AVIR Atea Pharmaceuticals Inc.

75.36
-5.93  -7%
Previous Close 81.29
Open 79.48
52 Week Low 24.15
52 Week High 94.1737
Market Cap $6,226,012,372
Shares 82,616,937
Float 74,951,988
Enterprise Value $6,192,506,107
Volume 408,327
Av. Daily Volume 337,278
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Upcoming Catalysts

Drug Stage Catalyst Date
AT-527
COVID-19
Phase 2
Phase 2
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Drug Pipeline

Drug Stage Notes
AT-527
COVID-19 (Non-Hospitalized) - Virology Trial
Phase 2
Phase 2
Phase 2 initiation of dosing announced February 4, 2021.
AT-752
Dengue
Phase 1
Phase 1
Phase 1 trial to be initiated 1H 2021.
AT-777
Hepatitis C
Phase 1/2
Phase 1/2
Phase 1/2a trial planned.

Latest News

  1. BOSTON, Feb. 19, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced that Chugai Pharmaceutical Co., Ltd. (TYO:4519) has in-licensed the rights for AT-527 for the treatment of COVID-19 in Japan from Roche ((SIX: RO, ROG, OTCQX:RHHBY). Under a strategic collaboration, Roche and Atea are jointly developing AT-527 for the treatment of COVID-19 and Roche has the right to commercialize AT-527 outside of the United States. AT-527 is an orally administered, direct-acting antiviral developmental agent derived from Atea's purine nucleotide prodrug platform and is in Phase 2 development for the treatment of COVID-19.

    "This agreement between Roche and Chugai underscores…

    BOSTON, Feb. 19, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced that Chugai Pharmaceutical Co., Ltd. (TYO:4519) has in-licensed the rights for AT-527 for the treatment of COVID-19 in Japan from Roche ((SIX: RO, ROG, OTCQX:RHHBY). Under a strategic collaboration, Roche and Atea are jointly developing AT-527 for the treatment of COVID-19 and Roche has the right to commercialize AT-527 outside of the United States. AT-527 is an orally administered, direct-acting antiviral developmental agent derived from Atea's purine nucleotide prodrug platform and is in Phase 2 development for the treatment of COVID-19.

    "This agreement between Roche and Chugai underscores a commitment to global accessibility of AT-527 to fight COVID-19 and accelerates its entry into this important Asian market," said Jean-Pierre Sommadossi, Ph.D., Founder and Chief Executive Officer of Atea Pharmaceuticals. "We are delighted that Chugai, who is closely aligned with Roche through a strategic alliance, will undertake this important work, as they have commercial and development expertise and are a market leader in Japan."

    Atea and Roche announced a strategic collaboration on October 22, 2020. The collaboration aims to accelerate the clinical development and manufacturing of AT-527, to investigate its safety and efficacy, and to provide this potential treatment option to patients around the world as quickly as possible.

    About AT-527

    AT-527 is an orally administered, direct-acting developmental antiviral agent derived from Atea's nucleotide prodrug platform. AT-527 is currently under evaluation as a treatment for patients with COVID-19. In collaboration with Roche, AT-527 is currently being evaluated in a global Phase 2 study for hospitalized patients with moderate COVID-19 and a Phase 2 virology study in patients with mild or moderate COVID-19 in an outpatient setting. A pivotal Phase 3 trial is planned in the outpatient setting.

    A direct-acting antiviral aims to prevent disease progression by minimizing or eliminating viral replication and thereby reducing the severity of the disease, preventing or shortening hospitalization, and also potentially preventing transmission of the virus to others. This makes it well suited for potential use in both pre- and post-exposure prophylactic settings and complementary to vaccines.

    About Atea Pharmaceuticals

    Atea Pharmaceuticals is a clinical stage biopharmaceutical company focused on discovering, developing and commercializing therapies to address the unmet medical needs of patients with life-threatening viral diseases. Leveraging the Company's deep understanding of antiviral drug development, nucleoside biology, and medicinal chemistry, Atea has built a proprietary nucleotide prodrug platform to develop novel product candidates to treat single stranded ribonucleic acid, or ssRNA, viruses, which are a prevalent cause of severe viral diseases. Currently, Atea is focused on the development of orally-available, potent, and selective nucleotide prodrugs for difficult-to-treat, life-threatening viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, dengue virus, hepatitis C virus (HCV) and respiratory syncytial virus (RSV). For more information, please visit www.ateapharma.com.

