1. SEATTLE, Sept. 16, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, will be presenting data from two studies employing Adaptive's immune medicine platform to understand the T-cell response to SARS-CoV-2 infection at IDWeek 2021, which takes places virtually from September 29-October 3, 2021.

    T-cell responses are more durable and broader than antibody responses, recognizing many different parts of the SARS-CoV-2 virus, including both spike and non-spike proteins. By studying T-cell epitopes, the small parts of viruses to which cells bind that trigger the…

    SEATTLE, Sept. 16, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, will be presenting data from two studies employing Adaptive's immune medicine platform to understand the T-cell response to SARS-CoV-2 infection at IDWeek 2021, which takes places virtually from September 29-October 3, 2021.

    T-cell responses are more durable and broader than antibody responses, recognizing many different parts of the SARS-CoV-2 virus, including both spike and non-spike proteins. By studying T-cell epitopes, the small parts of viruses to which cells bind that trigger the immune response, Adaptive can answer questions about T-cell contributions to vaccine efficacy and immunity to the SARS-CoV-2 virus and its variants, to uncover a better understanding of the full immune response. Examining the T-cell response has potential applications for clinical diagnosis and management, evaluation of protective immunity, and vaccine development and assessment.

    Adaptive will present new SARS-CoV-2 research at IDWeek that has implications for disease monitoring and vaccine development. A study evaluating the clinical performance of T-Detect™ COVID, the first T-cell-based test available in the U.S. to confirm recent or prior SARS-CoV-2 infection from whole blood samples, provides continued analysis and real-world evidence that confirms and extends previously published data regarding the durability of the detectable T-cell response, from 5 months up to nearly 12 months in a small number of evaluable patients after an initial positive Reverse Transcription (RT)-Polymerase Chain Reaction (PCR) test result. Similarly, a study employing Adaptive's T-cell assay produced a quantitative picture of the T-cell response to SARS-CoV-2 and demonstrated the assay's ability to distinguish a vaccine response from a natural infection based on the relative absence of T-cell receptors targeting non-spike antigens in vaccinated individuals.

    "When it comes to understanding SARS-CoV-2, the current focus on the vaccine-induced antibody response is incomplete, because antibodies do not provide the entire picture. T cells are contributing to vaccine efficacy even when the antibody response diminishes," said Lance Baldo M.D., Chief Medical Officer, Adaptive Biotechnologies. "Adaptive's immune medicine platform enables us to identify T-cell response signals repeatedly and reliably from the cells found in a tube of blood, and to translate those insights into therapeutic and diagnostic tools. As we support more patients and our knowledge accelerates, we can scale quickly, exploring applications in infectious diseases and beyond."

    The below oral presentations will be available for on-demand viewing starting September 29:

    AbstractTitle Session Details
    Oral presentation #126Magnitude and Dynamics of the T-Cell Response to SARS-CoV-2 Infection and Vaccination

    Presenting Author: Thomas M. Snyder, PhD
    Session O-26 – New Insights into Microbial Pathogenesis
    Oral presentation #144Clinical Validation and Performance of a Novel T-Cell Immunosequencing Assay to Identify Past SARS-CoV-2 Infection

    Presenting Author: Sudeb C. Dalai, MD, PhD
    Session O-30 - Research in COVID-19 Diagnostics

    Full abstracts can be found on the IDWeek website at https://www.idweek.org.

    About T Detect™

    T-Detect is a highly sensitive and specific diagnostic test under development for multiple diseases, translating the natural diagnostic capability of T cells into clinical practice. In 2018, Adaptive and Microsoft partnered to build a map of the immune system called the TCR-Antigen Map. This approach uses immunosequencing, proprietary computational modeling, and machine learning to map T-cell receptor sequences to disease-associated antigens for infectious diseases, autoimmune disorders and cancer. From a simple blood draw, T-Detect will leverage the map to provide an immunostatus for an individual, enabling early disease diagnosis, disease monitoring, and critical insights into immunity. T-Detect COVID is the first clinical test launched from this collaboration and the first commercially available T-cell test designed to detect recent or prior SARS-CoV-2 infections. T-Detect COVID is not FDA-cleared or approved, it has received an EUA from the FDA and is available for prescription use only.

    About Adaptive

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    MEDIA CONTACT:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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  2. SEATTLE, Sept. 07, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating virtually in the upcoming Morgan Stanley Global Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to participate in a fireside chat on Tuesday, September 14th at 8:00 a.m. Pacific Time / 11:00 a.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies
    Adaptive Biotechnologies is…

    SEATTLE, Sept. 07, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating virtually in the upcoming Morgan Stanley Global Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to participate in a fireside chat on Tuesday, September 14th at 8:00 a.m. Pacific Time / 11:00 a.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

     



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  3. Ultivue announces the addition of two independent board members, Fenel Eloi and Mary Pat Lancelotta, to help strengthen its position as a leader in advancing precision medicine solutions by accelerating tissue biomarker discovery and validation.

    Fenel Eloi is a highly seasoned life sciences executive experienced in leading the transformation of small and mid-size companies to large operating global organizations. Mr. Eloi served as the CFO and then COO at Cell Signaling Technology, a bio-reagents company, from 2005 to 2018, where he provided leadership in the transformation of the company to a global operation. He currently serves on the Board of Directors and chairs the audit committee of 908 Devices, Inc. (NASDAQ:MASS), a pioneer of purpose-built…

    Ultivue announces the addition of two independent board members, Fenel Eloi and Mary Pat Lancelotta, to help strengthen its position as a leader in advancing precision medicine solutions by accelerating tissue biomarker discovery and validation.

    Fenel Eloi is a highly seasoned life sciences executive experienced in leading the transformation of small and mid-size companies to large operating global organizations. Mr. Eloi served as the CFO and then COO at Cell Signaling Technology, a bio-reagents company, from 2005 to 2018, where he provided leadership in the transformation of the company to a global operation. He currently serves on the Board of Directors and chairs the audit committee of 908 Devices, Inc. (NASDAQ:MASS), a pioneer of purpose-built handheld and desktop mass spec devices for chemical and biomolecular analysis. He also serves on the board of directors of MitoTherapeutix, a privately held drug development biotech company.

    "I am very excited to join Ultivue and help them scale their operations to the next level. This is an exciting time for spatial biology and Ultivue has a great opportunity to rapidly grow and favorably impact both their customers' search for improved cancer treatments and patients' lives," said Mr. Eloi.

    Mary Pat Lancelotta is currently Vice President, Corporate Marketing and Communications at Adaptive Biotechnologies (NASDAQ:ADPT), a pioneer and leader in immune medicine. She is a seasoned healthcare strategist with a passion for precision medicine and brings over 20 years of business and strategy experience. Prior to Adaptive, Mary Pat led corporate and Product Marketing for Foundation Medicine, a molecular information company. Before joining Foundation Medicine, she led corporate strategic initiatives and strategic planning at Quest Diagnostics. Mary Pat holds an MBA with honors from Columbia Business School and a BS in Biochemistry from Boston College. She is also on the board of directors of Molecular Match, a clinical decision support company, and the TargetCancer Foundation.

    "I am delighted to join the Board of Ultivue and look forward to working with the management team and fellow Board members to help grow the business, especially in the area of artificial intelligence to support image analysis," said Mary Pat Lancelotta. "As we look to the future, working with big pharma, CRO and academic medical center customers, Ultivue has a tremendous opportunity to expand the impact of spatial biology on patients' lives."

    "It's an exciting time at Ultivue," noted Jacques Corriveau, President and CEO. "The combination of Mary Pat's ability to drive innovative commercial strategy for a global market alongside Fenel's experience enabling technology advancements within our partnership ecosystem will help our customers bring exciting new therapies to market and positively impact the drive toward personalized cancer treatment."

    About Ultivue

    Ultivue, Inc. provides researchers and scientists with multiplex biomarker assays for tissue phenotyping and digital pathology. Its proprietary InSituPlex® technology enables advanced exploration and interrogation of tissue samples for precision medicine research. For more information, visit ultivue.com.

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  4. SAN FRANCISCO and SEATTLE, Aug. 10, 2021 /PRNewswire/ -- Curebase, a company committed to democratizing access to clinical studies, and Adaptive Biotechnologies Corp. (NASDAQ:ADPT), a biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced an ongoing research collaboration to broaden patient participation in Adaptive's clinical studies. The initial two studies of the partnership involve Adaptive's T-Detect™ diagnostic test. T-Detect™ is under development for multiple diseases translating the natural diagnostics capability of T-Cells into clinical practice.

    SAN FRANCISCO and SEATTLE, Aug. 10, 2021 /PRNewswire/ -- Curebase, a company committed to democratizing access to clinical studies, and Adaptive Biotechnologies Corp. (NASDAQ:ADPT), a biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced an ongoing research collaboration to broaden patient participation in Adaptive's clinical studies. The initial two studies of the partnership involve Adaptive's T-Detect™ diagnostic test. T-Detect™ is under development for multiple diseases translating the natural diagnostics capability of T-Cells into clinical practice.

    The first study will validate the effectiveness of T-Detect™ for patients with Lyme disease. Lyme disease tends to impact people in rural areas, where a lack of clinical research sites makes it more challenging to recruit participants for clinical studies. In a second study, the two companies will collect and analyze long-term data from COVID-19 patients who have used Adaptive's T-Detect COVID clinically available test.

    Curebase has a unique decentralized clinical trial model that creates virtual research sites supported by the company's software platform and virtual research team of coordinators and investigators, making it possible to conduct clinical studies in the most remote locations and among broader, potentially more diverse populations. Another common barrier to study participation is a lack of trust by patients toward healthcare entities outside their own circle of practitioners. Curebase's clinical study software platform works with patients' own physicians, making it possible to keep this trusted relationship while participating in the trial, and better enabling long-term participation by the patient.

    "Clinical study modernization is a critical factor for keeping pace with medical innovation," said Dr. Lance Baldo, Adaptive's chief medical officer. "The flexibility of Curebase's platform expands our access to hard to reach and more diverse patient groups, while allowing patients to preserve relationships with their providers. The end result is a stronger study and more effective tests that benefit more people."

    Lyme disease is transmitted to humans and animals through the bite of infected blacklegged ticks. About 476,000 people in the U.S. are affected by Lyme disease transmitted through tick bites each year, but only 30% of people with acute Lyme infections receive a positive test result with existing laboratory tests. Delayed diagnosis, misdiagnosis, or leaving Lyme disease untreated can lead to devastating long-term health consequences from chronic joint inflammation, facial palsy to memory loss and irregular heart rhythm.

    "If you have an acute condition, you're not going to travel hundreds of miles to a research institution; you're going to see the provider you know and trust," said Curebase founder and CEO Tom Lemberg. "We see this happening with Lyme disease patients. So it's logical that we leverage technology to bring these forward-looking research studies to the patients."

    About Curebase

    At Curebase, our mission is to bring quality medical innovations to patients faster and improve human wellbeing through more efficient clinical studies. We are proving that clinical research can be radically accelerated if we empower physicians everywhere to enroll patients in the communities where they live. By applying cutting edge clinical software and remote study management techniques to the problem, we are reinventing clinical trials and research from the ground up. For more information, please visit www.curebase.com.

    About Adaptive Biotechnologies 

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech

    Media contact:

    media@curebase.com

    Adam Beeson

    Amendola Communications

    847-867-0048

     

    Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/curebase-adaptive-biotechnologies-announce-collaboration-to-expand-clinical-study-access-301352523.html

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  5. SEATTLE, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced the appointment of Nitin Sood to the newly created position of chief commercial officer, effective immediately. Nitin brings more than 15 years of proven commercial experience at leading life sciences and diagnostics companies, most recently at Guardant Health.

