DBTX Decibel Therapeutics Inc.

17.67
-0.41  -2%
Previous Close 18.08
Open 18.1
52 Week Low 17.62
52 Week High 24.39
Market Cap $429,408,866
Shares 24,301,577
Float 16,790,978
Enterprise Value $573,519,622
Volume 306,736
Av. Daily Volume 127,288
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Drug Pipeline

Drug Stage Notes
DB-020
Cisplatin-induced hearing loss
Phase 1b
Phase 1b
Phase 1b trial ongoing.

Latest News

  1. BOSTON, March 04, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, announced today that Laurence Reid, Ph.D., Chief Executive Officer of Decibel, will present at the Barclays Global Healthcare Conference on Thursday, March 11, 2021 at 9:10 a.m. ET.

    A live webcast of the presentation may be accessed by visiting the Investors section of the Decibel Therapeutics website at https://ir.decibeltx.com. An archived replay of the webcast will be available on the company's website for approximately 90 days following the presentation.

    About Decibel Therapeutics

    Decibel Therapeutics is…

    BOSTON, March 04, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, announced today that Laurence Reid, Ph.D., Chief Executive Officer of Decibel, will present at the Barclays Global Healthcare Conference on Thursday, March 11, 2021 at 9:10 a.m. ET.

    A live webcast of the presentation may be accessed by visiting the Investors section of the Decibel Therapeutics website at https://ir.decibeltx.com. An archived replay of the webcast will be available on the company's website for approximately 90 days following the presentation.

    About Decibel Therapeutics

    Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, one of the largest areas of unmet need in medicine. Decibel has built a proprietary platform that integrates single-cell genomics and bioinformatic analyses, precision gene therapy technologies and expertise in inner ear biology. Decibel is leveraging its platform to advance gene therapies designed to selectively replace genes for the treatment of congenital, monogenic hearing loss and to regenerate inner ear hair cells for the treatment of acquired hearing and balance disorders. Decibel's pipeline, including its lead gene therapy program, DB-OTO, to treat congenital, monogenic hearing loss, is designed to deliver on our vision of a world in which the privileges of hearing and balance are available to all.

    Investor Contact:

    Julie Seidel

    Stern Investor Relations, Inc.



    212-362-1200

    Media Contact:

    Stephanie Simon

    Ten Bridge Communications



    617-581-9333



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  2. BOSTON, Feb. 24, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage company developing treatments to restore and improve hearing and balance, presented preclinical data supporting the company's gene therapy product candidate, DB-OTO, a potential transformative treatment for individuals with hearing loss due to mutation of the otoferlin gene. These and other data were presented by the company at the 44th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO), which was held virtually February 20–24, 2021.

    Decibel's DB-OTO product candidate is designed to use dual AAV vectors and a cell-selective promoter to express functional otoferlin in hair cells of the inner ear, with the goal of…

    BOSTON, Feb. 24, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage company developing treatments to restore and improve hearing and balance, presented preclinical data supporting the company's gene therapy product candidate, DB-OTO, a potential transformative treatment for individuals with hearing loss due to mutation of the otoferlin gene. These and other data were presented by the company at the 44th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO), which was held virtually February 20–24, 2021.

    Decibel's DB-OTO product candidate is designed to use dual AAV vectors and a cell-selective promoter to express functional otoferlin in hair cells of the inner ear, with the goal of enabling the ear to transmit sound to the brain and enable hearing. DB-OTO is intended to be delivered to patients using the surgical approach employed by otologists and pediatric otolaryngologists during a standard cochlear implantation procedure. Exploratory studies highlighted in the presentations utilizing the delivery procedure in non-human primates showed successful distribution and expression across the cochlear length. In these studies, DB-OTO and the surgical administration were generally well tolerated. The company presented data which suggest hair cell selective expression of otoferlin may enable greater efficacy and durability and minimize potential toxicity. In addition to these data, Decibel presented preclinical findings demonstrating that DB-OTO restored normal hearing sensitivity in animal models of otoferlin deficiency. Decibel is developing DB-OTO in collaboration with Regeneron Pharmaceuticals and expects to submit an IND or CTA in 2022.

    "This is an exciting time for hearing and balance therapeutics, as we build preclinical evidence to support advancing gene therapies for the inner ear. We believe the data we shared at ARO, including potential benefits of cell-selective expression and utilization of an established surgical procedure, if shown in humans, would provide a competitive advantage for DB-OTO and support our approach to developing highly targeted gene therapies for hearing and balance," said John Lee, Executive Vice President, Pharmaceutical Development and Interim Chief Scientific Officer.

