. Cell-based 2D and 3D in vitro biochemical and pharmacologic assays were performed across nine melanoma models. The SK-MEL-2 melanoma xenograft mouse model was used to evaluate single agent activity of IMM-1-104 (50, 100, 125, 150 mg/kg BID p.o.) compared with binimetinib (3, 10, 30 mg/kg BID p.o.) for 21 days treatment after tumors had reached 150 to 200 mm2.

    Head-to-head comparison in vivo showed binimetinib had little effect on curtailing growth of SK-MEL-2 melanoma tumors (Tumor Growth Inhibition (TGI) range = 20.6% to 35.6%), whereas IMM-1-104 resulted in 74.9% to 99.9% TGI, with the top two doses driving mid-cycle regressions.

    Dr. King concluded, "Collectively, our data suggest that binimetinib may not effectively control MAPK pathway reactivation in RAS mutant tumors whereas the deep, cyclic dual-MEK approach of IMM-1-104 may offer a unique therapeutic advantage over first generation MEK inhibitors in this indication."

    Immuneering will be hosting a Key External Expert Event, which will review the data. Event details are below:

    Title: Better Medicines for NRAS Mutations Through Signaling Dynamics

    Day/Time: Thursday Jan 6 2022, 5PM ET - 6PM ET

    Key External Expert Presenter: Dr. Anna Pavlick, BSN, MSc, DO, MBA, Professor of Medicine in the Division of Hematology & Medical Oncology at Weill Cornell Medicine

    Registration: https://onlinexperiences.com/Launch/QReg/ShowUUID=32DFF896-4D52-496E-93BB-4A34DE05B0A2

    The poster in its entirety can be accessed via the Immuneering website for 30 days at https://immuneering.com/publications/.

    A replay of the Key External Expert event can be accessed via the Immuneering IR website for 30 days at https://ir.immuneering.com/news-events/events-presentations.

    Presenter Bio: Anna Pavlick, BSN, MSc, DO, MBA is a medical oncologist with over 20 years of experience treating patients with skin cancer, including melanoma, basal cell cancer, squamous cell cancer and Merkel cell carcinoma. She is also an expert in treating ocular melanoma, eyelid tumors and other rare solid tumor malignancies, including a research interest in neurofibromatosis-1 (NF1) malignancies. Dr. Pavlick is Professor of Medicine in the Division of Hematology & Medical Oncology at Weill Cornell Medicine. She is the founding Director of the Cutaneous Oncology Program at Weill Cornell Medicine and NewYork-Presbyterian. Dr. Pavlick's major research interests include investigating targeted therapies, combination therapies and immunotherapies.

    Dr. Pavlick earned her medical degree from the University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School; her Master of Science in Human Anatomy from Fairleigh Dickinson University; and her Bachelor of Science in Biology and Nursing degree from Fairfield University. She completed an internal medicine residency at UMDNJ and hematology and oncology fellowship training at Memorial Sloan Kettering Cancer Center. In addition to her undergraduate and medical training, Dr. Pavlick graduated from the Drexel School of Medicine Executive Leadership in Academic Medicine in 2012 and earned her Master of Business Administration (MBA) degree from Columbia University Business School in 2017. Dr. Pavlick has authored and co-authored over 100 publications and presented her research at international meetings. She serves on several editorial boards, including The Journal of Drugs in Dermatology and The Journal of ImmunoTherapeutics of Cancer (Associate Editor). She is a member of leading oncology societies including American Society of Clinical Oncology (ASCO), American Academy of Clinical Research (AACR), the Society for Melanoma Research, Society for Immunotherapy and Translational Research in Cancer and the European Society of Medical Oncology (ESMO).

    About Immuneering Corporation                                        

    Immuneering is a biopharmaceutical company with an emerging pipeline focused on improving patient outcomes across a spectrum of debilitating oncologic and neurologic diseases by applying its deep knowledge of translational bioinformatics to every stage of the drug development process. Immuneering has more than a decade of experience in translational bioinformatics and generating insights into drug mechanisms of action and patient treatment responses. Building on this experience, Immuneering has developed a disease-agnostic platform that enables the company to utilize human data, novel biology and chemistry, and translational planning to create and advance its wholly owned pipeline. Immuneering's current development programs in oncology are focused on providing potential treatments for patients with solid tumors caused by mutations of oncologic signaling pathways, including the MAPK pathway. Immuneering's lead product candidate, IMM-1-104, is designed to be a highly selective dual-MEK inhibitor that further disrupts KSR for the treatment of advanced solid tumors in patients harboring RAS mutant tumors. Additionally, Immuneering has six other oncology programs in the discovery stage that are designed to target either the MAPK or mTOR pathway, and two neuroscience programs in the discovery stage.        