    "Adaptive has set the stage for commercial success with well-defined growth strategies and a solid pipeline for our current research and diagnostic products. Nitin brings a unique set of skills and experience building…

    SEATTLE, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced the appointment of Nitin Sood to the newly created position of chief commercial officer, effective immediately. Nitin brings more than 15 years of proven commercial experience at leading life sciences and diagnostics companies, most recently at Guardant Health.

    "Adaptive has set the stage for commercial success with well-defined growth strategies and a solid pipeline for our current research and diagnostic products. Nitin brings a unique set of skills and experience building and scaling commercial organizations that will set us up to continue to deliver on the promise of the platform," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. "With multiple, anticipated product launches and plans for international growth, Nitin will lead the next important phase of Adaptive's commercial expansion."

    In this new role, Nitin will oversee sales and marketing of immunoSEQ, clonoSEQ, and T-Detect, as well as commercial operations and market access. At Adaptive, he will apply his extensive, past experience growing and scaling businesses that apply next-generation sequencing and technology to cancer and other diseases to improve the lives of patients. He will report directly to Chad Robins.

    "The team at Adaptive share a commitment to transforming medicine and helping patients by using technology to read the biology of the immune system to develop better diagnostic tests and treatments," said Nitin Sood, chief commercial officer, Adaptive Biotechnologies. "I'm deeply passionate about scaling the use of novel technologies to improve the lives of patients and look forward to joining the team to build a global, commercial organization to drive the field of immune medicine forward."

    Nitin joins Adaptive from Guardant Health, where he was SVP, Product Development, leading the commercial expansion of their oncology portfolio to cover advanced and early-stage cancers, including the launch of Guardant Reveal for solid tumor MRD. Prior to that he was CEO of NuGEN, a leader in NGS sample prep. His experience also includes driving global businesses at PerkinElmer and Agilent Technologies where he held GM roles spanning a portfolio of products in genomics, pathology and pre-clinical research.

    About Adaptive Biotechnologies 

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech. 

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com



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  6. SEATTLE, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today reported financial results for the quarter ended June 30, 2021.

    "We had another strong quarter with 83% revenue growth over prior year," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. "I am encouraged by our performance across the business and excited about the emerging data from our immune medicine platform, which we expect to monetize for multiple opportunities in research, diagnostics and drug discovery."

    Recent

    SEATTLE, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today reported financial results for the quarter ended June 30, 2021.

    "We had another strong quarter with 83% revenue growth over prior year," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. "I am encouraged by our performance across the business and excited about the emerging data from our immune medicine platform, which we expect to monetize for multiple opportunities in research, diagnostics and drug discovery."

    Recent Highlights

    • Revenue of $38.5 million for the second quarter 2021, representing an 83% increase from the second quarter 2020
    • clonoSEQ clinical sequencing volume in the second quarter 2021 grew 75% versus prior year and 15% over the first quarter of 2021
    • Signed a license agreement with Vaccibody to leverage Adaptive Biotechnologies' T-cell data to inform the development of a T-cell based SARS-CoV-2 vaccine
    • Signed an agreement with Moderna to use immunoSEQ T-MAP COVID to measure the T-cell response to their second generation COVID vaccine and their Zika vaccine
    • Published case control data in Lyme disease and completing enrollment in ImmuneSense study to enable T-Detect Lyme offering in our CLIA certified lab around year end
    • Advanced T-Detect pipeline in autoimmune diseases including Crohn's and Ulcerative Colitis for IBD differential diagnosis, and generated new early signal in Multiple Sclerosis

    Second Quarter 2021 Financial Results

    Revenue was $38.5 million for the quarter ended June 30, 2021, representing an 83% increase from the second quarter in the prior year. Sequencing revenue was $18.6 million for the quarter, representing a 132% increase from the second quarter in the prior year. Development revenue was $20.0 million for the quarter, representing a 53% increase from the second quarter in the prior year.

    Operating expenses were $88.3 million for the second quarter of 2021, compared to $57.9 million in the second quarter of the prior year, representing an increase of 53%.

    Net loss was $49.3 million for the second quarter of 2021, compared to $33.5 million for the same period in 2020.

    Adjusted EBITDA (non-GAAP) was a loss of $35.6 million for the second quarter of 2021, compared to a loss of $28.5 million for the second quarter of the prior year.

    Cash, cash equivalents and marketable securities was $689.5 million as of June 30, 2021.

    2021 Financial Guidance

    Adaptive Biotechnologies expects full year 2021 revenue to be in the range of $148 million to $155 million, representing 54% growth at the mid-point of the range over full year 2020 revenue. This compares to Adaptive Biotechnologies' previous outlook of $145 million to $155 million.

    Webcast and Conference Call Information

    Adaptive Biotechnologies will host a conference call to discuss its second quarter 2021 financial results after market close on Wednesday, August 4, 2021 at 4:30 PM Eastern Time. The conference call can be accessed at http://investors.adaptivebiotech.com. The webcast will be archived and available for replay at least 90 days after the event.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies ("we" or "our") is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    Forward-Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts and other matters regarding our business strategies, use of capital, results of operations and financial position and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    Use of Non-GAAP Financial Measure

    To supplement our unaudited condensed consolidated statements of operations and unaudited condensed consolidated balance sheets, which are prepared in conformity with generally accepted accounting principles in the United States of America ("GAAP"), this press release also includes references to Adjusted EBITDA, which is a non-GAAP financial measure that we define as net loss adjusted for interest and other income, net, income tax benefit (expense), depreciation and amortization and share-based compensation expenses. We have provided a reconciliation of net loss, the most directly comparable GAAP financial measure, to Adjusted EBITDA at the end of this press release.

    Management uses Adjusted EBITDA to evaluate the financial performance of our business and the effectiveness of our business strategies. We present Adjusted EBITDA because we believe it is frequently used by analysts, investors and other interested parties to evaluate companies in our industry and it facilitates comparisons on a consistent basis across reporting periods. Further, we believe it is helpful in highlighting trends in our operating results because it excludes items that are not indicative of our core operating performance.

    Adjusted EBITDA has limitations as an analytical tool and you should not consider it in isolation or as a substitute for analysis of our results as reported under GAAP. We may in the future incur expenses similar to the adjustments in the presentation of Adjusted EBITDA. In particular, we expect to incur meaningful share-based compensation expense in the future. Other limitations include that Adjusted EBITDA does not reflect:

    • all expenditures or future requirements for capital expenditures or contractual commitments;
    • changes in our working capital needs;
    • income tax benefit (expense), which may be a necessary element of our costs and ability to operate;
    • the costs of replacing the assets being depreciated and amortized, which will often have to be replaced in the future;
    • the non-cash component of employee compensation expense; and
    • the impact of earnings or charges resulting from matters we consider not to be reflective, on a recurring basis, of our ongoing operations.

    In addition, Adjusted EBITDA may not be comparable to similarly titled measures used by other companies in our industry or across different industries.

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com





    Adaptive Biotechnologies


    Condensed Consolidated Statements of Operations

    (in thousands, except share and per share amounts)

    (unaudited)

      Three Months Ended June 30,  Six Months Ended June 30, 
      2021  2020  2021  2020 
    Revenue                
    Sequencing revenue $18,555  $7,985  $33,729  $17,454 
    Development revenue  19,950   13,003   43,218   24,444 
    Total revenue  38,505   20,988   76,947   41,898 
    Operating expenses                
    Cost of revenue  10,765   4,912   20,756   10,255 
    Research and development  37,800   25,992   71,572   49,927 
    Sales and marketing  23,216   14,332   43,820   28,339 
    General and administrative  16,066   12,238   31,002   24,059 
    Amortization of intangible assets  423   423   842   847 
    Total operating expenses  88,270   57,897   167,992   113,427 
    Loss from operations  (49,765)  (36,909)  (91,045)  (71,529)
    Interest and other income, net  464   1,893   1,102   4,787 
    Income tax benefit     1,481      1,804 
    Net loss $(49,301) $(33,535) $(89,943) $(64,938)
    Net loss per share attributable to common shareholders, basic and diluted $(0.35) $(0.26) $(0.64) $(0.51)
    Weighted-average shares used in computing net loss per share attributable to common shareholders, basic and diluted  140,359,317   127,383,582   139,667,380   126,720,986 





    Adaptive Biotechnologies


    Condensed Consolidated Balance Sheets

    (in thousands, except share and per share amounts)

      June 30, 2021  December 31, 2020 
      (unaudited)     
    Assets        
    Current assets        
    Cash and cash equivalents $184,186  $123,436 
    Short-term marketable securities (amortized cost of $413,965 and $564,036, respectively)  414,227   564,833 
    Accounts receivable, net  14,174   10,047 
    Inventory  18,612   14,063 
    Prepaid expenses and other current assets  12,530   14,535 
    Total current assets  643,729   726,914 
    Long-term assets        
    Property and equipment, net  75,235   39,692 
    Operating lease right-of-use assets  92,067   99,350 
    Long-term marketable securities (amortized cost of $91,177 and $118,429, respectively)  91,131   118,525 
    Restricted cash  2,138   2,138 
    Intangible assets, net  9,383   10,225 
    Goodwill  118,972   118,972 
    Other assets  719   598 
    Total assets $1,033,374  $1,116,414 
    Liabilities and shareholders' equity        
    Current liabilities        
    Accounts payable $6,093  $3,237 
    Accrued liabilities  13,539   13,162 
    Accrued compensation and benefits  8,630   11,950 
    Current portion of operating lease liabilities  4,833   3,529 
    Current portion of deferred revenue  83,553   73,319 
    Total current liabilities  116,648   105,197 
    Long-term liabilities        
    Operating lease liabilities, less current portion  103,774   104,333 
    Deferred revenue, less current portion  119,642   163,618 
    Total liabilities  340,064   373,148 
    Commitments and contingencies        
    Shareholders' equity        
    Preferred stock: $0.0001 par value, 10,000,000 shares authorized at June 30, 2021 and December 31, 2020; no shares issued and outstanding at June 30, 2021 and December 31, 2020      
    Common stock: $0.0001 par value, 340,000,000 shares authorized at June 30, 2021 and December 31, 2020; 140,663,755 and 137,646,896 shares issued and outstanding at June 30, 2021 and December 31, 2020, respectively  14   14 
    Additional paid-in capital  1,294,506   1,253,971 
    Accumulated other comprehensive gain  216   893 
    Accumulated deficit  (601,555)  (511,612)
    Total Adaptive Biotechnologies Corporation shareholders' equity  693,181   743,266 
    Noncontrolling interest  129    
    Total shareholders' equity  693,310   743,266 
    Total liabilities and shareholders' equity $1,033,374  $1,116,414 

    Adjusted EBITDA

    The following table sets forth a reconciliation between our Adjusted EBITDA and our net loss, the most directly comparable GAAP financial measure, for each of the periods presented (in thousands, unaudited):

      Three Months Ended June 30,  Six Months Ended June 30, 
      2021  2020  2021  2020 
    Net loss $(49,301) $(33,535) $(89,943) $(64,938)
    Interest and other income, net  (464)  (1,893)  (1,102)  (4,787)
    Income tax benefit     (1,481)     (1,804)
    Depreciation and amortization expense  2,905   1,998   5,576   3,976 
    Share-based compensation expense  11,249   6,373   19,733   11,048 
    Adjusted EBITDA $(35,611) $(28,538) $(65,736) $(56,505)


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  7. SEATTLE, July 12, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT)  a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will report financial results for the second quarter 2021 after market close on Wednesday, August 4, 2021. Company management will webcast a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time.

    Live audio of the webcast will be available on the "Investors" section of the company website at: www.adaptivebiotech.com. The webcast will be archived and available for replay within 24 hours after the event.

    About Adaptive Biotechnologies

    SEATTLE, July 12, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT)  a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will report financial results for the second quarter 2021 after market close on Wednesday, August 4, 2021. Company management will webcast a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time.

