CATB Catabasis Pharmaceuticals Inc.

1.5
-0.01  -1%
Previous Close 1.51
Open 1.53
52 Week Low 1.25
52 Week High 8.59
Market Cap $115,423,205
Shares 76,948,803
Float 74,445,577
Enterprise Value $-20,612,452
Volume 310,823
Av. Daily Volume 1,290,798
Stock charts supplied by TradingView

Upcoming Catalysts

Drug Stage Catalyst Date
QLS-215
Hereditary angioedema (HAE)
Phase 1
Phase 1
Premium membership is required to view catalyst dates, analyst ratings, earnings dates and cash burn data. Click here to unlock and sign up to a 14-day FREE TRIAL.

Drug Pipeline

Drug Stage Notes
Edasalonexent (CAT-1004)
Duchenne muscular dystrophy (DMD)
Phase 3
Phase 3
Phase 3 trial did not meet primary endpoint - October 26, 2020.
CAT-2054
Hypercholesterolemia
Phase 2a
Phase 2a
Phase 2a did not meet primary endpoint - June 2016

Latest News

  1. Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today announced that Jill C. Milne, Ph.D., Chief Executive Officer, will be presenting during a fireside chat at the upcoming virtual Wedbush PacGrow Healthcare Conference on Tuesday, August 10th, 2021 at 8:35am ET. The session entitled "HAE There- Development Landscape in Hereditary Angioedema (HAE)" will include an overview of the HAE treatment landscape, information about Catabasis's lead program QLS-215, and a Q&A session.

    A webcast of the presentation will be available at the following link: https://wsw.com/webcast/wedbush39/panel11/2571740, and will also be available in the investors section of the Company's website, www.catabasis.com, and will be archived for…

    Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today announced that Jill C. Milne, Ph.D., Chief Executive Officer, will be presenting during a fireside chat at the upcoming virtual Wedbush PacGrow Healthcare Conference on Tuesday, August 10th, 2021 at 8:35am ET. The session entitled "HAE There- Development Landscape in Hereditary Angioedema (HAE)" will include an overview of the HAE treatment landscape, information about Catabasis's lead program QLS-215, and a Q&A session.

    A webcast of the presentation will be available at the following link: https://wsw.com/webcast/wedbush39/panel11/2571740, and will also be available in the investors section of the Company's website, www.catabasis.com, and will be archived for 30 days following the presentation.

    About Catabasis

    At Catabasis Pharmaceuticals, our mission is to bring hope with life-changing therapies to patients and families affected by rare and niche diseases. Our lead program, QLS-215, is a monoclonal antibody inhibitor of plasma kallikrein in preclinical development for the treatment of hereditary angioedema.

    View Full Article Hide Full Article
  2. Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today announced that Jill C. Milne, Ph.D., Chief Executive Officer, will present a corporate overview and provide information on its lead program QLS-215, which is in preclinical development for the treatment of hereditary angioedema, at the upcoming virtual Ladenburg Thalmann Healthcare Conference. The presentation will take place on Tuesday, July 13th, 2021 at 12:30pm ET.

    A webcast of the presentation will be available at the following link: https://wsw.com/webcast/ladenburg7/catb/2378558, and will also be available in the investors section of the Company's website, www.catabasis.com, and will be archived for 30 days following the presentation.

    About Catabasis

    At…

    Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today announced that Jill C. Milne, Ph.D., Chief Executive Officer, will present a corporate overview and provide information on its lead program QLS-215, which is in preclinical development for the treatment of hereditary angioedema, at the upcoming virtual Ladenburg Thalmann Healthcare Conference. The presentation will take place on Tuesday, July 13th, 2021 at 12:30pm ET.

    A webcast of the presentation will be available at the following link: https://wsw.com/webcast/ladenburg7/catb/2378558, and will also be available in the investors section of the Company's website, www.catabasis.com, and will be archived for 30 days following the presentation.

    About Catabasis

    At Catabasis Pharmaceuticals, our mission is to bring hope with life-changing therapies to patients and families affected by rare and niche diseases. Our lead program, QLS-215, is a monoclonal antibody inhibitor of plasma kallikrein in preclinical development for the treatment of hereditary angioedema.