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements," including, without limitation, statements regarding Immuneering's progress toward drugs targeting cancers driven by alterations that activate the RAS/MAPK pathway, the treatment potential of IMM-1-104, including in comparison to existing treatments, the timing of regulatory filings for IMM-1-104 with the FDA and commencement of clinical trials for IMM-1-104. Forward-looking statements are based on Immuneering's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the risks inherent in oncology and neuroscience drug development, including target discovery, target validation, lead compound identification, lead compound optimization, preclinical studies and clinical trials. These and other risks and uncertainties are described more fully in the section titled "Risk Factors" in the Company's most recent Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) as well as in Immuneering's subsequent filings it makes with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immuneering undertakes no duty to update such information except as required under applicable law.

    Corporate Contact:

    Rebecca Kusko, Ph.D.

    Immuneering Corporation



    617-500-8080

    Investor Contact:

    Susan A. Noonan

    S.A. Noonan Communications



    917-513-5303



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  4. CAMBRIDGE, Mass., Jan. 03, 2022 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced the appointment of Rimma Steinhertz, Ph.D., PMP to the newly created position of Vice President, Project and Alliance Management, effective immediately. In this role, Dr. Steinhertz will focus on working with Immuneering's leadership team as it advances IMM-1-104 as a monotherapy into clinical trials in 2022 and working with potential future partners to advance combination approaches with IMM-1-104 in select patient populations.

    "Rimma is a highly accomplished program…

    CAMBRIDGE, Mass., Jan. 03, 2022 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced the appointment of Rimma Steinhertz, Ph.D., PMP to the newly created position of Vice President, Project and Alliance Management, effective immediately. In this role, Dr. Steinhertz will focus on working with Immuneering's leadership team as it advances IMM-1-104 as a monotherapy into clinical trials in 2022 and working with potential future partners to advance combination approaches with IMM-1-104 in select patient populations.

    "Rimma is a highly accomplished program leader and project manager with decades of experience in preclinical and clinical development for oncology and neurology," stated Ben Zeskind, Ph.D., Co-Founder and Chief Executive Officer of Immuneering. "We welcome Rimma to the team and look forward to leveraging her broad expertise, deep knowledge of best practices in project management for pharmaceutical R&D, and industry relationships as we steadily advance our robust pipeline of novel product candidates, including IMM-1-104."

    "Immuneering is employing a novel, differentiated approach to drug development and I look forward to supporting the company's commitment to operational excellence as it transitions from preclinical development into human clinical trials," noted Dr. Steinhertz.

    Dr. Steinhertz joins Immuneering from Glenmark Pharmaceuticals/Ichnos Sciences, Inc., where, since 2019, she served as Executive Director, Global Program Leader, Portfolio & Program Management, Oncology. Previously, from 2016 to 2019, she was the Group Director, External Collaborations, Oncology at Merck & Co., Inc., where she led a group of more than 30 clinical scientists and project managers supporting over 250 combination Phase 1-3 studies in 30+ indications for Keytruda® in co-development with pharmaceutical and biotechnology companies, academic and U.S. government entities. Prior to that, from 2006 through 2015, Dr. Steinhertz held positions of increasing responsibility in the oncology group at Eisai, Inc., most recently serving as Director, Program & Alliance Management, Oncology Business Unit. Earlier in her career, from 2002 to 2006, she held various positions at Johnson & Johnson Pharmaceutical Research & Development, working on several pre-IND assets across multiple indications.

    Dr. Steinhertz earned the equivalent of a B.S. in chemical engineering from the Moscow Technological Institute, a B.S. in chemistry from Rhode Island College, a Ph.D. in medicinal/organic chemistry from Boston College and a Project Management Professional (PMP) from the Project Management Institute. She also completed a Postdoctoral Fellowship in medicinal/organic chemistry at Harvard University.

    About Immuneering Corporation

    Immuneering is a biopharmaceutical company with an emerging pipeline focused on improving patient outcomes across a spectrum of debilitating oncologic and neurologic diseases by applying its deep knowledge of translational bioinformatics to every stage of the drug development process. Immuneering has more than a decade of experience in translational bioinformatics and generating insights into drug mechanisms of action and patient treatment responses. Building on this experience, Immuneering has developed a disease-agnostic platform that enables the company to utilize human data, novel biology and chemistry, and translational planning to create and advance its wholly owned pipeline. Immuneering's current development programs in oncology are focused on providing potential treatments for patients with solid tumors caused by mutations of oncologic signaling pathways, including the MAPK pathway. Immuneering's lead product candidate, IMM-1-104, is designed to be a highly selective dual-MEK inhibitor that further disrupts KSR for the treatment of advanced solid tumors in patients harboring RAS mutant tumors. Additionally, Immuneering has six other oncology programs in the discovery stage that are designed to target either the MAPK or mTOR pathway, and two neuroscience programs in the discovery stage.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements," including, without limitation, statements regarding Immuneering's progress toward drugs targeting cancers driven by alterations that activate the RAS/MAPK pathway, the treatment potential of IMM-1-104, including in combination with other drugs, the timing of regulatory filings for IMM-1-104 with the FDA and commencement of clinical trials for IMM-1-104. Forward-looking statements are based on Immuneering's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the risks inherent in oncology and neuroscience drug development, including target discovery, target validation, lead compound identification, lead compound optimization, preclinical studies and clinical trials. These and other risks and uncertainties are described more fully in the section titled "Risk Factors" in the Company's most recent Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) as well as in Immuneering's subsequent filings it makes with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immuneering undertakes no duty to update such information except as required under applicable law.