    Live audio of the webcast will be available on the "Investors" section of the company website at: www.adaptivebiotech.com. The webcast will be archived and available for replay within 24 hours after the event.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com



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  8. SEATTLE, June 09, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced that immunoSEQ® T-MAP™ COVID was used in the Nature study to measure the T-cell immune response elicited by the Johnson & Johnson COVID-19 vaccine in the context of multiple variants of SARS-CoV-2, including B 1.351 and B.1.1.7. The study provides further evidence that the T-cell response may contribute to protection from COVID-19. Adaptive's Technology was used to quantify T-cell expansion across all regions of the virus, demonstrating that the T-cell response is broad and…

    SEATTLE, June 09, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced that immunoSEQ® T-MAP™ COVID was used in the Nature study to measure the T-cell immune response elicited by the Johnson & Johnson COVID-19 vaccine in the context of multiple variants of SARS-CoV-2, including B 1.351 and B.1.1.7. The study provides further evidence that the T-cell response may contribute to protection from COVID-19. Adaptive's Technology was used to quantify T-cell expansion across all regions of the virus, demonstrating that the T-cell response is broad and unaltered by mutations that render vaccine-generated antibodies less effective. The study was conducted by Beth Israel Deaconess Medical Center (BIDMC) in Boston, MA.

    "Our data generated in collaboration with Adaptive Biotechnologies highlight the potent and broad T-cell immune responses induced by the Ad26.COV2.S COVID-19 vaccine in humans, including against virus variants," said Dan Barouch, M.D., Ph.D., Director of the Center for Virology and Vaccine Research at BIDMC. "Using TCRbeta sequencing together with traditional functional T-cell assays, we are able to understand and quantify T-cell expansion to different parts of the spike protein with precision and scale that wouldn't have been possible even a few years ago."

    In the multinational phase 3 ENSEMBLE trial, participants given Johnson & Johnson's vaccine experienced similar efficacy against the B.1.351 variant. To understand the mechanism of protection, the COV1001 phase 1/2 trial analyzed blood samples from 20 vaccinated individuals to measure antibody immune response (humoral immune response) and T-cell response (cellular immune response) against the original SARS-CoV-2 strain WA1/2020 as well as against the B.1.1.7, CAL.20C, P.1., and B.1.351 variants. Post-vaccination, results showed that the levels of neutralizing antibodies were diminished against the variants, but that the T-cell immune response was preserved, suggesting T cells may provide protection against these emerging strains. Results indicate T-cells may be an important correlate of protection and should be considered as an endpoint for vaccine clinical trials.

    "These findings support a growing body of evidence that measuring T-cell response is critical to demonstrate immunity and guide development of COVID-19 vaccines, particularly in the growing presence of new variants," said Harlan Robins, Ph.D., co-founder and chief scientific officer, Adaptive Biotechnologies. "Until recently it has been challenging to incorporate measurement of T-cell response into vaccine clinical trials, but now immunoSEQ T-MAP COVID provides the ability to do this at scale and with precision using blood samples, and this technology can be applied to many different diseases."

    immunoSEQ T-MAP COVID combines the sequencing and mapping capabilities of Adaptive's immune medicine platform to show how T cells respond to different parts of the virus, including the various parts of the spike protein. Mapping exactly how the variants impact different parts of the virus can indicate if the immune response is likely to be affected.

    About the T cell

    T cells are the adaptive immune system's first responders to detect any virus. They quickly multiply and circulate in the blood to attack the virus, often before symptoms appear. Among many other jobs, T cells also recruit B cells to produce antibodies after about a week or two to potentially provide immunity against future infection. T cells contain a treasure trove of information that could provide one consistent and trackable measure of the immune response to COVID-19 from initial exposure through viral clearance.

    T cells can "remember" prior infections and kill pathogens if they reappear. Research shows that antibodies to SARS-CoV-2 decline over time. T cells hold important clues to immunity and correlates of protection and need to be studied to assess how long patients remain resistant to reinfection. Given T cells circulate freely in the blood, they are an easy and thus a desirable target for assessing SARS-CoV-2 exposure and potentially immunity.

    About immunoSEQ T-MAP COVID

    The immunoSEQ® T-MAP™ COVID offering provides tools for researchers to study the COVID-19 T-cell immune response, including detecting past SARS-CoV-2-specific immune response in research samples and the ability to track responses longitudinally. immunoSEQ T-MAP COVID can detect past SARS-CoV-2-specific T-cell immune response with a simple positive/negative result in research samples and track responses longitudinally. Users have access to Adaptive's SARS-CoV-2-specific T-cell receptor database (TCR) database to determine if samples show SARS-CoV-2-specific TCRs and the antigens to which these TCR responded. The tool can be used to study the T-cell immune response for vaccine research across COVID-19 variants., mapping across >160K SARS-CoV-2-specific antigen-TCR sequence-level data. immunoSEQ T-MAP COVID can dive into sequence, patient or population-level data, as well as determine TCR clones shared between cohorts and those that are public vs private clones. immunoSEQ T-MAP COVID is For Research Use Only. Not for use in diagnostic procedures.

    About Adaptive Biotechnologies 

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations, including forward-looking statements contained in this press release or elsewhere related to the immune response to COVID-19, vaccine development, and the accuracy and functionality of immunoSEQ T-MAP COVID. 

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    ADAPTIVE MEDIA:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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  9. SEATTLE, June 03, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, will be included in more than 20 abstracts studying the use of Adaptive's clonoSEQ® Assay for minimal residual disease (MRD) assessment at the American Society of Clinical Oncology (ASCO) Annual Meeting from June 4-8, and the European Hematology Association (EHA) Virtual Congress from June 9-17. clonoSEQ is the first and only U.S. Food and Drug Administration (FDA)-cleared assay for MRD assessment in chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and B-cell acute lymphoblastic…

    SEATTLE, June 03, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, will be included in more than 20 abstracts studying the use of Adaptive's clonoSEQ® Assay for minimal residual disease (MRD) assessment at the American Society of Clinical Oncology (ASCO) Annual Meeting from June 4-8, and the European Hematology Association (EHA) Virtual Congress from June 9-17. clonoSEQ is the first and only U.S. Food and Drug Administration (FDA)-cleared assay for MRD assessment in chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (B-ALL), and is widely available to clinicians and patients across the U.S.

    "What is particularly notable at ASCO and EHA this year is the breadth of clinical use cases for MRD that are represented," said Lance Baldo, MD, Chief Medical Officer of Adaptive Biotechnologies. "Both clinician investigators and pharmaceutical companies have found new settings in which deep responses by clonoSEQ are achievable, which is excellent news for patients and also evidence of the growing role that clonoSEQ MRD monitoring can play across the lymphoid cancer care continuum."

    Assessment of MRD is a way to directly detect and quantify remaining disease, even in the absence of symptoms, across a spectrum of blood cancers. A patient's MRD status gives clinicians information about how a patient may be responding to treatment, so patients and providers can be in control when it comes to managing the disease and treatment decisions.

    Data at ASCO and EHA illustrates the relevance of MRD assessment post-CAR T cell therapy, in MM patients who are often heavily pretreated and who in the past might not have been expected to have such deep responses. Similarly, data showing the ability to achieve deep responses in high-risk patients supports the growing range of patient settings in which MRD assessment is valuable. Both meetings also include data showcasing the importance of serial monitoring of MRD using clonoSEQ as a primary endpoint. These data demonstrate that understanding the kinetics of low-level disease over time – which can only be ascertained using a highly sensitive and precisely quantitative MRD assay like clonoSEQ – is vital to clinicians' ability to accurately understand prognosis and even more clinically meaningful than a single point-in-time measurement.

    Key presentations include:

     Title Presentation Timing
    CLL
    EHA S146 (oral) Venetoclax-obinutuzumab for previously untreated chronic lymphocytic leukemia: 4-year follow up analysis of the randomized CLL14 studyon demand
    Multiple Myeloma
    ASCO - 8005 (oral)Ciltacabtagene autoleucel, a B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy, in relapsed/refractory multiple myeloma (R/R MM): Updated results from CARTITUDE-1.Tuesday, June 8 8:00 AM - 11:00 AM EDT



    ASCO - 8016 (poster)Idecabtagene vicleucel (ide-cel, bb2121), a BCMA-directed CAR T cell therapy, in relapsed and refractory multiple myeloma: Updated KarMMa resultsFriday, June 4 9:00 AM EDT



    ASCO - TPS 8054Subcutaneous daratumumab (DARA SC) plus lenalidomide versus lenalidomide alone as maintenance therapy in patients (pts) with newly diagnosed multiple myeloma (NDMM) who are minimal residual disease (MRD) positive after frontline autologous stem cell transplant (ASCT): The phase 3 AURIGA study.Friday, June 4 9:00 AM EDT



    ASCO - 8011 (poster)/EHA EP1010Interim analysis of a phase 2 minimal residual disease (MRD)-adaptive trial of elotuzumab, carfilzomib, lenalidomide, and dexamethasone (Elo-KRd) for newly diagnosed multiple myeloma (MM).Friday, June 4 9:00 AM EDT/on demand



    ASCO - 8004 (oral)Daratumumab (DARA) maintenance or observation (OBS) after treatment with bortezomib, thalidomide and dexamethasone (VTd) with or without DARA and autologous stem cell transplant (ASCT) in patients (pts) with newly diagnosed multiple myeloma (NDMM): CASSIOPEIA Part 2Tuesday, June 8 8:00 AM - 11:00 AM EDT



    MCL
    7505 (oral)The combination of venetoclax, lenalidomide, and rituximab in patients with newly diagnosed mantle cell lymphoma induces high response rates and MRD undetectability.Monday, June 7 11:30 AM - 2:30 PM EDT

    About the clonoSEQ Assay

    The clonoSEQ Assay is the first and only FDA-cleared assay for MRD in chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (ALL). Minimal residual disease (MRD) refers to the small number of cancer cells that can stay in the body during and after treatment. clonoSEQ was initially granted De Novo designation and marketing authorization by the FDA for the detection and monitoring of MRD in patients with MM and B-ALL using DNA from bone marrow samples. In August 2020, clonoSEQ received additional clearance from the FDA to detect and monitor MRD in blood or bone marrow from patients with CLL. 

    The clonoSEQ Assay leverages Adaptive's proprietary immune medicine platform to identify and quantify specific DNA sequences found in malignant cells, allowing clinicians to assess and monitor MRD during and after treatment. The assay provides standardized, accurate and sensitive measurement of MRD that allows physicians to predict patient outcomes, assess response to therapy over time, monitor patients during remission and predict potential relapse. Clinical practice guidelines in hematological malignancies recognize that MRD status is a reliable indicator of clinical outcomes and response to therapy, and clinical outcomes have been shown to be strongly associated with MRD levels measured by the clonoSEQ Assay in patients diagnosed with CLL, MM and ALL. 

    The clonoSEQ Assay is a single-site test performed at Adaptive Biotechnologies. In addition to its FDA-cleared uses, clonoSEQ is also available as a CLIA-validated laboratory developed test (LDT) service for use in other lymphoid cancers and sample types. For important information about the FDA-cleared uses of clonoSEQ, including the full intended use, limitations, and detailed performance characteristics, please visit www.clonoSEQ.com/technical-summary.

    About Adaptive

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    MEDIA CONTACT:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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  10. SEATTLE, May 20, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating virtually in the following investor conferences.

    • William Blair 41st Annual Growth Stock Conference
      Fireside Chat on Tuesday, June 1st at 6:40 a.m. Pacific Time / 9:40 a.m. Eastern Time
    • Goldman Sachs 42nd Annual Global Healthcare Conference
      Fireside Chat on Tuesday, June 8th at 12:50 p.m. Pacific Time / 3:50 p.m. Eastern Time

    Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website…

    SEATTLE, May 20, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating virtually in the following investor conferences.