    View Full Article Hide Full Article
  3. Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today announced that Jill C. Milne, Ph.D., Chief Executive Officer, will present a corporate overview and provide information on its lead program QLS-215, which is in preclinical development for the treatment of hereditary angioedema, at the following upcoming virtual investor conferences:

    • Oppenheimer Rare and Orphan Disease Summit. Presentations will be available on-demand on May 21, 2021.
    • Jefferies Virtual Healthcare Conference on June 3, 2021 at 9:30am ET.

    Webcasts of the events can be accessed from the investors section of www.catabasis.com. Archived replays will be available for 30 days following the event.

    About Catabasis

    At Catabasis Pharmaceuticals, our…

    Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today announced that Jill C. Milne, Ph.D., Chief Executive Officer, will present a corporate overview and provide information on its lead program QLS-215, which is in preclinical development for the treatment of hereditary angioedema, at the following upcoming virtual investor conferences:

    • Oppenheimer Rare and Orphan Disease Summit. Presentations will be available on-demand on May 21, 2021.
    • Jefferies Virtual Healthcare Conference on June 3, 2021 at 9:30am ET.

    Webcasts of the events can be accessed from the investors section of www.catabasis.com. Archived replays will be available for 30 days following the event.

    About Catabasis

    At Catabasis Pharmaceuticals, our mission is to bring hope with life-changing therapies to patients and families. Our lead program, QLS-215, is a monoclonal antibody inhibitor of plasma kallikrein in preclinical development for the treatment of hereditary angioedema.

    View Full Article Hide Full Article
  4.  -- QLS-215, a Potential Best-in-Class Monoclonal Antibody Inhibitor of Plasma Kallikrein, Progresses in Preclinical Development for the Treatment of Hereditary Angioedema --

    -- Strong Cash Position of $146.9M Planned to Fund IND-Enabling Studies, Phase 1a and Phase 1b/2 Clinical Trials of QLS-215 --

    Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today reported financial results for the first quarter ended March 31, 2021 and provided a corporate update.

    "We see Catabasis as being in a strong position for 2021 thanks to the acquisition of Quellis and the concurrent financing earlier this year. Our team has completed the integration of the Quellis programs and are focused on advancing the development of our lead…

     -- QLS-215, a Potential Best-in-Class Monoclonal Antibody Inhibitor of Plasma Kallikrein, Progresses in Preclinical Development for the Treatment of Hereditary Angioedema --

    -- Strong Cash Position of $146.9M Planned to Fund IND-Enabling Studies, Phase 1a and Phase 1b/2 Clinical Trials of QLS-215 --

    Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a biopharmaceutical company, today reported financial results for the first quarter ended March 31, 2021 and provided a corporate update.

    "We see Catabasis as being in a strong position for 2021 thanks to the acquisition of Quellis and the concurrent financing earlier this year. Our team has completed the integration of the Quellis programs and are focused on advancing the development of our lead program, QLS-215, as a differentiated and potential best-in-class new therapy for the chronic treatment of patients affected by hereditary angioedema to prevent attacks," said Jill C. Milne, Ph.D., Chief Executive Officer of Catabasis. "The QLS-215 program is on track with the potential to demonstrate clinical proof of concept of its differentiated profile and long antibody half-life in Phase 1a next year."

    QLS-215 for the Treatment of Hereditary Angioedema (HAE)

    • The vision for the lead program, QLS-215, is to develop the best-in-class monoclonal antibody inhibitor of plasma kallikrein for HAE with infrequent dosing and sustained inhibitory blood levels. HAE is a rare, debilitating and potentially life-threatening disease in which plasma kallikrein is a critical component that triggers a cascade of pathologic vascular permeability, vasodilation and ultimately excessive tissue swelling.
    • QLS-215 is a humanized monoclonal antibody targeting plasma kallikrein that has demonstrated potent inhibition of plasma kallikrein as well as an extended plasma half-life in non-human primates.
    • Recent discussions with physicians and patients confirm the need for effective treatments that reduce HAE attacks as well as reduce the burden of treatment.
    • Catabasis expects to file an Investigational New Drug application for QLS-215 in the first half of 2022 and plans to initiate a Phase 1a clinical trial with initial results anticipated by the end of 2022. Subsequently, Catabasis expects to initiate a Phase 1b/2 trial in patients affected by HAE in 2023 with initial results anticipated by the end of 2023.

