1. Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, today announced that Purnanand Sarma, Ph.D., Immunome's President and CEO, will present at the Oppenheimer Fall Healthcare Life Sciences and MedTech Summit on Tuesday, September 21, 2021, at 9:55 a.m. ET.

    Interested parties can access the live audio webcast for this conference from the Investor Relations section of the company's website at www.immunome.com. The webcast replay will be available after the conclusion of the live presentation for approximately 30 days.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform…

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, today announced that Purnanand Sarma, Ph.D., Immunome's President and CEO, will present at the Oppenheimer Fall Healthcare Life Sciences and MedTech Summit on Tuesday, September 21, 2021, at 9:55 a.m. ET.

    Interested parties can access the live audio webcast for this conference from the Investor Relations section of the company's website at www.immunome.com. The webcast replay will be available after the conclusion of the live presentation for approximately 30 days.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its COVID-19 therapeutic antibody programs, execution of its regulatory, clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01, including expectations regarding therapeutic potential and benefits thereof. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy with respect to its R&D efforts, IND submissions and other regulatory filings, timing of these filings and governmental authority feedback regarding the same, initiation of clinical studies and other anticipated milestones as and when anticipated; the effectiveness of Immunome's product candidates, including the possibility that further preclinical data and any clinical trial data may be inconsistent with the data used for advancing the product candidates; Immunome's ability to fund operations; Immunome's reliance on vendors; the competitive landscape; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  2. -IMM-BCP-01 already shown to neutralize all other Centers for Disease Control (CDC) variants of concern in pre-clinical testing-

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced today that its three-antibody cocktail (IMM-BCP-01) has demonstrated potent neutralizing activity against SARS-CoV-2 Lambda (C.37) and Delta AY.1/2 (Delta Plus) variants, in pre-clinical testing conducted by Immunome on lentiviral-based pseudovirus. IMM-BCP-01 consists of three antibodies that bind to non-overlapping regions of the spike protein and show combinatorial activity against multiple strains of SARS-CoV-2.

    "IMM-BCP-01 continues…

    -IMM-BCP-01 already shown to neutralize all other Centers for Disease Control (CDC) variants of concern in pre-clinical testing-

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced today that its three-antibody cocktail (IMM-BCP-01) has demonstrated potent neutralizing activity against SARS-CoV-2 Lambda (C.37) and Delta AY.1/2 (Delta Plus) variants, in pre-clinical testing conducted by Immunome on lentiviral-based pseudovirus. IMM-BCP-01 consists of three antibodies that bind to non-overlapping regions of the spike protein and show combinatorial activity against multiple strains of SARS-CoV-2.

    "IMM-BCP-01 continues to demonstrate its broad neutralizing activity against emerging SARS-CoV-2 variants in preclinical testing, most recently against the Lambda and Delta plus variants. While the Delta lineage is the dominant strain in the U.S., the Lambda variant is rapidly spreading through South America, and is a designated variant of interest by World Health Organization (WHO). IMM-BCP-01 was designed to be resistant to SARS-CoV-2 variants, and we are delighted that our approach continues to be supported by our preclinical data," said Purnanand Sarma, PhD, President & CEO of Immunome. "These results give us further confidence that IMM-BCP-01 will be critical in the ongoing fight against SARS-CoV-2. IMM-BCP-01 has already been shown to neutralize all other current Centers for Disease Control (CDC) variants of concern in pre-clinical testing."

    This project was funded by the U.S. Department of Defense (DOD) Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense's (JPEO-CBRND) Joint Project Manager for Chemical, Biological, Radiological and Nuclear Medical (JPEO-CBRN Medical), in collaboration with the Defense Health Agency (DHA).

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its COVID-19 therapeutic antibody programs, execution of its regulatory, clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01, including expectations regarding therapeutic potential and benefits thereof. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy with respect to its R&D efforts, IND submissions and other regulatory filings, timing of these filings and governmental authority feedback regarding the same, initiation of clinical studies and other anticipated milestones as and when anticipated; the effectiveness of Immunome's product candidates, including the possibility that further preclinical data and any clinical trial data may be inconsistent with the data used for advancing the product candidates; Immunome's ability to fund operations; Immunome's reliance on vendors; the competitive landscape; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  3. - Demonstrated Potent Neutralization Activity of IMM-BCP-01 Against SARS-CoV-2 Delta Variant in Preclinical Pseudovirus Testing -

    - IMM-BCP-01: Selected Antibody Cocktail, Progressing Towards IND Filing -

    - Awarded an Additional $4.3 million by the U.S. Department of Defense -

    - Raised $27 million in Gross Proceeds in a Private Placement -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, today reported financial results for the second quarter ended June 30, 2021 and provided a corporate update.

    "We made strong progress during Q2 in the development of IMM-BCP-01, our antibody cocktail to combat SARS-CoV-2. We finalized the…

    - Demonstrated Potent Neutralization Activity of IMM-BCP-01 Against SARS-CoV-2 Delta Variant in Preclinical Pseudovirus Testing -

    - IMM-BCP-01: Selected Antibody Cocktail, Progressing Towards IND Filing -

    - Awarded an Additional $4.3 million by the U.S. Department of Defense -

    - Raised $27 million in Gross Proceeds in a Private Placement -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, today reported financial results for the second quarter ended June 30, 2021 and provided a corporate update.

    "We made strong progress during Q2 in the development of IMM-BCP-01, our antibody cocktail to combat SARS-CoV-2. We finalized the selection of antibodies for the cocktail, secured increased funding for the program from the Department of Defense, and demonstrated IMM-BCP-01's potent neutralization activity against all SARS-CoV-2 variants of concern, including the Delta variant, in preclinical testing. We believe we are well-positioned for an IND filing for this program in the third quarter," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "We have continued to strengthen the company through a number of executive and non-executive appointments, in addition to a successful fundraising. We believe these activities set us up for value-creating events in the near-term, including a planned IND filing for our IL-38 immuno-oncology program in the fourth quarter. I look forward to updating you further on our progress in the coming months."

    Second Quarter and Subsequent Highlights

    • Demonstrated Potent Neutralization Activity of IMM-BCP-01 Against SARS-CoV-2 Delta Variant. In July 2021, Immunome announced that its three-antibody cocktail (IMM-BCP-01) has demonstrated potent neutralizing activity against the SARS-CoV-2 Delta variant in pre-clinical pseudovirus testing. An Investigational New Drug (IND) filing for IMM-BCP-001 is planned for 3Q 2021.
    • Selected Antibodies for IMM-BCP-001 Antibody Cocktail. In April 2021, the company announced antibody selection for its IMM-BCP-01 cocktail and shared data showing that IMM-BCP-01 neutralizes CDC SARS-CoV-2 "Variants of Concern" in preclinical testing. The cocktail was efficacious in Syrian hamsters infected with SARS-CoV-2 (USA-WA1/2020) in both prophylactic and treatment schedules. Further, the cocktail neutralized Alpha and Beta variants in live virus testing and Gamma and Epsilon variants in pseudovirus testing.
    • Completed a $27 million Private Placement. In April 2021, the company announced a private placement of its common stock for gross proceeds to Immunome of approximately $27 million, before deducting placement agent commissions and other offering expenses.
    • Awarded $4.3 million by the U.S. Department of Defense (DoD). In May 2021, Immunome announced that the DoD's Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense had awarded the company $4.3 million. These funds were in addition to Immunome's original $13.3 million award provided by the DoD in July 2020. (Contract number: W911QY2090019)
    • Appointed Corleen Roche as Chief Financial Officer. In April 2021, Immunome announced that it had appointed Corleen Roche as its Chief Financial Officer. Ms. Roche is a highly accomplished CFO with over 30 years of industry experience.
    • Appointed Franklyn G. Prendergast, M.D., Ph.D., to Board of Directors. In June 2021, the company announced that it had appointed Dr. Prendergast to its Board of Directors. Dr. Prendergast is a renowned medical and academic research professional who received the 2019 Mayo Distinguished Alumni award and has over 45 years of association with the Mayo Foundation. Over the past 20 years, Dr. Prendergast has served on the Board of Directors or Scientific Advisory Board of several biotechnology companies.
    • Appointed Andrew Badley, M.D., to COVID-19 Advisory Board. In June 2021, Immunome announced the appointment of Andrew D. Badley, M.D., to the company's COVID-19 Advisory Board. Dr. Badley is a renowned infectious disease expert who has spent 19 years with the Mayo Clinic in various roles. He currently serves as the Chair of Mayo Clinic's COVID-19 Research Taskforce.

    Financial Highlights

    • Research and development (R&D) expenses: R&D expenses for the three months ended June 30, 2021 were $3.2 million.
    • General and administrative (G&A) expenses: G&A expenses for the three months ended June 30, 2021 were $2.5 million.
    • Net loss: Net loss for the three months ended June 30, 2021 was $5.2 million.
    • Cash and cash equivalents: As of June 30, 2021, cash and cash equivalents totaled $59.8 million.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; the uncertainties inherent in research and development, including Immunome's ability to execute on its strategy with respect to its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones as and when anticipated; the effectiveness of Immunome's product candidates including the possibility that further preclinical data and any clinical trial data may be inconsistent with the data used for advancing the product candidates; Immunome's ability to fund operations; the competitive landscape; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

    IMMUNOME, INC.

