1. - Advanced ALG-010133 and ALG-000184 into the clinic - both expected to generate safety and antiviral activity data in Chronic Hepatitis B (CHB) patients in 2021
    - Listed on NASDAQ Global Select Market under the symbol ALGS and raised $167.2 million in gross proceeds from the Initial Public Offering (IPO), inclusive of the underwriters' exercise of their overallotment option
    - Cash, Cash Equivalents and investments of $243.5 million as of December 31, 2020

    SOUTH SAN FRANCISCO, Calif., March 23, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced its financial results for…

    - Advanced ALG-010133 and ALG-000184 into the clinic - both expected to generate safety and antiviral activity data in Chronic Hepatitis B (CHB) patients in 2021

    - Listed on NASDAQ Global Select Market under the symbol ALGS and raised $167.2 million in gross proceeds from the Initial Public Offering (IPO), inclusive of the underwriters' exercise of their overallotment option

    - Cash, Cash Equivalents and investments of $243.5 million as of December 31, 2020

    SOUTH SAN FRANCISCO, Calif., March 23, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced its financial results for the fourth quarter and full year 2020 and provided an overview of recent business highlights.

    "Last year was a transformative year for Aligos," said Larry Blatt, PhD, MBA, CEO of Aligos. "During 2020, we became both a well-financed public company, via our $167.2 million IPO, as well as a clinical stage company by advancing our first two CHB assets, ALG-010133 and ALG-000184, into the clinic. This year is on track to be similarly impactful for Aligos as we expect to generate important proof of activity data in CHB patients for both ALG-010133 and ALG-000184 as well as advancing two more assets, ALG-020572 and ALG-055009, into the clinic."

    "The advancement of these four drug candidates towards and in the clinic this year represents the culmination of three years of hard work by all of our employees," noted Leo Beigelman, PhD, President of Aligos. "We look forward to seeing the clinical results of these efforts."

    Recent Business Highlights

    Aligos Portfolio of Drug Candidates:

    • ALG-010133 (an S-antigen Transport-inhibiting Oligonucleotide Polymer (STOPS™) molecule that is designed to decrease hepatitis B surface antigen (HBsAg) levels)
      • Single and multiple ascending dose (SAD/MAD) evaluation in healthy volunteers (HV) was completed generating data supportive of commencing dosing in CHB patients.
      • Enrollment of CHB patients is ongoing. The study is evaluating 12 weeks of once weekly subcutaneous ALG-010133/placebo dosing in virologically suppressed CHB patients. Safety and antiviral data from the initial cohort(s) is expected in the second half of 2021.
    • ALG-000184 is a small molecule class II capsid assembly modulator (CAM) that is designed to target hepatitis B virus (HBV) capsid assembly, resulting in decreased HBV DNA/RNA levels, as well as the establishment of covalently closed circular DNA (cccDNA)
      • SAD/MAD evaluation in HV was completed generating data supportive of commencing dosing in CHB patients.
      • Screening in CHB patients has commenced. The study is evaluating 28 days of once daily oral dosing of ALG-000184 or placebo in treatment naïve/currently not treated patients. Safety and antiviral data from the initial cohort(s) expected in the second half of 2021.
    • ALG-020572 (antisense oligonucleotide (ASO) that is designed to decrease HBsAg levels)
      • Advanced into clinical trial application (CTA)-enabling toxicology studies. Planned to begin Phase 1 study in the second half of 2021.
    • ALG-055009 (thyroid hormone beta agonist that is designed to reduce plasma and liver lipid levels in nonalcoholic steatohepatitis (NASH))
      • Advanced into CTA-enabling toxicology studies. Planned to begin Phase 1 study in the second half of 2021.
    • ALG-125755 (small interfering RNA (siRNA) that is designed to decrease HBsAg levels)
      • Drug candidate identified and advancing into nonclinical studies. CTA-enabling toxicology studies planned for the second half of 2021.

    Corporate:

    • Expanded the management team with the appointment of Lesley Ann Calhoun as Executive Vice President, Chief Financial Officer in June 2020. Ms. Calhoun is an experienced finance executive with 17+ years in the biopharmaceutical industry as well as an earlier career in U.S. and multinational technology companies and public accounting. Prior to Aligos, she served as Senior Vice President of finance & administration and Chief Accounting Officer at Global Blood Therapeutics, Inc.



    • Awarded €1.8 million Flemish Agency for Innovation and Entrepreneurship (VLAIO) grant to advance chronic hepatitis B research.

    CHB Related License & Collaboration Agreements:

    • Aligos and Emory University Announce Expanded License Agreement and Ink Collaboration Agreement for CHB (Q2'20)
      • The expanded license includes additional technology developed at Emory and relates to Aligos' CAM efforts in CHB.
      • The collaboration pertains to the synthesis and evaluation of CAM compounds arising from the additional licensed technology pursuant to a one-year research plan with an option to extend the plan for a second year.

    Coronavirus Related License & Collaboration Agreements:

    • Aligos Expands Licensing Agreement with Luxna Biotech in Oligonucleotide Technology to Include Novel Coronavirus Targets (Q3'20)
      • The expanded agreement grants Aligos exclusive rights to use Luxna's technology to target the genomes of certain families of respiratory viruses, including Coronaviridae, which includes SARS-CoV-2, the virus which causes COVID-19.
    • Aligos and KU Leuven Announce a Collaboration and License Agreement for the Development of a Therapeutic Candidate Targeting Coronavirus (Q3'20)
      • The agreement with KU Leuven pertains to the parties' collaboration to develop coronavirus protease inhibitors as potential therapeutic candidates to address the COVID-19 pandemic and grants to Aligos exclusive, worldwide rights to manufacture and commercialize any such resulting therapeutics.

    NASH Related License & Collaboration Agreement:

    • Aligos Enters into an Exclusive License and Research Collaboration Agreement with Merck to Discover and Develop an Oligonucleotide Therapy for NASH (Q4'20)
      • The collaboration relates to the parties' application of Aligos' oligonucleotide platform technology to discover, research, optimize and develop oligonucleotides directed against a NASH target (and up to one additional target of interest in the cardiometabolic/fibrosis space). Under the agreement, Merck is granted exclusive, worldwide rights to conduct subsequent research, clinical development and commercialization efforts of the oligonucleotides resulting from the collaboration efforts.