    • William Blair 41st Annual Growth Stock Conference

      Fireside Chat on Tuesday, June 1st at 6:40 a.m. Pacific Time / 9:40 a.m. Eastern Time
    • Goldman Sachs 42nd Annual Global Healthcare Conference

      Fireside Chat on Tuesday, June 8th at 12:50 p.m. Pacific Time / 3:50 p.m. Eastern Time

    Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com



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  11. SEATTLE, May 05, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today reported financial results for the quarter ended March 31, 2021.

    "We started the year strong with revenue increasing 84% year over year, driven by growth in both our sequencing and development revenue categories," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. "I am encouraged by the solid momentum across all areas of our business as we continue to capitalize on the multiple opportunities originating from our platform…

    SEATTLE, May 05, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today reported financial results for the quarter ended March 31, 2021.

    "We started the year strong with revenue increasing 84% year over year, driven by growth in both our sequencing and development revenue categories," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. "I am encouraged by the solid momentum across all areas of our business as we continue to capitalize on the multiple opportunities originating from our platform."

    Recent Highlights

    • Revenue of $38.4 million for the first quarter 2021, representing an 84% increase from the first quarter 2020
    • clonoSEQ clinical sequencing volume for the first quarter 2021 grew 35% versus prior year
    • Recognized $7.0 million in MRD regulatory milestones resulting from two biopharmaceutical partners who used data from our MRD assay to support their respective U.S. Food and Drug Administration (FDA) drug approvals
    • Received Emergency Use Authorization (EUA) from FDA for T-Detect™ COVID to confirm recent or prior COVID-19 infection
    • Generated new data that confirms the ability of T-Detect to diagnose patients with Crohn's disease and distinguish between patients with colitis
    • Named Leslie Trigg and Katey Einterz Owen, PhD to the Board of Directors

    First Quarter 2021 Financial Results

    Revenue was $38.4 million for the quarter ended March 31, 2021, representing an 84% increase from the first quarter in the prior year. Sequencing revenue was $15.2 million for the quarter, representing a 60% increase from the first quarter in the prior year. Development revenue was $23.3 million for the quarter, representing a 103% increase from the first quarter in the prior year.

    Operating expenses were $79.7 million for the first quarter of 2021, compared to $55.5 million in the first quarter of the prior year, representing an increase of 44%.

    Net loss was $40.6 million for the first quarter of 2021, compared to $31.4 million for the same period in 2020.

    Adjusted EBITDA (non-GAAP) was a loss of $30.1 million for the first quarter of 2021, compared to a loss of $28.0 million for the first quarter of the prior year.

    Cash, cash equivalents and marketable securities was $745.0 million as of March 31, 2021.

    2021 Financial Guidance

    Adaptive Biotechnologies expects full year 2021 revenue to be in the range of $145 million to $155 million, representing 52% growth at the mid-point of the range over full year 2020 revenue.

    Webcast and Conference Call Information

    Adaptive Biotechnologies will host a conference call to discuss its first quarter 2021 financial results after market close on Wednesday, May 5, 2021 at 4:30 PM Eastern Time. The conference call can be accessed at http://investors.adaptivebiotech.com. The webcast will be archived and available for replay at least 90 days after the event.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies ("we" or "our") is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    Forward-Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts and other matters regarding our business strategies, use of capital, results of operations and financial position and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    Use of Non-GAAP Financial Measure

    To supplement our unaudited condensed consolidated statements of operations and unaudited condensed consolidated balance sheets, which are prepared in conformity with generally accepted accounting principles in the United States of America ("GAAP"), this press release also includes references to Adjusted EBITDA, which is a non-GAAP financial measure that we define as net loss adjusted for interest and other income, net, income tax benefit (expense), depreciation and amortization and share-based compensation expenses. We have provided a reconciliation of net loss, the most directly comparable GAAP financial measure, to Adjusted EBITDA at the end of this press release.

    Management uses Adjusted EBITDA to evaluate the financial performance of our business and the effectiveness of our business strategies. We present Adjusted EBITDA because we believe it is frequently used by analysts, investors and other interested parties to evaluate companies in our industry and it facilitates comparisons on a consistent basis across reporting periods. Further, we believe it is helpful in highlighting trends in our operating results because it excludes items that are not indicative of our core operating performance.

    Adjusted EBITDA has limitations as an analytical tool and you should not consider it in isolation or as a substitute for analysis of our results as reported under GAAP. We may in the future incur expenses similar to the adjustments in the presentation of Adjusted EBITDA. In particular, we expect to incur meaningful share-based compensation expense in the future. Other limitations include that Adjusted EBITDA does not reflect:

    • all expenditures or future requirements for capital expenditures or contractual commitments;
    • changes in our working capital needs;
    • income tax benefit (expense), which may be a necessary element of our costs and ability to operate;
    • the costs of replacing the assets being depreciated and amortized, which will often have to be replaced in the future;
    • the non-cash component of employee compensation expense; and
    • the impact of earnings or charges resulting from matters we consider not to be reflective, on a recurring basis, of our ongoing operations.

    In addition, Adjusted EBITDA may not be comparable to similarly titled measures used by other companies in our industry or across different industries.

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    Adaptive Biotechnologies

    Condensed Consolidated Statements of Operations

    (in thousands, except share and per share amounts)

    (unaudited)

      Three Months Ended March 31, 
      2021  2020 
    Revenue        
    Sequencing revenue $15,174  $9,469 
    Development revenue  23,268   11,441 
    Total revenue  38,442   20,910 
    Operating expenses        
    Cost of revenue  9,991   5,343 
    Research and development  33,772   23,935 
    Sales and marketing  20,604   14,007 
    General and administrative  14,936   11,821 
    Amortization of intangible assets  419   424 
    Total operating expenses  79,722   55,530 
    Loss from operations  (41,280)  (34,620)
    Interest and other income, net  638   2,894 
    Income tax benefit     323 
    Net loss $(40,642) $(31,403)
    Net loss per share attributable to common shareholders, basic and diluted $(0.29) $(0.25)
    Weighted-average shares used in computing net loss per share attributable to common shareholders, basic and diluted  138,967,754   126,058,389 

    Adaptive Biotechnologies

    Condensed Consolidated Balance Sheets

    (in thousands, except share and per share amounts)

      March 31,

    2021
      December 31,

    2020
     
      (unaudited)     
    Assets        
    Current assets        
    Cash and cash equivalents $173,624  $123,436 
    Short-term marketable securities (amortized cost of $540,016 and $564,036, respectively)  540,640   564,833 
    Accounts receivable, net  19,754   10,047 
    Inventory  17,422   14,063 
    Prepaid expenses and other current assets  13,520   14,535 
    Total current assets  764,960   726,914 
    Long-term assets        
    Property and equipment, net  56,308   39,692 
    Operating lease right-of-use assets  88,504   99,350 
    Long-term marketable securities (amortized cost of $30,681 and $118,429, respectively)  30,688   118,525 
    Restricted cash  2,138   2,138 
    Intangible assets, net  9,806   10,225 
    Goodwill  118,972   118,972 
    Other assets  717   598 
    Total assets $1,072,093  $1,116,414 
    Liabilities and shareholders' equity        
    Current liabilities        
    Accounts payable $5,197  $3,237 
    Accrued liabilities  13,484   13,162 
    Accrued compensation and benefits  5,431   11,950 
    Current portion of operating lease liabilities  4,308   3,529 
    Current portion of deferred revenue  78,348   73,319 
    Total current liabilities  106,768   105,197 
    Long-term liabilities        
    Operating lease liabilities, less current portion  95,252   104,333 
    Deferred revenue, less current portion  144,356   163,618 
    Total liabilities  346,376   373,148 
    Commitments and contingencies        
    Shareholders' equity        
    Preferred stock: $0.0001 par value, 10,000,000 shares authorized at March 31, 2021 and December 31, 2020; no shares issued and outstanding at March 31, 2021 and December 31, 2020      
    Common stock: $0.0001 par value, 340,000,000 shares authorized at March 31, 2021 and December 31, 2020; 139,884,698 and 137,646,896 shares issued and outstanding at March 31, 2021 and December 31, 2020, respectively  14   14 
    Additional paid-in capital  1,277,197   1,253,971 
    Accumulated other comprehensive gain  631   893 
    Accumulated deficit  (552,254)  (511,612)
    Total Adaptive Biotechnologies Corporation shareholders' equity  725,588   743,266 
    Noncontrolling interest  129    
    Total shareholders' equity  725,717   743,266 
    Total liabilities and shareholders' equity $1,072,093  $1,116,414 

    Adjusted EBITDA

    The following table sets forth a reconciliation between our Adjusted EBITDA and our net loss, the most directly comparable GAAP financial measure, for each of the periods presented (in thousands, unaudited):

      Three Months Ended March 31, 
      2021  2020 
    Net loss $(40,642) $(31,403)
    Interest and other income, net  (638)  (2,894)
    Income tax benefit     (323)
    Depreciation and amortization expense  2,671   1,978 
    Share-based compensation expense  8,484   4,675 
    Adjusted EBITDA $(30,125) $(27,967)


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  12. SEATTLE, April 27, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating in the upcoming BofA Securities 2021 Virtual Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to participate in a fireside chat on Tuesday, May 11th at 8:45 a.m. Pacific Time / 11:45 a.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies
    Adaptive Biotechnologies is a commercial-stage…

    SEATTLE, April 27, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating in the upcoming BofA Securities 2021 Virtual Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to participate in a fireside chat on Tuesday, May 11th at 8:45 a.m. Pacific Time / 11:45 a.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com 



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  13. SEATTLE, April 12, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT)  a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will report financial results for the first quarter 2021 after market close on Wednesday, May 5, 2021. Company management will webcast a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time.

    Live audio of the webcast will be available on the "Investors" section of the company website at: www.adaptivebiotech.com. The webcast will be archived and available for replay within 24 hours after the event.

    About Adaptive Biotechnologies

    SEATTLE, April 12, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT)  a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will report financial results for the first quarter 2021 after market close on Wednesday, May 5, 2021. Company management will webcast a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time.

    Live audio of the webcast will be available on the "Investors" section of the company website at: www.adaptivebiotech.com. The webcast will be archived and available for replay within 24 hours after the event.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com



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  14. SEATTLE, March 17, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced the appointments of Leslie Trigg and Katey Owen, Ph.D. to its Board of Directors effective immediately. The collective commercial and scientific expertise of these industry leaders will strengthen Adaptive's ability to execute against its open-ended growth story. The company also announced that Eric Dobmeier and David Goel will retire from the Board after long-standing tenures.

    "I am excited to welcome Leslie and Katey to our Board during this pivotal period of commercial…

    SEATTLE, March 17, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced the appointments of Leslie Trigg and Katey Owen, Ph.D. to its Board of Directors effective immediately. The collective commercial and scientific expertise of these industry leaders will strengthen Adaptive's ability to execute against its open-ended growth story. The company also announced that Eric Dobmeier and David Goel will retire from the Board after long-standing tenures.

    "I am excited to welcome Leslie and Katey to our Board during this pivotal period of commercial expansion and scientific innovation. Diversity of thought, perspectives, and experience is essential as we seek to transform clinical care in many diagnostic and therapeutic areas," said Chad Robins, chief executive officer of Adaptive Biotechnologies. "I'd like to thank Eric and David for the invaluable roles they played to help position Adaptive as a leader in immune medicine, as well as their guidance during the transition from a private to public company."

    Leslie's expertise will be instrumental in the commercial adoption of Adaptive's products into the clinical setting. She has served as Chief Executive Officer of Outset Medical since 2014, where she has pioneered disruptive technology transformation in the kidney dialysis space. With rapidly growing revenue across several market segments, Outset completed a successful public offering in 2020. Prior to Outset Medical, Leslie held executive commercial strategy roles at numerous med tech companies that went public or were acquired, including Pro-Duct Health, FoxHollow, AccessClosure, and Lutonix. She received her undergraduate degree from Northwestern University and her MBA from the Haas School of Business, UC Berkeley.