    Contacts

    Investors:

    Jonae Barnes

    SVP, Investor Relations and Corporate Communications

    617-818-2985

    Will O'Connor

    Stern Investor Relations

    212-362-1200

    Media:

    Carol Guaccero

    301-606-4722



    View Full Article Hide Full Article
  2. BOSTON, Feb. 08, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced the publication of new data highlighting the highly potent in vitro antiviral activity of AT-527 against SARS-CoV-2. AT-527 is an orally administered, direct-acting antiviral developmental agent derived from Atea's purine nucleotide prodrug platform. The new findings are available in a manuscript published online in Antimicrobial Agents and Chemotherapy.

    "To be effective, a direct-acting antiviral needs to be administered orally, and early, in the course of viral infection in order to inhibit viral replication and thereby reduce disease progression. These new data underscore AT-527's potential…

    BOSTON, Feb. 08, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced the publication of new data highlighting the highly potent in vitro antiviral activity of AT-527 against SARS-CoV-2. AT-527 is an orally administered, direct-acting antiviral developmental agent derived from Atea's purine nucleotide prodrug platform. The new findings are available in a manuscript published online in Antimicrobial Agents and Chemotherapy.

    "To be effective, a direct-acting antiviral needs to be administered orally, and early, in the course of viral infection in order to inhibit viral replication and thereby reduce disease progression. These new data underscore AT-527's potential to treat COVID-19 and to have an impact on global health," said Jean-Pierre Sommadossi, Ph.D., Founder and Chief Executive Officer of Atea Pharmaceuticals. "The results demonstrated in several in vitro assays that AT-527 has highly potent antiviral activity against several human coronaviruses, including SARS-CoV-2, the causative agent of COVID-19. AT-527 was activated in cultured normal human nasal and bronchial epithelial cells, which are the primary targets of SARS-CoV-2 infection. Since the respiratory tract is the initial site of the SARS-CoV-2 infection, activation of AT-527 with its substantial half-life suggests sustained inhibition of viral replication of SARS-CoV-2 in these tissues."

    Antiviral therapeutics are expected to have the greatest effect if given in early stages of the COVID-19 infection when SARS-CoV-2 is rapidly replicating in the respiratory epithelium and viral load levels are high. The goal of a direct-acting antiviral is to prevent disease progression by minimizing, or eliminating, viral replication and thereby reducing the severity of the disease, preventing or shortening hospitalization, and also potentially preventing transmission of the virus to others. This makes it ideal for potential use in both pre- and post-exposure prophylactic settings and complementary to vaccines.

    In several in vitro assays, AT-511, which is the freebase of AT-527, demonstrated highly potent activity in inhibiting the replication of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. The results show that AT-511 is extensively activated in the key human primary cells, nasal and bronchial epithelial cells. Importantly, the half-life observed in these primary human cells of the upper and lower respiratory tract was approximately 40 hours, which is a key pharmacokinetic /pharmacodynamic (PK/PD) characteristic that allows accumulation of the active triphosphate metabolite of the drug candidate in these key tissues, thus resulting in the potent inhibition of SARS-CoV-2 viral replication by AT-527.

    A simulation using human PK data combined with non-human primate tissue levels was also detailed in the manuscript. The data indicate that within two hours of dosing, AT-9010 (triphosphate active metabolite of AT-527) achieved concentrations that should inhibit SARS-CoV-2 replication and that these effective levels should be maintained throughout therapy. Based on these data, a twice-daily oral regimen of AT-527 at 550 mg is currently being studied in clinical trials.

    In addition, the authors discussed RNA polymerase (nsp12) of SARS-CoV-2 and other coronaviruses, focusing on two functional domains, including RdRp and nidovirus RdRp-associated nucleotidyltransferase (NiRAN). Recent data indicate that AT-9010 (triphosphate active metabolite of AT-527) is a potent inhibitor of NiRAN, a function essential for viral replication. These findings will be published in an upcoming manuscript.