    Financial Results for the Fourth Quarter and Full Year 2020

    Cash, cash equivalents and investments totaled $243.5 million on December 31, 2020 compared with $127.7 million on December 31, 2019, reflecting the $167.2 million in gross proceeds from the Company's initial public offering in October 2020, inclusive of the underwriters' exercise of their overallotment option.

    Net losses for the fourth quarter and full year 2020 were $34.4 million and $108.5 million, respectively, or basic and diluted net loss per common share of $1.09 and $10.87, respectively. This compared to net losses of $18.2 million and $52.3 million, respectively, or basic and diluted net loss per common share of $7.27 and $26.04, respectively for the same periods in 2019.

    Research and development (R&D) expenses were $28.1 million and $79.9 million for the fourth quarter and full year 2020, respectively, compared to $15.0 million and $44.0 million for the same periods in 2019, respectively. The increase in R&D expenses for both comparative periods is primarily attributable to increased expenses related to the Company's development of ALG-010133 and ALG-000184 clinical trial activities, as well as increases in salaries and employee-related expenses. Total R&D stock-based compensation expense incurred for the three months ended December 31, 2020, was $0.7 million compared with $0.1 million for the same period in 2019. Total R&D stock-based compensation expense incurred in the year ended December 31, 2020, was $1.0 million, compared with $0.5 million for the same period in 2019.

    General and administrative (G&A) expenses were $6.2 million and $17.9 million for the fourth quarter and full year 2020, respectively, compared to $3.5 million and $10.0 million for the same periods of 2019, respectively. The increase in G&A for both comparative periods is primarily attributable to higher employee-related costs associated with the growth of the Company's operations and additional professional and consulting services related to being a public company. Total G&A stock-based compensation expense incurred for the three months ended December 31, 2020, was $0.6 million compared with $0.1 million for the same period in 2019. Total G&A stock-based compensation expense incurred in the year ended December 31, 2020, was $1.9 million, compared with $0.3 million for the same period in 2019.

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its team has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward-Looking Statement

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding Aligos's expectations in generating proof of activity data in CHB patients for both ALG-010133 and ALG-000184 as well as advancing ALG-020572 and ALG-055009 into the clinic in 2021; expectations in receiving safety and antiviral data from the initial CHB patient cohort(s) in the ALG-010133 study in the second half of 2021; expectations in receiving safety and antiviral data from the initial CHB patient cohort(s) in the ALG-000184 study in the second half of 2021; plans to begin Phase 1 study for ALG-020572 in the second half of 2021; plans to begin Phase 1 study for ALG-055009 in the second half of 2021; and plans to advance ALG-125755 into CTA-enabling toxicology studies in the second half of 2021. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's Annual Report on Form 10-K filed with the Securities and Exchange Commission on March 23, 2021 and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

     
    Aligos Therapeutics, Inc

    Condensed Consolidated Statements of Operations
    (In thousands, except share and per share amounts)
            
       Three Months Ended

      Year Ended

       December 31,

     December 31,

       2020   2019   2020   2019 
       (Unaudited)   (Unaudited)   (Unaudited)     
                     
    Operating Expenses:                
    Research and development $28,081  $14,973  $79,890  $44,038 
    Selling, general and administrative  6,205   3,463   17,944   10,005 
    Total operating expenses  34,286   18,436   97,834   54,043 
                     
    Loss from operations  (34,286)  (18,436)  (97,834)  (54,043)
                     
    Interest and other income (expense), net  85   337   (10,548)  1,864 
                     
    Loss before income tax expense  (34,201)  (18,099)  (108,382)  (52,179)
                     
    Income tax expense  (219)  (85)  (161)  (85)
                     
    Net loss $(34,420) $(18,184) $(108,543) $(52,264)
                     
    Basic and diluted net loss per common share  $(1.09) $(7.27) $(10.87) $(26.04)
    Weighted-average number of shares used in computing basic and diluted net loss per common share   31,465,208    2,500,501    9,988,191    2,007,173 
                    



     
    Aligos Therapeutics, Inc

    Condensed Consolidated Balance Sheets

    (in thousands)
     
      December 31, 2020  December 31, 2019
      (Unaudited)   
    Assets     
    Current assets:     
    Cash and cash equivalents$220,383 $69,565
    Short-term investments 23,130  48,098
    Prepaid expenses and other current assets 6,504  2,563
    Total current assets 250,017  120,226
    Long-term investments -  10,019
    Other assets 15,285  16,275
    Total assets$265,302 $146,520
          
    Current liabilities$30,274 $13,818
    Other liabilities, noncurrent 14,989  15,514
    Total liabilities 45,263  29,332
    Total stockholders' equity 220,039  117,188
    Total liabilities and stockholders' equity$265,302 $146,520
          

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577

     



    Primary Logo

    View Full Article Hide Full Article
  2. SOUTH SAN FRANCISCO, Calif., March 10, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company has started dosing in the first cohort of chronic hepatitis B (CHB) patients in the ongoing ALG-010133-101 study (NCT04485663). This trial is evaluating ALG-010133, a proprietary oligonucleotide S-antigen Transport-inhibiting Oligonucleotide Polymer (STOPS™) molecule, which was developed to reduce viral S-antigen (or HBsAg) levels in CHB patients.

    "S-antigen suppresses immune responses and plays a major role in maintaining HBV replication in patients with CHB…

    SOUTH SAN FRANCISCO, Calif., March 10, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company has started dosing in the first cohort of chronic hepatitis B (CHB) patients in the ongoing ALG-010133-101 study (NCT04485663). This trial is evaluating ALG-010133, a proprietary oligonucleotide S-antigen Transport-inhibiting Oligonucleotide Polymer (STOPS™) molecule, which was developed to reduce viral S-antigen (or HBsAg) levels in CHB patients.

    "S-antigen suppresses immune responses and plays a major role in maintaining HBV replication in patients with CHB," said Lawrence Blatt, Ph.D., MBA, Chief Executive Officer of Aligos. "Our lead STOPS candidate, ALG-010133, has demonstrated potent inhibition of S-antigen levels in preclinical studies. This observation, coupled with the drug's clinical profile to date, led us to initiate dosing with ALG-010133 in CHB patients to assess its ability to suppress S-antigen levels. It is exciting to have taken the first step in evaluating ALG-010133 in CHB patients. Our goal is to develop a therapeutic regimen that can lead to functional cure for patients living with CHB."