    Acquisition of Quellis Biosciences

    • In January 2021, Catabasis acquired Quellis Biosciences Inc. in a stock-for-stock transaction whereby all outstanding equity interests of Quellis were exchanged in a merger for a combination of shares of Catabasis common stock and shares of Series X Preferred Stock.

    Private Placement Financing

    • Concurrent with the acquisition of Quellis, Catabasis entered into definitive agreements for a private placement with institutional accredited investors to raise approximately $110 million before deducting placement agent and other offering expenses, through the issuance of shares of Series X Preferred Stock. The private placement closed on February 1, 2021.
    • The financing was led by Perceptive Advisors, with participation from Fairmount Funds Management LLC, RA Capital Management, Cormorant Asset Management, Venrock Healthcare Capital Partners, Logos Capital, Boxer Capital, Acorn Bioventures, Commodore Capital, Surveyor Capital (a Citadel company), Acuta Capital Partners, Sphera Healthcare, and Serrado Capital LLC.

    Capital Structure

    • After the acquisition of Quellis and the private placement, Catabasis had approximately 23.4 million shares of common stock and 86,077 shares of non-voting Series X Preferred Stock outstanding. Subject to stockholder approval, each share of Series X Preferred Stock is convertible automatically into 1,000 shares of Catabasis common stock, subject to certain beneficial ownership limitations set by each holder not to exceed 19.99%. On a post-conversion basis, common shares outstanding will be approximately 109.5 million. The Series X Preferred Stock conversion is one of the proposals for stockholder vote at the Catabasis 2021 Annual Meeting of Stockholders, which is scheduled for June 2, 2021.

    First Quarter 2021 Financial Results

    Cash Position: As of March 31, 2021, Catabasis had cash, cash equivalents and short-term investments of $146.9 million, compared to $44.9 million as of December 31, 2020. Assuming approval of the Preferred Stock conversion, the Company expects that it has sufficient cash to fund its current operating plan through 2023. Net cash used in operating activities for the three months ended March 31, 2021 was $8.7 million, compared to $7.0 million for the three months ended March 31, 2020.

    R&D Expenses: Research and development expenses were $2.6 million for the three months ended March 31, 2021, compared to $5.3 million for the three months ended March 31, 2020.

    G&A Expenses: General and administrative expenses were $2.9 million for the three months ended March 31, 2021, compared to $2.8 million for the three months ended March 31, 2020.

    Acquired In-Process Research and Development (IPR&D) Expense: Acquired IPR&D expense was $164.6 million for the three months ended March 31, 2021. IPR&D expense resulted from the acquisition of Quellis in January 2021. The acquisition cost allocated to acquired IPR&D with no alternative future use was recorded as expense at the acquisition date. No acquired IPR&D expenses were incurred in 2020.

    Operating Loss: Loss from operations was $170.1 million for the three months ended March 31, 2021, compared to $8.0 million for the three months ended March 31, 2020.

    Net Loss: Net loss was $170.1 million, or $7.60 per share, for the three months ended March 31, 2021, compared to a net loss of $8.0 million, or $0.50 per share, for the three months ended March 31, 2020. The increase in net loss in the three months ended March 31, 2021 was due to the IPR&D expense for the acquisition of Quellis in January 2021.

    About Catabasis

    At Catabasis Pharmaceuticals, our mission is to bring hope with life-changing therapies to patients and families. Our lead program, QLS-215, is a potential best-in-class monoclonal antibody inhibitor of plasma kallikrein in preclinical development for the treatment of Hereditary Angioedema.