    Data Highlights

    In cultured normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by 90% (EC90) was 0.47 µM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells. Little to no cytotoxicity was observed for AT-511 at concentrations up to 100 µM. Substantial levels of the active triphosphate metabolite AT-9010 were formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 ± 15 and 236 ± 14 µM, respectively), with a half-life of at least 38 hours. Results from steady-state pharmacokinetic and tissue distribution studies of non-human primates administered oral doses of AT-527, as well as pharmacokinetic data from subjects given daily oral doses of AT-527, predict that twice daily oral doses of 550 mg AT-527 will produce AT-9010 trough concentrations in human lung that exceed the EC90 observed for the prodrug against SARS-CoV-2 replication. This suggests that AT-527 may be an effective treatment option for COVID-19.

    About AT-527

    AT-527 is an orally administered, direct-acting developmental antiviral agent derived from Atea's nucleotide prodrug platform. AT-527 is currently under evaluation as a treatment for patients with COVID-19. In collaboration with Roche, AT-527 is currently being evaluated in a global Phase 2 study for hospitalized patients with moderate COVID-19 and a Phase 2 virology study in an outpatient setting. A pivotal Phase 3 trial is planned in the outpatient setting.

    About Atea Pharmaceuticals

    Atea Pharmaceuticals is a clinical stage biopharmaceutical company focused on discovering, developing and commercializing therapies to address the unmet medical needs of patients with life-threatening viral diseases. Leveraging the Company's deep understanding of antiviral drug development, nucleoside biology, and medicinal chemistry, Atea has built a proprietary nucleotide prodrug platform to develop novel product candidates to treat single stranded ribonucleic acid, or ssRNA, viruses, which are a prevalent cause of severe viral diseases. Currently, Atea is focused on the development of orally-available, potent, and selective nucleotide prodrugs for difficult-to-treat, life-threatening viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, dengue virus, hepatitis C virus (HCV) and respiratory syncytial virus (RSV). For more information, please visit www.ateapharma.com.

    Contacts

    Investors:

    Jonae Barnes

    SVP, Investor Relations and Corporate Communications

    617-818-2985

    Will O'Connor

    Stern Investor Relations

    212-362-1200

    Media:

    Carol Guaccero

    301-606-4722



    View Full Article Hide Full Article
  3. BOSTON, Feb. 04, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced that the first patient has been dosed in the Phase 2 virology trial evaluating AT-527 in mild or moderate COVID-19 patients in an outpatient setting. The trial will enroll patients in the United Kingdom (UK), Ireland and other countries. AT-527 is an orally administered, direct-acting developmental antiviral agent derived from Atea's purine nucleotide prodrug platform.

    "In collaboration with Roche, we are initiating a randomized virology study in the UK and Ireland, where COVID-19 is fast-spreading and an estimated 30-40% of new infections involve a new mutation. This study presents the…

    BOSTON, Feb. 04, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced that the first patient has been dosed in the Phase 2 virology trial evaluating AT-527 in mild or moderate COVID-19 patients in an outpatient setting. The trial will enroll patients in the United Kingdom (UK), Ireland and other countries. AT-527 is an orally administered, direct-acting developmental antiviral agent derived from Atea's purine nucleotide prodrug platform.

    "In collaboration with Roche, we are initiating a randomized virology study in the UK and Ireland, where COVID-19 is fast-spreading and an estimated 30-40% of new infections involve a new mutation. This study presents the opportunity to investigate the antiviral activity of AT-527 in these patients. Importantly, this study is evaluating patients in an outpatient setting, which is the anticipated patient population of the upcoming Phase 3 trial," said Jean-Pierre Sommadossi, Ph.D., Founder and Chief Executive Officer of Atea Pharmaceuticals. "While vaccines will play an important role in controlling the COVID-19 pandemic, we need additional treatment options to stay ahead of the virus, and direct-acting antivirals have the potential to be an essential complement to vaccines."

    AT-527 has been shown to inhibit viral replication of SARS-CoV-2 in vitro. The ultimate goal is to effectively address the ongoing need for a safe and effective oral antiviral that is suitable for easy and early administration to reduce the severity of the disease, thereby reducing the burden on the global healthcare system.