    ALG-010133-101 (NCT04485663) is a multi-part umbrella trial that is evaluating the safety, pharmacokinetics and antiviral activity of up to twelve weekly doses of subcutaneously administered ALG-010133 in healthy volunteers (HVs) and virologically suppressed patients with CHB. Seventy-two healthy volunteers have been dosed to date, and preliminary data indicate that ALG-010133 has an acceptable safety and PK profile after as many as three weekly subcutaneous doses. The drug levels achieved at doses evaluated in HVs are expected to result in antiviral activity, thus supporting further evaluation of ALG-010133 in CHB patients.

    Matthew W. McClure, M.D., Chief Medical Officer of Aligos, added, "This is an exciting next step for Aligos. We have now entered an important phase in the ALG-010133-101 study where we will define the clinical profile of ALG-010133 in our target population, patients with CHB. We expect to begin reporting safety, pharmacokinetic, and antiviral activity data for ALG-010133 from the initial patient cohorts of this study in the second half of 2021."

    Professor Ed Gane, MB ChB, Principal Investigator for the ALG-010133-101 study, added, "I believe that drugs that reduce S-antigen levels will play an important role in achieving much higher rates of functional cure than can be achieved with current therapies and look forward to evaluating the potential role that this promising drug candidate may play in future treatment regimens."

    Aligos' STOPS program represents one of several in the company's CHB portfolio that target different clinically validated mechanisms of action in the hepatitis B virus life cycle. The portfolio also includes capsid assembly modulator (CAM), antisense oligonucleotide (ASO), and small interfering RNA (siRNA) drug candidates. The properties of these candidates indicate that their use in combination could yield potentially best-in-class treatment regimens that may achieve higher rates of functional cure than current standard of care. For each of these drug candidates, Aligos plans to initially establish proof of concept as monotherapy in Phase 1 umbrella trials before evaluating them in combination in subsequent trials.

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its team has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward-Looking Statement

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding Aligos's goal to develop a therapeutic regimen that can lead to functional cure for patients living with CHB; expectations that the drug levels achieved at doses evaluated in HVs will result in antiviral activity and thus supporting further evaluation of ALG-010133 in CHB patients; plans to define the clinical profile of ALG-010133 in patients with CHB in its ALG-010133-101 study; expectations to begin reporting safety, pharmacokinetic, and antiviral activity data for ALG-010133 from the initial patient cohorts of the study in the second half of 2021; use of Aligos' candidates in its CHB portfolio in combination yielding potentially best-in-class treatment regimens that may achieve higher rates of functional cure than current standard of care; plans to initially establish proof of concept as monotherapy in Phase 1 umbrella trials before evaluating its CHB candidates in combination in subsequent trials; belief that drugs which reduce S-antigen levels will play an important role in achieving much higher rates of functional cure than can be achieved with current therapies; and evaluation of the potential role that ALG-010133 may play in future treatment regimens. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577

     



    Primary Logo

    View Full Article Hide Full Article
  3. SOUTH SAN FRANCISCO, Calif., March 08, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company delivered a presentation on its SARS-CoV-2 3CLpro inhibitor candidate, ALG-097111, at the 28th Conference on Retroviruses and Opportunistic Infections, being held virtually March 6 to March 10, 2021, during the meeting's Science Spotlight sessions on Saturday, March 6. Aligos performed all research in collaboration with Belgian University KU Leuven, in particular its Centre for Drug Design and Discovery (CD3), and the Rega Institute for Medical Research.

    "Along…

    SOUTH SAN FRANCISCO, Calif., March 08, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company delivered a presentation on its SARS-CoV-2 3CLpro inhibitor candidate, ALG-097111, at the 28th Conference on Retroviruses and Opportunistic Infections, being held virtually March 6 to March 10, 2021, during the meeting's Science Spotlight sessions on Saturday, March 6. Aligos performed all research in collaboration with Belgian University KU Leuven, in particular its Centre for Drug Design and Discovery (CD3), and the Rega Institute for Medical Research.

    "Along with our collaborators at CD3 and the Rega Institute, we are proud to have shown what we believe is the first instance of in vivo evidence of SARS-CoV-2 inhibition with a therapeutic candidate in the class of SARS-CoV-2 3CLpro inhibitor compounds," said Pierre J.M.B. Raboisson, Pharm.D. Ph.D., Executive Vice President, Head of Small Molecule Medicinal Chemistry and European Site Head at Aligos. "We have also observed highly specific, selective activity in vitro that is consistent with the robust viral inhibition we see in aggressive animal models of infection. These findings represent a significant advance toward a highly targeted therapeutic candidate that is urgently needed as the COVID-19 pandemic persists."

    The presentation, titled "The 3CLpro Inhibitor ALG-097111 Potently Inhibits SARS-CoV-2 Replication in Hamsters," demonstrated that Aligos' nonclinical SARS-CoV-2 therapeutic candidate, ALG-097111, potently inhibited SARS-CoV-2 replication in vivo in the lungs of SARS-CoV-2-infected hamsters, one of the most severe animal models of SARS-CoV-2 infection available. When ALG-097111 was dosed in hamsters challenged with SARS-CoV-2, the authors observed a robust and significant 3.5 log10 (RNA copies/mg) reduction of the viral RNA copies and 3.7 log10 (TCID50/mg) reduction in the infectious virus titers in the lungs. These results provide the first in vivo validation for the SARS-CoV-2 3-chymotrypsin-like cysteine protease (3CLpro), an essential SARS-CoV-2-encoded enzyme, as a promising therapeutic target in COVID-19.

    The anti-SARS-CoV-2 activity of ALG-097111 was confirmed in human small airway epithelial cell cultures: when ALG-097111 was added at a concentration of 1µM to the basolateral side of the cultures, the compound significantly reduced viral RNA yield at the apical site of the culture by over 3 log10 RNA copies/mg.

