APLS Apellis Pharmaceuticals Inc.

63.99
-2.64  -4%
Previous Close 66.63
Open 66.36
52 Week Low 25.49
52 Week High 73
Market Cap $5,534,430,342
Shares 86,488,988
Float 59,779,603
Enterprise Value $5,220,721,342
Volume 744,230
Av. Daily Volume 797,629
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Upcoming Catalysts

Drug Stage Catalyst Date
EMPAVELI (pegcetacoplan) - DERBY
Geographic atrophy (GA)
Phase 3
Phase 3
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EMPAVELI (pegcetacoplan) - OAKS
Geographic atrophy (GA) associated with age-related macular degeneration (AMD)
Phase 3
Phase 3
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Drug Pipeline

Drug Stage Notes
EMPAVELI (pegcetacoplan)
C3G and IC-MPGN
Phase 2
Phase 2
Phase 3 trial to commence 2H 2021.
EMPAVELI (pegcetacoplan)
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Approved
Approved
FDA approval announced May 14, 2021.
EMPAVELI (pegcetacoplan) subcutaneous
Complement-dependent Nephropathies (CDN)
Phase 2
Phase 2
Phase 2 initial data presented at ASN November 8, 2019.
EMPAVELI (pegcetacoplan) subcutaneous
Cold agglutinin disease (CAD)
Phase 2
Phase 2
Phase 3 trial to commence 2H 2021.
EMPAVELI (pegcetacoplan) - (MERIDIAN)
Amyotrophic lateral sclerosis (ALS)
Phase 2
Phase 2
Phase 2 initiation of dosing announced November 19, 2020.
EMPAVELI (pegcetacoplan) - PRINCE
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Phase 3
Phase 3
Phase 3 top-line data demonstrated statistical superiority on the co-primary endpoints of hemoglobin stabilization - May 25, 2021.
APL-9
COVID-19 / Acute respiratory distress syndrome (ARDS)
Phase 1/2
Phase 1/2
Phase 1/2 trial to be discontinued following Independent data monitoring committee (DMC) review which found no meaningful reduction in the overall mortality rate.

Latest News

  1. WALTHAM, Mass., July 29, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced that the company will host a conference call and webcast to discuss its second quarter 2021 financial results on Monday, August 9, 2021 at 4:30 p.m. ET.

    The event will be available live by dialing (866) 774-0323 (domestic) or (602) 563-8683 (international) and entering the conference ID # 5762347 or via webcast from the "Events and Presentations" page of the "Investors and Media" section of the company's website at https://investors.apellis.com/events-and-presentations. A replay of the webcast will be available for 90 days following the event.

    About Apellis

    WALTHAM, Mass., July 29, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced that the company will host a conference call and webcast to discuss its second quarter 2021 financial results on Monday, August 9, 2021 at 4:30 p.m. ET.

    The event will be available live by dialing (866) 774-0323 (domestic) or (602) 563-8683 (international) and entering the conference ID # 5762347 or via webcast from the "Events and Presentations" page of the "Investors and Media" section of the company's website at https://investors.apellis.com/events-and-presentations. A replay of the webcast will be available for 90 days following the event.

    About Apellis

    Apellis Pharmaceuticals, Inc. is a global biopharmaceutical company that is committed to leveraging courageous science, creativity, and compassion to deliver life-changing therapies. Leaders in targeted C3 therapies, we aim to develop transformative therapies for a broad range of debilitating diseases that are driven by excessive activation of the complement cascade, including those within hematology, ophthalmology, nephrology, and neurology. For more information, please visit www.apellis.com.

    Investor Contact:

    Argot Partners



    +1 212.600.1902

     



    Primary Logo

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  2. WALTHAM, Mass., July 26, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced the closing of its previously announced privately negotiated exchange transactions (the "Exchange Transactions") with certain holders of its 3.500% Convertible Senior Notes due 2026 (the "Notes"). In the Exchange Transactions, the holders exchanged approximately $201.1 million in aggregate principal amount of Notes and Apellis issued an aggregate of 5,992,217 shares of its common stock.

    The shares of Apellis' common stock issued in the exchanges were not registered under the Securities Act of 1933, as amended, or the securities laws of any state or other jurisdiction…

    WALTHAM, Mass., July 26, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced the closing of its previously announced privately negotiated exchange transactions (the "Exchange Transactions") with certain holders of its 3.500% Convertible Senior Notes due 2026 (the "Notes"). In the Exchange Transactions, the holders exchanged approximately $201.1 million in aggregate principal amount of Notes and Apellis issued an aggregate of 5,992,217 shares of its common stock.

    The shares of Apellis' common stock issued in the exchanges were not registered under the Securities Act of 1933, as amended, or the securities laws of any state or other jurisdiction, and may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act and such other jurisdictions.

