ENTA Enanta Pharmaceuticals Inc.

45.78
+0.95  (+2%)
Previous Close 44.83
Open 45.22
52 Week Low 38.4
52 Week High 67.88
Market Cap $918,902,752
Shares 20,072,144
Float 16,403,906
Enterprise Value $524,996,157
Volume 188,098
Av. Daily Volume 172,655
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Upcoming Catalysts

Drug Stage Catalyst Date
EDP-297
Non-alcoholic steatohepatitis (NASH)
Phase 1
Phase 1
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EDP-514
Hepatitis B virus (HBV)
Phase 1b
Phase 1b
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EDP-514
Hepatitis B - NUC-Suppressed
Phase 1b
Phase 1b
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EDP-938
Respiratory Syncytial Virus
Phase 2b
Phase 2b
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Drug Pipeline

Drug Stage Notes
EDP-305 ARGON-2
Non-alcoholic steatohepatitis (NASH)
Phase 2
Phase 2
Phase 2b trial dosing is ongoing.
EDP-305 INTREPID
Primary biliary cholangitis (PBC)
Phase 2
Phase 2
Phase 2 top-line data did not meet primary endpoint - May 6, 2020.
VIEKIRA PAK - once-daily, fixed-dose formulation through Abbvie
HCV - genotype
Approved
Approved
Approved July 25, 2017.
VIEKIRA PAK
HCV - genotype 1
Approved
Approved
Approved December 19, 2014.
Glecaprevir/Pibrentasvir (G/P)
Hepatitis C virus (HCV)
Approved
Approved
Approval announced August 3, 2017.

Latest News

  1. Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that Jay R. Luly, Ph.D., President and Chief Executive Officer, will participate in a fireside chat at the 4th Annual H.C. Wainwright Virtual NASH Investor Conference on October 5, 2020 at 2:00 pm ET.

    A live webcast of the fireside chat will be accessible by visiting the "Events and Presentations" section on the "Investors" page of Enanta's website at www.enanta.com. A replay of the webcast will be available following the presentation and will be archived for at least 30 days.

    About Enanta

    Enanta is using its robust, chemistry-driven approach and drug discovery…

    Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that Jay R. Luly, Ph.D., President and Chief Executive Officer, will participate in a fireside chat at the 4th Annual H.C. Wainwright Virtual NASH Investor Conference on October 5, 2020 at 2:00 pm ET.

    A live webcast of the fireside chat will be accessible by visiting the "Events and Presentations" section on the "Investors" page of Enanta's website at www.enanta.com. A replay of the webcast will be available following the presentation and will be archived for at least 30 days.

    About Enanta

    Enanta is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs for the treatment of viral infections and liver diseases. Enanta's research and development efforts have produced clinical candidates currently in development for the following disease targets: respiratory syncytial virus (RSV), non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV). Enanta is also conducting research in human metapneumovirus (hMPV) and SARS-CoV-2 (COVID-19).

    Enanta's research and development activities are funded by royalties from hepatitis C virus (HCV) products developed under its collaboration with AbbVie. Glecaprevir, a protease inhibitor discovered by Enanta, is sold by AbbVie in numerous countries as part of its leading treatment for chronic HCV infection under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). Please visit www.enanta.com for more information.

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  2. -- Initial clinical data including safety, tolerability and pharmacokinetics expected in 2Q 2021 –

    Enanta Pharmaceuticals, Inc., (NASDAQ:ENTA), a clinical stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that it has dosed the first subjects in its Phase 1 clinical trial of EDP-297, a highly potent and targeted follow-on farnesoid X receptor (FXR) agonist, being developed for the treatment of non-alcoholic steatohepatitis (NASH).

    "We are excited to advance our efforts in NASH and progress EDP-297, our follow-on FXR agonist, into clinical development," commented Jay R. Luly, Ph.D., President and Chief Executive Officer of Enanta Pharmaceuticals. "In preclinical studies…

    -- Initial clinical data including safety, tolerability and pharmacokinetics expected in 2Q 2021 –

    Enanta Pharmaceuticals, Inc., (NASDAQ:ENTA), a clinical stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that it has dosed the first subjects in its Phase 1 clinical trial of EDP-297, a highly potent and targeted follow-on farnesoid X receptor (FXR) agonist, being developed for the treatment of non-alcoholic steatohepatitis (NASH).