    ALG-097111 also demonstrated high specificity (IC50 = 7 nM) and selectivity in vitro for the viral protease relative to the similar human protease cathepsin L (IC50 > 10 µM), whose inhibition presents potential safety and efficacy concerns for other 3CLpro inhibitors in development.

    Aligos CEO Lawrence Blatt, Ph.D., MBA, added, "As the COVID-19 pandemic evolves, new strains of SARS-CoV-2 have emerged that may be resistant to vaccine-mediated immune responses. We therefore see a significant need to develop treatment options that effectively block SARS-CoV-2 replication in patients who either have not been vaccinated or who are infected with vaccine-resistant strains. The demonstration of potent preclinical activity in Aligos' viral protease inhibitor candidate is an important advancement toward this goal."

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its team has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward-Looking Statement

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding the advancement of any Aligos SARS-CoV-2 3CLpro inhibitor compound (e.g., ALG-097111) as a targeted therapeutic candidate and the development of treatment options that effectively block SARS-CoV-2 replication in patients who either have not been vaccinated or who are infected with vaccine resistant strains. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577

     



    Primary Logo

    View Full Article Hide Full Article
  4. SOUTH SAN FRANCISCO, Calif., Feb. 03, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company will deliver four poster presentations at the 30th Annual Conference of the Asian Pacific Association for the Study of the Liver (APASL), taking place virtually from February 4 through February 6, 2021.

    "We are proud to show progress for two of our clinical candidates from our chronic hepatitis B portfolio," said Aligos CEO Lawrence Blatt, Ph.D., MBA. "Both candidates are currently being evaluated in Phase 1a/b umbrella studies where we will evaluate each for antiviral…

    SOUTH SAN FRANCISCO, Calif., Feb. 03, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company will deliver four poster presentations at the 30th Annual Conference of the Asian Pacific Association for the Study of the Liver (APASL), taking place virtually from February 4 through February 6, 2021.

    "We are proud to show progress for two of our clinical candidates from our chronic hepatitis B portfolio," said Aligos CEO Lawrence Blatt, Ph.D., MBA. "Both candidates are currently being evaluated in Phase 1a/b umbrella studies where we will evaluate each for antiviral activity in CHB patients following demonstration of safety and tolerability in healthy volunteers. These trials are part of a larger plan to develop highly effective treatments using combinations of multiple novel drugs from our portfolio. We look forward to advancing our other lead candidates targeting other viral mechanisms of action into the clinic alongside ALG-010133 and ALG-000184."

    Three of the presentations highlight encouraging data from Aligos' two most advanced CHB candidates for development toward a combination therapy for chronic hepatitis B (CHB): STOPS™ (ALG-010133), a proprietary oligonucleotide designed to inhibit hepatitis B virus (HBV) S-antigen (or HBsAg) replication, and ALG-000184, a capsid assembly modulator (CAM), designed to inhibit HBV replication.

    The first presentation, titled "Preclinical Efficacy and Pharmacokinetics of ALG-010133, an S-Antigen Transport-inhibiting Oligonucleotide Polymers (STOPS) for the Treatment of Chronic Hepatitis B (CHB)", demonstrated that Aligos' lead STOPS candidate inhibited S-antigen release from cells in several lines of human hepatocytes. In vivo, ALG-010133 demonstrated high, rapid and sustained exposure in the liver following single subcutaneous injections given to nonclinical species, predicting once-weekly dosing in humans. Further, a nonclinical multiple dosing study in which animals were given three weekly subcutaneous doses demonstrated sufficient concentrations in the liver sufficient for projected efficacy in human CHB patients. Together, the combination of excellent in vitro efficacy and a favorable pharmacokinetic profile in vivo has justified ALG-010133's progression to a Phase 1a/b trial for evaluation as a potential treatment for CHB.

    A second presentation, "Safety, tolerability and pharmacokinetics of single ascending doses of ALG-000184, a Class II Capsid Assembly Modulator for the treatment of Chronic Hepatitis B (CHB), in healthy volunteers (HV)", outlined preliminary data supporting further evaluation of Aligos' small molecule candidate ALG-000184 in healthy volunteers and in CHB patients, as planned in the ongoing Phase 1a/b trial. At single oral doses of up to 500 mg, ALG-000184 was safe, well-tolerated and demonstrated a linear pharmacokinetic profile supporting once-daily oral dosing. Doses of 100 mg or higher resulted in plasma concentrations of active compound that are projected to result in antiviral activity in CHB patients.

    Two other poster presentations entitled "Excellent preclinical characteristics of ALG-000184, a prodrug of the HBV capsid assembly modulator ALG-001075" and "ALG-020572, a next generation hepatitis B virus (HBV) antisense oligonucleotide (ASO) with bridged nucleic acid chemistry, has a significantly improved preclinical profile" highlight the nonclinical characteristics of ALG-000184 and its parent compound, ALG-001075, and ALG-020572, Aligos' ASO candidate for chronic hepatitis B that significantly improves upon other ASOs in terms of nonclinical safety and efficacy.

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its workforce has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward-Looking Statement

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding our plan to evaluate each of our clinical candidates for antiviral activity in CHB patients following demonstration of safety and tolerability in healthy volunteers; our plan to develop highly effective treatments using combinations of multiple novel drugs from our portfolio; our advancing our other lead candidates targeting other viral mechanisms of action into the clinic alongside ALG-010133 and ALG-000184; ALG-010133's progression to a Phase 1a/b trial for evaluation as a potential treatment for CHB following excellent in vitro efficacy and a favorable pharmacokinetic profile in vivo; and further evaluation of Aligos' small molecule candidate ALG-000184 in healthy volunteers and in CHB patients as planned in the ongoing Phase 1a/b trial. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

     

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577

     



    Primary Logo

    View Full Article Hide Full Article
  5. SOUTH SAN FRANCISCO, Calif., Jan. 07, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that CEO Lawrence Blatt, Ph.D., MBA, will present at the 39th Annual J.P. Morgan Healthcare Conference on Monday, January 11, 2021 at 3:40 p.m. ET/12:40pm PT. The presentation will be followed by a virtual Q&A session.