    This press release does not constitute an offer to sell or a solicitation to buy any of the securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful.

    About Apellis

    Apellis Pharmaceuticals, Inc. is a global biopharmaceutical company that is committed to leveraging courageous science, creativity, and compassion to deliver life-changing therapies. Leaders in targeted C3 therapies, we aim to develop transformative therapies for a broad range of debilitating diseases that are driven by excessive activation of the complement cascade, including those within hematology, ophthalmology, nephrology, and neurology.

    Media:

    Tracy Vineis



    +1 617 420 4839

    Investor Contact:

    Argot Partners



    +1 212.600.1902



    Primary Logo

    View Full Article Hide Full Article
  3. WALTHAM, Mass., July 07, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced that it has entered into separate, privately negotiated exchange agreements with certain holders of its 3.500% Convertible Senior Notes due 2026 (the "Notes"). Under the terms of these exchange agreements, the holders have agreed to exchange with Apellis approximately $198.6 million in aggregate principal amount of Notes held by them for (i) 4,530,431 shares of Apellis' common stock, which is equal to 22.8065 shares per $1,000 principal amount of Notes exchanged plus (ii) an additional number of shares of Apellis' common stock per $1,000 principal amount of Notes…

    WALTHAM, Mass., July 07, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced that it has entered into separate, privately negotiated exchange agreements with certain holders of its 3.500% Convertible Senior Notes due 2026 (the "Notes"). Under the terms of these exchange agreements, the holders have agreed to exchange with Apellis approximately $198.6 million in aggregate principal amount of Notes held by them for (i) 4,530,431 shares of Apellis' common stock, which is equal to 22.8065 shares per $1,000 principal amount of Notes exchanged plus (ii) an additional number of shares of Apellis' common stock per $1,000 principal amount of Notes exchanged equal to the quotient of (a) $449.64 divided by (b) the average of the daily volume-weighted average prices of Apellis' common stock over the 10 consecutive trading days commencing on July 8, 2021. The exchange transactions are expected to close on July 23, 2021, subject to the satisfaction of customary closing conditions.

    The shares of Apellis' common stock issuable in the exchanges have not been registered under the Securities Act of 1933, as amended, or the securities laws of any state or other jurisdiction, and may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act and such other jurisdictions.

    This press release does not constitute an offer to sell or a solicitation to buy any of the securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful.

    About Apellis

    Apellis Pharmaceuticals, Inc. is a global biopharmaceutical company that is committed to leveraging courageous science, creativity, and compassion to deliver life-changing therapies. Leaders in targeted C3 therapies, we aim to develop transformative therapies for a broad range of debilitating diseases that are driven by excessive activation of the complement cascade, including those within hematology, ophthalmology, nephrology, and neurology.

    Forward-Looking Statements

    Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements" within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements in respect of the expected closing of the exchanges. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including whether the conditions for the closing of the exchanges will be satisfied and other factors discussed in the "Risk Factors" section of Apellis' Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on April 28, 2021 and the risks described in other filings that Apellis may make with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Apellis specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

    Media:

    Tracy Vineis



    +1 617 420 4839

    Investor Contact:

    Argot Partners



    +1 212.600.1902



    Primary Logo

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  4. WALTHAM, Mass., July 07, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced that the company approved the grant of equity awards to one new employee with a grant date of July 1, 2021, as equity inducement awards outside of the company's 2017 Stock Incentive Plan (but under the terms of the 2020 Inducement Stock Incentive Plan) and material to the employees' acceptance of employment with the company. The equity awards were approved in accordance with Nasdaq Listing Rule 5635(c)(4).

    The employees received options to purchase 8,000 shares of Apellis common stock and 4,000 restricted stock units (RSUs). The options have an exercise price…

    WALTHAM, Mass., July 07, 2021 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (NASDAQ:APLS), a global biopharmaceutical company and leader in targeted C3 therapies, today announced that the company approved the grant of equity awards to one new employee with a grant date of July 1, 2021, as equity inducement awards outside of the company's 2017 Stock Incentive Plan (but under the terms of the 2020 Inducement Stock Incentive Plan) and material to the employees' acceptance of employment with the company. The equity awards were approved in accordance with Nasdaq Listing Rule 5635(c)(4).

    The employees received options to purchase 8,000 shares of Apellis common stock and 4,000 restricted stock units (RSUs). The options have an exercise price of $67.80, which is equal to the closing price of Apellis common stock on July 1, 2021, the grant date of the options. One-fourth of the shares underlying the employee options will vest on the one year anniversary of the grant date and thereafter 1/48th of the shares underlying the employee options will vest monthly, such that the shares underlying the options granted to the employees will be fully vested on the fourth anniversary of the grant date, subject to the employees' continued employment with Apellis on such vesting dates. Each RSU will vest as to 25% of the shares underlying the RSU award on the first anniversary of the grant date and as to an additional 25% of the shares underlying the RSU award annually thereafter, subject to each such employee's continued employment on each vesting date.

