IKT Inhibikase Therapeutics Inc.

6.7
-0.39  -6%
Previous Close 7.09
Open 7.18
52 Week Low 6.4
52 Week High 11.8
Market Cap $67,636,446
Shares 10,094,992
Float 4,805,911
Enterprise Value $71,366,284
Volume 64,988
Av. Daily Volume 252,054
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Drug Pipeline

Drug Stage Notes
IkT-148009
Parkinson’s disease
Phase 1
Phase 1
Phase 1 initiation of dosing announced February 17, 2021.

Latest News

  1. ATLANTA, Feb. 22, 2021 /PRNewswire/ -- Inhibikase Therapeutics, Inc. (NASDAQ:IKT) (Inhibikase), a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders, today announced that it will present findings from its oral therapy studies for its lead agent IkT-148009 in progressive disease models of Parkinson's at the American Society of Experimental Neurotherapeutics (ASENT) 2021 Annual Meeting, being held virtually from February 22 - 25, 2021.

    Inhibikase's President and Chief Executive Officer, Milton Werner, Ph.D. will describe the benefits observed following therapeutic, oral, daily administration of IkT-148009 in humanized mouse models of slowly progressive Parkinson's disease (PD). These outcomes suggest a mechanistic understanding of the role of alpha-synuclein plaques in the onset of disease.

    Details for the presentation are below:

    Event: American Society of Experimental Neurotherapeutics Conference

    Session: Symposium on Parkinson's Disease: New Approaches

    Presentation Title: Disease modification of Parkinson's Disease through oral kinase inhibitor therapy

    Presentation Date: Thursday, February 25, 2021

    Time: 10:20-10:40am ET

    Following the presentation, there will be a live panel discussion and Q&A session from 11:00-11:15am ET.

    "We are excited to share some of the preclinical results of our IkT-148009 program at the ASENT 2021 conference. C-Abl is believed to be activated by the presence of alpha-synuclein plaque within affected neurons and subsequently, chemically modifies them, which we believe is a key event initiating the disease process in PD," stated Dr. Werner. "We believe that IkT-148009, may have the potential to alter the course of PD and transform the lives of millions of patients worldwide."

    IkT-148009 is intended to be a once daily oral therapy to modify the progression of PD and has demonstrated functional recovery in animal models of Parkinson's disease in the brain and gastrointestinal, or GI, tract, two major organs affected by PD in humans. IkT-148009 is currently in Phase 1 clinical trials for the treatment of PD.

    About Inhibikase (www.inhibikase.com)

    Inhibikase (NASDAQ:IKT) is a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders. Inhibikase's multi-therapeutic pipeline focuses on neurodegeneration and its lead program IkT-148009, an Abelson Tyrosine Kinase (c-Abl) inhibitor, targets the treatment of Parkinson's disease inside and outside the brain. Inhibikase is currently dosing patients in its Phase I, randomized single ascending dose and multiple ascending dose in study to determine the safety, tolerability and pharmacokinetics of IkT-148009 in older and healthy subjects. Inhibikase is headquartered in Atlanta, Georgia with offices in Boston, Massachusetts.

    Forward-Looking Statements

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking terminology such as "believes," "expects," "may," "will," "should," "anticipates," "plans," or similar expressions or the negative of these terms and similar expressions are intended to identify forward-looking statements. These forward-looking statements, including statements regarding the closing of the initial public offering and the proceeds of the initial public offering, are based on Inhibikase's current expectations and assumptions. Such statements are subject to certain risks and uncertainties, which could cause Inhibikase's actual results to differ materially from those anticipated by the forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in Inhibikase's filings with the SEC, including its registration statement on Form S-1, as amended (File No. 333-240036), including under the caption "Risk Factors." Any forward-looking statement in this release speaks only as of the date of this release. Inhibikase undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by any applicable securities laws.

    Contacts:

    Company Contact:

    Milton H. Werner, PhD

    President & CEO

    678-392-3419

     

    Investor Relations:

    Alex Lobo

    SternIR, Inc.

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  2. - IKT-148009 is a mechanistically defined disease-modifying therapy -

    Inhibikase Therapeutics, Inc. (NASDAQ:IKT) (Inhibikase), a clinical-stage pharmaceutical company developing therapeutics to modify the course of Parkinson's disease and related disorders, today announced dosing of the first patients in its Phase 1 clinical trial of IkT-148009, an Abelson Tyrosine Kinase, or c-Abl, inhibitor for the treatment of Parkinson's disease.

