CCXI ChemoCentryx Inc.

58.07
+0.06  (+0%)
Previous Close 58.01
Open 58.45
52 Week Low 6.16
52 Week High 65.43
Market Cap $3,939,121,251
Shares 67,834,015
Float 45,342,850
Enterprise Value $3,777,142,210
Volume 293,105
Av. Daily Volume 765,646
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Upcoming Catalysts

Drug Stage Catalyst Date
Avacopan - CCX168 (ADVOCATE)
Associated vasculitis (AAV)
NDA Filing
NDA Filing
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CCX140 - LUMINA-2
Focal Segmental Glomerulosclerosis and Nephrotic Syndrome
Phase 2
Phase 2
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Avacopan - CCX168
C3 glomerulopathy (C3G)
Phase 2
Phase 2
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Avacopan -AURORA
Hidradenitis Suppurativa (HS)
Phase 2b
Phase 2b
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Drug Pipeline

Drug Stage Notes
CCX140 - LUMINA-1
Focal Segmental Glomerulosclerosis
Phase 2
Phase 2
Phase 2 trial did not meet primary endpoint - May 18, 2020.

Latest News

  1. MOUNTAIN VIEW, Calif., June 24, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (NASDAQ:CCXI) today announced that it has identified an orally administered checkpoint inhibitor, CCX559, and plans to initiate clinical development in the first half of 2021. Data to be presented on Wednesday, June 24 at 10:35 a.m. ET, during the virtual meeting of the American Association for Cancer Research (AACR), showed that the Company's optimized checkpoint inhibitors led to marked inhibition of the PD-1/PD-L1 interaction and signaling in vitro and potent anti-tumor effects in animal models.

    "Our new highly-potent, highly-specific orally administered checkpoint inhibitor furthers the Company's aim to advance novel medications that offer precise modes of…

    MOUNTAIN VIEW, Calif., June 24, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (NASDAQ:CCXI) today announced that it has identified an orally administered checkpoint inhibitor, CCX559, and plans to initiate clinical development in the first half of 2021. Data to be presented on Wednesday, June 24 at 10:35 a.m. ET, during the virtual meeting of the American Association for Cancer Research (AACR), showed that the Company's optimized checkpoint inhibitors led to marked inhibition of the PD-1/PD-L1 interaction and signaling in vitro and potent anti-tumor effects in animal models.

    "Our new highly-potent, highly-specific orally administered checkpoint inhibitor furthers the Company's aim to advance novel medications that offer precise modes of action with convenient dosing and favorable safety for patients in need," said Thomas J. Schall, Ph.D., President and Chief Executive Officer of ChemoCentryx. "Beyond ease of use, our orally administered small molecule approach provides flexibility in dosing schedules to more specifically fine tune checkpoint inhibition to combat tumors and avoid side effects. We believe this approach may more effectively penetrate the tumor microenvironment as well, allowing us to target certain cancers that antibodies can't reach. Finally, we see potential for CCX559 as both a monotherapy or as a complement to antibody therapy regimens. We plan to advance CCX559 into clinical development in the first half of 2021, furthering our long-term goal of becoming a fully-integrated pharmaceutical company, driving revenue and re-investing in our pipeline."

    The PD-1/PD-L1 pathway protects tumor cells from the immune system's cancer-fighting activity. Inhibition of PD-L1 has the potential to prevent PD-1 binding to PD-L1, thereby exposing tumor cells to the full force of the immune system's anti-tumor response.

    ChemoCentryx optimized several small molecule PD-L1 inhibitors it designed to disrupt the interaction of PD-1 with PD-L1. Active compounds were found to be highly potent in several functional cell-based assays, a mixed lymphocyte reaction (MLR) assays, and by human peripheral blood mononuclear cell (PBMC)-mediated tumor cell killing assessments. Potential clinical candidate compounds were selected for potency and oral bioavailability and were evaluated in vivo using murine tumor models. Assessment of the tumor microenvironment demonstrated that the lead compounds almost completely blocked the interaction of PD-L1 on tumor cells with PD-1 on immune effector cells, thus enhancing the immune responses against tumor. Importantly, the in vivo anti-tumor effects of ChemoCentryx's small molecules were consistently as good or better than the antibody therapeutics to the PD-1/PD-L1 pathway in these models.