    Condensed Statements of Operations

    (Unaudited; In thousands, except share and per share data)

     

     

     

    Three Months Ended June 30,

     

    Six Months Ended June 30,

     

     

    2021

     

    2020

     

    2021

     

    2020

    Operating expenses:

     

     

     

     

     

     

     

     

     

     

     

     

    Research and development

     

    $

    3,233

     

     

    $

    1,892

     

     

    $

    5,212

     

     

    $

    4,007

     

    General and administrative

     

     

    2,507

     

     

     

    823

     

     

     

    4,425

     

     

     

    1,363

     

    Total operating expenses

     

     

    5,740

     

     

     

    2,715

     

     

     

    9,637

     

     

     

    5,370

     

    Loss from operations

     

     

    (5,740

    )

     

     

    (2,715

    )

     

     

    (9,637

    )

     

     

    (5,370

    )

    Other income

     

     

    500

     

     

     

     

     

     

    500

     

     

     

     

    Interest income (expense), net

     

     

    (1

    )

     

     

    5

     

     

     

    (2

    )

     

     

    (17

    )

    Net loss

     

    $

    (5,241

    )

     

    $

    (2,710

    )

     

    $

    (9,139

    )

     

    $

    (5,387

    )

    Per share information:

     

     

     

     

     

     

     

     

     

     

     

     

    Net loss per share of common stock, basic and diluted

     

    $

    (0.46

    )

     

    $

    (2.47

    )

     

    $

    (0.83

    )

     

    $

    (4.89

    )

    Weighted-average common shares outstanding, basic and diluted

     

     

    11,456,991

     

     

     

    1,099,270

     

     

     

    11,051,185

     

     

     

    1,101,798

     

     

    IMMUNOME, INC.

    Condensed Balance Sheets

    (Unaudited; In thousands, except share data)

     

     

     

    June 30, 2021

     

    December 31, 2020

     

    Assets

     

     

     

     

     

     

     

    Current assets:

     

     

     

     

     

     

     

    Cash

     

    $

    59,829

     

     

    $

    39,766

     

     

    Prepaid expenses and other current assets

     

     

    2,986

     

     

     

    3,128

     

     

    Total current assets

     

     

    62,815

     

     

     

    42,894

     

     

    Property and equipment, net

     

     

    1,226

     

     

     

    1,531

     

     

    Restricted cash

     

     

    100

     

     

     

    100

     

     

    Total assets

     

    $

    64,141

     

     

    $

    44,525

     

     

    Liabilities and stockholders' equity

     

     

     

     

     

     

     

    Current liabilities:

     

     

     

     

     

     

     

    Accounts payable

     

     

    1,790

     

     

     

    1,187

     

     

    Accrued expenses and other current liabilities

     

     

    1,687

     

     

     

    1,372

     

     

    Equipment loan payable

     

     

    44

     

     

     

    113

     

     

    Current portion of long-term debt

     

     

     

     

     

    366

     

     

    Total current liabilities

     

     

    3,521

     

     

     

    3,038

     

     

    Long-term debt, net of current portion

     

     

     

     

     

    134

     

     

    Deferred rent

     

     

    3

     

     

     

    8

     

     

    Total liabilities

     

     

    3,524

     

     

     

    3,180

     

     

    Commitments and contingencies (Note 6)

     

     

     

     

     

     

     

    Stockholders' equity:

     

     

     

     

     

     

     

    Common stock, $0.0001 par value; 200,000,000 shares authorized at June 30, 2021 and December 31, 2020; 11,812,792 shares issued and outstanding at June 30, 2021; 10,634,245 shares issued and outstanding at December 31, 2020

     

     

    1

     

     

     

    1

     

     

    Additional paid-in capital

     

     

    124,149

     

     

     

    95,738

     

     

    Accumulated deficit

     

     

    (63,533

    )

     

     

    (54,394

    )

     

    Total stockholders' equity

     

     

    60,617

     

     

     

    41,345

     

     

    Total liabilities and stockholders' equity

     

    $

    64,141

     

     

    $

    44,525

     

     

     

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  4. - IMM-BCP-01 already shown to neutralize all other CDC variants of concern in pre-clinical testing

    - IND submission planned for this quarter

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced today that its three-antibody cocktail (IMM-BCP-01) has demonstrated potent neutralizing activity against the SARS-CoV-2 Delta variant in pre-clinical pseudovirus testing. Furthermore, IMM-BCP-01 showed in-vitro activity via non-neutralizing mechanisms, such as complement fixation, which Immunome expects will enable viral clearance.

    "IMM-BCP-01's ability to maintain neutralizing activity against emerging SARS-CoV-2 variants…

    - IMM-BCP-01 already shown to neutralize all other CDC variants of concern in pre-clinical testing

    - IND submission planned for this quarter

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced today that its three-antibody cocktail (IMM-BCP-01) has demonstrated potent neutralizing activity against the SARS-CoV-2 Delta variant in pre-clinical pseudovirus testing. Furthermore, IMM-BCP-01 showed in-vitro activity via non-neutralizing mechanisms, such as complement fixation, which Immunome expects will enable viral clearance.

    "IMM-BCP-01's ability to maintain neutralizing activity against emerging SARS-CoV-2 variants, including the Delta variant, potentially positions our drug candidate as a long-term solution to the changing threat posed by COVID-19. We believe our lead candidate's mechanism of action, targeting at least three non-overlapping epitopes - informed by authentic human immune response - provides a robust defense against future mutational drift," said Purnanand Sarma, PhD, President & CEO of Immunome. "Currently, the delta variant accounts for a majority of coronavirus cases in the United States."

    Immunome was awarded a $17.6 million technology award from the U.S. Department of Defense's Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency, to support Immunome's COVID program.

    Given the near-term potential for a resurgence of COVID-19 infections driven by emerging variants, Immunome intends to explore opportunities to expedite the development of this potential therapeutic. The Company plans to submit an IND application with the U.S. Food and Drug Administration (FDA) this quarter.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its COVID-19 therapeutic antibody programs, execution of its regulatory, clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01, including expectations regarding therapeutic potential and benefits thereof, and IND submission. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; Immunome's IND submission and other regulatory filings, timing of these filings and governmental authority feedback regarding the same; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  5. Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced that Purnanand Sarma, Ph.D., Immunome's President and CEO, will present at the Ladenburg Thalmann 2021 Healthcare Conference on Tuesday, July 13, 2021, at 10:30 a.m. ET.

    Interested parties can access the live audio webcast for this conference from the Investor Relations section of the company's website at www.immunome.com. The webcast replay will be available after the conclusion of the live presentation for approximately 30 days.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform…

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced that Purnanand Sarma, Ph.D., Immunome's President and CEO, will present at the Ladenburg Thalmann 2021 Healthcare Conference on Tuesday, July 13, 2021, at 10:30 a.m. ET.

    Interested parties can access the live audio webcast for this conference from the Investor Relations section of the company's website at www.immunome.com. The webcast replay will be available after the conclusion of the live presentation for approximately 30 days.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  6. Dr. Badley is a renowned infectious disease expert who currently serves as the Chair of Mayo Clinic's COVID-19 Research Taskforce

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Andrew D. Badley, M.D., to the company's COVID-19 Advisory Board. Dr. Badley currently serves as the Chair of the Mayo COVID-19 Research Taskforce and is a leading voice in the fight against COVID-19.

    "Dr. Badley is a thought leader in infectious disease, and specifically COVID-19. I am delighted to announce his appointment to Immunome's COVID-19 Advisory Board," said Purnanand Sarma, Ph.D., President…

    Dr. Badley is a renowned infectious disease expert who currently serves as the Chair of Mayo Clinic's COVID-19 Research Taskforce

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Andrew D. Badley, M.D., to the company's COVID-19 Advisory Board. Dr. Badley currently serves as the Chair of the Mayo COVID-19 Research Taskforce and is a leading voice in the fight against COVID-19.

    "Dr. Badley is a thought leader in infectious disease, and specifically COVID-19. I am delighted to announce his appointment to Immunome's COVID-19 Advisory Board," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "Andrew's experience will be invaluable as we develop novel therapeutics to combat the evolving COVID-19 virus and other novel outbreaks."

    Dr. Badley is a well-known physician and researcher who focuses on virus-host interactions, particularly on how viral proteins modify the host-immune response and on cell survival. Dr. Badley has spent 19 years with the Mayo Clinic in various roles. Currently, Dr. Badley is a Professor of Infectious Disease, serves as the Chair of the Mayo Clinic COVID-19 Research Taskforce, and is Professor and Chair of the Department of Molecular Medicine. Dr. Badley began his career at the University of Ottawa, where he served as an Associate Professor and Infectious Disease Physician. Dr. Badley received his bachelors and medical degrees from Dalhousie University. After Dalhousie, Dr. Badley completed his residency in internal medicine and his fellowship in infectious disease at Mayo School of Graduate Medical Education.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  7. – Dr. Prendergast is a renowned scientific researcher with over 45 years of association with the Mayo Foundation and over 20 years' experience as a non-executive director of Eli Lilly –

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Franklyn G. Prendergast, M.D., Ph.D., to its Board of Directors. Dr. Prendergast is a renowned medical and academic research professional who received the 2019 Mayo Distinguished Alumni award and has over 45 years of association with the Mayo Foundation.

    "I am delighted to welcome Dr. Prendergast to Immunome's Board of Directors as we continue…

    – Dr. Prendergast is a renowned scientific researcher with over 45 years of association with the Mayo Foundation and over 20 years' experience as a non-executive director of Eli Lilly –

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Franklyn G. Prendergast, M.D., Ph.D., to its Board of Directors. Dr. Prendergast is a renowned medical and academic research professional who received the 2019 Mayo Distinguished Alumni award and has over 45 years of association with the Mayo Foundation.