    This randomized Phase 1 study is investigating the safety, tolerability and pharmacokinetics (PK) of IkT-148009 in healthy volunteers aged 45 to 70 years old with the objective of identifying the maximum tolerated dose and the PK profile of IkT-148009 in single and multiple ascending dose settings. In preclinical…

    - IKT-148009 is a mechanistically defined disease-modifying therapy -

    Inhibikase Therapeutics, Inc. (NASDAQ:IKT) (Inhibikase), a clinical-stage pharmaceutical company developing therapeutics to modify the course of Parkinson's disease and related disorders, today announced dosing of the first patients in its Phase 1 clinical trial of IkT-148009, an Abelson Tyrosine Kinase, or c-Abl, inhibitor for the treatment of Parkinson's disease.

    This randomized Phase 1 study is investigating the safety, tolerability and pharmacokinetics (PK) of IkT-148009 in healthy volunteers aged 45 to 70 years old with the objective of identifying the maximum tolerated dose and the PK profile of IkT-148009 in single and multiple ascending dose settings. In preclinical animal models of progressive disease, the Company demonstrated that once a day oral therapy with IkT-148009 can both halt and reverse functional loss in the brain and gastrointestinal tract.

    "The initiation of our Phase 1 study of IkT-148009 for the treatment of Parkinson's disease represents a significant milestone for Inhibikase. Based on preclinical data, we believe that c-Abl plays a critical role in the Parkinson's disease process and inhibition of c-Abl represents a promising new approach to disease modification," stated Milton Werner, Ph.D., Chief Executive Officer of Inhibikase Therapeutics. "We are excited to advance into the clinic, and believe that IKT-148009 could be a transformative therapy for millions of patients worldwide."

    Activation of c-Abl, in humans occurs once plaques of alpha-synuclein are internalized by the affected neurons. C-Abl then drives biochemical pathways and processes that lead to degradation of the neurons affected in Parkinson's disease. Inhibition of c-Abl may restore functional loss for neurons that have not fully degraded in the brain and remodel neurons in the gastrointestinal tract, two major organ systems affected by the disease.

    About Parkinson's Disease

    Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, affecting approximately 1,000,000 persons in the United States, with 60,000 new cases and 38,000 deaths annually. PD is a progressive neurodegenerative disease that initiates with dysfunction of a small protein known as alpha-synuclein, inside and outside of the brain. The common features of PD include tremors at a resting state, slowing or lack of control of movement and postural instability. These features of the disease arise from degeneration of neurons that secrete dopamine to transmit neurological signals. The degeneration of these dopaminergic neurons in nigrostriatal area of the brain near the brainstem, coupled with the accumulation of alpha-synuclein protein aggregates in cell bodies and terminals known as Lewy bodies, have long been thought to be the cause of the disease. Less well known are the features of this disease can affect serotonin levels, cholinergic, and norepinephrine neurons and nerve cells in the olfactory system, cerebral hemisphere, brain stem, spinal cord, and peripheral autonomic nervous system such as in the GI tract. Currently, these non-dopaminergic features are not properly controlled with dopamine-replacement or levodopa therapy.

    About Inhibikase (www.inhibikase.com)

    Inhibikase (NASDAQ:IKT) is a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders. Inhibikase's multi-therapeutic pipeline focuses on neurodegeneration and its lead program IkT-148009, an Abelson Tyrosine Kinase (c-Abl) inhibitor, targets the treatment of Parkinson's disease inside and outside the brain. Inhibikase is currently enrolling its Phase I, randomized single ascending dose and multiple ascending dose study to determine the safety, tolerability and pharmacokinetics of IkT-148009 in older and healthy subjects. Inhibikase is headquartered in Atlanta, Georgia with offices in Boston, Massachusetts.

    Forward-Looking Statements

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking terminology such as "believes," "expects," "may," "will," "should," "anticipates," "plans," or similar expressions or the negative of these terms and similar expressions are intended to identify forward-looking statements. These forward-looking statements, including statements regarding the closing of the initial public offering and the proceeds of the initial public offering, are based on Inhibikase's current expectations and assumptions. Such statements are subject to certain risks and uncertainties, which could cause Inhibikase's actual results to differ materially from those anticipated by the forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in Inhibikase's filings with the SEC, including its registration statement on Form S-1, as amended (File No. 333-240036), including under the caption "Risk Factors." Any forward-looking statement in this release speaks only as of the date of this release. Inhibikase undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by any applicable securities laws.