    Katey's expertise in developing late-stage biologics and vaccines at the Gates Foundation and Merck will help guide Adaptive's expansion into new therapeutic areas. As Director at the Bill & Melinda Gates Foundation, Dr. Owen has end-to-end responsibility for investments in diseases that impact a billion people on the planet. She also facilitates regular interaction between Bill Gates and the CEOs of pharmaceutical organizations to achieve global health goals.  Prior to joining the pharmaceutical industry, she carried out academic research on influenza at the National Institute for Medical Research in Mill Hill, London. She earned her Ph.D. in molecular virology from Purdue University.

    About Adaptive Biotechnologies 

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts and other matters regarding our business strategies, use of capital, results of operations and financial position and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    ADAPTIVE MEDIA:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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  15. First and only clinical T cell-based test for patients to detect the unique T-cell signature specific to SARS-CoV-2, the virus that causes COVID-19

    T-Detect COVID correctly confirmed recent or prior COVID-19 infections 97.1% of the time from date of RT-PCR diagnosis with 100% specificity

    SEATTLE, March 05, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced that the U.S. Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for T-Detect™ COVID to confirm recent or prior COVID-19 infection. This first-in-class T cell…

    First and only clinical T cell-based test for patients to detect the unique T-cell signature specific to SARS-CoV-2, the virus that causes COVID-19

    T-Detect COVID correctly confirmed recent or prior COVID-19 infections 97.1% of the time from date of RT-PCR diagnosis with 100% specificity

    SEATTLE, March 05, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced that the U.S. Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for T-Detect™ COVID to confirm recent or prior COVID-19 infection. This first-in-class T cell- based test is the first indication resulting from Adaptive's TCR-Antigen Map collaboration with Microsoft (NASDAQ:MSFT).

    "We are proud to receive FDA Emergency Use Authorization for T-Detect COVID, the first indication in an entirely new class of tests that use T cells in the blood to detect disease. People who have been unsure about a prior infection will now have another way to know if they had the virus," said Chad Robins, chief executive officer of Adaptive Biotechnologies. "The authorization of T-Detect COVID represents a true breakthrough for patients and a pivotal milestone for the diagnostic testing paradigm. We have proven that it is possible to read how T cells detect disease in the blood, and this is just the beginning of a pipeline of tests for many other indications."

    EUA was based on a clinical validation study showing that T-Detect COVID demonstrated sensitivity of 97.1% from date of diagnosis using RT-PCR. Sensitivity is the ability of the test to correctly identify a positive case (true positive). T-Detect COVID also showed a specificity of 100%. Specificity is the ability of the test to identify a negative case (true negative).

    "This is the first commercially available T-cell test that confirms recent or prior SARS-CoV-2 infections in people. T-Detect is accurate and what I find especially remarkable is how rapidly it was developed. Going from the lab to real-world human impact in a matter of months demonstrates the true value of our collaboration and the power of merging biology with cloud-scale machine learning technology," said Peter Lee, corporate vice president, Research & Incubations, Microsoft. "We are hopeful that this technology will have a meaningful impact not only in the global fight against COVID-19, but in many other disease areas in the future."

    The FDA provides an EUA for medical products to be used in an emergency to diagnose, treat, or prevent serious or life-threatening diseases or conditions when there are no adequate, approved, and available alternatives.

    About the T cell

    T cells are the adaptive immune system's first responders to detect any virus. They quickly multiply and circulate in the blood to attack the virus, often before symptoms appear. Among many other jobs, T cells also recruit B cells to produce antibodies after about a week or two to potentially provide immunity against future infection. T cells contain a treasure trove of information that could provide one consistent and trackable measure of the immune response to COVID-19 from initial exposure through viral clearance.

    T cells can "remember" prior infections and kill pathogens if they reappear. Research shows that antibodies to SARS-CoV-2 decline over time. T cells hold important clues to immunity and correlates of protection and need to be studied to assess how long patients remain resistant to reinfection. Given T cells circulate freely in the blood, they are an easy and thus a desirable target for assessing SARS-CoV-2 exposure and potentially immunity.

    About T-Detect 

    T-Detect is a highly sensitive and specific diagnostic test under development for multiple diseases, translating the natural diagnostic capability of T cells into clinical practice. In 2018, Adaptive and Microsoft partnered to build a map of the immune system called the TCR-Antigen Map. This approach uses immunosequencing, proprietary computational modeling, and machine learning to map T-cell receptor sequences to disease-associated antigens for infectious diseases, autoimmune disorders and cancer. From a simple blood draw, T-Detect will leverage the map to provide an immunostatus for an individual, enabling early disease diagnosis, disease monitoring, and critical insights into immunity. T-Detect COVID is the first clinical test launched from this collaboration and the first commercially available T-cell test designed to detect recent or prior SARS-CoV-2 infections. T-Detect COVID is an EUA authorized test that is available for prescription use only.

    About Adaptive Biotechnologies 

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations, including forward-looking statements contained in this press release or elsewhere related to T-Detect COVID and its ability to detect recent or prior COVID-19 infection, either in its current form or with respect to future mutations of the virus, as well as the potential application of T-Detect to additional disease states.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    MEDIA CONTACT:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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  16. SEATTLE, Feb. 25, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating in the upcoming Cowen 41st Annual Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to participate in a fireside chat on Tuesday, March 2nd at 7:30 a.m. Pacific Time / 10:30 a.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies 
    Adaptive Biotechnologies is a commercial-stage…

    SEATTLE, Feb. 25, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT) a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating in the upcoming Cowen 41st Annual Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to participate in a fireside chat on Tuesday, March 2nd at 7:30 a.m. Pacific Time / 10:30 a.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies 

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics, and drug discovery. We have three commercial products, and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com



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  17. SEATTLE, Feb. 24, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today reported financial results for the fourth quarter and full year ended December 31, 2020.

    "Adaptive's launch of T-Detect COVID marks a pivotal moment in the diagnostic testing paradigm. We have now proven that it is possible to read how T cells detect disease in the blood and we are on a fast path to develop this product for many other indications," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. "As we move into 2021…

    SEATTLE, Feb. 24, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today reported financial results for the fourth quarter and full year ended December 31, 2020.

    "Adaptive's launch of T-Detect COVID marks a pivotal moment in the diagnostic testing paradigm. We have now proven that it is possible to read how T cells detect disease in the blood and we are on a fast path to develop this product for many other indications," said Chad Robins, chief executive officer and co-founder of Adaptive Biotechnologies. "As we move into 2021, we are poised to execute on several key catalysts across all business areas that will accelerate our vision to power the age of immune medicine."

    Recent Highlights

    • Revenues of $30.2 million for the fourth quarter and $98.4 million for the full year of 2020, representing a 25% increase and 16% increase, respectively, over the corresponding periods in 2019.
    • Clinical sequencing volume increased 41% to 4,539 clinical tests delivered in the fourth quarter of 2020, compared to the fourth quarter 2019 and ended the year with 15,216 clinical tests delivered, up 50% versus 2019.
    • Launched T-Detect™ COVID, first clinical T-cell based test for patients to confirm recent or prior COVID-19 infection. In final review by the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA).
    • Extended collaboration agreement with Labcorp to enable broader access to our growing portfolio of immune-driven clinical diagnostic and research products.
    • Submitted a 510(k) application to the FDA for the use of clonoSEQ in blood for B-cell acute lymphoblastic leukemia (ALL) patients.

    Fourth Quarter 2020 Financial Results

    Revenue was $30.2 million for the quarter ended December 31, 2020, representing a 25% increase from the fourth quarter in the prior year. Sequencing revenue was $12.7 million for the quarter, representing an 8% decrease from the fourth quarter in the prior year. Development revenue was $17.5 million for the quarter, representing a 69% increase from the fourth quarter in the prior year.

    Operating expenses were $74.4 million for the fourth quarter of 2020, compared to $48.4 million in the fourth quarter of the prior year, representing an increase of 54%.

    Net loss was $44.6 million for the fourth quarter of 2020, compared to $20.6 million for the same period in 2019.

    Adjusted EBITDA (non-GAAP) was a loss of $34.6 million for the fourth quarter of 2020, compared to a loss of $18.7 million for the fourth quarter of the prior year.

    Full Year 2020 Financial Results

    Revenue was $98.4 million for the year ended December 31, 2020, representing a 16% increase from the prior year. Sequencing revenue was $41.4 million in 2020, representing a 5% decrease from 2019. Development revenue was $56.9 million in 2020, representing a 37% increase from the prior year.

    Operating expenses for 2020 were $251.2 million, compared to $163.5 million for 2019, representing an increase of 54%.

    Net loss was $146.2 million in 2020, compared to $68.6 million in 2019.

    Adjusted EBITDA (non-GAAP) was a loss of $119.6 million for 2020, compared to a loss of $57.5 million in the prior year.

    Cash, cash equivalents and marketable securities was $806.8 million as of December 31, 2020.

    2021 Financial Guidance

    Management will provide the 2021 outlook during the conference call scheduled to discuss the 2020 financial results.

    Webcast and Conference Call Information

    Adaptive Biotechnologies will host a conference call to discuss its fourth quarter and full year 2020 financial results after market close on Wednesday, February 24, 2021 at 4:30 PM Eastern Time. The conference call can be accessed at http://investors.adaptivebiotech.com. The webcast will be archived and available for replay at least 90 days after the event.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies ("we" or "our") is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    Forward-Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts and other matters regarding our business strategies, use of capital, results of operations and financial position and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    Use of Non-GAAP Financial Measure

    To supplement our balance sheets and statements of operations, which are prepared in conformity with generally accepted accounting principles in the United States of America ("GAAP"), this press release also includes references to Adjusted EBITDA, which is a non-GAAP financial measure that we define as net loss adjusted for interest and other income, net, income tax (expense) benefit, depreciation and amortization and share-based compensation expenses. We have provided a reconciliation of net loss, the most directly comparable GAAP financial measure, to Adjusted EBITDA at the end of this press release.

    Management uses Adjusted EBITDA to evaluate the financial performance of our business and the effectiveness of our business strategies. We present Adjusted EBITDA because we believe it is frequently used by analysts, investors and other interested parties to evaluate companies in our industry and it facilitates comparisons on a consistent basis across reporting periods. Further, we believe it is helpful in highlighting trends in our operating results because it excludes items that are not indicative of our core operating performance.

    Adjusted EBITDA has limitations as an analytical tool and you should not consider it in isolation, or as a substitute for analysis of our results as reported under GAAP. We may in the future incur expenses similar to the adjustments in the presentation of Adjusted EBITDA. In particular, we expect to incur meaningful share-based compensation expense in the future. Other limitations include that Adjusted EBITDA does not reflect:

    • all expenditures or future requirements for capital expenditures or contractual commitments;
    • changes in our working capital needs;
    • income tax (expense) benefit, which may be a necessary element of our costs and ability to operate;
    • the costs of replacing the assets being depreciated and amortized, which will often have to be replaced in the future;
    • the non-cash component of employee compensation expense; and
    • the impact of earnings or charges resulting from matters we consider not to be reflective, on a recurring basis, of our ongoing operations.

    In addition, Adjusted EBITDA may not be comparable to similarly titled measures used by other companies in our industry or across different industries.