    Corporate Contact:

    Rebecca Kusko, Ph.D.

    Immuneering Corporation

    617-500-8080

    Investor Contact:

    Susan A. Noonan

    S.A. Noonan Communications

    917-513-5303



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  5. CAMBRIDGE, Mass., Dec. 16, 2021 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced that it will be added to the Nasdaq Biotechnology Index (NASDAQ:NBI) effective prior to the market open on Monday, December 20, 2021.

    The Nasdaq Biotechnology Index (NBI) is designed to measure the performance of a set of securities listed on the Nasdaq Stock Market that are classified as either biotechnology or pharmaceutical according to the Industry Classification Benchmark (ICB). The NBI is calculated under a modified market capitalization-weighted methodology…

    CAMBRIDGE, Mass., Dec. 16, 2021 (GLOBE NEWSWIRE) -- Immuneering Corporation (NASDAQ:IMRX), a biopharmaceutical company advancing a robust pipeline of oncology and neuroscience product candidates that are designed to uniquely disrupt cellular signaling dynamics, today announced that it will be added to the Nasdaq Biotechnology Index (NASDAQ:NBI) effective prior to the market open on Monday, December 20, 2021.

    The Nasdaq Biotechnology Index (NBI) is designed to measure the performance of a set of securities listed on the Nasdaq Stock Market that are classified as either biotechnology or pharmaceutical according to the Industry Classification Benchmark (ICB). The NBI is calculated under a modified market capitalization-weighted methodology. Companies in the NBI must meet eligibility requirements, including minimum market capitalization, average daily trading volume and seasoning as a public company, among other criteria. Nasdaq selects constituents once annually in December. For more information about the NBI, please visit https://indexes.nasdaqomx.com/Index/Overview/NBI.

    "Immuneering's addition to the NBI, less than five months after our upsized initial public offering, is a welcome development which will help to expand our visibility within the investment community," said Ben Zeskind, Ph.D., Immuneering's Co-Founder, President and Chief Executive Officer. "IMM-1-104 has demonstrated tumor growth inhibition across 5 different animal models each driven by a different RAS or RAF mutation. We are honored by the excitement investors have shown for IMM-1-104 and our earlier stage programs, all driven by translational bioinformatics. Our inclusion in the NBI reflects the strength of our pipeline and our platform, and we remain focused on executing our plans to advance IMM-1-104 and the rest of our pipeline."

    About Immuneering Corporation                                        

    Immuneering is a biopharmaceutical company with an emerging pipeline focused on improving patient outcomes across a spectrum of debilitating oncologic and neurologic diseases by applying its deep knowledge of translational bioinformatics to every stage of the drug development process. Immuneering has more than a decade of experience in translational bioinformatics and generating insights into drug mechanisms of action and patient treatment responses. Building on this experience, Immuneering has developed a disease-agnostic platform that enables the company to utilize human data, novel biology and chemistry, and translational planning to create and advance its wholly owned pipeline. Immuneering's current development programs in oncology are focused on providing potential treatments for patients with solid tumors caused by mutations of oncologic signaling pathways, including the MAPK pathway. Immuneering's lead product candidate, IMM-1-104, is designed to be a highly selective dual-MEK inhibitor that further disrupts KSR for the treatment of advanced solid tumors in patients harboring RAS mutant tumors. Additionally, Immuneering has six other oncology programs in the discovery stage that are designed to target either the MAPK or mTOR pathway, and two neuroscience programs in the discovery stage.        

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements," including, without limitation, statements regarding Immuneering's progress toward drugs targeting cancers driven by alterations that activate the RAS/MAPK pathway, the treatment potential of IMM-1-104, and the strength of Immuneering's translational bioinformatics approach and technology platform. Forward-looking statements are based on Immuneering's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the risks inherent in oncology and neuroscience drug development, including target discovery, target validation, lead compound identification, lead compound optimization, preclinical studies and clinical trials. These and other risks and uncertainties are described more fully in the section titled "Risk Factors" in the Company's most recent Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) as well as in Immuneering's subsequent filings it makes with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immuneering undertakes no duty to update such information except as required under applicable law.

    Corporate Contact:

    Rebecca Kusko, Ph.D.

    Immuneering Corporation

    617-500-8080

    rkusko@immuneering.com

    Investor Contact:

    Susan A. Noonan

    S.A. Noonan Communications



    917-513-5303 



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