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  3. ATLANTA, Jan. 4, 2021 /PRNewswire/ -- Inhibikase Therapeutics, Inc. (NASDAQ:IKT) (Inhibikase), a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders, announced today that it has formed a partnership with Clintrex Research Corporation (CLINTREX), a leading provider of clinical development and regulatory services with specific expertise in development of therapeutics for neurodegenerative diseases. CLINTREX will oversee clinical trials, clinical operations, and regulatory issues for Inhibikase's pipeline programs across multiple therapeutic areas. As part of this partnership, C. Warren Olanow, MD, FRCPC, FRCP (Hon), CEO of CLINTREX, will serve as Interim Chief Medical Officer of Inhibikase…

    ATLANTA, Jan. 4, 2021 /PRNewswire/ -- Inhibikase Therapeutics, Inc. (NASDAQ:IKT) (Inhibikase), a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders, announced today that it has formed a partnership with Clintrex Research Corporation (CLINTREX), a leading provider of clinical development and regulatory services with specific expertise in development of therapeutics for neurodegenerative diseases. CLINTREX will oversee clinical trials, clinical operations, and regulatory issues for Inhibikase's pipeline programs across multiple therapeutic areas. As part of this partnership, C. Warren Olanow, MD, FRCPC, FRCP (Hon), CEO of CLINTREX, will serve as Interim Chief Medical Officer of Inhibikase.

    This partnership rounds out Inhibikase's core clinical development team for development of IkT-148009 as a treatment for Parkinson's disease in the brain and gastrointestinal tract and the development of IkT-001Pro for stable-phase chronic myelogenous leukemia. Clintrex will further guide the entry of additional molecules into clinical development for multiple systems atrophy and dementia with Lewy body. Dr. Olanow (CEO of CLINTREX) will work closely with CLINTREX President, Karl Kieburtz, MD, MPH, to advance the clinical development programs of Inhibikase.

    Dr. C. Warren Olanow will serve as Interim Chief Medical Officer of Inhibikase and Chief Executive Officer of CLINTREX. He is the former Henry P. and Georgette Goldschmidt Professor and Chairman of the Department of Neurology at the Mount Sinai School of Medicine in New York City, where he is presently Professor Emeritus in the Department of Neurology and in the Department of Neuroscience. Prior to joining Mount Sinai, he served on the faculties of McGill University, Duke University, and the University of South Florida. He is the former President of the Movement Disorder Society, past President of the International Society of Motor Disturbances, and former Treasurer of the American Neurological Association. He has served on the Board of Directors of the National Space Biomedical Research Institute and the executive committee of the Michael J. Fox Foundation Scientific Advisory Board, and he is the former Chairman of the Scientific Advisory Board of the Bachmann-Strauss Dystonia & Parkinson Foundation. Dr. Olanow is the former Co-Editor-in-Chief of the journal, Movement Disorders. He has been principal investigator of numerous studies leading to approval of drugs and devices for treating neurodegenerative diseases. Dr. Olanow received his medical degree from the University of Toronto, performed his neurology training at the New York Neurological Institute at Columbia Presbyterian Medical Center at Columbia University, and undertook postgraduate studies in neuroanatomy at Columbia University.

    Dr. Karl Kieburtz is President of CLINTREX. He is the former Robert J. Joynt Professor in the Department of Neurology at the University of Rochester, where he is currently a Professor of Neurology. He is the founding Director of the Center of Human Experimental Therapeutics and served as the Director of the Clinical and Translational Science Institute and as Senior Associate Dean for Clinical Research at the University of Rochester. He has served on the Executive Committee of the Michael J. Fox Foundation, was Chair of the FDA Peripheral and Central Nervous System Advisory Committee, served as Chair of the Parkinson Study Group Executive Committee, and is a former member of the Huntington Study Group Executive Committee. He has served as Vice President of the American Neurological Association, was a member of the International Executive Committee of the Movement Disorder Society, and was Associate Editor of the journals, Neurology and Movement Disorders. He has been principal investigator of numerous studies leading to approval of treatments for neurodegenerative diseases. Dr. Kieburtz received MD and MPH degrees and performed a Neurology residency at the University of Rochester.

    About Inhibikase (www.inhibikase.com)

    Inhibikase is a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders that arise inside and outside of the brain. Inhibikase is headquartered in Atlanta, Georgia with additional offices in Boston, Massachusetts.