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com





    Adaptive Biotechnologies

    Statements of Operations

    (in thousands, except share and per share amounts)

    (unaudited)

      Three Months Ended December 31,  Year Ended December 31, 
      2020  2019  2020  2019 
    Revenue                
    Sequencing revenue $12,709  $13,888  $41,439  $43,519 
    Development revenue  17,476   10,321   56,943   41,552 
    Total revenue  30,185   24,209   98,382   85,071 
    Operating expenses                
    Cost of revenue  6,222   5,951   22,530   22,274 
    Research and development  35,831   21,189   116,072   70,705 
    Sales and marketing  18,545   12,640   61,358   38,453 
    General and administrative  13,398   8,189   49,536   30,332 
    Amortization of intangible assets  428   428   1,703   1,698 
    Total operating expenses  74,424   48,397   251,199   163,462 
    Loss from operations  (44,239)  (24,188)  (152,817)  (78,391)
    Interest and other income, net  785   3,577   6,590   9,785 
    Income tax expense  (1,116)         
    Net loss  (44,570)  (20,611)  (146,227)  (68,606)
    Fair value adjustment to Series E-1 convertible preferred stock

     options
               (964)
    Net loss attributable to common shareholders $(44,570) $(20,611) $(146,227) $(69,570)
    Net loss per share attributable to common shareholders, basic

     and diluted
     $(0.33) $(0.17) $(1.11) $(1.01)
    Weighted-average shares used in computing net loss per share

     attributable to common shareholders, basic and diluted
      136,954,148   124,397,150   131,216,468   69,165,315 
                     





    Adaptive Biotechnologies


    Balance Sheets

    (in thousands, except share and per share amounts)

    (unaudited)

      December 31, 
      2020  2019 
    Assets        
    Current assets        
    Cash and cash equivalents $123,436  $96,576 
    Short-term marketable securities (amortized cost of $564,036 and $479,791, respectively)  564,833   480,290 
    Accounts receivable, net  10,047   12,676 
    Inventory  14,063   9,069 
    Prepaid expenses and other current assets  14,535   14,079 
    Total current assets  726,914   612,690 
    Long-term assets        
    Property and equipment, net  39,692   60,355 
    Operating lease right-of-use assets  99,350    
    Long-term marketable securities (amortized cost of $118,429 and $105,263, respectively)  118,525   105,435 
    Restricted cash  2,138   2,138 
    Intangible assets, net  10,225   11,928 
    Goodwill  118,972   118,972 
    Other assets  598   784 
    Total assets $1,116,414  $912,302 
    Liabilities and shareholders' equity        
    Current liabilities        
    Accounts payable $3,237  $4,453 
    Accrued liabilities  13,162   4,371 
    Accrued compensation and benefits  11,950   8,124 
    Current portion of deferred rent     371 
    Current portion of operating lease liabilities  3,529    
    Current portion of deferred revenue  73,319   60,994 
    Total current liabilities  105,197   78,313 
    Long-term liabilities        
    Deferred rent liability, less current portion     6,918 
    Operating lease liabilities, less current portion  104,333    
    Financing obligation     36,607 
    Deferred revenue, less current portion  163,618   219,332 
    Other long-term liabilities     93 
    Total liabilities  373,148   341,263 
    Commitments and contingencies        
    Shareholders' equity        
    Preferred stock: $0.0001 par value, 10,000,000 shares authorized at December 31, 2020

     and 2019; no shares issued and outstanding at December 31, 2020 and 2019
          
    Common stock: $0.0001 par value, 340,000,000 shares authorized at December 31, 2020

     and 2019; 137,646,896 and 125,238,142 shares issued and outstanding at

     December 31, 2020 and 2019, respectively
      14   12 
    Additional paid-in capital  1,253,971   935,834 
    Accumulated other comprehensive gain  893   671 
    Accumulated deficit  (511,612)  (365,478)
    Total shareholders' equity  743,266   571,039 
    Total liabilities and shareholders' equity $1,116,414  $912,302 
             





    Adjusted EBITDA



    The following table sets forth a reconciliation between our Adjusted EBITDA and our net loss, the most directly comparable GAAP financial measure, for each of the periods presented (in thousands, unaudited):

      Three Months Ended December 31,  Year Ended December 31, 
      2020  2019  2020  2019 
    Net loss $(44,570) $(20,611) $(146,227) $(68,606)
    Interest and other income, net  (785)  (3,577)  (6,590)  (9,785)
    Income tax expense  1,116          
    Depreciation and amortization expense  2,352   2,075   8,472   7,791 
    Share-based compensation expense  7,243   3,411   24,761   13,124 
    Adjusted EBITDA $(34,644) $(18,702) $(119,584) $(57,476)
                     


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  18. SEATTLE, Feb. 23, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced an expansion of its collaboration with Labcorp (NYSE:LH), a leading global life sciences company, to enable broader access to Adaptive's growing portfolio of immune-driven clinical diagnostic and research products. The expanded collaboration includes a commercial agreement for Adaptive's clonoSEQ® and immunoSEQ® assays and a lab services agreement for Adaptive's recently launched T-Detect COVID™ test, the first clinical T-cell based test for patients to confirm recent or prior…

    SEATTLE, Feb. 23, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced an expansion of its collaboration with Labcorp (NYSE:LH), a leading global life sciences company, to enable broader access to Adaptive's growing portfolio of immune-driven clinical diagnostic and research products. The expanded collaboration includes a commercial agreement for Adaptive's clonoSEQ® and immunoSEQ® assays and a lab services agreement for Adaptive's recently launched T-Detect COVID™ test, the first clinical T-cell based test for patients to confirm recent or prior COVID-19 infection.

    The collaboration builds on the parties' initial agreement signed in May 2020 to provide safe blood collection services at nearly 2,000 Labcorp patient service centers (PSCs) for patients using clonoSEQ, the first and only FDA-cleared assay for minimal residual disease (MRD) in select blood cancers. As part of the companies' deeper collaboration, patients can now have convenient blood collection for both the clonoSEQ and T-Detect™ COVID tests at any Labcorp PSC.

    "We are proud to partner with Labcorp to expand patient access to blood draws necessary for novel tests like clonoSEQ and T-Detect," said Chad Robins, co-founder and chief executive officer of Adaptive. "By providing patients with easy and safe ways to access critical health services, especially during this difficult time, we can expand the impact we can have on patients impacted by blood cancers, COVID-19, and eventually many other immune-mediated diseases."

    The two companies will work closely together to expand the commercial reach of clonoSEQ and operational capacity for T-Detect COVID. Labcorp's oncology sales force will promote clonoSEQ at hematology-oncology clinics in the U.S. In addition, Labcorp is preparing to perform T-Detect COVID as a secondary site laboratory once the test has received Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (FDA).

    In addition, Labcorp will expand its immunosequencing portfolio by offering its biopharmaceutical customers the immunoSEQ and immunoSEQ® T-MAP™ COVID assays using Research Use Only (RUO) test kits.

    "By expanding access to Adaptive's growing portfolio of clinical and research products, Labcorp is helping to guide patient care decisions during a time when access to healthcare is challenging," said Brian Caveney, M.D., chief medical officer and president of Labcorp Diagnostics. "We are thrilled to deepen our commercial collaborations in multiple therapeutic areas across both drug development and clinical diagnostics with innovative, science-driven companies like Adaptive."

    About T-Detect™

    T-Detect™ is a highly sensitive and specific diagnostic test under development for multiple diseases, translating the natural diagnostic capability of T cells into clinical practice. In 2018, Adaptive and Microsoft partnered to build a map of the immune system called the TCR-Antigen Map. This approach uses immunosequencing, proprietary computational modeling, and machine learning to map T-cell receptor sequences to disease-associated antigens for infectious diseases, autoimmune disorders and cancer. From a simple blood draw, T-Detect will leverage the map to provide an immunostatus for an individual, enabling early disease diagnosis, disease monitoring, and critical insights into immunity. T-Detect COVID is the first clinical test launched from this collaboration and the first commercially available T-cell test designed to detect recent or prior SARS-CoV-2 infections. T-Detect COVID is an in vitro diagnostic that is available for prescription use only. This test has not been cleared or approved by the FDA and is available for use as a CLIA-validated laboratory developed test. T-Detect COVID is not indicated for use in patients under age 18.

    About the clonoSEQ(R) Assay

    The clonoSEQ Assay is the first and only FDA-cleared assay for MRD in chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (ALL). Minimal residual disease (MRD) refers to the small number of cancer cells that can stay in the body during and after treatment. clonoSEQ was initially granted De Novo designation and marketing authorization by the FDA for the detection and monitoring of MRD in patients with MM and B-ALL using DNA from bone marrow samples. In August 2020, clonoSEQ received additional clearance from the FDA to detect and monitor MRD in blood or bone marrow from patients with CLL. 

    The clonoSEQ Assay leverages Adaptive's proprietary immune medicine platform to identify and quantify specific DNA sequences found in malignant cells, allowing clinicians to assess and monitor MRD during and after treatment. The assay provides standardized, accurate and sensitive measurement of MRD that allows physicians to predict patient outcomes, assess response to therapy over time, monitor patients during remission and predict potential relapse. Clinical practice guidelines in hematological malignancies recognize that MRD status is a reliable indicator of clinical outcomes and response to therapy, and clinical outcomes have been shown to be strongly associated with MRD levels measured by the clonoSEQ Assay in patients diagnosed with CLL, MM and ALL. 

    The clonoSEQ Assay is a single-site test performed at Adaptive Biotechnologies. In addition to its FDA-cleared uses, clonoSEQ is also available as a CLIA-validated laboratory developed test (LDT) service for use in other lymphoid cancers and sample types.  For important information about the FDA-cleared uses of clonoSEQ, including the full intended use, limitations, and detailed performance characteristics, please visit www.clonoSEQ.com/technical-summary.

    About the immunoSEQ® Assay

    The immunoSEQ Assay is the industry gold standard in immunosequencing and helps researchers make discoveries in areas such as oncology, autoimmune disorders, infectious diseases, neurobiology, transplant, and basic immunology. The immunoSEQ® Technology is a quantitative and sensitive immunosequencing solution for academic researchers and pharmaceutical companies to understand the immune response to diseases and therapeutics by sequencing the DNA of immune receptors at high throughput scale. The immunoSEQ® T-MAP COVID offering is the first and only service of its kind to accurately and reproducibly assess the T-cell immune response to COVID-19 vaccines in development and longitudinally track the persistence of that response over time.

    The immunoSEQ Assay can identify millions of T- and B-cell receptors from a single sample in exquisite detail. Offered as a Service or Kit, the immunoSEQ Assay is used to ask and answer translational research questions and discover new prognostic and relevant signals in clinical research. The immunoSEQ Assay provides quantitative, scalable, and reproducible sequencing results along with access to a powerful, easy-to-use analysis tools via the immunoSEQ® Analyzer software. The immunoSEQ Assay is for research use only and is not for use in diagnostic procedures. For more information visit us at www.immunoseq.com

    About Labcorp

    Labcorp is a leading global life sciences company that provides vital information to help doctors, hospitals, pharmaceutical companies, researchers, and patients make clear and confident decisions. Through our unparalleled diagnostics and drug development capabilities, we provide insights and accelerate innovations to improve health and improve lives. With more than 75,000 employees, we serve clients in more than 100 countries. Labcorp (NYSE:LH) reported revenue of $14 billion in FY2020. Learn more about us at www.Labcorp.com or follow us on LinkedIn and Twitter @Labcorp.

    About Adaptive

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics, and drug discovery. We have three commercial products, and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.

    Adaptive Biotechnologies Forward Looking Statements

    This press release contains forward-looking statements that are based on Adaptive Biotechnologies' management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    LABCORP CONTACTS:

    Media: Christopher Allman-Bradshaw

    336-436-8263

    Media@Labcorp.com

    Investors: Chas Cook

    336-436-5076

    Investor@Labcorp.com



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  19. T-Detect is currently under review by the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA)

    Patients can conveniently opt to visit one of nearly 2,000 Labcorp sites or arrange for a mobile phlebotomy service at their home 

    SEATTLE, Feb. 23, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced the launch of T-Detect COVID, the first clinical T-cell based test to confirm recent or prior COVID-19 infection. In real-world studies, this first-in-class test outperformed leading antibody tests.