    To view the full abstract and AACR presentation information, visit: https://www.abstractsonline.com/pp8/#!/9045/presentation/5435.

    About ChemoCentryx

    ChemoCentryx is a biopharmaceutical company developing new medications targeted at inflammatory and autoimmune diseases and cancer. ChemoCentryx targets the chemokine and chemoattractant systems to discover, develop and commercialize orally administered therapies. ChemoCentryx's lead drug candidate, avacopan (CCX168), successfully completed a pivotal Phase III trial in ANCA-associated vasculitis.

    ChemoCentryx also has early stage drug candidates that target chemoattractant receptors in other inflammatory and autoimmune diseases and in cancer.

    Forward-Looking Statements

    ChemoCentryx cautions that statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as "may," "could," "will," "would," "should," "expect," "plan," "anticipate," "believe," "estimate," "intend," "predict," "seek," "contemplate," "potential," "continue" or "project" or the negative of these terms or other comparable terminology are intended to identify forward-looking statements. These statements include the Company's statements regarding the achievement of anticipated goals and milestones, whether CCX559 will enter clinical development in the first half of 2021 and whether the Company's drug candidates will be shown to be effective in ongoing or future clinical trials. The inclusion of forward-looking statements should not be regarded as a representation by ChemoCentryx that any of its plans will be achieved. Actual results may differ from those set forth in this release due to the risks and uncertainties inherent in the ChemoCentryx business and other risks described in the Company's filings with the Securities and Exchange Commission ("SEC").  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and ChemoCentryx undertakes no obligation to revise or update this news release to reflect events or circumstances after the date hereof. Further information regarding these and other risks is included under the heading "Risk Factors" in ChemoCentryx's periodic reports filed with the SEC, including ChemoCentryx's Annual Report on Form 10-K filed with the SEC on March 10, 2020 and its other reports which are available from the SEC's website (www.sec.gov) and on ChemoCentryx's website (www.chemocentryx.com) under the heading "Investors." All forward-looking statements are qualified in their entirety by this cautionary statement. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

    Contacts:

    Susan M. Kanaya

    Executive Vice President,

    Chief Financial and Administrative Officer

    Media:

    Stephanie Tomei

    408.234.1279

    Investors:

    William Slattery, Jr., Burns McClellan

    212.213.0006 

     

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  2. MOUNTAIN VIEW, Calif., June 15, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc. (NASDAQ:CCXI) announced today the completion of its follow-on offering of 5,200,000 shares of its common stock. ChemoCentryx also announced today that the underwriters of its follow-on offering exercised in full their option to purchase an additional 780,000 shares of common stock. All such shares were sold by ChemoCentryx at the follow-on public offering price of $58.00 per share. The net proceeds to ChemoCentryx from this offering are approximately $325.4 million, after deducting underwriting discounts and commissions and estimated offering costs.

    SVB Leerink and Piper Sandler acted as joint lead bookrunning managers for the offering, Canaccord Genuity and Raymond…

    MOUNTAIN VIEW, Calif., June 15, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc. (NASDAQ:CCXI) announced today the completion of its follow-on offering of 5,200,000 shares of its common stock. ChemoCentryx also announced today that the underwriters of its follow-on offering exercised in full their option to purchase an additional 780,000 shares of common stock. All such shares were sold by ChemoCentryx at the follow-on public offering price of $58.00 per share. The net proceeds to ChemoCentryx from this offering are approximately $325.4 million, after deducting underwriting discounts and commissions and estimated offering costs.

    SVB Leerink and Piper Sandler acted as joint lead bookrunning managers for the offering, Canaccord Genuity and Raymond James acted as joint bookrunning managers for the offering and H.C. Wainwright & Co. acted as lead manager for the offering.