    "We are excited to advance our efforts in NASH and progress EDP-297, our follow-on FXR agonist, into clinical development," commented Jay R. Luly, Ph.D., President and Chief Executive Officer of Enanta Pharmaceuticals. "In preclinical studies, EDP-297 demonstrated a compelling product profile, with a potency greater than that published on any FXR agonist in clinical development and high target-tissue distribution in the liver and intestine. Based on these data, we believe we may be able to effectively dose EDP-297 at lower doses and with reduced drug levels in non-targeted tissues, potentially improving tolerability by reducing pruritis. We look forward to reporting clinical data in the second quarter of 2021."

    The Phase 1, randomized, double-blind, placebo-controlled, first-in-human study is designed to assess the safety, tolerability, and pharmacokinetics, including the effect of food intake, of orally administered EDP-297 in approximately 74 healthy adult subjects. Two phases are planned: a single ascending dose phase enrolling six cohorts, including a two-part food effect cohort, and a multiple ascending dose phase enrolling three cohorts.

    In two recent poster presentations at the European Association for the Study of the Liver (EASL) Digital International Liver Congress™ 2020, treatment with EDP-297 demonstrated significantly reduced fibrosis progression and improved liver function in a rat model of NASH. Additionally, in 3D NASH microtissues, EDP-297 modulated multiple pathways associated with the pathogenesis of NASH, including decreased expression of genes encoding multiple lipogenic and inflammatory proteins, and significantly reduced expression of inflammatory and fibrotic genes and normalized circulating markers of liver injury.

    About NASH and FXR

    NASH is a serious form of non-alcoholic fatty liver disease (NAFLD) which is common in the United States and around the world and is closely associated with diabetes and obesity. Characterized by an excessive build-up of fat in the liver causing stress and damage to liver cells, NASH can lead to inflammation and fibrosis, causing permanent damage, including cirrhosis and impaired liver function, as well as cancer and eventually death. NASH is the leading cause of liver transplants in the United States and Europe and currently has no FDA-approved treatment.1 A farnesoid X receptor is a main regulator of bile acid levels in the liver and small intestine. It responds to bile acids by regulating gene transcription of key enzymes and transporters, many of which play important roles in lipid metabolism, insulin resistance, inflammation and fibrosis.

    About EDP-297, a FXR Agonist

    EDP-297 is a potent FXR agonist and Enanta's follow-on FXR agonist candidate being developed for the treatment of NASH. EDP-297 represents a class of FXR agonists that has been designed to take advantage of increased binding interactions with the receptor. Preclinical findings of EDP-297 demonstrate potent anti-fibrotic, anti-inflammatory and hepatoprotective effects. EDP-297 has demonstrated preclinical potency greater than that published on any FXR agonist in clinical development today. Further, in preclinical models EDP-297 has been shown to be targeted to tissues important for efficacy, namely liver and intestine, versus plasma and skin.

    About Enanta

    Enanta is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs for the treatment of viral infections and liver diseases. Enanta's research and development efforts have produced clinical candidates for the following disease targets: respiratory syncytial virus (RSV), non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV). Enanta is also conducting research in human metapneumovirus (hMPV) and SARS-CoV-2 (COVID-19).

    Enanta's research and development activities are funded by royalties from hepatitis C virus (HCV) products developed under its collaboration with AbbVie. Glecaprevir, a protease inhibitor discovered by Enanta, is sold by AbbVie in numerous countries as part of its leading treatment for chronic HCV infection under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). Please visit www.enanta.com for more information.