    "I am delighted to welcome Dr. Prendergast to Immunome's Board of Directors as we continue to attract a rich team of distinguished thought leaders to help drive the development of our antibody therapies," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "Dr. Prendergast's experience will be invaluable in our mission to discover and develop novel antibody therapeutics for diseases with high unmet medical need."

    "Immunome is entering an exciting period in the company's history, as the group transitions from a preclinical to clinical setting," said Franklyn Prendergast, M.D., Ph.D. "With an innovative therapeutic platform and promising early data, I am excited to be joining Immunome's Board of Directors. I look forward to working collaboratively with the rest of the Board and the company's executive leadership to maximize Immunome's opportunities for the benefit of patients and our shareholders."

    Dr. Prendergast received his medical degree with honors from the University of the West Indies in 1968 and after an internship attended Lincoln College, University of Oxford, as a Rhodes Scholar where he obtained a BA with First Class Honors in 1971 and MA in 1979. He commenced a residency in Internal Medicine at the Mayo Clinic in 1971 and subsequently obtained a Ph.D. in Biochemistry from the joint Mayo Graduate School / University of Minnesota program in 1977.

    Dr. Prendergast was appointed to the Faculty of the Department of Pharmacology at the Mayo Graduate School immediately after receiving his Ph.D. and rose through the ranks quickly to become a full Professor simultaneously in that Department and in the Department of Biochemistry and Molecular Biology in 1986. That same year, he was named the Edmond and Marion Guggenheim Professor and also Chair of the Department of Biochemistry and Molecular Biology.

    Dr. Prendergast was appointed as the Director for Research of Mayo Clinic, Rochester in 1989, serving for the subsequent four years in that capacity. In 1990, he was also appointed to Mayo's highest administrative committees, the Board of Governors and the Mayo Foundation's Board of Trustees. He served on these bodies continuously until 2009. In 1995, he was appointed as Director of the Mayo Clinic Comprehensive Cancer Center, a position he held until September 2006. His last administrative role at Mayo was as the charter Director of the Mayo Center for Individualized Medicine. He retired from that position and also from the Mayo Foundation in December 2014.

    Throughout his academic career, Dr. Prendergast participated extensively in numerous NIH and NSF grant review groups, task forces and advisory committees. Additionally, he was appointed as a non-executive member of the Board of Directors of Eli Lilly and Co., a post he held from 1995 until 2017. He has been awarded several honors, including honorary doctorates from Purdue University and the University of the West Indies, Distinguished Alumni awards from the University of the West Indies, University of Minnesota and, most recently, in 2019 the Mayo Clinic.

    Over the past 20 years, Dr. Prendergast has served on the Board of Directors or Scientific Advisory Board of several biotechnology companies.

    Concurrent with Dr. Prendergast joining the Board, Michael Widlitz, M.D., a long-term Director, will be stepping down. "Immunome's management and Board of Directors would like to thank Dr. Widlitz for his service, and we are delighted to continue to work with him in his new role as Advisor, Medical Affairs," said Dr. Sarma.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and regulatory filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, results, data, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  8. Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced that Purnanand Sarma, Ph.D., President and CEO of Immunome, will present at the Jefferies Virtual Healthcare Conference on Friday, June 4, 2021, at 8:00 a.m. ET.

    Interested parties can access the live audio webcast for this conference from the Investor Relations section of the company's website at www.immunome.com. The webcast replay will be available after the conclusion of the live presentation for approximately 30 days.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover…

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced that Purnanand Sarma, Ph.D., President and CEO of Immunome, will present at the Jefferies Virtual Healthcare Conference on Friday, June 4, 2021, at 8:00 a.m. ET.

    Interested parties can access the live audio webcast for this conference from the Investor Relations section of the company's website at www.immunome.com. The webcast replay will be available after the conclusion of the live presentation for approximately 30 days.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM-ONC-01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  9. - Additional $4.3 million in funding brings total DOD funding to $17.6 million.

    - Antibody cocktail (IMM-BCP-01) is a combination of three antibodies that bind to complementary, non-overlapping regions of the SARS-CoV-2 spike protein.

    - Neutralizes South Africa (B.1.351) and UK (B.1.1.7) in live virus testing and Brazil (P.1) and California (B.1.429, also containing B.1.427 mutations) in pseudovirus testing, all of which are CDC-designated "Variants of Concern."

    - Binds to several mutations, including E484Q and L452R, which are associated with the India variant (B.1.617) in mechanistic testing.

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop…

    - Additional $4.3 million in funding brings total DOD funding to $17.6 million.

    - Antibody cocktail (IMM-BCP-01) is a combination of three antibodies that bind to complementary, non-overlapping regions of the SARS-CoV-2 spike protein.

    - Neutralizes South Africa (B.1.351) and UK (B.1.1.7) in live virus testing and Brazil (P.1) and California (B.1.429, also containing B.1.427 mutations) in pseudovirus testing, all of which are CDC-designated "Variants of Concern."

    - Binds to several mutations, including E484Q and L452R, which are associated with the India variant (B.1.617) in mechanistic testing.

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced a $4.3 million increase awarded by the U.S. Department of Defense's (DOD) Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency (DHA), for the continued development of an antibody cocktail (IMM-BCP-01) to combat SARS-CoV-2 and its variants. The additional capital comes less than a year after an initial DOD award of $13.3 million, bringing the total commitment to Immunome to $17.6 million. The additional funding is to support expansion of the clinical study following feedback from the FDA. Immunome is continuing efforts towards an IND filing for IMM-BCP-01 in late 2Q/early 3Q 2021.

    IMM-BCP-01 contains three monoclonal antibodies that bind to non-overlapping regions of the spike protein with picomolar affinity. The antibodies exhibit combinatorial effects in vitro against multiple SARS-CoV-2 variants, including those exhibiting both increased transmission in the United States and resistance to current antibody therapeutics and vaccines.

    "We are thrilled to have secured additional funding from the Department of Defense," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "We are grateful to the DOD for their continued support and we are eager to move our antibody cocktail into the clinic."

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  10. - IMM-BCP-01: Selected antibody cocktail demonstrating neutralization of CDC SARS-CoV-2 "variants of concern" in preclinical testing, progressing towards IND filing -

    - IMM-ONC-01: Advanced proprietary antibody against IL-38, a novel innate immune checkpoint, into IND-enabling studies -

    - Dennis Giesing, Ph.D. appointed as Chief Development Officer and Corleen Roche appointed as Chief Financial Officer -

    - Raised $27 million in gross proceeds in a private placement -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today reported financial results for the first quarter ended March 31, 2021 and provided a…

    - IMM-BCP-01: Selected antibody cocktail demonstrating neutralization of CDC SARS-CoV-2 "variants of concern" in preclinical testing, progressing towards IND filing -

    - IMM-ONC-01: Advanced proprietary antibody against IL-38, a novel innate immune checkpoint, into IND-enabling studies -

    - Dennis Giesing, Ph.D. appointed as Chief Development Officer and Corleen Roche appointed as Chief Financial Officer -

    - Raised $27 million in gross proceeds in a private placement -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today reported financial results for the first quarter ended March 31, 2021 and provided a corporate update.

    First Quarter and Subsequent Highlights

    • IMM-BCP-001: In February 2021, Immunome announced that it discovered antibodies capable of neutralizing multiple SARS-CoV-2 variants, including the South African Variant, in pseudovirus testing. In April 2021, the company announced antibody selection for its IMM-BCP-01 cocktail and shared data showing that IMM-BCP-01 neutralizes CDC SARS-CoV-2 "Variants of Concern" in preclinical testing. The cocktail was efficacious in Syrian hamsters infected with SARS-CoV-2 (USA-WA1/2020) in both prophylactic and treatment schedules. Further, the cocktail neutralized South Africa and UK variants in live virus testing and Brazil and California variants in pseudovirus testing. An Investigational New Drug (IND) filing for IMM-BCP-001 is planned for late 2Q/early 3Q 2021.
    • IMM-ONC-001: In March 2021, Immunome announced its proprietary antibody against IL-38 advanced into IND-enabling studies. Based on Immunome's research findings, IL-38 functions as a novel innate immune checkpoint that inhibits infiltration and pro-inflammatory activity of innate immune cells. The company's analysis also suggests that IL-38 is over-expressed in certain tumors and is potentially linked to reduced infiltration of innate immune cells. Immunome anticipates filing an IND for this product candidate in 2H 2021.
    • Appointed Dr. Dennis Giesing as Chief Development Officer and Corleen Roche as Chief Financial Officer. In March 2021, the company announced the appointment of Dennis Giesing, Ph.D. to the role of Chief Development Officer. Dr. Giesing brings more than 35 years of pharmaceutical industry experience to Immunome and will be responsible for driving Immunome's programs into clinical development. In April 2021, Immunome announced that it appointed Corleen Roche as its Chief Financial Officer. Ms. Roche is a highly accomplished CFO with over 30 years of industry experience to lead the company's finance and corporate strategy functions.
    • Completed a $27 million private placement. In April 2021, the company announced a private placement of its common stock for gross proceeds to Immunome of approximately $27 million, before deducting placement agent commissions and other offering expenses. The company currently expects the proceeds from this private placement, together with its cash on hand, will be sufficient to fund its operations through fiscal year 2022.

    "I am thrilled with the significant progress that Immunome has made in the development of our product pipeline," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "We are excited to welcome Dr. Giesing and Ms. Roche to the Immunome team as we move towards becoming a clinical stage biopharmaceutical company."

    Financial Highlights

    • Research and development (R&D) expenses: R&D expenses for the three months ended March 31, 2021 were $2.0 million.
    • General and administrative (G&A) expenses: G&A expenses for the three months ended March 31, 2021 were $1.9 million.
    • Net loss: Net loss for the three months ended 2021 was $3.9 million.
    • Cash and cash equivalents: As of March 31, 2021, cash and cash equivalents totaled $36.3 million (excluding $27.0 million in proceeds from the private placement in April 2021).