    A recording of the webcast presentation will be available within 24 hours of the presentation and will be available for 30 days through the Investors section of the Aligos website. https://investor.aligos.com

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage…

    SOUTH SAN FRANCISCO, Calif., Jan. 07, 2021 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that CEO Lawrence Blatt, Ph.D., MBA, will present at the 39th Annual J.P. Morgan Healthcare Conference on Monday, January 11, 2021 at 3:40 p.m. ET/12:40pm PT. The presentation will be followed by a virtual Q&A session.

    A recording of the webcast presentation will be available within 24 hours of the presentation and will be available for 30 days through the Investors section of the Aligos website. https://investor.aligos.com

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its team has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward-Looking Statement

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements". Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577



    Primary Logo

    View Full Article Hide Full Article
  6. SOUTH SAN FRANCISCO, Calif., Dec. 17, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company delivered an oral and poster presentation today at the RespiDART & Emerging Viruses 2020 meeting. The presentation highlighted the company's progress with developing a SARS-CoV-2 therapeutic candidate, as well as the development of a screening method to assess potential candidates. Aligos performed all research in collaboration with Belgian University KU Leuven, in particular its Centre for Drug Design and Discovery (CD3), and the Rega Institute for Medical Research…

    SOUTH SAN FRANCISCO, Calif., Dec. 17, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company delivered an oral and poster presentation today at the RespiDART & Emerging Viruses 2020 meeting. The presentation highlighted the company's progress with developing a SARS-CoV-2 therapeutic candidate, as well as the development of a screening method to assess potential candidates. Aligos performed all research in collaboration with Belgian University KU Leuven, in particular its Centre for Drug Design and Discovery (CD3), and the Rega Institute for Medical Research.

    The presentation, titled "Structure-based discovery of potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitors using a multiplex screening platform," describes the authors' mass spectrometry-based assay developed to assess putative coronaviral 3-chymotrypsin-like cysteine protease (3CLpro) inhibitors in development for therapeutic use against SARS-CoV-2, including Aligos' own 3CLpro inhibitor candidate, ALG-097111. Coronaviral 3CLpro is a promising therapeutic target, as it is essential and conserved among coronaviruses but is not found in humans.

    Aligos and collaborators launched a structure-based approach to identify novel coronaviral 3CLpro inhibitors that were evaluated in the in-house developed multiplex SARS-CoV-2 3CLpro/human rhinovirus 3C (HRV3C) protease assay to assess their specificity and selectivity.

    Unlike all other SARS-CoV-2 3CLpro compounds tested with the screening platform to date, Aligos' lead compound ALG-097111 demonstrated potent SARS-CoV-2 3CLpro inhibition, without inhibiting human cathepsin L protease activity up to the highest concentration tested (IC50 > 10 µM). Cathepsin L has been shown to be involved in a highly redundant entry pathway of SARS-CoV-2 into different cell types. As the competition between the viral 3CLpro and the host cathepsin L might eventually act as a decoy mechanism in vivo, the identification of potent inhibitors selective for the viral 3CLpro represents an important breakthrough.

    "We are pleased that our work with CD3 and the Rega Institute has yielded a platform that we can use to optimize our SARS-CoV-2 3CLpro inhibitors," said Pierre J.M.B. Raboisson, Pharm.D. Ph.D., Vice President, Head of Small Molecule Medicinal Chemistry and European Site Head at Aligos. "A highly specific, selective small molecule anti-coronaviral therapeutic will likely be indispensable as part of an effective treatment regimen against SARS-CoV-2, whereas treatments repurposed from other viral indications may fall short. We are encouraged to see potent protease inhibition activity with ALG-097111 and we continue to refine the candidate's chemistry for optimal potency."

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its workforce has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward-Looking Statement

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding the ability to use the platform arising from the collaboration with CD3 and the Rega Institute to optimize SARS-CoV-2 3CLpro inhibitors; the likelihood of specific, selective small molecule anti-coronaviral therapeutic being indispensable as part of an effective treatment regimen against SARS-CoV-2; and the continued refinement of the chemistry of ALG-097111 for optimal potency. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577



    Primary Logo

    View Full Article Hide Full Article
  7. SOUTH SAN FRANCISCO, Calif., Dec. 07, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS) today announced that it has entered into an Exclusive License and Research Collaboration Agreement with Merck, known as MSD outside the United States and Canada, under which Merck and Aligos will apply Aligos' oligonucleotide platform technology to discover, research, optimize and develop oligonucleotides directed against a non-alcoholic steatohepatitis (NASH) target and up to one additional target of interest in the cardiometabolic/fibrosis space.

    "We have assembled a team of scientists and medical professionals with significant experience in oligonucleotide-based drug discovery and we have developed a proprietary oligonucleotide chemistry…

    SOUTH SAN FRANCISCO, Calif., Dec. 07, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS) today announced that it has entered into an Exclusive License and Research Collaboration Agreement with Merck, known as MSD outside the United States and Canada, under which Merck and Aligos will apply Aligos' oligonucleotide platform technology to discover, research, optimize and develop oligonucleotides directed against a non-alcoholic steatohepatitis (NASH) target and up to one additional target of interest in the cardiometabolic/fibrosis space.

    "We have assembled a team of scientists and medical professionals with significant experience in oligonucleotide-based drug discovery and we have developed a proprietary oligonucleotide chemistry platform that has broad applicability across diverse therapeutic areas," said Lawrence Blatt, Ph.D., MBA, Chief Executive Officer of Aligos. "Given the imperative to find new innovative treatments for NASH, a chronic liver disease that can progress to fibrosis, cirrhosis, end-stage liver disease and hepatocellular carcinoma, we are pleased to collaborate with Merck to advance the development of potentially effective therapeutic regimens."

    Aligos is a clinical-stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in liver diseases, including chronic hepatitis B (CHB) and NASH. The company has extensive expertise and resources necessary to develop oligonucleotide candidates for liver diseases, including STOPS™ molecules as well as antisense oligonucleotide (ASO) and small interfering RNA (siRNA) candidates in development for Aligos' program in CHB.

    "NASH continues to represent a serious unmet need and will likely require multiple targeted therapeutic approaches," said Dr. Ajay Chawla, Vice President, Cardiometabolic Disease Discovery, Merck Research Laboratories. "We look forward to working with the scientists at Aligos to apply their novel oligonucleotide-based platform."