    Forward Looking Statements Disclaimer

    This press release contains forward-looking statements, including statements with respect to the prospects for further development of EDP-297 for NASH. Statements that are not historical facts are based on management's current expectations, estimates, forecasts and projections about Enanta's business and the industry in which it operates and management's beliefs and assumptions. The statements contained in this release are not guarantees of future performance and involve certain risks, uncertainties and assumptions, which are difficult to predict. Therefore, actual outcomes and results may differ materially from what is expressed in such forward-looking statements. Important factors and risks that may affect actual results include: the development risks of early stage discovery efforts in the disease areas in Enanta's research and development pipeline, such as NASH; the impact of development, regulatory and marketing efforts of others with respect to competitive treatments for NASH; Enanta's limited clinical development experience; Enanta's need to attract and retain senior management and key scientific personnel; Enanta's need to obtain and maintain patent protection for its product candidates and avoid potential infringement of the intellectual property rights of others; and other risk factors described or referred to in "Risk Factors" in Enanta's most recent Form 10-Q for the quarter ended June 30, 2020 and other periodic reports filed more recently with the Securities and Exchange Commission. Enanta cautions investors not to place undue reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this release, and Enanta undertakes no obligation to update or revise these statements, except as may be required by law.

    1 https://www.worldhepatitisalliance.org/latest-news/infohep/3548835/nash-fastest-growing-reason-liver-transplant-united-states

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  3. Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that Jay R. Luly, Ph.D., President and Chief Executive Officer, will participate in three upcoming virtual conferences in September:

    • Baird 2020 Global Healthcare Conference, Fireside Chat at 9:40 a.m. ET on September 10, 2020
    • H.C. Wainwright 22nd Annual Global Investment Conference, Presentation at 1:00 p.m. ET on September 15, 2020
    • Oppenheimer Fall Healthcare Life Sciences & MedTech Summit, Presentation at 3:20 p.m. ET on September 22, 2020

    A live webcast of each of the above presentations will be accessible by visiting the "Events and Presentations" section…

    Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that Jay R. Luly, Ph.D., President and Chief Executive Officer, will participate in three upcoming virtual conferences in September:

    • Baird 2020 Global Healthcare Conference, Fireside Chat at 9:40 a.m. ET on September 10, 2020
    • H.C. Wainwright 22nd Annual Global Investment Conference, Presentation at 1:00 p.m. ET on September 15, 2020
    • Oppenheimer Fall Healthcare Life Sciences & MedTech Summit, Presentation at 3:20 p.m. ET on September 22, 2020

    A live webcast of each of the above presentations will be accessible by visiting the "Events and Presentations" section on the "Investors" page of Enanta's website at www.enanta.com. Replays of the webcasts will be available following the presentations and will be archived for at least 30 days.

    About Enanta

    Enanta is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs for the treatment of viral infections and liver diseases. Enanta's research and development efforts have produced clinical candidates for the following disease targets: respiratory syncytial virus (RSV), non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV). Enanta is also conducting research in human metapneumovirus (hMPV) and SARS-CoV-2 (COVID-19).

    Enanta's research and development activities are funded by royalties from hepatitis C virus (HCV) products developed under its collaboration with AbbVie. Glecaprevir, a protease inhibitor discovered by Enanta, is sold by AbbVie in numerous countries as part of its leading treatment for chronic HCV infection under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). Please visit www.enanta.com for more information.

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    • New Pharmacokinetic and Safety Results from Phase 1a Study of HBV Core Inhibitor EDP-514, Highlighting Good Safety and Tolerability, and Pharmacokinetics Suitable for Once Daily Dosing
    • Phase 2a ARGON-1 Study for FXR Agonist EDP-305 Targeting NASH, Showing Significant Alanine Transaminase and Liver Fat Content Reduction
    • Preclinical Findings for Follow-on FXR Agonist EDP-297 Targeting NASH, Demonstrating Potent Anti-Fibrotic, Anti-Inflammatory and Hepatoprotective Effects

    Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, announced that data from Enanta's wholly-owned development programs for non-alcoholic steatohepatitis…

    • New Pharmacokinetic and Safety Results from Phase 1a Study of HBV Core Inhibitor EDP-514, Highlighting Good Safety and Tolerability, and Pharmacokinetics Suitable for Once Daily Dosing
    • Phase 2a ARGON-1 Study for FXR Agonist EDP-305 Targeting NASH, Showing Significant Alanine Transaminase and Liver Fat Content Reduction
    • Preclinical Findings for Follow-on FXR Agonist EDP-297 Targeting NASH, Demonstrating Potent Anti-Fibrotic, Anti-Inflammatory and Hepatoprotective Effects

    Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, announced that data from Enanta's wholly-owned development programs for non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV) will be presented at the European Association for the Study of the Liver (EASL) Digital International Liver Congress™ 2020.