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations as anticipated; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

    IMMUNOME, INC.

    Condensed Statements of Operations

    (Unaudited; In thousands, except share and per share data)

     

     

     

     

    Three Months Ended March 31,

     

    2021

    2020

    Operating expenses:

     

     

    Research and development

    $

    1,979

     

    $

    2,115

     

    General and administrative

     

    1,918

     

     

    540

     

    Total operating expenses

     

    3,897

     

     

    2,655

     

    Loss from operations

     

    (3,897

    )

     

    (2,655

    )

    Interest expense, net

     

    (1

    )

     

    (22

    )

    Net loss

    $

    (3,898

    )

    $

    (2,677

    )

    Per share information:

     

     

    Net loss per share of common stock, basic and diluted

    $

    (0.37

    )

    $

    (2.44

    )

    Weighted-average common shares outstanding, basic and diluted

     

    10,640,870

     

     

    1,099,270

     

     

    IMMUNOME, INC.

    Condensed Balance Sheets

    (Unaudited; In thousands, except share data)

     

     

     

     

    March 31, 2021

    December 31, 2020

    Assets

     

     

    Current assets:

     

     

    Cash

    $

    36,276

     

    $

    39,766

     

    Prepaid expenses and other current assets

     

    4,831

     

     

    3,128

     

    Total current assets

     

    41,107

     

     

    42,894

     

    Property and equipment, net

     

    1,386

     

     

    1,531

     

    Restricted cash

     

    100

     

     

    100

     

    Total assets

    $

    42,593

     

    $

    44,525

     

    Liabilities and stockholders' equity

     

     

    Current liabilities:

     

     

    Current portion of long-term debt

    $

    366

     

    $

    366

     

    Equipment loan payable

     

    78

     

     

    113

     

    Accounts payable

     

    2,958

     

     

    1,187

     

    Accrued expenses and other current liabilities

     

    1,169

     

     

    1,372

     

    Total current liabilities

     

    4,571

     

     

    3,038

     

    Long-term debt, net of current portion

     

    134

     

     

    134

     

    Deferred rent

     

    5

     

     

    8

     

    Total liabilities

     

    4,710

     

     

    3,180

     

    Stockholders' equity:

     

     

    Common stock

     

    1

     

     

    1

     

    Additional paid-in capital

     

    96,174

     

     

    95,738

     

    Accumulated deficit

     

    (58,292

    )

     

    (54,394

    )

    Total stockholders' equity

     

    37,883

     

     

    41,345

     

    Total liabilities and stockholders' equity

    $

    42,593

     

    $

    44,525

     

     

    View Full Article Hide Full Article
    • Antibody cocktail (IMM-BCP-01) is a combination of three antibodies that bind to complementary, non-overlapping regions of the SARS-CoV-2 spike protein.
    • Efficacious in Syrian hamsters infected with SARS-CoV-2 (USA-WA1/2020) in both prophylactic and treatment schedules.
    • Neutralizes South Africa (B.1.351) and UK (B.1.1.7) in live virus testing; Brazil (P.1) and California (B.1.429, also containing B.1.427 mutations) in pseudovirus testing, all of which are CDC-designated "Variants of Concern."
    • Investigational New Drug (IND) Filing planned for late 2Q/early 3Q 2021.

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its patient memory B cell platform to develop antibody therapeutics, announced antibody selection for…

    • Antibody cocktail (IMM-BCP-01) is a combination of three antibodies that bind to complementary, non-overlapping regions of the SARS-CoV-2 spike protein.
    • Efficacious in Syrian hamsters infected with SARS-CoV-2 (USA-WA1/2020) in both prophylactic and treatment schedules.
    • Neutralizes South Africa (B.1.351) and UK (B.1.1.7) in live virus testing; Brazil (P.1) and California (B.1.429, also containing B.1.427 mutations) in pseudovirus testing, all of which are CDC-designated "Variants of Concern."
    • Investigational New Drug (IND) Filing planned for late 2Q/early 3Q 2021.

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its patient memory B cell platform to develop antibody therapeutics, announced antibody selection for its IMM-BCP-01 antibody cocktail and shared data showing that IMM-BCP-01 neutralizes CDC SARS-CoV-2 "Variants of Concern" in preclinical testing.

    IMM-BCP-01 contains three monoclonal antibodies that bind to non-overlapping regions of the spike protein with picomolar affinity. The antibodies exhibit combinatorial effects in vitro against multiple SARS-CoV-2 variants, including those exhibiting both increased transmission in the United States and resistance to current antibody therapeutics and vaccines. In summary, the Immunome antibodies have shown to be effective against the current SARS-CoV-2 and its variants.

    Preclinical testing results:

    • In Syrian hamsters infected with live SARS-CoV-2 virus (USA-WA1/2020), IMM-BCP-01 reduced lung viral load as a treatment and prophylaxis.
    • Live virus studies demonstrated full neutralization by IMM-BCP-01 of CDC-designated "Variants of Concern," South Africa (B.1.351) and UK (B.1.1.7), as well as the U.S. and European reference strains USA-WA1/2020 and BavPat1/2020.
    • Pseudovirus studies demonstrated full neutralization by IMM-BCP-01 of CDC-designated "Variants of Concern," Brazil (P.1) and California (B.1.429, which also contains B.1.427 mutations).
    • Mechanistic studies demonstrate the selected antibodies bind not only to SARS-CoV-2 spike proteins with complex mutations, including the UK (B.1.1.7), SA (B.1.351), Brazil (P1/P2) and California (B.1.429/427) variants, but also to those with several individual mutations, including E484Q and L452R, which are associated with the recently emerged double mutant (B.1.617, or the India variant).
    • Two of the three selected antibodies bind to areas of the Spike protein that may be resistant to evolutionary change.
    • In addition to viral neutralization, the antibodies also demonstrated additional mechanisms in vitro that may be of relevance in viral clearance.

    "Put simply, the preclinical results we have shared today bear witness to our discovery engine's ability to rapidly identify powerful and rare antibodies for inclusion in our IMM-BCP-01 antibody cocktail," said Purnanand Sarma, Ph.D., President & CEO of Immunome. "The strength of our data gives us the confidence to continue advancing IMM-BCP-01 towards an IND filing. We believe that a combination of antibodies targeting epitopes conserved across known variants is an important, and potentially necessary, aspect of addressing the mutational drift currently seen with SARS-CoV-2."

    "Despite the numerous challenges created by the COVID-19 pandemic, it provided an opportunity to enhance government-industry partnerships to rapidly identify solutions," said Dr. Jason Roos, the Joint Program Executive Officer for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND). "Demonstrating the ability to collect blood from convalescent patients and quickly identify multiple antibodies as preventatives or therapeutics may not only combat the current pandemic, but can also establish a platform to combat future novel viruses. We are very encouraged by the current results of testing and product development."

    In July 2020, Immunome was awarded a $13.3 million agreement from the U.S. Department of Defense's Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency, to support Immunome's COVID program. The research discussed in this press release is part of that program.

    Immunome anticipates filing an IND for its IMM-BCP-001 program in late Q2/early Q3 2021.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery platform identifies novel therapeutic antibodies and their targets by leveraging the highly-educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  11. Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced it has entered into a definitive securities purchase agreement for the sale of its equity securities in a private placement with certain accredited investors for gross proceeds to Immunome of approximately $27 million, before deducting placement agent commissions and other offering expenses.

    The agreement provides for the sale of an aggregate of 1,000,000 units at a price of $27.00 per unit. Each unit consists of one share of Immunome's common stock and a warrant to purchase one half of a share of common stock at an exercise price of $45.00.

    Ladenburg…

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced it has entered into a definitive securities purchase agreement for the sale of its equity securities in a private placement with certain accredited investors for gross proceeds to Immunome of approximately $27 million, before deducting placement agent commissions and other offering expenses.

    The agreement provides for the sale of an aggregate of 1,000,000 units at a price of $27.00 per unit. Each unit consists of one share of Immunome's common stock and a warrant to purchase one half of a share of common stock at an exercise price of $45.00.

    Ladenburg Thalmann & Co. Inc. acted as Immunome's placement agent in the transaction.

    Immunome intends to use the net proceeds to accelerate the development of its oncology and infectious disease portfolio, including COVID-19, and for other general corporate purposes.

    The private placement is expected to close on or about April 28, 2021, subject to the satisfaction of customary closing conditions. Additional details regarding the private placement will be included in a Form 8-K to be filed by Immunome with the Securities and Exchange Commission ("SEC").

    The securities being sold in the private placement have not been registered under the Securities Act of 1933, as amended, or state securities laws and may not be offered or sold in the United States absent registration with the SEC or an applicable exemption from such registration requirements. Immunome has agreed to file a registration statement with the SEC covering the resale of the shares of common stock issuable in connection with the private placement and upon exercise of the warrants.

    This press release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the anticipated use of proceeds from the private placement, Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  12. - Seasoned biopharmaceutical executive with more than 30 years of corporate finance and business strategy experience -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Corleen Roche as Chief Financial Officer. Ms. Roche is a highly accomplished CFO with an extensive background in corporate finance and strategy in the biopharmaceutical industry, and served most recently as the US CFO for Biogen.

