ETNB 89bio Inc.

13.55
-1.39  -9%
Previous Close 14.94
Open 14.64
52 Week Low 14.22
52 Week High 28.28
Market Cap $274,823,973
Shares 20,282,212
Float 9,906,197
Enterprise Value $147,124,247
Volume 62,390
Av. Daily Volume 70,542
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Upcoming Catalysts

Drug Stage Catalyst Date
BIO89-100 (ENTRIGUE)
Severe hypertriglyceridemia
Phase 2
Phase 2
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Drug Pipeline

Drug Stage Notes
BIO89-100
Nonalcoholic steatohepatitis (NASH)
Phase 1/2
Phase 1/2
Phase 1b/2a data reported that treatment reduced spleen volume by an average of 11.8% in NASH patients, noted November 14, 2021. Phase 1b/2a additional top-line data due mid-January 2022.
BIO89-100 (ENLIVEN)
Nonalcoholic Steatohepatitis (NASH)
Phase 2b
Phase 2b
Phase 2b trial enrollment commenced and continues, noted November 11, 2021.

Latest News

  1. New sub-analysis presented at The Liver Meeting® 2021 shows treatment with BIO89-100 reduced spleen volume by an average of 11.8% in NASH patients

    Oral presentation was highlighted by the AASLD Scientific Program Committee as a key presentation in The Liver Meeting® 2021

    SAN FRANCISCO, Nov. 14, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced the presentation of new data from a post-hoc analysis of the Phase 1b/2a proof-of-concept study evaluating BIO89-100 in patients with nonalcoholic steatohepatitis (NASH) at The Liver Meeting® 2021 of the American…

    New sub-analysis presented at The Liver Meeting® 2021 shows treatment with BIO89-100 reduced spleen volume by an average of 11.8% in NASH patients

    Oral presentation was highlighted by the AASLD Scientific Program Committee as a key presentation in The Liver Meeting® 2021

    SAN FRANCISCO, Nov. 14, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced the presentation of new data from a post-hoc analysis of the Phase 1b/2a proof-of-concept study evaluating BIO89-100 in patients with nonalcoholic steatohepatitis (NASH) at The Liver Meeting® 2021 of the American Association for the Study of Liver Diseases (AASLD). The sub-analysis, which assessed the correlation between liver fat and spleen volume (SV), demonstrated that treatment with BIO89-100 reduced spleen volume by an average of 11.8% in patients with NASH. These data will be presented virtually on Sunday, November 14, as an oral presentation entitled "Treatment with BIO89-100 Led to Decreased Spleen Volume That was Correlated with Relative Change in Liver Fat Volume and Pro-C3 Level in a Phase 1b/2a, Placebo-controlled, Double-blind, NASH Proof of Concept (POC) Study" during the Parallel 21: NAFLD and NASH: Clinical Trials of Novel Therapeutics session.

    "Prior to this study, correlations between increased spleen volume and improvements in NASH had not been systematically evaluated," said Rohit Loomba, MD, MHSc, Director of the NAFLD Research Center and Director of Hepatology at UC San Diego School of Medicine. "These exciting data from the BIO89-100 study demonstrate that improvement in liver fat and liver volume result in decreasing spleen volume likely due to improved portal flow."

    The post-hoc analysis of the Phase 1b/2a study assessed the effect of BIO89-100 on SV in NASH patients without advanced fibrosis. SV was evaluated in all eligible patients on BIO89-100 27mg every week dose (n=8), BIO89-100 36mg every two-week dose (n=8) and 16 patients on placebo. These patients were assessed by MRI at baseline, on Day 50 and on Day 92. At baseline, it was observed that SV was correlated with liver volume, vibration-controlled transient elastography (VCTE) score and body mass index (BMI), and negatively correlated with platelet count. Findings at study Day 50 and Day 92 demonstrated that treatment with BIO89-100 led to a progressive and significant decrease in spleen volume compared to placebo (on Day 50, treated patients saw an average of 7.4% decrease in SV and by Day 92 patients saw an average 11.8% decrease in SV).

    These preliminary observations suggest that increased fat in the liver and inflammation may lead to subclinical worsening of portal blood flow, which in turn leads to increased spleen volume in NASH patients without advanced fibrosis. Based on these study findings, portal flow may be improved with treatment that significantly reduces liver fat.