    Data presented include results from the Phase 1a clinical trial of EDP-514, Enanta's core inhibitor for HBV. Additionally, Enanta's NASH program will be discussed in an oral presentation detailing the Phase 2a ARGON-1 study of EDP-305, Enanta's lead Farnesoid X receptor (FXR) agonist, and two posters highlighting preclinical data on EDP-297, Enanta's follow-on FXR agonist.

    "We are pleased to share scientific data across multiple candidates in our pipeline, supporting our chemistry-driven approach to developing innovative treatments for viral infections and liver diseases," stated Jay R. Luly, Ph.D., President and Chief Executive Officer of Enanta Pharmaceuticals. "The positive results from our first-in-human Phase 1a study of EDP-514, demonstrating a strong safety, tolerability and pharmacokinetic profile, gave us the confidence to advance our HBV program into two ongoing Phase 1b clinical studies in HBV patients. Additionally, the data presented for our NASH candidates further demonstrate the potential of both FXR agonists. EDP-305 shows statistically significant improvements in liver biochemistry and hepatic steatosis, and our follow-on NASH candidate EDP-297 demonstrates a potent anti-fibrotic effect."

    August 28, 2020, 12:15 PM - 12:30 PM CEST

    ASO78: "EDP-305, a Non-Bile Acid Farnesoid X Receptor (FXR) Agonist, Showed Statistically Significant Improvements in Liver Biochemistry and Hepatic Steatosis in the Phase 2a ARGON-1 Study," Vlad Ratziu, M.D., Ph.D., France

    This oral presentation highlights the final results at week 12 of the randomized, double-blind, placebo-controlled Phase 2a ARGON-1 trial. The study's primary endpoint was achieved with a statistically significant alanine transaminase (ALT) reduction of 28 U/L in the EDP-305 2.5mg arm versus 15 U/L in the placebo arm at week 12 (p=0.049). There was a statistically significant reduction in liver fat content with EDP-305 at the 2.5mg dose as measured by MRI-PDFF (p<0.001). EDP-305 also exhibited strong target engagement as shown by reductions in C4 and increases in FGF-19 and alkaline phosphatase (ALP). A robust gamma-glutamyl transferase (GGT) reduction was also observed. Overall, EDP-305 was generally safe, with the majority of treatment-emergent adverse events (TEAEs) being mild to moderate. In this study, mild to moderate pruritis was more frequent with the 2.5mg dose and there was a higher frequency of treatment discontinuation compared to the 1mg dose or placebo. Treatment with EDP-305 was associated with a modest effect on lipids as demonstrated by a minimal absolute change of 6 mg/dL, 5 mg/dL, and -4 mg/dL, with the 2.5mg dose, 1mg dose and placebo, respectively. These data warrant further development of EDP-305 in a NASH proven liver-biopsy patient population.

    August 28, 2020, 09:30 AM - 19:30 PM CEST

    FRI109: "EDP-297, a Novel and Potent FXR Agonist, Exhibits Robust Anti-Fibrotic Effects with Significant Liver Function Improvement in a Rat Model of Non-Alcoholic Steatohepatitis," Mozhdeh Sojoodi, Ph.D., United States

    Data in this poster demonstrate that treatment with EDP-297 significantly reduced fibrosis progression and improved liver function measured by key biomarkers in a rat model that closely resembles the human disease progression of NASH. Rats were randomized to receive either vehicle control (0.5% methylcellulose), 0.1 mg/kg EDP-297, or 0.3 mg/kg EDP-297 by once-daily oral gavage at the first signs of fibrosis (5 weeks, n=8 per group). EDP-297 demonstrated a highly statistically significant improvement in liver function as measured by a 78.9% reduction (p<0.001) in ALT, a 73.5% reduction (p<0.001) in aspartate aminotransferase (AST) and a 75.7% reduction (p<0.001) in total bilirubin. These results suggest that EDP-297 may have a potent anti-fibrotic effect in NASH patients, including those with late-stage F3/4 fibrosis.