    Knowledge of prior COVID-19…

    T-Detect is currently under review by the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA)

    Patients can conveniently opt to visit one of nearly 2,000 Labcorp sites or arrange for a mobile phlebotomy service at their home 

    SEATTLE, Feb. 23, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced the launch of T-Detect COVID, the first clinical T-cell based test to confirm recent or prior COVID-19 infection. In real-world studies, this first-in-class test outperformed leading antibody tests.

    Knowledge of prior COVID-19 infection is critically important for those who believe they may have been infected with the virus but have not been able to confirm a diagnosis. T-Detect is currently under review by the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA).

    "The impact of COVID-19 has become its own public health crisis, with millions of people, like me, who are dealing with serious, long-term effects of this virus," said Diana Berrent, founder, Survivor Corps, the largest grassroots movement in America dedicated to actively ending this pandemic. "A T-cell test is an important tool for people who want to know if they had COVID-19 and may help them to understand and address ongoing health issues. It is important for patients to participate in ongoing research so that in the future, the same test may help answer questions about immunity to and protection from the virus or to a vaccine."

    Patients can order T-Detect COVID online at www.t-detect.com by answering a few eligibility questions through a secure portal. A virtual provider will authorize a prescription and patients can have their blood drawn by a mobile phlebotomist at their home or they can visit one of nearly 2,000 Labcorp patient service centers. Patients will receive an email notification when their results are available, and they can view them via a secure portal.

    "T-Detect COVID is the first T-cell test for patients and the first product resulting from Adaptive's TCR-Antigen Map collaboration with Microsoft," said Adaptive Biotechnologies Chief Executive Officer, Chad Robins. "By mapping the human immune response to COVID-19, we have developed a simple blood-based clinical test to help detect recent or prior infections from our T cells. This approach will be scaled for more accurate and early diagnosis of many infectious diseases, autoimmune disorders and cancer." 

    Until now, antibody tests have been the primary way to determine recent or prior COVID-19 infection. T-cell tests take an entirely new approach to determine prior infection by looking at a different but equally important part of our immune system, the T cell. In the setting of COVID-19, T-cell responses arise earlier than antibodies and persist in the blood for longer. 

    Patients ordering T-Detect COVID have the opportunity to contribute to ongoing research to further the understanding of T cell-based immunity to COVID-19. This is particularly important as scientists work to define immunity and establish correlates of protection to SARS-CoV-2, the virus that causes COVID-19, resulting from natural infection or vaccination.  

    About the T cell

    T cells are the adaptive immune system's first responders to detect any virus. They quickly multiply and circulate in the blood to attack the virus, often before symptoms appear. Among many other jobs, T cells also recruit B cells to produce antibodies after about a week or two to potentially provide immunity against future infection. T cells contain a treasure trove of information that could provide one consistent and trackable measure of the immune response to COVID-19 from initial exposure through viral clearance. 

    T cells can "remember" prior infections and kill pathogens if they reappear. Research shows that antibodies to SARS-CoV-2 decline over time. T cells hold important clues to immunity and correlates of protection and need to be studied to assess how long patients remain resistant to reinfection. Given T cells circulate freely in the blood, they are an easy and thus a desirable target for assessing SARS-CoV-2 exposure and potentially immunity.

    About T-Detect 

    T-Detect is a highly sensitive and specific diagnostic test under development for multiple diseases, translating the natural diagnostic capability of T cells into clinical practice. In 2018, Adaptive and Microsoft partnered to build a map of the immune system called the TCR-Antigen Map. This approach uses immunosequencing, proprietary computational modeling, and machine learning to map T-cell receptor sequences to disease-associated antigens for infectious diseases, autoimmune disorders and cancer. From a simple blood draw, T-Detect will leverage the map to provide an immunostatus for an individual, enabling early disease diagnosis, disease monitoring, and critical insights into immunity. T-Detect COVID is the first clinical test launched from this collaboration and the first commercially available T-cell test designed to detect recent or prior SARS-CoV-2 infections. T-Detect COVID is an in vitro diagnostic that is available for prescription use only. This test has not been cleared or approved by the FDA and is available for use as a CLIA-validated laboratory developed test (LDT). T-Detect COVID is not indicated for use in patients under age 18.

     

    About Adaptive Biotechnologies 

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have three commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech. 

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations, including forward-looking statements contained in this press release or elsewhere related to T-Detect COVID and its ability to detect recent or past COVID-19 infection, either in its current form or with respect to future mutations of the virus, as well as the potential application of T-Detect to additional disease states.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    MEDIA CONTACT:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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  20. SEATTLE, Feb. 02, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT)  a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will report financial results for the fourth quarter and full year of 2020 after market close on Wednesday, February 24, 2021. Company management will webcast a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time.

    Live audio of the webcast will be available on the "Investors" section of the company website at: www.adaptivebiotech.com. The webcast will be archived and available for replay within 24 hours after the event.

    About Adaptive

    SEATTLE, Feb. 02, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT)  a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will report financial results for the fourth quarter and full year of 2020 after market close on Wednesday, February 24, 2021. Company management will webcast a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time.

    Live audio of the webcast will be available on the "Investors" section of the company website at: www.adaptivebiotech.com. The webcast will be archived and available for replay within 24 hours after the event.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics, and drug discovery. We have three commercial products, and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com



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  21. Multi-year, pan-portfolio deal extends Adaptive's proprietary immunoSEQ T-MAP offering, originally launched for COVID-19, into oncology

    This transaction highlights the value of immune receptor data generated by Adaptive's proprietary immune medicine platform

    SEATTLE, Jan. 11, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced a translational collaboration with AstraZeneca (NASDAQ:AZN) to investigate the use of immunoSEQ T-MAP, a product that combines the sequencing and mapping capabilities of Adaptive's proprietary immune medicine platform…

    Multi-year, pan-portfolio deal extends Adaptive's proprietary immunoSEQ T-MAP offering, originally launched for COVID-19, into oncology

    This transaction highlights the value of immune receptor data generated by Adaptive's proprietary immune medicine platform

    SEATTLE, Jan. 11, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced a translational collaboration with AstraZeneca (NASDAQ:AZN) to investigate the use of immunoSEQ T-MAP, a product that combines the sequencing and mapping capabilities of Adaptive's proprietary immune medicine platform to map T-cell receptors (TCRs) to antigens, across AstraZeneca's oncology portfolio.         

    Under this collaboration, AstraZeneca will provide biological samples from patients with cancer; Adaptive will sequence these samples and deliver TCR-antigen mapping data using its growing and dynamic clinical immunomics database of more than 58 billion immune cell receptors and thousands of antigens. This mapping data may inform signatures of immune response (or resistance) to cancer therapies which may provide information to guide treatment decisions. Additionally, mapping of unique TCRs to antigens at scale can provide powerful information regarding the potential for early and accurate detection of a disease and the specificity of a given patient's immune response to therapy.

    "We continue to demonstrate that specific T-cell immune receptor data can be utilized to inform the diagnosis and treatment for most diseases," said Sharon Benzeno, Chief Business Development Officer, Adaptive Biotechnologies. "We are thrilled to partner with AstraZeneca to realize the value of antigen-specific T-cell response data across their portfolio of transformative cancer medicines."

    Adaptive will receive from AstraZeneca quarterly payments plus sequencing and data mapping fees. In addition, AstraZeneca has an option to enter into a separate agreement with Adaptive for the development and commercialization of a companion diagnostic or therapeutic application based on T-MAP data. Specific financial terms of the agreement will not be disclosed.

    The scope of this non-exclusive, pan-portfolio oncology collaboration may be expanded to cover additional therapeutic areas, including autoimmunity and infectious diseases.

    About Adaptive

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics, and drug discovery. We have three commercial products, and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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  22. SEATTLE, Dec. 30, 2020 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating in the upcoming 39th Annual J.P. Morgan Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to present on Monday, January 11th at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies
    Adaptive Biotechnologies is a commercial-stage…

    SEATTLE, Dec. 30, 2020 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation ("Adaptive Biotechnologies") (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating in the upcoming 39th Annual J.P. Morgan Healthcare Conference.

    Adaptive Biotechnologies' management is scheduled to present on Monday, January 11th at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time. Interested parties may access a live and archived webcast of the presentation on the "Investors" section of the company website at: www.adaptivebiotech.com.

    About Adaptive Biotechnologies

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have two commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    ADAPTIVE INVESTORS

    Karina Calzadilla, Vice President, Investor Relations

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com

    ADAPTIVE MEDIA

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com



    Primary Logo

    View Full Article Hide Full Article
  23. SEATTLE, Dec. 06, 2020 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced new real-world data highlighting the clinical utility of Adaptive's next-generation sequencing (NGS) clonoSEQ® Assay to assess minimal residual disease (MRD) in patients with multiple myeloma. The data are being presented at the American Society of Hematology (ASH) 62nd Annual Meeting and Exposition, held virtually December 5-8. Additional study results demonstrating the impact of Adaptive's clonoSEQ Assay in chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia…

    SEATTLE, Dec. 06, 2020 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced new real-world data highlighting the clinical utility of Adaptive's next-generation sequencing (NGS) clonoSEQ® Assay to assess minimal residual disease (MRD) in patients with multiple myeloma. The data are being presented at the American Society of Hematology (ASH) 62nd Annual Meeting and Exposition, held virtually December 5-8. Additional study results demonstrating the impact of Adaptive's clonoSEQ Assay in chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL) and mantle cell lymphoma (MCL) are also being presented at the meeting in 45 other abstracts.

    MRD refers to the small number of cancer cells that can remain in a patient's body after treatment, which often cause no signs or symptoms but eventually can lead to recurrence of the disease. These residual cells can be present at very low levels and require highly sensitive tests to identify them. clonoSEQ, which is the only FDA-cleared test for MRD assessment in lymphoid malignancies, is highly accurate, sensitive, and standardized compared to other technologies.

    "The data presented at ASH this year reflect the growing evidence supporting clonoSEQ's ability to provide meaningful benefit for patients with blood cancers in a variety of clinical settings," said Lance Baldo, MD, Chief Medical Officer of Adaptive Biotechnologies. "It is increasingly clear that MRD testing with clonoSEQ, utilizing our immune medicine platform, is playing an important role in treatment decision-making which can have a dramatic impact not only on patients, but could also enable cost savings for the healthcare system overall."

    Real-world evidence generated by clinicians at the University of California San Francisco (UCSF) and in Madrid demonstrated that MRD-based decision-making with the clonoSEQ Assay improved outcomes for multiple myeloma patients. This study will be presented in a poster presentation titled, "Making Clinical Decisions to Change Therapy Using Measurable Residual Disease Improves the Outcome in Multiple Myeloma" (Abstract 2273). The retrospective review evaluated 373 multiple myeloma patients from three health centers who had at least one MRD assessment. Of the 373 patients, physicians made a clinical decision to change treatment for 58 patients based on their MRD status. Results showed that these 58 patients had a significantly improved progression-free survival (PFS) versus patients who did not change treatment (n=312) (median PFS 97 vs. 75 months, p=0.006).

    "We are encouraged by these real-world data and the impact MRD testing can have on the way we manage patients who have had great but not perfect responses to therapy, and the way we can make earlier decisions," said Jeffrey Wolf, MD, Clinical Professor, Department of Medicine, UCSF; and Director, Myeloma Program, UCSF Helen Diller Family Comprehensive Cancer Center. "These results support the integration of MRD assessment as a standard of care in the management of multiple myeloma patients. MRD assessment allows physicians and patients alike to have more confidence in their treatment decisions."

    Myeloma patient advocates agree that there are meaningful, practical real-world benefits for patients who undergo MRD testing.