    "We are encouraged by the preliminary findings that suggest BIO89-100 has the potential to promote meaningful reductions in spleen volume, which correlate with reductions in liver fat by MRI-PDFF and liver fat volume," said Hank Mansbach, Chief Medical Officer of 89bio. "These exciting data continue to advance our understanding of fatty liver disease and provide new insights about evaluating treatment response in NASH."

    In addition to being presented at the meeting, the abstract has been selected by members of the AASLD Scientific Program Committee as a key presentation in The Best of Liver Meeting 2021. A copy of the oral presentation will be accessible under ‘Scientific Publications' in the pipeline section of 89bio's website.

    About the Phase 1b/2a Study

    This multicenter, randomized, double-blind, placebo-controlled, multiple ascending dose-ranging trial was designed to assess the safety, tolerability and pharmacokinetic (PK) properties of BIO89-100 as well as change in liver fat measured by MRI-PDFF and key biomarker assessments in patients with biopsy-proven NASH with fibrosis or patients with phenotypical NASH (PNASH). PNASH was defined as patients with steatosis greater than 10% who have central obesity and Type 2 diabetes or central obesity and evidence of liver injury. Both patient populations had similar disease characteristics at baseline. A total of 81 patients were randomized to receive weekly or every-two-week subcutaneous dosing of BIO89-100 or placebo for up to 12 weeks. Results showed robust reductions in liver fat and key liver markers, a strong efficacy profile, and favorable tolerability with weekly and every-two-week dosing. These findings highlight the promising clinical profile of BIO89-100 and add to the growing body of evidence suggesting it could be a leading FGF21 analog in a class that could become the backbone of treatment for NASH.

    About 89bio 

    89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, BIO89-100, is a specifically engineered glycoPEGylated analog of FGF21. BIO89-100 is being developed for the treatment of nonalcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG). 89bio is headquartered in San Francisco with operations in Herzliya, Israel.

    Forward-looking Statements

    Certain statements in this press release may constitute "forward-looking statements" within the meaning of the federal securities laws, including, but not limited to, the therapeutic potential and clinical benefits of BIO89-100 with respect to spleen volume and the potential efficacy of BIO89-100 in reducing spleen volume. Words such as "may," "might," "will," "objective," "intend," "should," "could," "can," "would," "expect," "believe," "design," "estimate," "predict," "potential," "develop," "plan" or the negative of these terms, and similar expressions, or statements regarding intent, belief, or current expectations, are forward looking statements. While 89bio believes these forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements, which are based on information available to us on the date of this release. These forward-looking statements are based upon current estimates and assumptions and are subject to various risks and uncertainties (including, without limitation, those set forth in 89bio's filings with the SEC), many of which are beyond 89bio's control and subject to change. Actual results could be materially different. Risks and uncertainties include: positive results from a clinical study may not necessarily be predictive of the results of future or ongoing clinical studies; and other risks and uncertainties identified in 89bio's Annual Report on Form 10-K for the year ended December 31, 2020, its Quarterly Reports on Form 10-Q and other subsequent disclosure documents filed with the SEC. 89bio claims the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. 89bio expressly disclaims any obligation to update or alter any statements whether as a result of new information, future events or otherwise, except as required by law.

    Investor Contact:

    Ryan Martins

    Chief Financial Officer

    Media Contact:

    Peter Duckler

    773-343-3069



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  2. SAN FRANCISCO, Nov. 11, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today reported its financial results for the quarter ended September 30, 2021.

    "In the third quarter of 2021, we took important steps to advance our ongoing clinical development program for BIO89-100: a highly differentiated FGF21 analog with a validated and potentially transformational profile for patients suffering from NASH and SHTG," said Rohan Palekar, Chief Executive Officer of 89bio. "With multiple ongoing studies in these indications, we look forward to reporting data from our open-label…

    SAN FRANCISCO, Nov. 11, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today reported its financial results for the quarter ended September 30, 2021.

    "In the third quarter of 2021, we took important steps to advance our ongoing clinical development program for BIO89-100: a highly differentiated FGF21 analog with a validated and potentially transformational profile for patients suffering from NASH and SHTG," said Rohan Palekar, Chief Executive Officer of 89bio. "With multiple ongoing studies in these indications, we look forward to reporting data from our open-label histology cohort in NASH patients in early to mid-January 2022 and our proof-of-concept study in SHTG in the first half of 2022. Additionally, we continue to make progress on the ENLIVEN Phase 2b study in NASH patients with F2 and F3 fibrosis."