    A selection of Decibel's presentations from ARO are available on the company's website:

    • A podium presentation by Adam Palermo, Ph.D., Decibel's Vice President, Head of Genomics and Computational Biology, provided an overview of preclinical DB-OTO data from mice and non-human primates. The presentation can be found here.
    • A podium presentation by Gabriela Pregernig, Ph.D., Associate Director of Computational Biology at Decibel, highlighted potential mechanisms of ubiquitous promoter-driven AAV toxicity in the ear. The presentation can be found here.
    • Peter Weber, MBA, M.D., Decibel's Senior Medical Advisor, delivered a podium presentation that described the surgical approach for DB-OTO. He presented data in which dual vector AAV and Decibel's cell-selective promoter drove highly selective expression of GFP in hair cells of non-human primates. Details can be found here.
    • A poster by Lars Becker, Ph.D., Associate Director of Discovery at Decibel, demonstrated that a variety of capsids are able to transduce inner hair cells of the inner ear in non-human primates and that the presence of neutralizing antibodies was not observed to impact transduction. The presentation can be found here.

    About Decibel Therapeutics

    Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, one of the largest areas of unmet need in medicine. Decibel has built a proprietary platform that integrates single-cell genomics and bioinformatic analyses, precision gene therapy technologies and expertise in inner ear biology. Decibel is leveraging its platform to advance gene therapies designed to selectively replace genes for the treatment of congenital, monogenic hearing loss and to regenerate inner ear hair cells for the treatment of acquired hearing and balance disorders. Decibel's pipeline, including its lead gene therapy product candidate, DB-OTO, to treat congenital, monogenic hearing loss, is designed to deliver on our vision of a world in which the privileges of hearing and balance are available to all.

    Forward-Looking Statements

    This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this press release, including statements regarding Decibel's strategy, future operations, prospects, plans, objectives of management, the therapeutic potential for Decibel's product candidates and preclinical programs, the potential benefits of cell-selective expression and intracochlear injection, the expected timeline for submitting investigational new drug applications and expectations regarding the translation of preclinical findings to human disease, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "might," "objective," "ongoing," "plan," "predict," "project," "potential," "should," or "would," or the negative of these terms, or other comparable terminology are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Decibel may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including: uncertainties inherent in the identification and development of product candidates, including the conduct of research activities and the initiation and completion of preclinical studies and clinical trials; the timing of and Decibel's ability to submit and obtain approval to initiate clinical development of its program candidates; whether results from preclinical studies will be predictive of the results of later preclinical studies and clinical trials; whether Decibel's cash resources are sufficient to fund its foreseeable and unforeseeable operating expenses and capital expenditure requirements; uncertainties related to the impact of the COVID-19 pandemic on Decibel's business and operations; as well as the risks and uncertainties identified in Decibel's filings with the Securities and Exchange Commission (SEC), including those risks detailed under the caption "Risk Factors" in the final prospectus for Decibel's initial public offering filed with the SEC on February 12, 2021. In addition, the forward-looking statements included in this press release represent Decibel's views as of the date of this press release. Decibel anticipates that subsequent events and developments will cause its views to change. However, while Decibel may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Decibel's views as of any date subsequent to the date of this press release.

    Investor Contact:

    Julie Seidel

    Stern Investor Relations, Inc.



    212-362-1200

    Media Contact:

    Stephanie Simon

    Ten Bridge Communications



    617-581-9333



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  3. BOSTON, Feb. 19, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, announced today that it will present findings from its drug discovery and development programs at the 44th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO), which will be held virtually February 20–24, 2021.

    The Decibel team will have a total of eight podium and poster presentations during this year's meeting. Several presentations will focus on DB-OTO, Decibel's investigational gene therapy being developed to restore hearing in children with a deficiency in the otoferlin gene, and DB-ATO…

    BOSTON, Feb. 19, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, announced today that it will present findings from its drug discovery and development programs at the 44th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO), which will be held virtually February 20–24, 2021.

    The Decibel team will have a total of eight podium and poster presentations during this year's meeting. Several presentations will focus on DB-OTO, Decibel's investigational gene therapy being developed to restore hearing in children with a deficiency in the otoferlin gene, and DB-ATO, a regenerative gene therapy program designed to restore balance in patients with bilateral vestibulopathy, or BVP, by regenerating lost hair cells within the vestibule.

    Podium Presentations

    Podium 18.3 | Promoter Control Optimizes AAV-ATOH1 Gene Therapy for Vestibular Hair Cell Regeneration

    Presenter: Tian Yang, Ph.D.

    Session Title: Regeneration of Hair Cells & Synapses

    Date & Time: Monday, February 22, 3:30–3:45 p.m. ET

    Podium 25.2 | Development of an AAV-Based Gene Therapy for Children with Congenital Hearing Loss Due to Otoferlin Deficiency (DB-OTO)

    Presenter: Adam Palermo, Ph.D.

    Session Title: Inner Ear Therapeutics

    Date & Time: Tuesday, February 23, 3:15–3:30 p.m. ET

    Podium 25.3 | Mechanisms of Promoter-Driven AAV Toxicity in the Ear

    Presenter: Gabriela Pregernig, Ph.D.

    Session Title: Inner Ear Therapeutics

    Date & Time: Tuesday, February 23, 3:30–3:45 p.m. ET

    Podium 25.4 | Safely Delivering Adeno-Associated Viral Vectors to the Ear for Therapeutics

    Presenter: Peter Weber, MBA, M.D.