    About Clintrex Research Corporation (www.clintrex.com)

    Clintrex Research Corporation (CLINTREX) is a clinical research organization that works with pharmaceutical and biotech companies to design clinical trials, operationalize development plans, and develop regulatory pathways for new treatments for CNS diseases. CLINTREX incorporates an integrated team of internationally renowned experts with disease-specific knowledge to identify, clarify, and solve preclinical, clinical trial, biostatistical, and regulatory issues essential to product development and approval.

    Forward-Looking Statements

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking terminology such as "believes," "expects," "may," "will," "should," "anticipates," "plans," or similar expressions or the negative of these terms and similar expressions are intended to identify forward-looking statements. These forward-looking statements, including statements regarding the closing of the initial public offering and the proceeds of the initial public offering, are based on Inhibikase's current expectations and assumptions. Such statements are subject to certain risks and uncertainties, which could cause Inhibikase's actual results to differ materially from those anticipated by the forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in Inhibikase's filings with the SEC, including its registration statement on Form S-1, as amended (File No. 333-240036), including under the caption "Risk Factors." Any forward-looking statement in this release speaks only as of the date of this release. Inhibikase undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by any applicable securities laws.

    Contacts:

    Investor Relations:

    Milton H. Werner, PhD

    President & CEO, Inhibikase

    678-392-3419

    Media:

    Mary Moynihan

    M2Friend Biocommunications

    802-951-9600

     

    Cision View original content:http://www.prnewswire.com/news-releases/inhibikase-therapeutics-announces-partnership-with-clintrex-research-corporation-c-warren-olanow-md-to-serve-as-interim-chief-medical-officer-301200048.html

    SOURCE Inhibikase Therapeutics

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  4. ATLANTA, Dec. 28, 2020 /PRNewswire/ -- Inhibikase Therapeutics, Inc. (NASDAQ:IKT) ("Inhibikase"), a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders that arise inside and outside of the brain, announced today the closing of its initial public offering of 1,800,000 shares of common stock at a public offering price of $10.00 per share. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Inhibikase, were $18 million. In addition, Inhibikase has granted the underwriters a 45-day option to purchase up to an additional 270,000 shares of Inhibikase's common stock at the initial public offering price, less underwriting…

    ATLANTA, Dec. 28, 2020 /PRNewswire/ -- Inhibikase Therapeutics, Inc. (NASDAQ:IKT) ("Inhibikase"), a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders that arise inside and outside of the brain, announced today the closing of its initial public offering of 1,800,000 shares of common stock at a public offering price of $10.00 per share. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Inhibikase, were $18 million. In addition, Inhibikase has granted the underwriters a 45-day option to purchase up to an additional 270,000 shares of Inhibikase's common stock at the initial public offering price, less underwriting discounts and commissions.

    Inhibikase's common stock began trading on the Nasdaq Capital Market on December 23, 2020 under the ticker symbol "IKT."

    ThinkEquity, a division of Fordham Financial Management, Inc., is acting as sole book-running manager for the offering.

    A registration statement relating to the securities being sold in the offering was declared effective by the Securities and Exchange Commission (SEC) on December 22, 2020. This offering was made only by means of a prospectus. Copies of the final prospectus relating to this offering may be obtained from the offices of ThinkEquity, a division of Fordham Financial Management, Inc., 17 State Street, 22nd Floor, New York, New York 10004, by telephone at (877) 436-3673, or by email at . These documents may also be obtained free of charge, when they are available, by visiting the SEC's website at www.sec.gov.

    This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Any offers, solicitations or offers to buy, or any sales of securities will be made in accordance with the registration requirements of the Securities Act of 1933, as amended.

    About Inhibikase (www.inhibikase.com

    Inhibikase is a clinical-stage pharmaceutical company developing therapeutics for Parkinson's Disease and related disorders that arise inside and outside of the brain. Inhibikase is headquartered in Atlanta, Georgia with additional offices in Boston, Massachusetts.

    Forward Looking Statements

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking terminology such as "believes," "expects," "may," "will," "should," "anticipates," "plans," or similar expressions or the negative of these terms and similar expressions are intended to identify forward-looking statements. These forward-looking statements, including statements regarding the closing of the initial public offering and the proceeds of the initial public offering, are based on Inhibikase's current expectations and assumptions. Such statements are subject to certain risks and uncertainties, which could cause Inhibikase's actual results to differ materially from those anticipated by the forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in Inhibikase's filings with the SEC, including its registration statement on Form S-1, as amended (File No. 333-240036), including under the caption "Risk Factors." Any forward-looking statement in this release speaks only as of the date of this release. Inhibikase undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by any applicable securities laws.