    August 29, 2020, 09:30 AM - 19:30 PM CEST

    SAT042: "A Novel FXR Agonist EDP-297 Exerts Anti-Inflammatory and Hepatoprotective Effects in Human Liver 3D Microtissues and Rodent NASH and Liver Injury Models," Mary Chau, Ph.D., United States

    Data in this poster highlight the pharmacologic activity of EDP-297 as evaluated in multiple in vitro assays and further characterized in a human liver 3D microtissue system and in rodent models of NASH and liver injury. In 3D NASH microtissues, EDP-297 modulated multiple pathways associated with the pathogenesis of NASH. Specifically, decreased expression of genes encoding multiple lipogenic and inflammatory proteins was observed. EDP-297 treated rats with bile duct ligation showed significantly reduced expression of inflammatory and fibrotic genes and normalized circulating markers of liver injury, including ALT (76% reduction, p<0.001), AST (83% reduction, p<0.001) and GGT (76% reduction, p<0.001). Histological analysis confirmed the hepatoprotective effects of EDP-297 with reduced immune cell infiltration and necrosis. EDP-297 was shown to be hepatoprotective in a diet-induced obese NASH model in mice.

    August 29, 2020, 09:30 AM - 19:30 PM CEST

    SAT440: "EDP-514, a Novel Pangenotypic Class II Hepatitis B Virus Core Inhibitor: Final Results of a Phase 1 Study in Healthy Adult Subjects," Kajal Larson, Ph.D., United States

    Data in this poster present the safety and pharmacokinetic results of single ascending doses and multiple ascending doses of EDP-514 in a first-in-human, Phase 1 study. EDP-514 was rapidly absorbed and its exposure increased with escalating single and multiple dosing of 600 mg and 400 mg, respectively. EDP-514 was generally safe and well-tolerated over a broad range of single and multiple doses for up to 14 days, with all TEAEs being of mild severity. There were no severe or serious TEAEs and no discontinuations due to adverse events. Further, there were no significant individual lab data findings or pattern of lab abnormalities. EDP-514 exhibited pharmacokinetics suitable for once daily oral dosing. Following multiple dosing with EDP-514 when administered with and without a standard meal, the geometric mean plasma concentration at 24 hours (C24) was several fold higher than the in vitro serum protein adjusted EC50 (paEC50) of 71 ng/mL under fasted conditions (5.8- to 9.3-fold) and fed conditions (standard meal, 22.1-fold), suggesting that EDP-514 can be administered without regard to meals.

    EDP-514 is currently being studied in two ongoing Phase 1b clinical studies, in viremic HBV patients, and in HBV patients treated with a nucleos(t)ide reverse transcriptase inhibitor (NUC-suppressed patients). Enanta anticipates reporting preliminary safety and virologic data from the viremic study in the first half of 2021, and preliminary data in NUC-suppressed patients in the second quarter of 2021.

    The full scientific program for The Digital International Liver Congress 2020, as well as the abstracts, can be found at https://ilc-congress.eu/programme-digital-ilc-2020/.

    About Enanta

    Enanta is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs for the treatment of viral infections and liver diseases. Enanta's research and development efforts have produced clinical candidates for the following disease targets: respiratory syncytial virus (RSV), non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV). Enanta is also conducting research in human metapneumovirus (hMPV) and SARS-CoV-2 (COVID-19).

    Enanta's research and development activities are funded by royalties from hepatitis C virus (HCV) products developed under its collaboration with AbbVie. Glecaprevir, a protease inhibitor discovered by Enanta, is sold by AbbVie in numerous countries as part of its leading treatment for chronic HCV infection under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). Please visit www.enanta.com for more information.