    Under the terms of the agreement, Aligos will receive an upfront payment from Merck as well as an additional payment upon designation of a second target for the collaboration. With respect to each collaboration target, Aligos will be eligible for up to $458M in development and commercialization milestones as well as tiered royalties on net sales. Aligos will be primarily responsible for designing, preparing and evaluating the oligonucleotide molecules and delivering optimized lead molecules, and Merck will be responsible for subsequent research, clinical development and commercialization efforts.

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the discovery and development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its workforce has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward-Looking Statement

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding the advancement of the development of potentially effective therapeutic regimens for NASH, Aligos' eligibility on receiving development and commercialization milestones and royalties from Merck as well as Aligos' strategy to advance its own pipeline of potentially best-in-class molecules. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577

    com



    Primary Logo

    View Full Article Hide Full Article
  8. SOUTH SAN FRANCISCO, Calif., Nov. 16, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company has delivered six poster presentations and an oral presentation at this year's American Association for the Study of Liver Diseases (AASLD) Liver Meeting Digital Experience™ (TLMdX) 2020, held virtually on November 13-16, 2020. The data presented includes updates from three of Aligos' assets in its lead chronic hepatitis B (CHB) combination therapy platform, as well as data from the company's nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) programs…

    SOUTH SAN FRANCISCO, Calif., Nov. 16, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that the company has delivered six poster presentations and an oral presentation at this year's American Association for the Study of Liver Diseases (AASLD) Liver Meeting Digital Experience™ (TLMdX) 2020, held virtually on November 13-16, 2020. The data presented includes updates from three of Aligos' assets in its lead chronic hepatitis B (CHB) combination therapy platform, as well as data from the company's nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) programs.

    "We are proud of the progress we have made for the Aligos' liver disease programs as outlined in our presentations during this year's AASLD Liver Meeting," said Lawrence Blatt, Ph.D., MBA, Chief Executive Officer of Aligos. "We are working towards producing a combination regimen of promising therapeutics that have the potential to lead to functional cures for patients living with chronic hepatitis B. Additionally, our team has made substantial progress on ALG-055009, a potent and selective purpose built THR beta agonist for the treatment of NASH. Two of our drug candidates, ALG-010133 (STOPS™) and ALG-000184 (CAM), aimed at the treatment of chronic hepatitis B have already begun Phase 1 clinical trials and we look forward to advancing the remainder of our liver disease portfolio towards clinical development over the coming year."

    Chronic hepatitis B

    Antisense oligonucleotide (ASO)

    Title: Development of a Best-in-Class HBV ASO, ALG-020572, for the Treatment of Chronic Hepatitis B: Potential for Combination with other Anti-HBV Agents

    Authors: Jin Hong, et al.

    Presentation type: Oral presentation

    Summary: Aligos' ASO candidates for chronic hepatitis B significantly improve upon other ASOs in terms of nonclinical safety. ALG-020572, which targets the open reading frame (ORF) of the small HBsAg, demonstrates excellent in vivo potency and safety profiles in an AAV-HBV mouse efficacy model. ALG-020572 or its unconjugated form demonstrated additive to synergistic activity when combined with other anti-HBV agents in vivo or in vitro.

    Capsid assembly modulator (CAM)

    Title: Best-in-class preclinical characteristics of ALG-000184, a prodrug of the capsid assembly modulator ALG-001075 for the treatment of chronic hepatitis B

    Abstract number: 0823

    Presentation type: Poster

    Authors: Andreas Jekle, et al.

    Summary: The in vitro antiviral profile and ADME characteristics of ALG-000184, Aligos' capsid assembly modulator (CAM) candidate for chronic hepatitis B, are described. ALG-001075 is a class-II CAM with broad and potent anti-HBV activity.

    In cell-based assays, both compounds inhibited HBV DNA with nanomolar EC50 values. ALG-001075 had broad antiviral activity against 37 clinical isolates of the hepatitis B virus and retained activity against 6 known CAM resistance mutations, while T33N reduced ALG-001075's antiviral activity 28-fold.

    Oral administration of ALG-000184 in a tablet formulation at doses of 1 to 12.6 mg/kg resulted in complete oral absorption and high exposure to ALG-001075.

    S-antigen Transport-inhibiting Oligonucleotide Polymer (STOPS™)

    Title: ALG-010133, a Representative S-Antigen Transport-inhibiting Oligonucleotide Polymer (STOPS™) Effectively Inhibits Hepatitis B Surface Antigen (HBsAg) Secretion in Multiple Hepatitis B Virus (HBV) Cell Models

    Abstract number: 0821

    Presentation type: Poster

    Authors: Yuchun Nie et al.

    Summary: ALG-010133 demonstrated robust inhibition of HBsAg release in multiple cell lines and infected liver cells across HBV genotypes, with enhanced activity compared to the structurally similar clinical-stage nucleic acid polymer REP-2139. Additionally, intracellular HBsAg was also reduced, suggesting that HBsAg was degraded inside the cell rather than trapped intracellularly.

    ALG-010133 inhibited HBsAg release with the following EC50 values in respective cell models:

    • 3.9 nM in HepG2.2.15
    • 23.7 nM in PLC/PRF 5
    • 3.2 nM in HBV-infected HepG2-NTCP cells
    • 5.9 nM in HBV-infected PHH cells

    Title: The S-Antigen Transport-Inhibiting Oligonucleotide Polymer (STOPS™) ALG-010133 Demonstrates a Favorable Preclinical Profile for the Treatment of Chronic Hepatitis B

    Abstract number: 0831

    Presentation type: Poster

    Authors: Vikrant Gohil, et al.

    Summary: Aligos' STOPS candidate for use in chronic hepatitis B, currently in a Phase 1a/b trial, was evaluated for pharmacokinetic and overall safety profile in nonclinical species through subcutaneous or intravenous dosing.

    Results included the following:

    • 2-week repeat dose studies with weekly SC dosing in nonclinical species showed that ALG-010133 was well tolerated to up to the highest dose tested (50 mg/kg).
    • Rapid uptake and long half-life were demonstrated, with significant recovery in all tissues four weeks after the final dose in nonclinical species.

    NASH

    Title: Characterization of Thyroid Hormone Receptor (THR) Agonists for the Treatment of Non-Alcoholic Steatohepatitis (NASH) by Quantification of Gene Transcription in Human Hepatocytes

    Abstract number: 1665

    Presentation type: Poster

    Authors: Xuan Luong, et al.