    "On behalf of the entire company, I am pleased to welcome Corleen to Immunome and look forward to partnering with her as we grow the company together," said Purnanand Sarma, Ph.D…

    - Seasoned biopharmaceutical executive with more than 30 years of corporate finance and business strategy experience -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Corleen Roche as Chief Financial Officer. Ms. Roche is a highly accomplished CFO with an extensive background in corporate finance and strategy in the biopharmaceutical industry, and served most recently as the US CFO for Biogen.

    "On behalf of the entire company, I am pleased to welcome Corleen to Immunome and look forward to partnering with her as we grow the company together," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "As we continue our rapid growth into a clinical-stage company, Corleen's significant experience will be integral to our success in furthering our promising portfolio of development candidates. Corleen brings with her a deep understanding of financial strategy, capital markets, and business development and I am thrilled that Immunome will benefit from her business and financial acumen."

    "I would like to thank Sarma and the Immunome team for welcoming me to the company," said Corleen Roche, Chief Financial Officer of Immunome. "I was drawn to Immunome by the promise of the company's proprietary human memory B cell platform, as well as the quality of the team overseeing its deployment. I look forward to leveraging my financial expertise to progress the company's development plans and help Immunome achieve its full potential."

    Corleen Roche is a corporate finance and business strategist with extensive executive experience in the biopharmaceutical industry. Prior to her most recent role as the U.S. CFO for Biogen, Ms. Roche was a CFO at various biopharmaceutical companies including Sandoz, IoGenetics Inc, and Wyeth Pharmaceuticals.

    Ms. Roche received a Bachelor of Science in Accountancy from Villanova University.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  13. - Pharmaceutical industry veteran brings more than three decades of experience developing innovative therapies -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Dennis Giesing, Ph.D., to the role of Chief Development Officer (CDO). In this position, Dr. Giesing will lead Immunome's product development, clinical and regulatory strategy and drive the progression of the company's pipeline.

    "I am pleased to welcome Dennis to the Immunome team. With two IND filings planned for 2021, Dennis joins our company at an exciting time, and we look forward to leveraging his extensive…

    - Pharmaceutical industry veteran brings more than three decades of experience developing innovative therapies -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today announced the appointment of Dennis Giesing, Ph.D., to the role of Chief Development Officer (CDO). In this position, Dr. Giesing will lead Immunome's product development, clinical and regulatory strategy and drive the progression of the company's pipeline.

    "I am pleased to welcome Dennis to the Immunome team. With two IND filings planned for 2021, Dennis joins our company at an exciting time, and we look forward to leveraging his extensive experience to further our pipeline candidates through their next stages of development," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "Dennis brings a deep and unique combination of skills and expertise across multiple therapeutic areas, including oncology, inflammation and anti-infectives, and I am confident he will be a great asset for our company."

    "I am excited to join Immunome and particularly impressed by the potential of the company's human memory B cell discovery engine and its capacity to generate unique development candidates," said Dennis Giesing, Ph.D., Chief Development Officer of Immunome. "Harnessing the information stored in human B cells and using it to create novel antibody therapeutics is an incredible breakthrough that I hope to play an integral part in developing fully in my new role."

    Dr. Giesing has more than 35 years of pharmaceutical industry experience, and was most recently at Johnson & Johnson Oncology. Prior to that he served as Chief Scientific Officer at Taris Biomedical for nearly 12 years, heading the development of innovative treatments for bladder diseases including overactive bladder and bladder cancer, leading to its acquisition by Johnson & Johnson in 2019. Previously, Dr. Giesing was Head of Pharmaceutical Development at Medivector, leading the development of treatments to combat infectious diseases, including pandemic influenza and hemorrhagic viruses. Before that, he served as Senior Vice President of Lead Optimization at Aventis Pharmaceuticals, advancing novel therapies into late-stage clinical development.

    Dr. Giesing received his B.S. in chemistry and a Ph.D. in biochemical pharmacology from the University of Missouri, Kansas City.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  14. - IMM-BCP-01: Isolated antibodies capable of neutralizing SARS-CoV-2 variants, including the South African variant (B.1.351), in pseudovirus testing -

    - IMM-ONC-01: Advanced proprietary antibody against IL-38 into IND-enabling studies -

    - Raised $44.9 million in gross proceeds in NASDAQ IPO -

    - Program updates expected in 2Q 2021 -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today reported financial results for the fourth quarter and full year ended December 31, 2020 and provided a corporate update.

    "The fourth quarter of 2020 was a transformational period for Immunome thanks to our successful initial…

    - IMM-BCP-01: Isolated antibodies capable of neutralizing SARS-CoV-2 variants, including the South African variant (B.1.351), in pseudovirus testing -

    - IMM-ONC-01: Advanced proprietary antibody against IL-38 into IND-enabling studies -

    - Raised $44.9 million in gross proceeds in NASDAQ IPO -

    - Program updates expected in 2Q 2021 -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell discovery engine platform to discover and develop first-in-class antibody therapeutics, today reported financial results for the fourth quarter and full year ended December 31, 2020 and provided a corporate update.

    "The fourth quarter of 2020 was a transformational period for Immunome thanks to our successful initial public offering on the NASDAQ exchange, which raised $44.9 million in gross proceeds," said Purnanand Sarma, Ph.D., President and CEO of Immunome. "That positive momentum continued into 2021, with our recent announcements covering the isolation of antibodies capable of neutralizing SARS-CoV-2 variants in pseudovirus testing as part of our IMM-BCP-01 program, and the advancement of IMM-ONC-01, our proprietary antibody against IL-38 for the potential treatment of solid tumors including malignancies of high unmet need such as cancers of the head and neck and the lung, into IND-enabling studies."

    Dr. Sarma continued: "Looking ahead, we expect to provide development program updates in the second quarter of 2021 and to file INDs for both IMM-BCP-01 and IMM-ONC-01 in 2021. We remain excited about the prospects for both of our current development programs and reiterate the confidence we have in our discovery engine to move one to two new candidates into IND-enabling studies per year. I very much look forward to updating you on our progress in the months ahead."

    Financial Highlights

    • Cash and cash equivalents: As of December 31, 2020, cash and cash equivalents totaled $39.8 million.
    • Research and development (R&D) expenses: R&D expenses for the three months ended December 31, 2020 were $1.8 million. R&D expenses for the year ended December 31, 2020 were $7.5 million.
    • General and administrative (G&A) expenses: G&A expenses for the three months ended December 31, 2020 were $2.2 million. G&A expenses were $4.8 million for the year ended December 31, 2020.
    • Net loss: Net loss attributable to common stockholders was $4.1 million, or $0.40 per share, for the three months ended December 31, 2020. Net loss attributable to common stockholders was $17.8 million, or $5.26 per share, for the year ended December 31, 2020.
    • As of December 31, 2020, Immunome had 10,634,245 shares of common stock outstanding.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek," "potential" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones; Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones; the timing and effectiveness of any antibody therapeutics which may be developed by Immunome; Immunome's ability to fund operations; and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (SEC) on March 25, 2021, and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

     

    IMMUNOME, INC.

    Statements of operations

    (in thousands, except share and per share amounts)

     

    Three Months Ended December 31,

     

    Year ended December 31,

     

     

    2020

     

     

     

    2019

     

     

     

    2020

     

     

     

    2019

     

    Operating expenses:

     

     

     

     

    Research and development

    $

    1,835

     

    $

    2,432

     

    $

    7,486

     

    $

    8,823

     

    General and administrative

     

    2,238

     

     

    456

     

     

    4,775

     

     

    1,525

     

    Total operating expenses

     

    4,073

     

     

    2,888

     

     

    12,261

     

     

    10,348

     

    Loss from operations

     

    (4,073

    )

     

    (2,888

    )

     

    (12,261

    )

     

    (10,348

    )

    Other expenses:

    Change in fair value of warrant liability

     

    11

     

     

     

     

    (5,538

    )

     

     

    Interest expense, net

     

    (11

    )

     

    (34

    )

     

    (38

    )

     

    (96

    )

    Total other expenses

     

    -

     

     

    (34

    )

     

    (5,576

    )

     

    (96

    )

    Net loss

    $

    (4,073

    )

    $

    (2,922

    )

    $

    (17,837

    )

    $

    (10,444

    )

    Per share information:

     

     

     

     

    Net loss per share of common stock, basic and diluted

    $

    (0.40

    )

    $

    (2.66

    )

    $

    (5.26

    )

    $

    (9.55

    )

    Weighted-average common shares outstanding, basic and diluted

     

    10,190,607

     

     

    1,097,907

     

     

    3,389,592

     

     

    1,093,959

     

    IMMUNOME, INC.

    Balance sheets

    (in thousands, except share and per share amounts)

     

     

     

     

     

     

     

     

     

    December 31,

     

     

    2020

     

    2019

    Assets

     

     

     

     

     

     

    Current assets:

     

     

     

     

     

     

    Cash

     

    $

    39,766

     

    $

    2,543

    Prepaid expenses and other current assets

     

     

    3,128

     

     

    579

    Total current assets

     

     

    42,894

     

     

    3,122

    Property and equipment, net

     

     

    1,531

     

     

    1,700

    Restricted cash

     

     

    100

     

     

    100

    Other assets

     

     

     

     

    138

    Total assets

     

    $

    44,525

     

    $

    5,060

    Liabilities, convertible preferred stock, and stockholders' equity (deficit)

     

     

     

     

     

     

    Current liabilities:

     

     

     

     

     

     

    Current portion of capital lease obligations

     

    $

     

    $

    239

    Current portion of long-term debt

     

     

    366

     

     

    Current portion of equipment loan payable

     

     

    113

     

     

    212

    Accounts payable

     

     

    1,187

     

     

    548

    Accrued expenses and other current liabilities

     

     

    1,372

     

     

    666

    Total current liabilities

     

     

    3,038

     

     

    1,665

    Equipment loan payable, net of current portion

     

     

     

     

    113

    Long-term debt, net of current portion

     

     

    134

     

     

    Deferred rent

     

     

    8

     

     

    18

    Total liabilities

     

     

    3,180

     

     

    1,796

     

     

     

     

     

     

     

    Series A convertible preferred stock

     

     

     

     

    38,894

    Stockholders' equity (deficit):

     

     

     

     

     

     

    Common stock

     

     

    1

     

     

    Additional paid-in capital

     

     

    95,738

     

     

    927

    Accumulated deficit

     

     

    (54,394)

     

     

    (36,557)

    Total stockholders' equity (deficit)

     

     

    41,345

     

     

    (35,630)

    Total liabilities, convertible preferred stock, and stockholders' equity (deficit)

     

    $

    44,525

     

    $

    5,060

     

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  15. First oncology product candidate identified using the company's human memory B-cell platform, and intended for potential treatment of solid tumors

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced that it advanced its first oncology program into IND-enabling studies and anticipates filing an IND in the second half of 2021.