    Forward Looking Statements

    This press release contains forward-looking statements within the meaning of applicable securities laws and regulations including, but not limited to, statements regarding: the Company's projected cash runway; expectations regarding the timing for the filing of an IND and commencement and completion of clinical trials for QLS-215; the potential attributes of QLS-215; future product development plans; and stockholder approval of the conversion rights of the Series X preferred stock. The use of words such as, but not limited to, "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "might," "plan," "potential," "predict," "project," "should," "target," "will," or "would" and similar words expressions are intended to identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on the Company's current beliefs, expectations and assumptions regarding the future of its business, future plans and strategies, results of pre-clinical and clinical results of the Company's product candidates and other future conditions. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including risks and uncertainties: related to the Company's ability to recognize the anticipated benefits of the Quellis acquisition; the outcome of any legal proceedings that may be instituted against the Company or Quellis following the announcement of the Quellis acquisition and related transactions; costs related to the Quellis acquisition; changes in applicable laws or regulations; the possibility that the Company may be adversely affected by other economic, business, and/or competitive factors, including the COVID-19 pandemic; risks inherent in pharmaceutical research and development, such as: adverse results in our drug discovery, preclinical and clinical development activities, the risk that the results of pre-clinical studies may not be replicated in clinical studies, the Company's ability to enroll patients in our clinical trials, and the risk that any of the Company's clinical trials may not commence, continue or be completed on time, or at all; decisions made by the U.S. FDA and other regulatory authorities, investigational review boards at clinical trial sites and other review bodies with respect to QLS-215 and any future product candidates; the Company's ability to manufacture sufficient quantities of drug substance and drug product on a cost-effective and timely basis; the Company's ability to obtain, maintain and enforce intellectual property rights for QLS-215 and any other future product candidates; competition; the Company's ability to manage our cash usage and the possibility of unexpected cash expenditures; the Company's ability to obtain necessary financing to conduct our planned activities and to manage unplanned cash requirements; the Company's ability to obtain stockholder approval of the conversion rights of the Series X preferred stock within six months of the closing of the Quellis acquisition, which, if the Company is unable to obtain, would trigger the rights of such stockholders to require repayment, in cash, for the shares of common stock underlying their shares of Series X Preferred Stock at their then fair market value; general economic and market conditions; as well as the risks and uncertainties set forth under the caption "Risk Factors" in the Company's most recent Annual Report on Form 10-K filed with the SEC, as well as discussions of potential risks, uncertainties, and other important factors in the Company's subsequent filings with the SEC. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. The Company may not actually achieve the forecasts or expectations disclosed in our forward-looking statements, and investors and potential investors should not place undue reliance on the Company's forward-looking statements. Neither the Company, nor its affiliates, advisors or representatives, undertake any obligation to publicly update or revise any forward-looking statement, whether as result of new information, future events or otherwise, except as required by law. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date hereof.

     

    Catabasis Pharmaceuticals, Inc.

    Consolidated Statements of Operations

    (In thousands, except share and per share data)

    (Unaudited)

     
    Three Months Ended March 31,

     

    2021

     

     

    2020

     

     
    Operating expenses:
    Research and development

    $

    2,593

     

    $

    5,289

     

    General and administrative

     

    2,880

     

     

    2,753

     

    Acquired in-process research and development

     

    164,612

     

     

    -

     

    Total operating expenses

     

    170,085

     

     

    8,042

     

    Loss from operations

     

    (170,085

    )

     

    (8,042

    )

    Total other income, net

     

    1

     

     

    90

     

    Net loss

    $

    (170,084

    )

    $

    (7,952

    )

    Net loss per share - basic and diluted

    $

    (7.60

    )

    $

    (0.50

    )

    Weighted-average common shares outstanding used in net loss per share - basic and diluted

     

    22,380,176

     

     

    15,898,664

     

     

    Catabasis Pharmaceuticals, Inc.