    Summary: A fast, high-throughput strategy to rank THR agonist compound efficacy was implemented by using human-derived hepatocytes and quantifying changes in the hepatocytes' transcription of specific genes specific to cholesterol and fatty acid biosynthesis and metabolism directly downstream of THR binding and activation. The ability of three THR agonists to modulate the expression of genes specific to cholesterol and fatty acid biosynthesis and metabolism were compared to one another in vitro and replicated in vivo in a high fat diet-fed rat model for confirmation. Using human-derived hepatocytes provides more biologically relevant data compared to biochemical or non-hepatocyte screening assays.

    Title: ALG-055009, a Potent and Selective THR Beta Agonist for the Treatment of NASH, Demonstrates Significant Cholesterol Reduction in a Diet-Induced Obese (DIO) Mouse Efficacy Model

    Abstract number: 1656

    Presentation type: Poster

    Authors: Kusum Gupta, et al.

    Summary: Aligos' THR-β agonist candidate ALG-055009 in development for NASH is highly efficacious in a diet-induced obese mouse model. With its high and selective potency combined with projected low doses in humans, ALG-055009 has the potential to be a best-in-class THR-β agonist for the treatment of NASH.

    In DIO mouse models, the minimum efficacious dose of 0.15 mg/kg/dose twice daily resulted in 17% and 34% reductions in total and LDL cholesterol, respectively. None of the doses induced any significant changes in gene expression in the heart, indicating a potentially wide safety margin.

    Hepatocellular carcinoma

    Title: Tumor Regression in a Mouse Model of Hepatocellular Carcinoma Upon Treatment with the STING Agonist ALG-031048

    Abstract number: 1118

    Authors: Andreas Jekle, et al.

    Summary: Aligos' novel STING agonist ALG-031048 was evaluated in the Hepa1-6 HCC mouse model, for potential use in the treatment of advanced hepatocellular carcinoma.

    Three intratumorally administrated doses of ALG-031048 induced robust dose-dependent anti-tumor activity, resulting in an average 14% tumor reduction (TR) at 25 μg dosing, with tumor regression achieved in 7 of 10 mice; and 88% tumor regression at 100 μg dosing, with tumor regression achieved in all 10 mice. Both were an improvement over single agent anti-PD-1 treatment.

    After intratumoral and subcutaneous administration in CT26 and MC38-hPD-L1 murine models of colon carcinoma, ALG-031048 showed strong anti-tumor activity, which was augmented in combination with antibodies against the immune checkpoint inhibitor CTLA-4 in the CT26 model or in combination with the anti-PD-L1 antibody, atezolizumab, in the MC38-hPD-L1 model.

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its workforce has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward Looking Statements

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," Including without limitation statements regarding our working towards producing a combination regimen of therapeutics that may lead to functional cures for patients living with CHB and our looking forward to advancing the remainder of our liver disease portfolio towards clinical development over the coming year. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577



    Primary Logo

    View Full Article Hide Full Article
  9. SOUTH SAN FRANCISCO, Calif., Nov. 13, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that management will be participating in two upcoming virtual investor conferences and invites investors to participate by webcast. Please see additional details below:

    • Jefferies 2020 Virtual London Healthcare Conference, November 17-19, 2020
      Management will deliver a company presentation on Thursday, November 19 at 10:50 a.m. ET (3:50 p.m. GMT) and will also be available for one-on-one meetings. A live and archived webcast of the presentation will be available on the Investors…

    SOUTH SAN FRANCISCO, Calif., Nov. 13, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that management will be participating in two upcoming virtual investor conferences and invites investors to participate by webcast. Please see additional details below:

    • Jefferies 2020 Virtual London Healthcare Conference, November 17-19, 2020

      Management will deliver a company presentation on Thursday, November 19 at 10:50 a.m. ET (3:50 p.m. GMT) and will also be available for one-on-one meetings. A live and archived webcast of the presentation will be available on the Investors section of the Aligos website: https://investor.aligos.com
    • Piper Sandler 32nd Annual Virtual Healthcare Conference, December 1-3, 2020

      Management will present in a fireside chat format and will be available for one-on-one meetings. The presentations will be available prior to the dates of the conference. A replay of the fireside chat will be available in the Investors section of the Aligos website: https://investor.aligos.com

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its workforce has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Please visit www.aligos.com for more information.

    Forward Looking Statements

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements." Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577



    Primary Logo

    View Full Article Hide Full Article
  10. SOUTH SAN FRANCISCO, Calif. and LEUVEN, Belgium, Nov. 12, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that its Belgian subsidiary Aligos Belgium BV has been awarded a €1.8M grant by the Flemish Agency for Innovation and Entrepreneurship (VLAIO) to support a nonclinical research project related to combination therapy for Hepatitis B at Aligos (CoHeBA).

    "CoHeBA aims to elucidate the mechanism of action of the therapeutic candidates for chronic hepatitis B (CHB) currently in development at Aligos," said Yannick Debing, Ph.D., principal scientist and lead on the project…

    SOUTH SAN FRANCISCO, Calif. and LEUVEN, Belgium, Nov. 12, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that its Belgian subsidiary Aligos Belgium BV has been awarded a €1.8M grant by the Flemish Agency for Innovation and Entrepreneurship (VLAIO) to support a nonclinical research project related to combination therapy for Hepatitis B at Aligos (CoHeBA).

    "CoHeBA aims to elucidate the mechanism of action of the therapeutic candidates for chronic hepatitis B (CHB) currently in development at Aligos," said Yannick Debing, Ph.D., principal scientist and lead on the project application. "The support from VLAIO will allow us to collaborate with some of the most esteemed leaders in the hepatitis B field to identify how Aligos' CHB assets target components of the hepatitis B virus life cycle. Developing a greater understanding of the candidates' mechanism of action will empower our scientific team to develop pharmacologically best-in-class therapies."

    The three-year project will include collaborations with the laboratories of Prof. Jan Paeshuyse (KU Leuven, Belgium), Profs. Stephen Locarnini and Hans Netter (VIDRL, Melbourne, Australia), Profs. Patrick Kennedy and Upkar Gill (Queen Mary University London, United Kingdom), and Profs. Thomas Baumert and Eloi Verrier (INSERM U1110, University of Strasbourg, France).