    About Apellis

    Apellis Pharmaceuticals, Inc. is a global biopharmaceutical company that is committed to leveraging courageous science, creativity, and compassion to deliver life-changing therapies. Leaders in targeted C3 therapies, we aim to develop transformative therapies for a broad range of debilitating diseases that are driven by excessive activation of the complement cascade, including those within hematology, ophthalmology, nephrology, and neurology. For more information, please visit www.apellis.com.

    Apellis Forward-Looking Statement

    Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements" within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements relating to the implications of preliminary clinical data. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether the company's clinical trials will be fully enrolled and completed when anticipated; whether preliminary or interim results from a clinical trial will be predictive of the final results of the trial; whether results obtained in preclinical studies and clinical trials will be indicative of results that will be generated in future clinical trials; whether pegcetacoplan will successfully advance through the clinical trial process on a timely basis, or at all; whether the results of the company's clinical trials will warrant regulatory submissions and whether pegcetacoplan will receive approval from the FDA or equivalent foreign regulatory agencies for GA, PNH, CAD, C3G, IC-MPGN, ALS or any other indication when expected or at all; whether, if Apellis' products receive approval, they will be successfully distributed and marketed; and other factors discussed in the "Risk Factors" section of Apellis' Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 2, 2020 and the risks described in other filings that Apellis may make with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Apellis specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.

    Investor Contact:

    Argot Partners



    +1 212.600.1902



    Primary Logo

    View Full Article Hide Full Article
  5. Cognito Therapeutics, a Phase 3-ready disease-modifying digital therapeutics company, today announced the appointment of Gerald Chan, ScD. as Chairman of the Board. Cognito is a pioneer in using neuromodulation to engage novel targets of neuronal pathophysiology to achieve disease modification in neurodegenerative diseases. Dr. Chan is the co-founder of Morningside, a privately held venture capital and private equity firm. Since inception, Morningside has focused on the development and commercialization of novel scientific discoveries in both the life sciences and technology sectors.

    "The use of non-pharmacological interventions to treat neurocognitive decline represents a fundamental shift in approach and an important expansion of biotech…

    Cognito Therapeutics, a Phase 3-ready disease-modifying digital therapeutics company, today announced the appointment of Gerald Chan, ScD. as Chairman of the Board. Cognito is a pioneer in using neuromodulation to engage novel targets of neuronal pathophysiology to achieve disease modification in neurodegenerative diseases. Dr. Chan is the co-founder of Morningside, a privately held venture capital and private equity firm. Since inception, Morningside has focused on the development and commercialization of novel scientific discoveries in both the life sciences and technology sectors.

    "The use of non-pharmacological interventions to treat neurocognitive decline represents a fundamental shift in approach and an important expansion of biotech targets in neurodegenerative diseases," said Dr. Chan. "By broadening the therapeutic target from a single protein to the underlying neuronal pathophysiology, Cognito has shown that it can fundamentally alter disease processes more than traditional modalities. I am particularly gratified to see encouraging Phase 2 results in mild-to-moderate Alzheimer's patients, and am looking forward to driving this technology forward for the benefit of patients worldwide."

    "Dr. Chan recognized early on that abnormalities in the brain's electrophysiology represent exciting novel targets for the treatment of neurodegenerative diseases and that Cognito's unique intersection of biology and technology positioned it to be a leader in this new paradigm," said Brent Vaughan, Chief Executive Officer of Cognito Therapeutics. "Gerald is a highly respected investor and driver of innovation in healthcare and technology. We are thrilled to have him as our Chairman as we advance our digital therapeutic for Alzheimer's into pivotal studies, under the FDA Breakthrough Designation granted earlier this year."

    Dr. Chan received his training from UCLA and Harvard University. He currently serves as the Chairman of Apellis Pharmaceuticals (NASDAQ:APLS) and Stealth Biotherapeutics (NASDAQ:MITO), and sits on the boards of multiple private biotechnology companies. He is the past Chairman of the Innovation Advisory Committee of the Wellcome Trust, and was recently named an Honorary Professor of Translational Medicine at the University of Manchester.

    About Cognito Therapeutics

    Cognito Therapeutics is a clinical-stage company developing a pipeline of disease-modifying digital therapeutics targeting neurodegenerative disorders. Its non-invasive neuromodulation platform was developed by MIT Professors and scientific founders Li-Huei Tsai and Ed Boyden. The Company's lead digital therapeutic reported positive Phase 2 results in Alzheimer's Disease, and was awarded FDA Breakthrough Device Designation by the FDA. Cognito is based in Cambridge, MA. For more information, visit www.cognitotx.com. Follow us on Twitter at @cognitotx.

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