    Selected Consolidated Balance Sheets Data

    (In thousands)

    (Unaudited)

     
    March 31, December 31,

     

    2021

     

     

    2020

    Assets
    Cash and cash equivalents

    $

    146,920

     

    $

    24,930

    Short-term investments

     

    -

     

     

    20,000

    Right-of-use asset

     

    874

     

     

    966

    Other current and long-term assets

     

    946

     

     

    1,560

    Total assets

     

    148,740

     

     

    47,456

    Liabilities, redeemable convertible preferred stock and stockholders' equity (deficit)
    Current portion of operating lease liabilities

     

    652

     

     

    649

    Long-term portion of operating lease liabilities

     

    229

     

     

    397

    Other current and long-term liabilities

     

    8,123

     

     

    5,741

    Total liabilities

     

    9,004

     

     

    6,787

    Total redeemable convertible preferred stock

     

    240,881

     

     

    -

    Total stockholders' equity (deficit)

    $

    (101,145

    )

    $

    40,669

     

    Catabasis Pharmaceuticals, Inc.

    Selected Consolidated Statements of Cash Flows Data

    (In thousands)

    (Unaudited)

     
    Three Months Ended March 31,

     

    2021

     

     

    2020

     

    Net cash used in operating activities

    $

    (8,716

    )

    $

    (6,989

    )

    Net cash provided by (used in) investing activities

     

    26,445

     

     

    (15,432

    )

    Net cash provided by financing activities

     

    104,261

     

     

    25,624

     

    Net increase in cash, cash equivalents and restricted cash

    $

    121,990

     

    $

    3,203

     

     

    View Full Article Hide Full Article
  5. – Five new drug therapeutic companies supported with strategic and operational guidance and seed capital –

    – Programs include a diverse portfolio of therapeutic modalities across a wide range of disease areas –

    Xontogeny LLC, a Boston-based accelerator that provides seed-stage investments along with strategic and operational support to early-stage life science companies, unveiled five of its latest portfolio companies. These early-stage startups, developing promising therapeutics for a wide range of diseases, have received seed investment and collaboration from Xontogeny to advance their preclinical programs. Since inception in 2016, Xontogeny has supported more than 10 companies through incubation, including two Xontogeny portfolio companies…

    – Five new drug therapeutic companies supported with strategic and operational guidance and seed capital –

    – Programs include a diverse portfolio of therapeutic modalities across a wide range of disease areas –

    Xontogeny LLC, a Boston-based accelerator that provides seed-stage investments along with strategic and operational support to early-stage life science companies, unveiled five of its latest portfolio companies. These early-stage startups, developing promising therapeutics for a wide range of diseases, have received seed investment and collaboration from Xontogeny to advance their preclinical programs. Since inception in 2016, Xontogeny has supported more than 10 companies through incubation, including two Xontogeny portfolio companies that had liquidity events in Q1 2021.

    This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210512005343/en/

    Xontogeny Collaborative Seed Investments (Photo: Business Wire)

    Xontogeny Collaborative Seed Investments (Photo: Business Wire)

    "We're helping founders build companies around life-saving technologies while showing that capital can be deployed more efficiently to benefit both founders and investors," said Chris Garabedian, Chairman and CEO of Xontogeny. "Through smartly deploying seed-stage investments, providing early development expertise, and active collaboration on program development, we help entrepreneurs, founding scientists, and first-time CEOs create value for their life science startups. Additionally, Xontogeny's team is fully integrated with Perceptive Advisors, serving as Perceptive's early-stage venture arm. This unique partnership gives our companies access to capital from the Perceptive Xontogeny Venture Funds (the "PXV Funds") and enables us to stay committed to our mission to support and advance life science technologies from early preclinical development through clinical proof-of-concept."

    Xontogeny provides access to seed capital and strategic support to advance companies in preclinical stages through important de-risking activities and key milestones in preparation for the next stage of financing. Once achieved, Xontogeny-supported companies will be considered for Series A financings through Xontogeny's affiliation with Perceptive Advisors and the PXV Funds. These complementary investment strategies enable the Xontogeny and Perceptive teams to support companies through the most challenging development stages: from early preclinical development to clinical proof-of-concept studies in patients. While the PXV Funds are focused on Series A and subsequent Series B financings, they are just some of Perceptive Advisors' various investment vehicles that can support life sciences companies across all stages of their investment life cycle, including late-stage private/mezzanine/crossover financings, debt financings, SPACs, and IPO/follow-on public offerings. Perceptive Advisors recently announced the final close of an oversubscribed $515 million Perceptive Xontogeny Venture Fund II, LP ("PXV Fund II"), the raise coming less than 18 months after closing of Perceptive Xontogeny Venture Fund I, LP ("PXV Fund I", collectively with PXV Fund II, the "PXV Funds"). Companies that are seeded and incubated by Xontogeny will be one source of prospective investments for PXV Fund II, along with direct Series A investments in companies that may have received investment capital and support from other seed funds, incubators, and accelerators in the life sciences sector.