    A registration statement on Form S-3 relating to these securities became effective upon filing with the U.S. Securities and Exchange Commission (SEC) on June 10, 2020. The offering was made only by means of a prospectus supplement and accompanying prospectus, which were filed with the SEC and are available on the SEC's website located at http://www.sec.gov. These documents may also be obtained from: SVB Leerink LLC, Attn: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525, ext. 6218, or by email at ; or Piper Sandler & Co., Attn: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, by telephone at (800) 747-3924, or by email at .

    This press release shall not constitute an offer to sell, or the solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state or other jurisdiction.

    About ChemoCentryx

    ChemoCentryx is a biopharmaceutical company developing new medications targeted at inflammatory and autoimmune diseases and cancer. ChemoCentryx targets the chemokine and chemoattractant systems to discover, develop and commercialize orally-administered therapies.  

    Forward-Looking Statements

    ChemoCentryx cautions that statements included in this press release that are not a description of historical facts are forward-looking statements.  Words such as "may," "could," "will," "would," "should," "expect," "plan," "anticipate," "believe," "estimate," "intend," "predict," "seek," "contemplate," "potential," "continue" or "project" or the negative of these terms or other comparable terminology are intended to identify forward-looking statements.  These statements are based on the Company's current beliefs and expectations.  The inclusion of forward-looking statements should not be regarded as a representation by ChemoCentryx that any of its plans will be achieved.  Actual results may differ from those set forth in this release due to the risks and uncertainties inherent in the ChemoCentryx business and other risks described in the Company's filings with the SEC.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and ChemoCentryx undertakes no obligation to revise or update this news release to reflect events or circumstances after the date hereof.  Further information regarding these and other risks is included under the heading "Risk Factors" in ChemoCentryx's periodic reports filed with the SEC, including ChemoCentryx's Annual Report on Form 10-K filed with the SEC on March 10, 2020 and its other reports which are available from the SEC's website (www.sec.gov). All forward-looking statements are qualified in their entirety by this cautionary statement.  This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

    Contacts:

    Susan M. Kanaya

    Executive Vice President, Chief Financial and Administrative Officer

    Media:

    Stephanie Tomei

    408.234.1279

    Investors:

    Burns McClellan, Inc.

    William Slattery, Jr.

    212.213.0006

    Source: ChemoCentryx, Inc.

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  3. MOUNTAIN VIEW, Calif., June 10, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc. (NASDAQ:CCXI) announced today that it has priced an underwritten public offering of 5,200,000 shares of its common stock at a price to the public of $58.00 per share. The gross proceeds to ChemoCentryx from the offering, before underwriting discounts and commissions and offering costs, are expected to be $301,600,000. ChemoCentryx has granted the underwriters a 30-day option to purchase up to an additional 780,000 shares of its common stock on the same terms and conditions. All shares of the common stock to be sold in the offering will be offered by ChemoCentryx. The offering is expected to close on June 15, 2020, subject to satisfaction of customary closing conditions…

    MOUNTAIN VIEW, Calif., June 10, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc. (NASDAQ:CCXI) announced today that it has priced an underwritten public offering of 5,200,000 shares of its common stock at a price to the public of $58.00 per share. The gross proceeds to ChemoCentryx from the offering, before underwriting discounts and commissions and offering costs, are expected to be $301,600,000. ChemoCentryx has granted the underwriters a 30-day option to purchase up to an additional 780,000 shares of its common stock on the same terms and conditions. All shares of the common stock to be sold in the offering will be offered by ChemoCentryx. The offering is expected to close on June 15, 2020, subject to satisfaction of customary closing conditions.

    SVB Leerink and Piper Sandler are acting as joint lead bookrunning managers for the offering, Canaccord Genuity and Raymond James are acting as passive joint bookrunning managers for the offering and H.C. Wainwright & Co. is acting as lead manager for the offering.