    Forward Looking Statements Disclaimer

    This press release contains forward-looking statements, including statements with respect to the prospects for further developments with respect to EDP-305 and EDP-297 for NASH and EDP-514 for HBV. Statements that are not historical facts are based on management's current expectations, estimates, forecasts and projections about Enanta's business and the industry in which it operates and management's beliefs and assumptions. The statements contained in this release are not guarantees of future performance and involve certain risks, uncertainties and assumptions, which are difficult to predict. Therefore, actual outcomes and results may differ materially from what is expressed in such forward-looking statements. Important factors and risks that may affect actual results include: the development risks of early stage discovery efforts in the disease areas in Enanta's research and development pipeline, such as NASH and HBV; the impact of development, regulatory and marketing efforts of others with respect to competitive treatments for NASH and HBV; Enanta's limited clinical development experience; Enanta's need to attract and retain senior management and key scientific personnel; Enanta's need to obtain and maintain patent protection for its product candidates and avoid potential infringement of the intellectual property rights of others; and other risk factors described or referred to in "Risk Factors" in Enanta's most recent Form 10-Q for the quarter ended June 30, 2020 and other periodic reports filed more recently with the Securities and Exchange Commission. Enanta cautions investors not to place undue reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this release, and Enanta undertakes no obligation to update or revise these statements, except as may be required by law.

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  4. Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that clinical data from Enanta's wholly-owned development programs for non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV) have been accepted for presentations at the European Association for the Study of the Liver (EASL) Digital International Liver Congress 2020 being held August 27-29, 2020.

    Clinical data will include an oral presentation of the Phase 2a ARGON-1 study of EDP-305, Enanta's Farnesoid X receptor (FXR) agonist for the treatment of NASH, as well as a poster on new Phase 1 data of EDP-514, Enanta's core inhibitor for HBV. Preclinical…

    Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, today announced that clinical data from Enanta's wholly-owned development programs for non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV) have been accepted for presentations at the European Association for the Study of the Liver (EASL) Digital International Liver Congress 2020 being held August 27-29, 2020.

    Clinical data will include an oral presentation of the Phase 2a ARGON-1 study of EDP-305, Enanta's Farnesoid X receptor (FXR) agonist for the treatment of NASH, as well as a poster on new Phase 1 data of EDP-514, Enanta's core inhibitor for HBV. Preclinical data on EDP-297, Enanta's follow-on FXR agonist for NASH, will also be highlighted in two poster presentations.

    The full scientific program for The Digital International Liver Congress 2020, as well as the abstracts, can be found at https://ilc-congress.eu/programme-digital-ilc-2020/. Further details will be available at the time of these presentations.

    Oral Presentation:

    August 28, 2020, 12:15 - 12:30 CEST

    AS078: "EDP-305, A Non-Bile Acid Farnesoid X Receptor (FXR) Agonist, Showed Statistically Significant Improvements in Liver Biochemistry and Hepatic Steatosis in the Phase 2a ARGON-1 Study"

    Location: Channel 3

    Presenter: Vlad Ratziu, M.D., Ph.D., France

    Poster Presentations:

    August 28, 2020, 09:30 - 19:30 CEST

    FRI109: "EDP-297, A Novel and Potent FXR Agonist, Exhibits Robust Anti-Fibrotic Effects with Significant Liver Function Improvement in a Rat Model of Non-Alcoholic Steatohepatitis"

    Presenter: Mozhdeh Sojoodi, Ph.D., United States

    August 29, 2020, 09:30 - 19:30 CEST

    SAT042: "A Novel FXR Agonist EDP-297 Exerts Anti-Inflammatory and Hepatoprotective Effects in Human Liver 3D Microtissues and in Rodent Models of Liver Injury and NASH"

    Presenter: Mary Chau, Ph.D., United States

    August 29, 2020, 09:30 - 19:30 CEST

    SAT440: "EDP-514, a Novel Pangenotypic Class II Hepatitis B Virus Core Inhibitor: Final Results of a Phase 1 Study in Healthy Adult Subjects"

    Presenter: Kajal Larson, Ph.D., United States

    About Enanta

    Enanta is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs for the treatment of viral infections and liver diseases. Enanta's research and development efforts have produced clinical candidates for the following disease targets: respiratory syncytial virus (RSV), non-alcoholic steatohepatitis (NASH) and hepatitis B virus (HBV). Enanta is also conducting research in human metapneumovirus (hMPV) and SARS-CoV-2 (COVID-19).

    Enanta's research and development activities are funded by royalties from hepatitis C virus (HCV) products developed under its collaboration with AbbVie. Glecaprevir, a protease inhibitor discovered by Enanta, is sold by AbbVie in numerous countries as part of its leading treatment for chronic HCV infection under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). Please visit www.enanta.com for more information.

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