    Recent Highlights and Anticipated Milestones

    Report topline data from the open-label histology cohort in biopsy-confirmed fibrosis stage F2 – F3 NASH patients in early to mid-January 2022. The paired-biopsy, open-label histology cohort is an expansion of the Phase 1b/2a trial of BIO89-100 in NASH. In this cohort, biopsy-confirmed NASH patients are treated for 20 weeks with 27 mg of BIO89-100 once weekly. This cohort is intended to support both the clinical utility of BIO89-100 and our overall clinical development strategy in NASH.

    Report topline data from the Phase 2 ENTRIGUE trial of BIO89-100 in severe hypertriglyceridemia patients in the first half of 2022. Recently presented data at the National Lipid Association (NLA) meeting in September showed patients with SHTG also had high levels of liver fat by MRI-PDFF (mean = 20%; n=14 in this sub-analysis) underscoring the potential of BIO89-100 to address the broader metabolic dysregulation seen in this patient population.

    Present new analyses from the Phase 1b/2a NASH trial of BIO89-100 showing beneficial effects on spleen volume in an oral presentation at AASLD's The Liver Meeting 2021. Data from a sub-analysis looking at the correlation of liver fat and spleen volume suggests BIO89-100 can reduce spleen volume (abstract #139). A poster with new data on population pharmacokinetics and pharmacodynamics of BIO89-100 that helped inform the dose selection for ENLIVEN will also be presented (abstract # 1931).

    Continue to enroll patients in the ENLIVEN Phase 2b trial of BIO89-100 for the treatment of NASH. ENLIVEN is a multi-center, randomized, double-blind, placebo-controlled Phase 2b trial designed to evaluate the safety and efficacy of BIO89-100 for the treatment of patients with fibrosis stage F2 - F3 NASH.

    Third Quarter 2021 Financial Results

    Cash Position. As of September 30, 2021, 89bio had cash, cash equivalents, and short-term investments of $157.4 million.

    Research and Development (R&D) Expenses. R&D expenses were $23.6 million and $49.4 million for the three and nine months ended September 30, 2021, respectively, compared to $11.2 million and $27.4 million for the comparable periods in 2020, respectively. The increase in R&D expenses was primarily driven by increases in clinical development, contract manufacturing, and personnel expenses. 

    General and Administrative (G&A) Expenses. G&A expenses were $4.6 million and $14.2 million for the three and nine months ended September 30, 2021, respectively, compared to $3.2 million and $9.4 million for the comparable periods in 2020, respectively. The increase in G&A expenses was primarily due to an increase in costs related to personnel expenses, insurance-related expenses, and expenses for professional services.

    Net Loss. 89bio reported a net loss of $28.3 million and $63.8 million for the three and nine months ended September 30, 2021, respectively, compared to a net loss of $14.6 million and $36.9 million for the comparable periods in 2020, respectively. The increase in net loss is primarily attributable to increased R&D expenses for our programs and increased G&A expenses associated with our growth and operating as a public company.

    About 89bio 

    89bio is a clinical-stage biopharmaceutical company dedicated to the development of best-in-class therapies for patients with liver and cardiometabolic diseases who lack optimal treatment options. The company is focused on rapidly advancing its lead candidate, BIO89-100, through clinical development for the treatment of non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG). BIO89-100 is a specifically engineered, potentially best-in-class fibroblast growth factor 21 (FGF21) analog with unique glycoPEGylated technology that optimizes biological activity through an extended half-life. The company is headquartered in San Francisco with operations in Herzliya, Israel. For more information, visit www.89bio.com or follow the company on LinkedIn.