    A registration statement on Form S-3 relating to these securities became effective upon filing with the U.S. Securities and Exchange Commission (SEC) on June 10, 2020. The offering is being made only by means of a prospectus supplement and accompanying prospectus, which have been filed with the SEC and are available on the SEC's website located at http://www.sec.gov. These documents may also be obtained from: SVB Leerink LLC, Attn: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525, ext. 6218, or by email at ; or Piper Sandler & Co., Attn: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, by telephone at (800) 747-3924, or by email at .

    This press release shall not constitute an offer to sell, or the solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state or other jurisdiction.

    About ChemoCentryx

    ChemoCentryx is a biopharmaceutical company developing new medications targeted at inflammatory and autoimmune diseases and cancer. ChemoCentryx targets the chemokine and chemoattractant systems to discover, develop and commercialize orally-administered therapies.

    Forward-Looking Statements

    ChemoCentryx cautions that statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as "may," "could," "will," "would," "should," "expect," "plan," "anticipate," "believe," "estimate," "intend," "predict," "seek," "contemplate," "potential," "continue" or "project" or the negative of these terms or other comparable terminology are intended to identify forward-looking statements. These statements are based on the Company's current beliefs and expectations and include the Company's statements regarding the completion of its offering. The inclusion of forward-looking statements should not be regarded as a representation by ChemoCentryx that any of its plans will be achieved. Actual results may differ from those set forth in this release due to the risks and uncertainties inherent in the ChemoCentryx business and other risks described in the Company's filings with the SEC. Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and ChemoCentryx undertakes no obligation to revise or update this news release to reflect events or circumstances after the date hereof. Further information regarding these and other risks is included under the heading "Risk Factors" in ChemoCentryx's periodic reports filed with the SEC, including ChemoCentryx's Annual Report on Form 10-K filed with the SEC on March 10, 2020 and its other reports which are available from the SEC's website (www.sec.gov). All forward-looking statements are qualified in their entirety by this cautionary statement. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

    Contacts:

    Susan M. Kanaya

    Executive Vice President, Chief Financial and Administrative Officer

    Media:

    Stephanie Tomei

    408.234.1279

    Investors:

    Burns McClellan, Inc.

    William Slattery, Jr.

    212.213.0006

    Source: ChemoCentryx, Inc.

    Primary Logo

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  4. MOUNTAIN VIEW, Calif., June 10, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc. (NASDAQ:CCXI) announced today that it has commenced an underwritten public offering of its common stock.  In connection with this offering, ChemoCentryx plans to grant the underwriters a 30-day option to purchase up to an additional 15 percent of the number of shares sold.  SVB Leerink and Piper Sandler are acting as joint bookrunning managers for the offering. All shares of the common stock to be sold in the offering will be offered by ChemoCentryx.  The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

    The offering will be made by ChemoCentryx…

    MOUNTAIN VIEW, Calif., June 10, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc. (NASDAQ:CCXI) announced today that it has commenced an underwritten public offering of its common stock.  In connection with this offering, ChemoCentryx plans to grant the underwriters a 30-day option to purchase up to an additional 15 percent of the number of shares sold.  SVB Leerink and Piper Sandler are acting as joint bookrunning managers for the offering. All shares of the common stock to be sold in the offering will be offered by ChemoCentryx.  The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

    The offering will be made by ChemoCentryx pursuant to a registration statement on Form S-3 previously filed with the U.S. Securities and Exchange Commission (SEC), which became effective upon filing on June 10, 2020.  A preliminary prospectus supplement related to the offering and the accompanying prospectus have been filed with the SEC and are available on the SEC's website located at http://www.sec.gov.  These documents may also be obtained from: SVB Leerink LLC, Attn: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525, ext. 6218, or by email at ; or Piper Sandler & Co., Attn: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, by telephone at (800) 747-3924, or by email at .

    This press release shall not constitute an offer to sell, or the solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state or other jurisdiction.

    About ChemoCentryx

    ChemoCentryx is a biopharmaceutical company developing new medications targeted at inflammatory and autoimmune diseases and cancer. ChemoCentryx targets the chemokine and chemoattractant systems to discover, develop and commercialize orally-administered therapies.  