    The IL-38 target was identified through the interrogation of a B cell sample from a head and neck cancer patient using the Immunome discovery engine. IL-38 appears to function as a novel innate immune checkpoint, secreted by tumors to inhibit myeloid cell activation and dampen innate anti-tumor…

    First oncology product candidate identified using the company's human memory B-cell platform, and intended for potential treatment of solid tumors

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced that it advanced its first oncology program into IND-enabling studies and anticipates filing an IND in the second half of 2021.

    The IL-38 target was identified through the interrogation of a B cell sample from a head and neck cancer patient using the Immunome discovery engine. IL-38 appears to function as a novel innate immune checkpoint, secreted by tumors to inhibit myeloid cell activation and dampen innate anti-tumor immunity. A correlation between high IL-38 expression and poor clinical outcomes in lung cancer was noted in a recent published study (Takada et al., PLoS One, 2018).

    Purnanand Sarma, PhD, CEO of Immunome, said, "We are very excited to advance our lead oncology program targeting IL-38, a novel innate immune checkpoint that appears to inhibit infiltration and pro-inflammatory activity of innate immune cells. Our analysis of publicly available data (The Cancer Genome Atlas) further confirms that IL-38 is over-expressed in certain tumors with high unmet clinical need, such as carcinomas of the head, neck and lung and that its expression appears to be correlated to reduced infiltration of innate immune cells."

    Dr. Anthony Tolcher, MD, FRCPC, medical oncologist and co-founder of NEXT Oncology as well as a member of Immunome's Scientifc Advisory Board, said, "Agents targeting the innate immune system, specifically myeloid biology, represent novel approaches in the treatment of solid tumors. Immunome's target, IL-38, appears to play a key role in keeping the tumor microenvironment immunologically unresponsive, and reversing this dampened immunity may lead to favorable treatment modalities, especially in high unmet medical need diseases where it is overexpressed. I am excited to see this agent moving into IND-enabling studies and head towards the clinic."

    About Immunome

    Immunome is a biopharmaceutical company utilizing our proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics designed to change the way diseases are currently being treated with an initial focus on oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery platform identifies novel therapeutic antibodies and their targets by leveraging highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones, Immunome's ability to execute on its strategy including with respect to the timing of IND filings and other anticipated milestones, Immunome's ability to fund operations, as well as those risks and uncertainties set forth more fully under the caption "Risk Factors" in the final prospectus dated October 1, 2020 and filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, with the United States Securities and Exchange Commission (SEC) and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  16. Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced today that its discovery engine has isolated potent antibodies capable of neutralizing several SARS-CoV-2 variants, including the South African Variant (B.1.351), in pseudovirus testing.

    This effort is part of the company's ongoing program to develop a cocktail of antibodies targeting spike and non-spike proteins that can serve as a prophylaxis or a treatment for COVID-19. Immunome's COVID-19 antibody research demonstrates that SARS-CoV-2 "super-responders" who recover from SARS-CoV-2 mount a robust immune response to a broad range of viral targets, including spike…

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced today that its discovery engine has isolated potent antibodies capable of neutralizing several SARS-CoV-2 variants, including the South African Variant (B.1.351), in pseudovirus testing.

    This effort is part of the company's ongoing program to develop a cocktail of antibodies targeting spike and non-spike proteins that can serve as a prophylaxis or a treatment for COVID-19. Immunome's COVID-19 antibody research demonstrates that SARS-CoV-2 "super-responders" who recover from SARS-CoV-2 mount a robust immune response to a broad range of viral targets, including spike and non-spike proteins (https://www.biorxiv.org/content/10.1101/2021.01.27.428534v1).

    As part of developing our antibody cocktail (IMM-BCP-001), Immunome has identified antibodies that bind to non-overlapping regions of the spike protein, including those regions containing the critical mutational variants. Immunome's research shows that certain of our antibodies neutralize pseudoviruses expressing the spike protein of the South African Variant (B.1.351). Recent literature suggests that this South African Variant reduces the effectiveness of certain vaccines and antibody therapies (https://www.biorxiv.org/content/10.1101/2021.01.25.427948v1, https://www.biorxiv.org/content/10.1101/2021.01.25.428137v2).

    Purnanand Sarma, PhD, CEO of Immunome, said, "Our findings underscore the power of Immunome's discovery engine to quickly identify antibodies that are broadly effective against SARS-CoV-2 and its variants. Of note, Immunome's discovery engine has identified antibodies that bind to conserved epitopes of SARS-CoV-1 and SARS-CoV-2 spike, as well as to other non-spike targets. We believe that our comprehensive strategy could combat the negative impact of escape mutants. We are encouraged by these results and plan to continue development efforts on these antibodies."

    Jeffrey P Henderson, MD, PhD, Associate Professor of Medicine and of Molecular Microbiology at Washington University School of Medicine in St. Louis, and a member of Immunome's COVID-19 Advisory Board, said, "Interrogating the overall immune responses in recovered COVID-19 patients allows Immunome to identify not only broadly neutralizing anti-spike antibodies but also promising non-spike antibodies that have the potential to enhance viral clearance. Broadly targeting multiple viral proteins in this way may provide alternative approaches to combat future SARS-CoV-2 variants."

    In July 2020, Immunome was awarded a $13.3 million technology award from the U.S. Department of Defense's Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency, to support Immunome's COVID program. The research discussed in this press release and the article is part of that program.

    About Immunome

    Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics that are designed to change the way diseases are treated. The company's initial focus is on developing therapeutics to treat oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery engine identifies novel therapeutic antibodies and their targets by leveraging the highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release and the article referenced within includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones, Immunome's ability to execute on its strategy including with respect to the timing of its R&D efforts, IND filings, initiation of clinical studies and other anticipated milestones, the timing and effectiveness of any antibody therapeutics which may be developed by Immunome, Immunome's ability to fund operations and the additional risks and uncertainties set forth more fully under the caption "Risk Factors" in Immunome's final prospectus dated October 1, 2020 and filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, with the United States Securities and Exchange Commission (SEC) and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  17. Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, and Abzena, a partner research organization for integrated discovery to cGMP manufacturing solutions for biologics, today announced that Abzena was selected as Immunome's partner research organization for IMM-BCP-01, an investigational therapeutic antibody cocktail for the treatment of COVID-19 being developed to target multiple SARS-CoV-2 antigens. Abzena will work with Immunome to produce the antibody cocktail for clinical testing. In July 2020, Immunome was awarded a $13.3 million agreement executed by the United States Department of Defense's Joint Program Executive…

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, and Abzena, a partner research organization for integrated discovery to cGMP manufacturing solutions for biologics, today announced that Abzena was selected as Immunome's partner research organization for IMM-BCP-01, an investigational therapeutic antibody cocktail for the treatment of COVID-19 being developed to target multiple SARS-CoV-2 antigens. Abzena will work with Immunome to produce the antibody cocktail for clinical testing. In July 2020, Immunome was awarded a $13.3 million agreement executed by the United States Department of Defense's Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency, to support this program.

    Jonathan Goldman, MD, CEO of Abzena, said, "Immunome has used an innovative biologics research platform to conduct large-scale B cell interrogation of COVID-19 super-responders to identify suitable antibodies. Sarma and his team at Immunome are visionary scientists and leaders in the field and we are very honored to have been selected as the service provider of choice for clinical good manufacturing practice (GMP) manufacturing of the Immunome antibody cocktail. We strongly believe in the potential clinical benefit of this agent and look forward to helping patients in need."

    Purnanand Sarma, PhD, CEO of Immunome, said, "We selected Abzena as our Contract Development and Manufacturing Organization (CDMO) partner due to scientific expertise, flexibility and ability to execute on our timeline, critical in these times when rapid response to the pandemic is required. We are excited that Jonathan and his team share our passion for science and delivering high quality patient outcomes. We hope to positively impact the landscape of the global pandemic through our new antibody-based therapeutic approach."

    About Immunome

    Immunome is a biopharmaceutical company utilizing our proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics designed to change the way diseases are currently being treated with an initial focus on oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery platform identifies novel therapeutic antibodies and their targets by leveraging highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    About Abzena

    Abzena is a leading contract provider of integrated discovery, development and manufacturing services for biologics and bioconjugates. Abzena provides the most complete set of solutions in integrated early discovery to mid-phase biotherapeutic and bioconjugation drug development and manufacturing in the biopharmaceutical industry. The company maintains resources around the world, with facilities in the US and UK.