    Forward-looking Statements

    Certain statements in this press release may constitute "forward-looking statements" within the meaning of the federal securities laws, including, but not limited to, the therapeutic potential and clinical benefits of BIO89-100, clinical development plans and timing for BIO89-100, including the Phase 2b ENLIVEN trial and Phase 2 ENTRIGUE trial, the expected trial design for the ENLIVEN trial and the ENTRIGUE trial, including patient enrollment, dosing schedules and trial endpoints, and the timing for topline data for the open-label histology cohort and the Phase 2 ENTRIGUE trial. Words such as "may," "might," "will," "objective," "intend," "should," "could," "can," "would," "expect," "believe," "design," "estimate," "predict," "potential," "anticipate," "goal," "opportunity," "develop," "plan" or the negative of these terms, and similar expressions, or statements regarding intent, belief, or current expectations, are forward looking statements. While 89bio believes these forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements, which are based on information available to us on the date of this release. These forward-looking statements are based upon current estimates and assumptions and are subject to various risks and uncertainties (including, without limitation, those set forth in 89bio's filings with the SEC), many of which are beyond 89bio's control and subject to change. Actual results could be materially different. Risks and uncertainties include: expectations regarding the timing and outcome of 89bio's initiation of the Phase 2b ENLIVEN trial in NASH and Phase 2 ENTRIGUE trial in SHTG; expectations regarding the timing of topline data; 89bio's ability to execute on its strategy; positive results from a clinical study may not necessarily be predictive of the results of future or ongoing clinical studies; 89bio's substantial dependence on the success of it lead product candidate; competition from competing products; the effect of the COVID-19 pandemic on 89bio's clinical trials and business operations, and the impact of general economic, health, industrial or political conditions in the United States or internationally; and other risks and uncertainties identified in 89bio's Quarterly Report on Form 10-Q for the quarter ended June 30, 2021 and other subsequent disclosure documents filed with the SEC. 89bio claims the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. 89bio expressly disclaims any obligation to update or alter any statements whether as a result of new information, future events or otherwise, except as required by law.



    89bio, Inc.

    Condensed Consolidated Statement of Operations Data

    (Unaudited)

    (In thousands, except share and per share amounts)
             
      Three Months Ended Nine Months Ended
      September 30, September 30,
       2021   2020   2021   2020 
             
    Operating expenses:        
    Research and development $23,590  $11,208  $49,351  $27,429 
    General and administrative  4,622   3,225   14,151   9,379 
    Total operating expenses  28,212   14,433   63,502   36,808 
    Loss from operations  28,212   14,433   63,502   36,808 
    Other expenses, net  117   146   332   87 
    Net loss before tax  28,329   14,579   63,834   36,895 
    Income tax expense (benefit)     24      23 
    Net loss $28,329  $14,603  $63,834  $36,918 
    Comprehensive loss $28,327  $14,606  $63,818  $36,921 
    Net loss per share, basic and diluted $1.41  $0.86  $3.18  $2.49 
    Weighted-average shares used to compute net loss per share, basic and diluted  20,092,094   16,884,244   20,043,301   14,809,131 
             



    89bio, Inc.

    Condensed Consolidated Balance Sheet Data

    (Unaudited)

    (In thousands)
        
     September 30, December 31,
      2021   2020 
        
    Cash, cash equivalents and Short term investments$157,358  $204,654 
    Total Assets 168,056   211,074 
    Total current liabilities 19,845   8,113 
    Total stockholders' equity 146,770   202,961 



    Investor Contact: 

    Ryan Martins 

    Chief Financial Officer 

     

    Media Contact: 

    Peter Duckler 

    773-343-3069 

     

     



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  3. SAN FRANCISCO, Nov. 03, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced the appointment of Kathy LaPorte to its Board of Directors, effective immediately. Ms. LaPorte brings deep expertise and valuable experience in the industry to the Company.

    "It is a pleasure to welcome Kathy, an esteemed industry leader, to our Board of Directors," said Rohan Palekar, Chief Executive Officer of 89bio. "Kathy has a strong track record for enhancing operational capabilities to drive growth. Her extensive experience serving on numerous public boards, and her diverse…

    SAN FRANCISCO, Nov. 03, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced the appointment of Kathy LaPorte to its Board of Directors, effective immediately. Ms. LaPorte brings deep expertise and valuable experience in the industry to the Company.

    "It is a pleasure to welcome Kathy, an esteemed industry leader, to our Board of Directors," said Rohan Palekar, Chief Executive Officer of 89bio. "Kathy has a strong track record for enhancing operational capabilities to drive growth. Her extensive experience serving on numerous public boards, and her diverse background across the biotech industry will be invaluable as we continue efforts to advance our ongoing clinical development program for BIO89-100: a highly differentiated FGF21 analog with a validated and potentially transformational profile for patients suffering from NASH. Kathy is a tremendous addition to our board, and we look forward to working with her."

    Ms. LaPorte added, "I am delighted to join 89Bio, whose emerging data suggests BIO89-100 has the potential to combine strong efficacy, a favorable safety and tolerability profile, and potentially best-in-class dosing convenience. I look forward to working with 89bio's outstanding team to advance the company's mission."