    Forward-Looking Statements

    ChemoCentryx cautions that statements included in this press release that are not a description of historical facts are forward-looking statements.  Words such as "may," "could," "will," "would," "should," "expect," "plan," "anticipate," "believe," "estimate," "intend," "predict," "seek," "contemplate," "potential," "continue" or "project" or the negative of these terms or other comparable terminology are intended to identify forward-looking statements.  These statements are based on the Company's current beliefs and expectations and include the Company's statements regarding the completion, timing and size of its offering.  The inclusion of forward-looking statements should not be regarded as a representation by ChemoCentryx that any of its plans will be achieved.  Actual results may differ from those set forth in this release due to the risks and uncertainties inherent in the ChemoCentryx business and other risks described in the Company's filings with the SEC.  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and ChemoCentryx undertakes no obligation to revise or update this news release to reflect events or circumstances after the date hereof.  Further information regarding these and other risks is included under the heading "Risk Factors" in ChemoCentryx's periodic reports filed with the SEC, including ChemoCentryx's Annual Report on Form 10-K filed with the SEC on March 10, 2020 and its other reports which are available from the SEC's website (www.sec.gov). All forward-looking statements are qualified in their entirety by this cautionary statement.  This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

    Contacts:

    Susan M. Kanaya

    Executive Vice President, Chief Financial and Administrative Officer

    Media:

    Stephanie Tomei

    408.234.1279

    Investors:

    Burns McClellan, Inc.

    William Slattery, Jr.

    212.213.0006

    Source: ChemoCentryx, Inc.

    Primary Logo

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  5. MOUNTAIN VIEW, Calif., June 03, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (NASDAQ:CCXI) today announced presentations highlighting outcomes of the Company's Phase III ADVOCATE trial as part of the virtual annual meetings of the leading European rheumatology and nephrology organizations, EULAR (European League Against Rheumatism) and ERA-EDTA (European Renal Association - European Dialysis and Transplant Association), being held June 3-6 and June 6-9, respectively.

    EULAR – Open Plenary Abstract Session
    Title: A Randomized, Double-Blind, Active-Controlled Study of Avacopan in Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis
    Date: Wednesday, June 3, 2020
    Time: 15:10-15:20 CEST (9:10-9:20 a.m. ET)
    Presenter: Dr. Peter Merkel

    MOUNTAIN VIEW, Calif., June 03, 2020 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (NASDAQ:CCXI) today announced presentations highlighting outcomes of the Company's Phase III ADVOCATE trial as part of the virtual annual meetings of the leading European rheumatology and nephrology organizations, EULAR (European League Against Rheumatism) and ERA-EDTA (European Renal Association - European Dialysis and Transplant Association), being held June 3-6 and June 6-9, respectively.

    EULAR – Open Plenary Abstract Session
    Title: A Randomized, Double-Blind, Active-Controlled Study of Avacopan in Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis
    Date: Wednesday, June 3, 2020
    Time: 15:10-15:20 CEST (9:10-9:20 a.m. ET)
    Presenter: Dr. Peter Merkel

    ERA-EDTA – Oral Presentation, Plenary
    Title: A Randomized, Double-Blind, Active Controlled Study of Avacopan in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    Date: Sunday, June 7, 2020
    Time: 12:15-12:25 CEST (6:15-6:25 a.m. ET)
    Presenter: Dr. David Jayne

    About ADVOCATE and ANCA Vasculitis
    The ADVOCATE trial of avacopan was a global randomized, double-blind, active-controlled, double-dummied Phase III trial of 331 patients with ANCA-associated vasculitis in 20 countries. Eligible study subjects were randomized to receive avacopan plus either rituximab or cyclophosphamide (followed by azathioprine/mycophenolate) or prednisone plus either rituximab or cyclophosphamide (followed by azathioprine/mycophenolate). The treatment period was 52 weeks.

    ANCA vasculitis is a systemic disease in which over-activation of the complement pathway further activates neutrophils, leading to inflammation and destruction of small blood vessels. This results in organ damage and failure, with the kidney as the major target, and is fatal if not treated. Currently treatment for ANCA vasculitis consists of courses of non-specific immuno-suppressants (cyclophosphamide or rituximab), combined with high-dose corticosteroid administration for prolonged periods of time, which can be associated with significant clinical risk including death from infection.