    "Our team at Aligos Belgium BV contributes greatly to our success in discovering potential therapies for an infection that affects hundreds of millions of people, increasing their risk of end-stage liver disease," said Lawrence Blatt, Ph.D., MBA, Chief Executive Officer of Aligos. "We expect that the outcomes of this project will help us design the most promising combination therapies and next-generation therapeutics for those patients."

    About Chronic Hepatitis B (CHB)

    CHB is a major cause of chronic liver disease that affects over 290 million people worldwide. Serious complications of CHB include cirrhosis and liver cancer, which are associated with significant mortality. Approximately 900,000 people died from CHB-related causes in 2015 alone and the mortality rate associated with HBV-related liver cancer continues to increase. Although current standard of care for patients with CHB is effective in suppressing HBV, it is associated with very low rates of functional cure, which is the goal for future CHB treatments.

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its workforce has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    About the Agency for Innovation & Entrepreneurship

    (Agentschap Innoveren & Ondernemen, VLAIO)www.vlaio.be

    This project is supported by the Agency for Innovation & Entrepreneurship, the point of contact of the Flemish Government for all entrepreneurs in Flanders. VLAIO stimulates and supports innovation and entrepreneurship and contributes to a favorable entrepreneurial climate, in collaboration with many partners.

    Forward Looking Statements

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding Aligos's expectations that the outcomes of the CoHebA project will enable Aligos' development of next generation, pharmacologically best-in-class therapies and Aligos' design of combination therapies. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192

    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577

     

    Primary Logo

    View Full Article Hide Full Article
  11. SOUTH SAN FRANCISCO, Calif., Oct. 30, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that it has dosed its first subject in a first-in-human Phase 1a/b clinical trial, ALG-000184-201 (NCT04536337). The study will evaluate ALG-000184, a small molecule class II capsid assembly modulator (CAM) that targets hepatitis B virus (HBV) capsid assembly as well as the establishment of covalently closed circular DNA (cccDNA).

    "We are excited to advance ALG-000184 into clinical studies," said Lawrence Blatt, Ph.D., MBA, Chief Executive Officer of Aligos. "In collaboration with…

    SOUTH SAN FRANCISCO, Calif., Oct. 30, 2020 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (NASDAQ:ALGS), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in viral and liver diseases, today announced that it has dosed its first subject in a first-in-human Phase 1a/b clinical trial, ALG-000184-201 (NCT04536337). The study will evaluate ALG-000184, a small molecule class II capsid assembly modulator (CAM) that targets hepatitis B virus (HBV) capsid assembly as well as the establishment of covalently closed circular DNA (cccDNA).

    "We are excited to advance ALG-000184 into clinical studies," said Lawrence Blatt, Ph.D., MBA, Chief Executive Officer of Aligos. "In collaboration with Dr. Raymond Schinazi's laboratory at Emory University, our experienced discovery and development team has optimized ALG-000184 to have best-in-class pharmacological potential. We look forward to learning how these optimized drug properties may translate into benefits for patients living with chronic hepatitis B."

    Matthew W. McClure, M.D., Chief Medical Officer at Aligos, noted, "ALG-000184-201 is a multipart Phase 1a/1b umbrella trial that will evaluate the safety and pharmacokinetics of single and multiple ascending doses of ALG-000184 in healthy volunteers, and the antiviral activity of ALG-000184 given once-daily over 28 days in patients with chronic hepatitis B (CHB). This is Aligos' second CHB drug candidate to enter the clinic this year and we expect the 201 study will provide important proof of concept data related to the antiviral activity of ALG-000184. We look forward to sharing initial topline results from this study in the second half of 2021."

    ALG-000184 is one of several drug candidates in Aligos' chronic hepatitis B (CHB) portfolio, which targets different clinically validated mechanisms of action in the HBV life cycle. The portfolio also includes: ALG-010133, a S-antigen Transport-inhibiting Oligonucleotide Polymers (STOPSTM) molecule, which entered clinical development earlier this year; ALG-020572, an antisense oligonucleotide (ASO); and ALG125097, a small interfering RNA (siRNA). Initially, Aligos plans to evaluate the antiviral activity of each of these drug candidates individually in Phase 1 umbrella trials before evaluating them in combination in subsequent trials.

    About Aligos

    Aligos Therapeutics, Inc. is a clinical stage biopharmaceutical company that was founded in 2018 with the mission to become a world leader in the treatment of viral infections and liver diseases. Aligos is focused on the development of targeted antiviral therapies for chronic hepatitis B (CHB) and coronaviruses as well as leveraging its expertise in liver diseases to create targeted therapeutics for nonalcoholic steatohepatitis (NASH). Aligos' strategy is to harness the deep expertise and decades of drug development experience its workforce has in liver disease, particularly viral hepatitis, to rapidly advance its pipeline of potentially best-in-class molecules.

    Forward Looking Statements

    This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered "forward-looking statements," including without limitation statements regarding Aligos's expectations that the 201 study will provide important proof of concept data related to the antiviral activity of ALG-000184, the timing of initial topline results from the 201 study, and Aligos's clinical development plans for the drug candidates in its portfolio. Forward-looking statements are typically, but not always, identified by the use of words such as "may," "will," "would," "believe," "intend," "plan," "anticipate," "estimate," "expect," and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause our development programs, future results, performance or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including Aligos's clinical-stage of development, the process of designing and conducting clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Aligos's ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of Aligos's capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape and the effects on our business of the worldwide COVID-19 pandemic. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Aligos in general, see Aligos's prospectus filed with the Securities and Exchange Commission on October 19, 2020, and its future periodic reports to be filed with the Securities and Exchange Commission. Except as required by law, Aligos undertakes no obligation to update any forward-looking statements to reflect new information, events or circumstances, or to reflect the occurrence of unanticipated events.

    Media Contact

    Amy Jobe, Ph.D.

    LifeSci Communications

    +1 315 879 8192



    Investor Contact

    Corey Davis, Ph.D.

    LifeSci Advisors

    +1 212 915 2577



    Primary Logo

    View Full Article Hide Full Article