    Ms. LaPorte brings over 30 years of experience in executive leadership and venture investing within the biotech industry. Ms. LaPorte previously served as Chief Executive Officer and Board Member of Nodality Inc. Ms. LaPorte was a Co-Founder of Health Tech Capital and a Founding Partner of New Leaf Venture Partners, which was a spin-out from the Sprout Group, where she served as a General Partner. She has extensive Board experience and currently serves on the Boards of Bolt Biotherapeutics (NASDAQ:BOLT), Precipio Inc., (NASDAQ:PRPO), and Phoenix Biotech Acquisition Corporation (NASDAQ:PBAXU). Additionally, Ms. LaPorte has served on multiple public boards including Onyx Pharmaceuticals (NASDAQ:ONXX), Affymax (NASDAQ:AFFY), and ISTA Pharmaceuticals (NASDAQ:ISTA). Ms. LaPorte received her MBA from the Stanford University Graduate School of Business and her B.S. in Biology from Yale University.

    About 89bio

    89bio is a clinical-stage biopharmaceutical company dedicated to the development of best-in-class therapies for patients with liver and cardiometabolic diseases who lack optimal treatment options. The company is focused on rapidly advancing its lead candidate, BIO89-100, through clinical development for the treatment of non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG). BIO89-100 is a specifically engineered, potentially best-in-class fibroblast growth factor 21 (FGF21) analog with unique glycoPEGylated technology that optimizes biological activity through an extended half-life. The company is headquartered in San Francisco with operations in Herzliya, Israel. For more information, visit www.89bio.com or follow the company on LinkedIn.

    Investor Contact:

    Ryan Martins

    Chief Financial Officer

    Media Contact:

    Peter Duckler

    773-343-3069



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  4. SAN FRANCISCO, Oct. 25, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced that a sub-analysis of its Phase 1b/2a proof-of-concept study of BIO89-100 in non-alcoholic steatohepatitis (NASH) looking at the correlation of liver fat and spleen volume will be an oral presentation at the American Association for the Study of Liver Diseases (AASLD) The Liver Meeting 2021. A poster with new data on the population pharmacokinetics and pharmacodynamics of BIO89-100 will also be presented. The meeting will be held virtually November 12-15, 2021.

    Both abstracts…

    SAN FRANCISCO, Oct. 25, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced that a sub-analysis of its Phase 1b/2a proof-of-concept study of BIO89-100 in non-alcoholic steatohepatitis (NASH) looking at the correlation of liver fat and spleen volume will be an oral presentation at the American Association for the Study of Liver Diseases (AASLD) The Liver Meeting 2021. A poster with new data on the population pharmacokinetics and pharmacodynamics of BIO89-100 will also be presented. The meeting will be held virtually November 12-15, 2021.

    Both abstracts were published in the October supplement of AASLD's peer-reviewed journal, Hepatology. The presentations will also be available on the 89bio website after the meeting.

    Presentation details are as follows:

    Abstract Title: Treatment with BIO89-100 Led to Decreased Spleen Volume That was Correlated with Relative Change in Liver Fat Volume and Pro-C3 Level in a Phase 1b/2a, Placebo-controlled, Double-blind, NASH Proof of Concept (POC) Study

    Abstract Number: 139

    Presenting Author: Rohit Loomba, MD, MHSc, Director, NAFLD Research Center, University of California San Diego

    Session Title: Parallel 21: NAFLD and NASH: Clinical Trials of Novel Therapeutics

    Presentation Date and Time: Sunday, November 14th 6:30-8:00 PM / EST

    Abstract Title: Population Pharmacokinetics (PK) and Pharmacodynamics (PD) of BIO89-100, a Novel GlycoPegylated FGF21, in a Phase 1b/2a POC Study in Nonalcoholic Steatohepatitis (NASH)

    Abstract Number: 1931

    Presenting Author: Leo Tseng, PHD, 89bio Clinical Development

    Session Title: NAFLD and NASH: Therapeutics - Pharmacologic and Other.