    The randomized, double-blind, placebo-controlled Phase 2 trial will evaluate the antiviral activity, safety, and pharmacokinetics of AT-527 550 mg twice-daily in adult patients with mild or moderate COVID-19 in an outpatient setting. There will be multiple cohorts included in the trial investigating potentially alternative dosing regimens in addition to the 550 mg twice-daily dosing. The study will enroll up to 220 patients in the UK, Ireland and other countries.

    The primary endpoint of this trial is change from baseline in amount of SARS-CoV-2 virus RNA as measured by reverse transcription polymerase chain reaction (RT-PCR) at specified timepoints.

    "We look forward to rapid enrollment of this important study and hope it will provide further evidence of AT-527's antiviral activity against SARS-CoV-2. Our goal is to provide as soon as possible an easily administered and widely accessible treatment to fight this global pandemic and to treat and curtail its spread worldwide," said Janet Hammond, MD, Ph.D., Chief Development Officer of Atea Pharmaceuticals.

    About AT-527

    AT-527 is an orally administered, direct-acting developmental antiviral agent derived from Atea's nucleotide prodrug platform. AT-527 is currently under evaluation as a treatment for patients with COVID-19. AT-527 is currently being evaluated in a global Phase 2 study for hospitalized patients with moderate COVID-19 and a Phase 2 virology study. A pivotal Phase 3 trial is planned in the outpatient setting.

    About Atea Pharmaceuticals

    Atea Pharmaceuticals is a clinical stage biopharmaceutical company focused on discovering, developing, and commercializing therapies to address the unmet medical needs of patients with life-threatening viral diseases. Leveraging the company's deep understanding of antiviral drug development, nucleoside biology, and medicinal chemistry, Atea has built a proprietary nucleotide prodrug platform to develop novel product candidates to treat single stranded ribonucleic acid, or ssRNA, viruses, which are a prevalent cause of severe viral diseases. Currently, Atea is focused on the development of orally-available, potent, and selective nucleotide prodrugs for difficult-to-treat, life-threatening viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, dengue virus, hepatitis C virus (HCV) and respiratory syncytial virus (RSV). For more information, please visit www.ateapharma.com.

    Contacts

    Investors:

    Jonae Barnes

    SVP, Investor Relations and Corporate Communications

    617-818-2985

    Will O'Connor

    Stern Investor Relations

    212-362-1200

    Media:

    Carol Guaccero

    301-606-4722



    View Full Article Hide Full Article
  4. Senior executives bring proven industry experience to leadership roles in regulatory affairs and communications

    BOSTON, Jan. 19, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced that it has expanded its senior management team with the appointments of Jayanthi Wolf, Ph.D., Senior Vice President of Regulatory Affairs and Jonae Barnes, Senior Vice President of Investor Relations and Corporate Communications.

    "We are very pleased to welcome Jayanthi and Jonae to Atea," said Jean-Pierre Sommadossi, Ph.D., Founder and Chief Executive Officer of Atea Pharmaceuticals. "They bring with them extensive and highly valuable industry experience, which will expand Atea's…

    Senior executives bring proven industry experience to leadership roles in regulatory affairs and communications

    BOSTON, Jan. 19, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company, today announced that it has expanded its senior management team with the appointments of Jayanthi Wolf, Ph.D., Senior Vice President of Regulatory Affairs and Jonae Barnes, Senior Vice President of Investor Relations and Corporate Communications.

    "We are very pleased to welcome Jayanthi and Jonae to Atea," said Jean-Pierre Sommadossi, Ph.D., Founder and Chief Executive Officer of Atea Pharmaceuticals. "They bring with them extensive and highly valuable industry experience, which will expand Atea's capability as we continue to advance our corporate initiatives and our product candidates, including moving forward with the Phase 3 program for AT-527 for COVID-19 and AT-752 as a potential therapeutic for Dengue fever."

    Dr. Wolf has had an extensive career in research and development at Merck over a 19-year period. During her tenure at Merck, she served in a series of roles ranging from scientific to safety assessment and regulatory, with increasing responsibility in global regulatory affairs and clinical safety. Dr. Wolf has broad experience in regulatory affairs, including clinical, nonclinical and manufacturing and has managed programs from preclinical development through regulatory approval. She served as the global regulatory team leader for several products, including ERVEBO®, the first Ebola vaccine approved by the U.S. Food and Drug Administration, the European Medicines Agency and prequalified by the World Health Organization. Dr. Wolf earned a Ph.D. and master's degree in molecular biology and immunology from Princeton University and a B.S. in biochemistry from Susquehanna University.