    Session Title: Inner Ear Therapeutics

    Date & Time: Tuesday, February 23, 3:45–4:00 p.m. ET

    Poster Presentations

    SU97 | Leveraging single cell genomics with tissue culture to identify and screen targets for vestibular regeneration

    M117 | Gentamicin-Induced Models of Vestibular Dysfunction in Mice for Evaluating Therapeutic Potential of Vestibular Hair Cell Regeneration

    T96 | Transcriptional comparison of AAV-Atoh1 and AAV-Atoh1/Pou4f3/Gfi1 regenerated hair cells in the neonatal mouse cochlea

    W78 | Inner Ear Tropism of Natural and Engineered AAV Serotypes in Non-Human Primate Enables Therapeutic Targeting of a Diverse Set of Cochlear Cell Types

    About Decibel Therapeutics

    Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, one of the largest areas of unmet need in medicine. Decibel has built a proprietary platform that integrates single-cell genomics and bioinformatic analyses, precision gene therapy technologies and expertise in inner ear biology. Decibel is leveraging its platform to advance gene therapies designed to selectively replace genes for the treatment of congenital, monogenic hearing loss and to regenerate inner ear hair cells for the treatment of acquired hearing and balance disorders. Decibel's pipeline, including its lead gene therapy program, DB-OTO, to treat congenital, monogenic hearing loss, is designed to deliver on our vision of a world in which the privileges of hearing and balance are available to all.

    Investor Contact:

    Julie Seidel

    Stern Investor Relations, Inc.



    212-362-1200

    Media Contact:

    Matthew Corcoran

    Ten Bridge Communications



    617-866-7350



    Primary Logo

    View Full Article Hide Full Article
  4. BOSTON, Feb. 11, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, today announced the pricing of its initial public offering of 7,062,000 shares of its common stock at a price to the public of $18.00 per share. All of the shares of common stock are being offered by Decibel. In addition, Decibel has granted the underwriters a 30-day option to purchase up to an additional 1,059,300 shares of common stock at the public offering price, less underwriting discounts and commissions.

    Decibel's common stock is expected to begin trading on the Nasdaq Global Select Market on Friday, February…

    BOSTON, Feb. 11, 2021 (GLOBE NEWSWIRE) -- Decibel Therapeutics (NASDAQ:DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, today announced the pricing of its initial public offering of 7,062,000 shares of its common stock at a price to the public of $18.00 per share. All of the shares of common stock are being offered by Decibel. In addition, Decibel has granted the underwriters a 30-day option to purchase up to an additional 1,059,300 shares of common stock at the public offering price, less underwriting discounts and commissions.

    Decibel's common stock is expected to begin trading on the Nasdaq Global Select Market on Friday, February 12, 2021, under the symbol "DBTX." The gross proceeds of the offering, before deducting underwriting discounts and commissions and offering expenses payable by Decibel, are expected to be approximately $127.1 million, excluding any exercise of the underwriters' option to purchase additional shares. The offering is expected to close on or about Wednesday, February 17, 2021, subject to customary closing conditions.

    Citigroup, SVB Leerink, BMO Capital Markets and Barclays are acting as joint book-running managers for the offering.

    A registration statement relating to the securities being sold in this offering was declared effective by the Securities and Exchange Commission ("SEC") on February 11, 2021. Copies of the registration statement can be accessed by visiting the SEC website at www.sec.gov. The offering is being made only by means of a prospectus. A preliminary prospectus describing the terms of the offering has been filed with the SEC and forms a part of the effective registration statement. A copy of the final prospectus relating to the offering may be obtained, when available, by visiting the SEC's website or from Citigroup Global Markets Inc., c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (800) 831 9146; or SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808 7525, ext. 6105, or by email at 

    This press release shall not constitute an offer to sell, or a solicitation of an offer to buy these securities, nor shall there be any offer or sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

    About Decibel Therapeutics

    Decibel Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, one of the largest areas of unmet need in medicine. Decibel has built a proprietary platform that integrates single-cell genomics and bioinformatic analyses, precision gene therapy technologies and expertise in inner ear biology. Decibel is leveraging its platform to advance gene therapies designed to selectively replace genes for the treatment of congenital, monogenic hearing loss and to regenerate inner ear hair cells for the treatment of acquired hearing and balance disorders. Decibel's pipeline, including its lead gene therapy program, DB-OTO, to treat congenital, monogenic hearing loss, is designed to deliver on our vision of a world in which the privileges of hearing and balance are available to all.

    Forward-Looking Statements

    Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements." These statements include, but are not limited to, statements relating to the expected trading commencement and closing dates. The words, without limitation, "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these or similar identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties related to market conditions and the completion of the public offering on the anticipated terms of the offering or at all, and other factors discussed in the "Risk Factors" section of the preliminary prospectus that forms a part of the effective registration statement filed with the SEC. Any forward-looking statements contained in this press release are based on the current expectations of the Company's management team and speak only as of the date hereof, and Decibel specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

    Investor Contact:

    Julie Seidel

    Stern Investor Relations, Inc.



    212-362-1200

    Media Contact:

    Matthew Corcoran

    Ten Bridge Communications



    617-866-7350



    Primary Logo

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