    About Avacopan
    Avacopan is a first-in-class, orally-administered molecule that employs a novel, highly targeted mode of action in the treatment of ANCA-associated vasculitis and other complement-driven autoimmune and inflammatory diseases.  By precisely blocking the receptor (the C5aR) for the pro-inflammatory complement system fragment known as C5a on destructive inflammatory cells such as blood neutrophils, avacopan arrests the ability of those cells to do damage in response to C5a activation, which is known to be the driver of ANCA-associated vasculitis.  Current therapies for ANCA vasculitis and other related illnesses typically include broad immunosuppression with high doses of glucocorticoids (steroids) such as prednisone or methylprednisone, which cause significant illness and even death. Avacopan therapy was designed to prevent these outcomes. Moreover, avacopan's selective inhibition of only the C5aR leaves the beneficial C5a pathway through the C5L2 receptor functioning normally.  

    ChemoCentryx is also developing avacopan for the treatment of patients with C3 glomerulopathy (C3G) and hidradenitis suppurativa (HS). The U.S. Food and Drug Administration has granted avacopan orphan-drug designation for ANCA-associated vasculitis and C3G. The European Commission has granted orphan medicinal product designation for avacopan for the treatment of two forms of ANCA-associated vasculitis: microscopic polyangiitis and granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis), as well as for C3G.

    ChemoCentryx's Kidney Health Alliance with Vifor Pharma provides Vifor Pharma with exclusive rights to commercialize avacopan in markets outside of the U.S.

    About ChemoCentryx
    ChemoCentryx is a biopharmaceutical company developing new medications targeted at inflammatory and autoimmune diseases and cancer. ChemoCentryx targets the chemokine and chemoattractant systems to discover, develop and commercialize orally-administered therapies. ChemoCentryx's lead drug candidate, avacopan (CCX168), recently completed a pivotal Phase III trial in ANCA-associated vasculitis.

    ChemoCentryx also has early stage drug candidates that target chemoattractant receptors in other inflammatory and autoimmune diseases and in cancer.

    Forward-Looking Statements
    ChemoCentryx cautions that statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as "may," "could," "will," "would," "should," "expect," "plan," "anticipate," "believe," "estimate," "intend," "predict," "seek," "contemplate," "potential," "continue" or "project" or the negative of these terms or other comparable terminology are intended to identify forward-looking statements. These statements include the Company's statements regarding the achievement of anticipated goals and milestones, whether the avacopan NDA for ANCA vasculitis will be filed mid-year, whether avacopan will be approved for the treatment of ANCA vasculitis, the timing of topline data from the avacopan Phase II studies in the treatment of HS and C3G and whether the Company's drug candidates will be shown to be effective in ongoing or future clinical trials. The inclusion of forward-looking statements should not be regarded as a representation by ChemoCentryx that any of its plans will be achieved. Actual results may differ from those set forth in this release due to the risks and uncertainties inherent in the ChemoCentryx business and other risks described in the Company's filings with the Securities and Exchange Commission ("SEC").  Investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and ChemoCentryx undertakes no obligation to revise or update this news release to reflect events or circumstances after the date hereof. Further information regarding these and other risks is included under the heading "Risk Factors" in ChemoCentryx's periodic reports filed with the SEC, including ChemoCentryx's Annual Report on Form 10-K filed with the SEC on March 10, 2020 and its other reports which are available from the SEC's website (www.sec.gov) and on ChemoCentryx's website (www.chemocentryx.com) under the heading "Investors." All forward-looking statements are qualified in their entirety by this cautionary statement. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

    Contacts:
    Susan M. Kanaya
    Executive Vice President,
    Chief Financial and Administrative Officer

    Media:
    Stephanie Tomei
    408.234.1279

    Investors:
    William Slattery, Jr., Burns McClellan
    212.213.0006               

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