    Ms. Barnes has more than 20 years of experience in the pharmaceutical and biotechnology industry. Her experience in strategic investor relations and corporate communications spans the full life cycle of drug development and commercialization. She began her career at Sepracor (now Sunovion Pharmaceuticals; acquired by Dainippon Sumitomo Pharma Co.), where she held a series of progressively responsible management and executive roles over a 14-year period and served most recently as Senior Vice President, Investor Relations, Corporate Communications and Internal Communications. Ms. Barnes has also served in senior leadership roles at several biotechnology companies including Idenix Pharmaceuticals, Agenus, and most recently at Poxel SA. Ms. Barnes earned a B.S. in political science from Suffolk University and master's degrees in financial economics and multinational commerce from Boston University.

    About Atea Pharmaceuticals

    Atea Pharmaceuticals is a clinical stage biopharmaceutical company focused on discovering, developing and commercializing therapies to address the unmet medical needs of patients with life-threatening viral diseases. Leveraging the Company's deep understanding of antiviral drug development, nucleoside biology, and medicinal chemistry, Atea has built a proprietary nucleotide prodrug platform to develop novel product candidates to treat single stranded ribonucleic acid, or ssRNA, viruses, which are a prevalent cause of severe viral diseases. Currently, Atea is focused on the development of orally-available, potent, and selective nucleotide prodrugs for difficult-to-treat, life-threatening viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, dengue virus, hepatitis C virus (HCV) and respiratory syncytial virus (RSV). For more information, please visit www.ateapharma.com.

    Contacts

    Investors:

    Jonae Barnes

    SVP, Investor Relations and Corporate Communications

    617-818-2985

     

    Will O'Connor

    Stern Investor Relations

    212-362-1200

     

    Media:

    Carol Guaccero

    301-606-4722

     



    View Full Article Hide Full Article
  5. BOSTON, Dec. 21, 2020 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing antiviral therapeutics to improve the lives of patients suffering from life-threatening viral infections, today announced that Jean-Pierre Sommadossi, Ph.D., Founder, Chairman and Chief Executive Officer of Atea will present a corporate overview at the 39th Annual J.P. Morgan Healthcare Conference on Monday, January 11, 2021 at 9:10 a.m. ET.

    A live webcast of the presentation will be available on the Company's website at www.ateapharma.com. A replay of the webcast will be available for 90 days following the presentation.

    About Atea Pharmaceuticals

    Atea…

    BOSTON, Dec. 21, 2020 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (NASDAQ:AVIR) ("Atea"), a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing antiviral therapeutics to improve the lives of patients suffering from life-threatening viral infections, today announced that Jean-Pierre Sommadossi, Ph.D., Founder, Chairman and Chief Executive Officer of Atea will present a corporate overview at the 39th Annual J.P. Morgan Healthcare Conference on Monday, January 11, 2021 at 9:10 a.m. ET.

    A live webcast of the presentation will be available on the Company's website at www.ateapharma.com. A replay of the webcast will be available for 90 days following the presentation.

    About Atea Pharmaceuticals

    Atea Pharmaceuticals is a clinical stage biopharmaceutical company focused on discovering, developing and commercializing therapies to address the unmet medical needs of patients with life-threatening viral diseases. Leveraging the Company's deep understanding of antiviral drug development, nucleoside biology, and medicinal chemistry, Atea has built a proprietary purine nucleotide prodrug platform to develop novel product candidates to treat single stranded ribonucleic acid, or ssRNA, viruses, which are a prevalent cause of severe viral diseases. Currently, Atea is focused on the development of orally-available, potent, and selective nucleotide prodrugs for difficult-to-treat, life-threatening viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, dengue virus, hepatitis C virus (HCV) and respiratory syncytial virus (RSV). For more information, please visit www.ateapharma.com.

    Contacts

    Investors:

    Will O'Connor

    Stern Investor Relations

    212-362-1200

    Media:

    Carol Guaccero

    301-606-4722



    View Full Article Hide Full Article
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