    Contacts: 

    Investor Relations:

    Milton H. Werner, PhD

    President & CEO, Inhibikase

    678-392-3419

     

    Media:

    Mary Moynihan

    M2Friend Biocommunications

    802-951-9600

     

     

    Cision View original content:http://www.prnewswire.com/news-releases/inhibikase-therapeutics-announces-closing-of-initial-public-offering-301198661.html

    SOURCE Inhibikase Therapeutics

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  5. ATLANTA, Dec. 22, 2020 /PRNewswire/ -- Inhibikase Therapeutics, Inc. (Inhibikase), a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders that arise inside and outside of the brain, announced today the pricing of its initial public offering of 1,800,000 shares of common stock at a public offering price of $10.00 per share, for gross proceeds of $18 million, before deducting underwriting discounts and commissions and other offering expenses payable by Inhibikase. All of the shares are being offered by Inhibikase. In addition, Inhibikase has granted the underwriters a 45-day option to purchase up to an additional 270,000 shares of common stock at the initial public offering price, less underwriting…

    ATLANTA, Dec. 22, 2020 /PRNewswire/ -- Inhibikase Therapeutics, Inc. (Inhibikase), a clinical-stage pharmaceutical company developing therapeutics for Parkinson's disease and related disorders that arise inside and outside of the brain, announced today the pricing of its initial public offering of 1,800,000 shares of common stock at a public offering price of $10.00 per share, for gross proceeds of $18 million, before deducting underwriting discounts and commissions and other offering expenses payable by Inhibikase. All of the shares are being offered by Inhibikase. In addition, Inhibikase has granted the underwriters a 45-day option to purchase up to an additional 270,000 shares of common stock at the initial public offering price, less underwriting discounts and commissions. 

    The shares are expected to begin trading on the Nasdaq Capital Market on December 23, 2020 under the ticker symbol "IKT." The offering is expected to close on December 28, 2020, subject to the satisfaction of customary closing conditions. 

    ThinkEquity, a division of Fordham Financial Management, Inc., is acting as sole book-running manager for the offering.

    A registration statement relating to the securities being sold in the offering was declared effective by the Securities and Exchange Commission (SEC) on December 22, 2020. This offering is being made only by means of a prospectus. Copies of the final prospectus relating to this offering may be obtained, when available, from the offices of ThinkEquity, a division of Fordham Financial Management, Inc., 17 State Street, 22nd Floor, New York, New York 10004, by telephone at (877) 436-3673, or by email at . These documents may also be obtained free of charge, when they are available, by visiting the SEC's website at www.sec.gov.

    This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Any offers, solicitations or offers to buy, or any sales of securities will be made in accordance with the registration requirements of the Securities Act of 1933, as amended.

    About Inhibikase (www.inhibikase.com)

    Inhibikase is a clinical-stage pharmaceutical company developing therapeutics for Parkinson's Disease and related disorders that arise inside and outside of the brain. Inhibikase is headquartered in Atlanta, Georgia with additional offices in Boston, Massachusetts.

    Forward Looking Statements

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking terminology such as "believes," "expects," "may," "will," "should," "anticipates," "plans," or similar expressions or the negative of these terms and similar expressions are intended to identify forward-looking statements. These forward-looking statements, including statements regarding the closing of the initial public offering and the proceeds of the initial public offering, are based on Inhibikase's current expectations and assumptions. Such statements are subject to certain risks and uncertainties, which could cause Inhibikase's actual results to differ materially from those anticipated by the forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in Inhibikase's filings with the SEC, including its registration statement on Form S-1, as amended (File No. 333-240036), including under the caption "Risk Factors." Any forward-looking statement in this release speaks only as of the date of this release. Inhibikase undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by any applicable securities laws.

    Contacts:

    Investor Relations:

    Milton H. Werner, PhD

    President & CEO, Inhibikase

    678-392-3419

    Media:

    Mary Moynihan

    M2Friend Biocommunications

    802-951-9600

    Cision View original content:http://www.prnewswire.com/news-releases/inhibikase-therapeutics-inc-announces-pricing-of-its-initial-public-offering-301197852.html

    SOURCE Inhibikase Therapeutics

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