    Abzena investors include Welsh, Carson, Anderson & Stowe, one of the world's leading private equity investors, and Biospring Partners (https://www.biospring.com/). For more information, please see www.abzena.com.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones, Immunome's ability to execute on its strategy including with respect to the timing of IND filings and other anticipated milestones, Immunome's ability to fund operations, as well as those risks and uncertainties set forth more fully under the caption "Risk Factors" in the final prospectus dated October 1, 2020 and filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, with the United States Securities and Exchange Commission (SEC) and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  18. Findings support the potential of Immunome's approach to developing IMM-BCP-01 as an optimized antibody cocktail for the treatment and prophylaxis of COVID-19

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced the release of findings from its ongoing preclinical COVID-19 research program in a manuscript entitled "Unbiased Interrogation of Memory B Cells from Convalescent COVID-19 Patients Reveals A Broad Anti-Viral Humoral Response Targeting SARS-CoV-2 Antigens Beyond the Spike Protein."

    Key findings discussed in the manuscript include:

    • More than 50% of the antibodies isolated from super-responders are directed

    Findings support the potential of Immunome's approach to developing IMM-BCP-01 as an optimized antibody cocktail for the treatment and prophylaxis of COVID-19

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced the release of findings from its ongoing preclinical COVID-19 research program in a manuscript entitled "Unbiased Interrogation of Memory B Cells from Convalescent COVID-19 Patients Reveals A Broad Anti-Viral Humoral Response Targeting SARS-CoV-2 Antigens Beyond the Spike Protein."

    Key findings discussed in the manuscript include:

    • More than 50% of the antibodies isolated from super-responders are directed at non-Spike antigens, suggesting non-Spike related antibodies may play a significant role in the effective immunological clearance of this virus
    • Nucleocapsid proteins and the open reading frame-encoded (ORF) proteins, ORF8 and ORF10, represent the most prevalent non-Spike targets
    • Antibody response against both neutralizing and non-neutralizing epitopes on Spike protein are committed to B-cell memory
    • Response appears to extend beyond immunoglobulin G (IgG), comprising affinity-matured antibodies with specialized function (IgA and IgM)

    A pre-print of the article is available at this link; the article has not yet been peer reviewed.

    Purnanand Sarma, PhD, CEO of Immunome, said, "We believe that the broad response we observed to multiple viral proteins beyond just the Spike protein points towards an approach for developing an antibody cocktail, which could better mimic the natural human immune response against the SARS-Cov-2 infection. Furthermore, an optimized combination of antibodies could potentially overcome the high level of mutational drift we are seeing in the Spike protein."

    In July 2020, Immunome was awarded a $13.3 million agreement executed by the United States Department of Defense's Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency, to support Immunome's COVID program. The research discussed in this press release and the article is part of that program.

    About Immunome

    Immunome is a biopharmaceutical company utilizing our proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics designed to change the way diseases are currently being treated with an initial focus on oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery platform identifies novel therapeutic antibodies and their targets by leveraging highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease. For more information, please visit www.immunome.com.

    Forward-Looking Statements

    This press release and the article referenced within includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones, Immunome's ability to execute on its strategy including with respect to the timing of IND filings, the initiation of clinical studies and other anticipated milestones, the timing and effectiveness of any antibody therapeutics which may be developed by Immunome, Immunome's ability to fund operations, as well as those risks and uncertainties set forth more fully under the caption "Risk Factors" in the final prospectus dated October 1, 2020 and filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, with the United States Securities and Exchange Commission (SEC) and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  19. President & CEO Purnanand Sarma Announced as the Recipient of TiE Boston's 2020 Lifetime Achievement Award

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, with a focus on oncology and infectious diseases including COVID-19, today announced the recent appointments of Richard Baron to Immunome's Board of Directors and as Audit Committee Chair, and Sandra Stoneman, Esq. as Chief Legal Officer and Corporate Secretary. The company also today announced that its President and Chief Executive Officer, Purnanand Sarma, Ph.D. is the recipient of TiE Boston's 2020 Lifetime Achievement Award. The award recognizes individuals who…

    President & CEO Purnanand Sarma Announced as the Recipient of TiE Boston's 2020 Lifetime Achievement Award

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, with a focus on oncology and infectious diseases including COVID-19, today announced the recent appointments of Richard Baron to Immunome's Board of Directors and as Audit Committee Chair, and Sandra Stoneman, Esq. as Chief Legal Officer and Corporate Secretary. The company also today announced that its President and Chief Executive Officer, Purnanand Sarma, Ph.D. is the recipient of TiE Boston's 2020 Lifetime Achievement Award. The award recognizes individuals who have made invaluable contributions in the fields of science, business and entrepreneurship.

    "I am thrilled to welcome Richard and Sandra to the Immunome team as we accelerate our efforts in discovering novel antibodies and advancing our lead programs into the clinic," said President and CEO, Purnanand Sarma, Ph.D. "The combination of their expertise and experience will be invaluable in supporting Immunome's growth." He further stated, "I am also honored to receive TiE Boston's 2020 Lifetime Achievement Award and very much appreciate the opportunity to continue to work with TiE in driving innovation and fostering next generation entrepreneurs."

    Richard Baron has over 30 years of experience as an advisor to companies in the pharmaceutical, biotechnology and medical device industries and as a Chief Financial Officer. He was previously the Chief Financial Officer of Zynerba Pharmaceuticals (NASDAQ:ZYNE), Globus Medical (NYSE:GMED), Avid Radiopharmaceuticals, Animas Corporation (NASDAQ:PUMP) and others. Baron was a practicing certified public accountant, beginning his career in audit and tax services at Coopers & Lybrand and Arthur Young. He received his B.S. in economics at The Wharton School of the University of Pennsylvania. Baron's background and experience advising life sciences companies and in finance and accounting added significantly to the Board's skills in these areas.

    Sandra Stoneman, Esq. is a seasoned attorney, with more than 20 years of experience advising high-growth companies in the life sciences and technology sectors. Prior to joining Immunome, Stoneman was an attorney at Duane Morris, leading the Firm's life sciences practice group. She has received numerous accolades for her transactional work in the life sciences field, including being continuously listed in U.S. News/Best Lawyers, Chambers USA and LMG Life Sciences. Stoneman received her J.D. from Temple University School of Law and her B.A. from the State University of New York at Binghamton.

    About Immunome, Inc.

    Immunome is a biopharmaceutical company utilizing our proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics designed to change the way diseases are currently being treated with an initial focus on oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery platform identifies novel therapeutic antibodies and their targets by leveraging highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones, Immunome's ability to execute on its strategy including with respect to the timing of IND filings, Immunome's ability to fund operations, as well as those risks and uncertainties set forth more fully under the caption "Risk Factors" in the final prospectus dated October 1, 2020 and filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, with the United States Securities and Exchange Commission (SEC) and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

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  20. - Completed $44.9M IPO in October -
    - Identified COVID 19 Neutralizing antibodies -
    - Significant progress made on lead programs, including IMM-BCP-01 for the treatment of COVID-19 in collaboration with US Department of Defense -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, with a focus on oncology and infectious diseases including COVID-19, today announced third quarter 2020 financial results and recent highlights.

    "The completion of our recent IPO marks a significant milestone for Immunome and positions us to further accelerate the output of new discoveries from our platform, and to rapidly advance our lead oncology…

    - Completed $44.9M IPO in October -

    - Identified COVID 19 Neutralizing antibodies -

    - Significant progress made on lead programs, including IMM-BCP-01 for the treatment of COVID-19 in collaboration with US Department of Defense -

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, with a focus on oncology and infectious diseases including COVID-19, today announced third quarter 2020 financial results and recent highlights.

    "The completion of our recent IPO marks a significant milestone for Immunome and positions us to further accelerate the output of new discoveries from our platform, and to rapidly advance our lead oncology and COVID-19 therapeutic antibody programs into the clinic," said Purnanand Sarma, PhD, President and CEO of Immunome. "We are on track to execute on our near-term clinical and strategic plans, including filing IND applications for two of our programs in 2021." Dr. Sarma further stated, "I am proud of the tremendous progress our team has made this year, particularly with regard to the notable effort and dedication supporting our accelerated development of antibody-based treatment targeting multiple viral antigens to treat the COVID-19 virus. As previously announced, Immunome was awarded a $13.3 million contract from the US Department of Defense to develop an antibody cocktail discovered by the interrogation of memory B cells from 'super-responders' to the SARS-CoV-2 virus (DoD Press Release)."

    Recent Highlights

    • In October 2020, Immunome completed an IPO, including the full exercise of the underwriters' option to purchase additional shares, resulting in gross proceeds of $44.9 million, before deducting underwriting commissions and offering expenses.
    • IMM-BCP-01: Unlike approaches solely directed at neutralizing the Spike protein by other companies, we aim to develop an antibody cocktail directed at multiple SARS-CoV-2 antigens. Unbiased interrogation of SARS-CoV-2 "super-responder" memory B cells using Immunome's discovery engine has resulted in the following advances:
      • We discovered that more than 50% of the antibodies isolated from super-responders are directed at non-Spike antigens, suggesting non-Spike related antibodies may play a significant role in the effective immunological clearance of this virus.
      • We also identified multiple neutralizing antibodies with picomolar affinity directed at SARS-CoV-2 Spike protein.
      • We discovered that, in addition to affinity matured IgG antibodies, COVID-19 "super-responders" appear to mount robust affinity-matured IgA responses. IgA antibodies are naturally found at the surface of respiratory track and function to prevent initial viral infection.
    • IMM-ONC-01: Our further pre-clinical testing continues to demonstrate that IL-38 appears to be a novel immune checkpoint. In animal models, our inhibitory antibody demonstrates antitumor effects in IL-38 expressing tumors.