    About BIO89-100

    BIO89-100, with its differentiated profile, is a potentially best-in-class fibroblast growth factor 21 (FGF21) analog and an ideal candidate for the treatment of non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG). FGF21 is an endogenous hormone that modulates important drivers of NASH including glycemic control, steatosis, inflammation and fibrosis. BIO89-100 was specifically engineered using a unique glycoPEGylated technology with site-specific mutations to prolong the biological activity (half-life) of FGF21, allowing for weekly or every two-week dosing, while maintaining its nanomolar potency. BIO89-100 combines efficacy, best-in-class dosing convenience, and favorable safety and tolerability. Recent Phase 1b/2a data demonstrated that BIO89-100 significantly improved the root cause of liver problems in patients with NASH and has the potential to address underlying metabolic comorbidities. 89bio has advanced BIO89-100 into the Phase 2b ENLIVEN trial in NASH, which is now ongoing. Given the potential of BIO89-100 to meaningfully reduce triglycerides, 89bio is also developing it for the treatment of SHTG and is currently evaluating it in the Phase 2 ENTRIGUE trial.

    About 89bio 

    89bio is a clinical-stage biopharmaceutical company dedicated to the development of best-in-class therapies for patients with liver and cardiometabolic diseases who lack optimal treatment options. The company is focused on rapidly advancing its lead candidate, BIO89-100, through clinical development for the treatment of non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG). BIO89-100 is a specifically engineered, potentially best-in-class fibroblast growth factor 21 (FGF21) analog with unique glycoPEGylated technology that optimizes biological activity through an extended half-life. The company is headquartered in San Francisco with operations in Herzliya, Israel. For more information, visit www.89bio.com or follow the company on LinkedIn.

    Forward-looking Statements

    Certain statements in this press release may constitute "forward-looking statements" within the meaning of the federal securities laws, including, but not limited to, the potential benefits of BIO89-100. Words such as "may," "might," "will," "objective," "intend," "should," "could," "can," "would," "expect," "believe," "design," "estimate," "predict," "potential," "anticipate," "goal," "opportunity," "develop," "plan" or the negative of these terms, and similar expressions, or statements regarding intent, belief, or current expectations, are forward looking statements. While 89bio believes these forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements, which are based on information available to us on the date of this release. These forward-looking statements are based upon current estimates and assumptions and are subject to various risks and uncertainties (including, without limitation, those set forth in 89bio's filings with the SEC), many of which are beyond 89bio's control and subject to change. Actual results could be materially different. Risks and uncertainties include: positive results from a clinical study may not necessarily be predictive of the results of future or ongoing clinical studies; 89bio's substantial dependence on the success of it lead product candidate; the effect of the COVID-19 pandemic on 89bio's clinical trials and business operations, and the impact of general economic, health, industrial or political conditions in the United States or internationally; and other risks and uncertainties identified in 89bio's Quarterly Report on Form 10-Q for the quarter ended June 30, 2021 and other subsequent disclosure documents filed with the SEC. 89bio claims the protection of the Safe Harbor contained in the Private Securities Litigation Reform Act of 1995 for forward-looking statements. 89bio expressly disclaims any obligation to update or alter any statements whether as a result of new information, future events or otherwise, except as required by law.

    Investor Contact: 

    Ryan Martins 

    Chief Financial Officer 

     

    Media Contact: 

    Peter Duckler 

    773-343-3069 



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  5. SAN FRANCISCO, Sept. 21, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced that Company's Management will provide a corporate update and participate in one-on-one investor meetings at the Cantor Global Healthcare Conference, a virtul event, on Tuesday, September 28, 2021 at 2:40 p.m. ET.

    The webcast of the presentation will be accessible in the investor section of 89bio's website.

    About 89bio
    89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic…

    SAN FRANCISCO, Sept. 21, 2021 (GLOBE NEWSWIRE) -- 89bio, Inc. (NASDAQ:ETNB), a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases, today announced that Company's Management will provide a corporate update and participate in one-on-one investor meetings at the Cantor Global Healthcare Conference, a virtul event, on Tuesday, September 28, 2021 at 2:40 p.m. ET.

    The webcast of the presentation will be accessible in the investor section of 89bio's website.

    About 89bio

    89bio is a clinical-stage biopharmaceutical company focused on the development and commercialization of innovative therapies for the treatment of liver and cardio-metabolic diseases. The company's lead product candidate, BIO89-100, is a specifically engineered glycoPEGylated analog of FGF21. BIO89-100 is being developed for the treatment of nonalcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG). 89bio is headquartered in San Francisco with operations in Herzliya, Israel.

    Investor Contact:

    Ryan Martins

    Chief Financial Officer

    Media Contact:

    Peter Duckler

    773-343-3069

     



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