    Xontogeny and the PXV Funds support opportunities across all therapeutic areas and drug modalities, including small molecules, peptides, antibodies, genetic technologies, and cell therapy. Additionally, the team can support company creation and provide financing for technologies beyond drug therapeutics, such as medical devices, diagnostics, and emerging healthtech opportunities. Two companies managed and supported by Xontogeny and PXV Fund I have already achieved public liquidity events: Landos Biopharma (NASDAQ:LABP) successfully completed its IPO in February 2021, and Quellis Biosciences was acquired by Catabasis Pharmaceuticals (NASDAQ:CATB) through a reverse merger transaction in January 2021.

    The recent additions to the Xontogeny seed-funded portfolio of companies are:

    • Nephraegis Therapeutics: Developing potential first-in-class compounds to treat renal disease with a lead program in preventing acute kidney injury (AKI) following surgical procedures such as heart valve replacement, abdominal surgery, and liver transplant. NPH-022 is a next-generation epoxyeicosatraenoic acid (EET) analog being developed in both IV and oral formulations.
    • NephroDI Therapeutics: Developing a novel AMPK activator for the treatment of the congenital rare disease of Nephrogenic Diabetes Insipidus (NDI). NDI-5033 is an oral AMPK activator that has expanded application to chronic lithium users and heterozygote NDI patients.
    • Peroxitech: Developing a novel PRDX6 inhibitory peptide-2 (PIP-2) product for the treatment of Acute Lung Injury (ALI). The PIP-2 product works through a novel pathway to eliminate reactive oxygen species that build up in the lung leading to respiratory failure with hypoxemia and tissue acidosis. The technology was developed at the University of Pennsylvania.
    • Shifa Biomedical: Developing an oral small molecule inhibitor of PCSK9 (proprotein convertase subtilisin/kexin type 9) for the treatment of dyslipidemia through lowering of LDL cholesterol. The lead product, P-21, has demonstrated good oral bioavailability and pharmacokinetics to allow for oral dosing to provide an alternative to the commercially available injectable PCSK9 monoclonal antibodies. The technology was internally developed at Shifa through NIH Phase I and Phase II SBIR grants.
    • Tellus Therapeutics: Developing an oxysterol derivative synthesized from the cholesterol found in human breast milk for the prevention and treatment of white matter brain injury in pre-term neonates. TT-20 will be delivered on top of parenteral nutrition given to neonatal intensive care unit (NICU) patients. The technology was developed at Duke University.

    About Xontogeny, LLC

    Based in Boston, MA, Xontogeny seeks to accelerate the development of life science technologies by providing entrepreneurs with funding options as well as the leadership, strategic guidance and operational support necessary to increase the probability of success in early drug and technology development. Through a differentiated approach, the Xontogeny team partners with founding scientists and entrepreneurs to support their vision while allowing a more efficient development model that benefits company founders and early equity holders. For more information visit www.xontogeny.com.

    About Perceptive Xontogeny Venture Funds

    The Perceptive Xontogeny Venture Funds are Perceptive Advisors investment vehicles focused purely on early-stage, private venture investments in life sciences companies. Primary investments for the Funds include companies that are seeking a lead investor for Series A financings, which include both companies that are seeded and incubated at Xontogeny and companies that are seeded and incubated by other organizations, accelerators and seed investors. The PXV Funds are also open to participating in syndicated Series A financings as a co-lead or passive investor with other venture capital firms. For more information, visit www.perceptivelife.com.

    View Full Article Hide Full Article
View All Catabasis Pharmaceuticals Inc. News