    Third Quarter 2020 Financial Results:

    • Cash and cash equivalents: Cash and cash equivalents were $6.7 million as of September 30, 2020 compared to $2.5 million as of December 31, 2019.
    • IPO and net proceeds: On October 2, 2020 the Company's common stock began trading on the Nasdaq Capital Market under the ticker (IMNM) and on October 6, 2020 the IPO closed with the Company receiving net proceeds of $41.7 million, after deducting underwriting discounts but before deducting other offering expenses. After deducting other offering costs of approximately $2.8 million, aggregate net IPO proceeds to the Company were $38.9 million.
    • Research and development (R&D) expenses: R&D expenses were $1.6 million for the quarter ended September 30, 2020 compared to $2.2 million for the quarter ended September 30, 2019 and $5.7 million for the nine month period ended September 30, 2020 compared to $6.4 million for the nine month period ended September 30, 2019.
    • General and administrative (G&A) expenses: G&A expenses were $1.2 million for the quarter ended September 30, 2020 compared to $0.5 million for the quarter ended September 30, 2019 and $2.5 million for the nine month period ended September 30, 2020 compared to $1.1 million for the nine month period ended September 30, 2019.
    • Net loss: Net loss attributable to common stockholders was $8.4 million or $7.52 per share for the quarter ended September 30, 2020 compared to $2.7 million or $2.50 per share for the quarter ended September 30, 2019 and $13.8 million or $12.44 per share for the nine month period ended September 30, 2020 compared to $7.5 million or $6.88 per share for the nine month period ended September 30, 2019.

    About Immunome, Inc.

    Immunome is a biopharmaceutical company utilizing our proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics designed to change the way diseases are currently being treated. Immunome's proprietary discovery platform identifies novel therapeutic antibodies and their targets by leveraging highly educated components of the immune system, memory B cells, from patients whose bodies have learned to fight off their disease.

    Forward-Looking Statements

    This press release includes certain disclosures that contain "forward-looking statements" intended to qualify for the "safe harbor" from liability established by the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding Immunome's beliefs and expectations regarding the advancement of its oncology and COVID-19 therapeutic antibody programs, execution of its clinical and strategic plans, anticipated upcoming milestones for IMM-BCP-01 and IMM‐ONC‐01, including expectations regarding therapeutic potential and benefits thereof, and IND filings. Forward-looking statements may be identified by the words "anticipate," believe," "estimate," "expect," "intend," "plan," "project," "may," "will," "could," "should," "seek" and similar expressions. Forward-looking statements are based on Immunome's current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those risks and uncertainties associated with: the impact of the COVID-19 pandemic on Immunome's business, operations, strategy, goals and anticipated milestones, Immunome's ability to execute on its strategy including with respect to the timing of IND filings, Immunome's ability to fund operations, as well as those risks and uncertainties set forth more fully under the caption "Risk Factors" in the final prospectus dated October 1, 2020 and filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, with the United States Securities and Exchange Commission (SEC) and elsewhere in Immunome's filings and reports with the SEC. Forward-looking statements contained in this announcement are made as of this date, and Immunome undertakes no duty to publicly update or revise any forward looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable law.

     

    IMMUNOME, INC.

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    December 31, 2019

    Assets

     

     

     

     

     

     

    Current assets:

     

     

     

     

     

     

    Cash

     

    $

    6,744

     

    $

    2,543

    Prepaid expenses and other current assets

     

     

    739

     

     

    579

    Total current assets

     

     

    7,483

     

     

    3,122

    Property and equipment, net

     

     

    1,741

     

     

    1,700

    Restricted cash

     

     

    100

     

     

    100

    Other assets

     

     

    2,659

     

     

    138

    Total assets

     

    $

    11,983

     

    $

    5,060

    Liabilities, convertible preferred stock, and stockholders' deficit

     

     

     

     

     

     

    Current liabilities:

     

     

     

     

     

     

    Current portion of capital lease obligations

     

    $

     

    $

    239

    Current portion of equipment loan payable

     

     

    144

     

     

    212

    Current portion of long-term debt

     

     

    305

     

     

    Accounts payable

     

     

    2,627

     

     

    548

    Accrued expenses and other current liabilities

     

     

    2,330

     

     

    666

    Total current liabilities

     

     

    5,406

     

     

    1,665

    Equipment loan payable, net of current portion

     

     

    16

     

     

    113

    Long-term debt, net of current portion

     

     

    195

     

     

    Warrant liability

     

     

    7,071

     

     

    Deferred rent

     

     

    11

     

     

    18

    Total liabilities

     

     

    12,699

     

     

    1,796

     

     

     

     

     

     

     

    Series A convertible preferred stock, $0.0001 par value; 45,000,000 and 30,000,000 shares authorized and 5,670,184 and 4,443,259 shares issued and outstanding at September 30, 2020 and December 31, 2019, respectively (liquidation value of $51,033 at September 30, 2020)

     

     

    48,369

     

     

    38,894

    Stockholders' deficit:

     

     

     

     

     

     

    Common stock, $0.0001 par value; 65,000,000 and 50,000,000 shares authorized and 1,124,616 and 1,099,270 shares issued and outstanding at September 30, 2020 and December 31, 2019, respectively

     

     

     

     

    Additional paid-in capital

     

     

    1,236

     

     

    927

    Accumulated deficit

     

     

    (50,321)

     

     

    (36,557)

    Total stockholders' deficit

     

     

    (49,085)

     

     

    (35,630)

    Total liabilities, convertible preferred stock, and stockholders' deficit

     

    $

    11,983

     

    $

    5,060

     

    IMMUNOME, INC.

    Condensed Statements of Operations

    (Unaudited; In thousands, except share and per share data)

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Three Months Ended September 30,

     

    Nine Months Ended September 30,

     

     

    2020

     

    2019

     

    2020

     

    2019

     

     

     

     

     

     

     

     

     

     

     

     

     

    Operating expenses:

     

     

     

     

     

     

     

     

     

     

     

     

    Research and development

     

    $

    1,644

     

    $

    2,234

     

    $

    5,651

     

    $

    6,391

    General and administrative

     

     

    1,174

     

     

    486

     

     

    2,537

     

     

    1,069

    Total operating expenses

     

     

    2,818

     

     

    2,720

     

     

    8,188

     

     

    7,460

    Loss from operations

     

     

    (2,818)

     

     

    (2,720)

     

     

    (8,188)

     

     

    (7,460)

    Other expenses:

     

     

     

     

     

     

     

     

     

     

     

     

    Change in fair value of warrant liability

     

     

    (5,549)

     

     

     

     

    (5,549)

     

     

    Interest expense, net

     

     

    (10)

     

     

    (17)

     

     

    (27)

     

     

    (62)

    Total other expenses

     

     

    (5,559)

     

     

    (17)

     

     

    (5,576)

     

     

    (62)

    Net loss

     

    $

    (8,377)

     

    $

    (2,737)

     

    $

    (13,764)

     

    $

    (7,522)

    Per share information:

     

     

     

     

     

     

     

     

     

     

     

     

    Net loss per share of common stock, basic and diluted

     

    $

    (7.52)

     

    $

    (2.50)

     

    $

    (12.44)

     

    $

    (6.88)

    Weighted-average common shares outstanding, basic and diluted

     

     

    1,114,427

     

     

    1,093,028

     

     

    1,106,039

     

     

    1,092,630

     

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  21. Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, with a focus on oncology and infectious diseases, including COVID-19, today announced the full exercise of the underwriters' option to purchase an additional 487,500 shares of common stock at the public offering price of $12.00 per share, resulting in additional gross proceeds of approximately $5.9 million, in connection with the Company's previously announced initial public offering of common stock. After giving effect to the full exercise of the over-allotment option, the total number of shares sold by Immunome in the initial public offering was 3,737,500 shares and the…

    Immunome, Inc. (NASDAQ:IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics, with a focus on oncology and infectious diseases, including COVID-19, today announced the full exercise of the underwriters' option to purchase an additional 487,500 shares of common stock at the public offering price of $12.00 per share, resulting in additional gross proceeds of approximately $5.9 million, in connection with the Company's previously announced initial public offering of common stock. After giving effect to the full exercise of the over-allotment option, the total number of shares sold by Immunome in the initial public offering was 3,737,500 shares and the gross proceeds were approximately $44.9 million, before deducting underwriting discounts and commissions and estimated offering expenses payable by the Company. All of the shares were sold by Immunome. Immunome's common stock began trading on the Nasdaq Capital Market on October 2, 2020, under the ticker symbol "IMNM".

    Ladenburg Thalmann & Co. Inc. and Chardan acted as book-running managers for the offering.

    A registration statement relating to the offering of these securities has been declared effective by the Securities and Exchange Commission on October 1, 2020. The offering was made only by means of a prospectus. Copies of the final prospectus relating to the offering may be obtained by vising www.sec.gov or from Ladenburg Thalmann & Co. Inc., 277 Park Avenue, 26th Floor, New York, NY 10172, or by calling (212) 409-2000, or by emailing prospectus@ladenburg.com or Chardan Capital Markets, LLC, 17 State Street, 21st floor, New York, New York 10004, or by calling (646) 465-9001.

    This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

    About Immunome

    Immunome is a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop first-in-class antibody therapeutics designed to change the way diseases are currently being treated and an initial focus on oncology and infectious diseases, including COVID-19. Immunome's proprietary discovery platform identifies novel therapeutic antibodies and their targets by leveraging highly educated components of the immune system, memory B cells, from patients who have learned to fight off their disease.

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