    "The ability to accurately monitor disease burden in multiple myeloma is critical when making decisions that impact each patient's care," said Daniel Auclair, PhD, Chief Scientific Officer of the Multiple Myeloma Research Foundation. "We are encouraged by the data emerging in MRD assessment, which we believe will help myeloma patients and their doctors better manage their disease."

    Patients may also benefit from potential MRD-informed treatment changes which may reduce the cost of their care. Additionally, researchers from the Winship Cancer Institute of Emory University will present results from a poster presentation titled "Cost-Effectiveness of Implementing clonoSEQ NGS-MRD Testing Using the Emory MRD Decision Protocol in Multiple Myeloma" (Abstract 3426). This study evaluated a framework which allowed patients with sustained MRD negativity (defined as MRD <10-5 across two assessments at least 12-months apart) to discontinue indefinite maintenance therapy. Results showed that, based on savings of maintenance therapy costs or no longer requiring active treatment for relapsed/refractory (R/R) disease, MRD testing with clonoSEQ provided estimated lifetime savings of $916,000 per patient annually for the institution. Additionally, results showed MRD testing with clonoSEQ resulted in improved health outcomes in comparison to no testing (0.009 QALYs), primarily due to the avoidance of treatment-related adverse events.

    Additional Key clonoSEQ Data Presented at the Meeting:

    Monitoring Measurable Residual Disease Using Peripheral Blood in Acute Lymphoblastic Leukemia: Results of a Prospective, Observational Study (Abstract 975)

    • This prospective study investigated the prognostic and predictive utility of peripheral blood (PB) based MRD assessment in 62 ALL patients who received a cellular therapy.
    • The study demonstrated a strong correlation between MRD assessed from PB and bone marrow (BM) using clonoSEQ, and concluded that less-invasive clonoSEQ MRD monitoring in PB represents an alternative to serial BM examinations in patients undergoing curative intent cellular therapies.

    Clonal Dynamics after Venetoclax-Obinutuzumab Therapy: Novel Insights from the Randomized, Phase 3 CLL14 Trial (Abstract 127)

    • This Phase 3 study evaluated MRD as a secondary endpoint in 432 CLL patients with previously untreated CLL and co-existing conditions who were randomized to receive chlorambucil or venetoclax in combination with obinutuzumab. MRD was assessed every 3-6 months in PB. The subset of data presented at ASH analyzes MRD and clonal growth patterns in both cohorts of patients to better understand disease dynamics during and after treatment.
    • Results showed that clonal growth, a measure for how quickly cancer cells grow, was significantly lower after treatment with venetoclax plus obinutuzumab than after treatment with chlorambucil and obinutuzumab, indicating more effective MRD eradication and clonal growth modulation with venetoclax plus obinutuzumab. Additionally, 40% of patients in the venetoclax arm had undetectable MRD levels of <10-6 compared to just 7% of patients in the chlorambucil arm.
    • This analysis of the trial data demonstrates that understanding patient-specific cancer growth rates in addition to MRD status may be helpful in informing treatment duration.

    Frontline Sequential Immunochemotherapy Plus Lenalidomide for Mantle Cell Lymphoma Incorporating MRD Evaluation: Phase II, Investigator-Initiated, Single-Center Study (Abstract 119)

    • This study evaluated frontline sequential immunochemotherapy plus lenalidomide for the treatment of patients with MCL.
    • During the study, MRD testing with clonoSEQ was performed on PB after each phase of treatment and at six months post end of treatment.
    • There was a high rate of MRD negativity after induction chemoimmunotherapy (Len-R-CHOP + R-HiDAC) at thresholds of 10-5 (97%) and 10-6 (80%), with the deepest responses (10-6) shown to be predictive of remission duration. Several patients converted from MRD-negative to MRD-positive at six months post-treatment and eventually relapsed, suggesting that a more prolonged period of maintenance may be beneficial.

    About the clonoSEQ Assay

    The clonoSEQ Assay is the first and only FDA-cleared assay for MRD in chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (ALL). Minimal residual disease (MRD) refers to the small number of cancer cells that can stay in the body during and after treatment. clonoSEQ was initially granted De Novo designation and marketing authorization by the FDA for the detection and monitoring of MRD in patients with MM and B-ALL using DNA from bone marrow samples. In August 2020, clonoSEQ received additional clearance from the FDA to detect and monitor MRD in blood or bone marrow from patients with CLL. 

    The clonoSEQ Assay leverages Adaptive's proprietary immune medicine platform to identify and quantify specific DNA sequences found in malignant cells, allowing clinicians to assess and monitor MRD during and after treatment. The assay provides standardized, accurate and sensitive measurement of MRD that allows physicians to predict patient outcomes, assess response to therapy over time, monitor patients during remission and predict potential relapse. Clinical practice guidelines in hematological malignancies recognize that MRD status is a reliable indicator of clinical outcomes and response to therapy, and clinical outcomes have been shown to be strongly associated with MRD levels measured by the clonoSEQ Assay in patients diagnosed with CLL, MM and ALL. 

    The clonoSEQ Assay is a single-site test performed at Adaptive Biotechnologies. In addition to its FDA-cleared uses, clonoSEQ is also available as a CLIA-validated laboratory developed test (LDT) service for use in other lymphoid cancers and sample types.  For important information about the FDA-cleared uses of clonoSEQ, including the full intended use, limitations, and detailed performance characteristics, please visit www.clonoSEQ.com/technical-summary.

    About Adaptive

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have two commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    MEDIA CONTACT:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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    • Studies reinforce clonoSEQ as standard of care in minimal residual disease (MRD) across eight disease states

    • Real-world evidence shows treatment decisions based on precise MRD measurement directly correlate with improved patient outcomes and cost savings

    SEATTLE, Nov. 23, 2020 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, together with its collaborators will present data from more than 35 abstracts studying the use of Adaptive's clonoSEQ® Assay for minimal residual disease (MRD) assessment at the American Society of Hematology (ASH) virtual 62nd Annual Meeting…

    • Studies reinforce clonoSEQ as standard of care in minimal residual disease (MRD) across eight disease states



    • Real-world evidence shows treatment decisions based on precise MRD measurement directly correlate with improved patient outcomes and cost savings

    SEATTLE, Nov. 23, 2020 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (NASDAQ:ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, together with its collaborators will present data from more than 35 abstracts studying the use of Adaptive's clonoSEQ® Assay for minimal residual disease (MRD) assessment at the American Society of Hematology (ASH) virtual 62nd Annual Meeting and Exposition, December 5-8. clonoSEQ is the first and only U.S. Food and Drug Administration (FDA)-cleared assay for MRD assessment in chronic lymphocytic leukemia (CLL), multiple myeloma and B-cell acute lymphoblastic leukemia (B-ALL) and is widely available to clinicians and patients across the U.S.

    "We are thrilled to see so many investigators presenting clonoSEQ data at ASH this year, among the more than 300 ASH studies highlighting MRD data, significantly growing the body of evidence validating this tool as a critical measure of patient outcomes," said Lance Baldo, MD, Chief Medical Officer of Adaptive Biotechnologies. "As innovation continues for the treatment of blood cancers with novel and highly targeted therapies that create deep and durable responses for patients, we see clinicians increasingly utilizing clonoSEQ to help guide day-to-day patient care."

    Assessment of MRD is a way to directly detect and quantify remaining disease, even in the absence of symptoms, across a spectrum of blood cancers. A patient's MRD status gives clinicians timely information about how a patient may be responding to treatment, so patients and providers can be in control when it comes to managing their disease and treatment decisions.

    clonoSEQ, the first clinical application of Adaptive's immune medicine platform, will be featured in 14 oral presentations and 23 posters at ASH. Data on clinical and research utility from studies, as well as findings based on real-world experience, will be presented across a range of cancers including multiple myeloma, ALL, CLL and non-Hodgkin's lymphoma (NHL). These new data show a correlation between clonoSEQ MRD results and improved blood cancer patient outcomes, enhanced clinical decision-making, and potential savings to the healthcare system.

    Additional data at ASH this year will highlight Adaptive's immune profiling research tool, immunoSEQ®, to quantitatively assess the immune response to novel therapies in development.

    Key presentations include:

    Abstract  Title Presentation

    Timing
    Oral Presentations
    Acute Lymphoblastic Leukemia
    583





    Ultrasensitive Next-Generation Sequencing-Based Measurable Residual Disease Assessment in Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia after Frontline Therapy: Correlation with Flow Cytometry and Impact on Clinical OutcomesMonday, December 7, 2020: 9:15 AM
    Chronic Lymphocytic Leukemia
    127



    Clonal Dynamics after Venetoclax-Obinutuzumab Therapy: Novel Insights from the Randomized, Phase 3 CLL14 TrialSaturday, December 5, 2020: 10:30 AM



    544



    Transcend CLL 004: Phase 1 Cohort of Lisocabtagene Maraleucel (liso-cel) in Combination with Ibrutinib for Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)Monday, December 7, 2020: 7:30 AM



    546





    Updated Follow-up of Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Treated with Lisocabtagene Maraleucel in the Phase 1 Monotherapy Cohort of Transcend CLL 004, Including High-Risk and Ibrutinib-Treated PatientsMonday, December 7, 2020: 8:00 AM
    Diffuse Large B-Cell Lymphoma
    531



    Prognostic Value of Circulating Tumor DNA (ctDNA) in Autologous Stem Cell Graft and Post-Transplant Plasma Samples Among Patients with Diffuse Large B-Cell Lymphoma



    Monday, December 7, 2020: 7:15 AM
    Graft-Versus-Host-Disease
    730TCR Repertoires in Graft-Versus-Host-Disease (GVHD)-Target Tissues Reveals Tissue Specificity of the Alloimmune ResponseMonday, December 7, 2020: 1:30 PM



    Lymphoma
    530



    Cerebrospinal Fluid (CSF) Analysis of Tumor-Specific Cell-Free DNA (cfDNA) As a Diagnostic and Prognostic Tool for Central Nervous System (CNS) Invasion in Lymphoma



    Monday, December 7, 2020: 7:00 AM



    Mantle Cell Lymphoma
    119



    Frontline Sequential Immunochemotherapy Plus Lenalidomide for Mantle Cell Lymphoma Incorporating MRD Evaluation: Phase II, Investigator-Initiated, Single-Center Study



    Saturday, December 5, 2020: 10:00 AM



    Multiple Myeloma
    143



    Early Versus Late Autologous Stem Cell Transplant in Newly Diagnosed Multiple Myeloma: Long-Term Follow-up Analysis of the IFM 2009 Trial



    Saturday, December 5, 2020: 10:00 AM



    722Spatiotemporal Assessment of Immunogenomic Heterogeneity in Multiple Myeloma



    Monday, December 7, 2020: 2:15 PM



    Poster Presentations
    Acute Lymphoblastic Leukemia
    975



    Monitoring Measurable Residual Disease Using Peripheral Blood in Acute Lymphoblastic Leukemia: Results of a Prospective, Observational Study



    Saturday, December 5, 2020, 7:00 AM-3:30 PM



    Cutaneous T-Cell Lymphoma
    2082



    Patient Characteristics of Long-Term Responders to Mogamulizumab: Results from the MAVORIC Study



    Sunday, December 6, 2020, 7:00 AM-3:30 PM



    Diffuse Large B-Cell Lymphoma
    1450



    Blinatumomab Consolidation Post Autologous Hematopoietic Stem Cell Transplantation in Patients with Diffuse Large B Cell Lymphoma



    Saturday, December 5, 2020, 7:00 AM-3:30 PM



    Mantle Cell Lymphoma
    3031



    Ibrutinib Maintenance (I-M) Following Intensive Induction in Mantle Cell Lymphoma (MCL): Efficacy, Safety and Changes in Minimal Residual Disease



    Monday, December 7, 2020, 7:00 AM-3:30 PM



    Multiple Myeloma
    1328



    Improving the Definition of Response Assessment: Prognostic Value of Minimal Residual Disease Combined with PET/CT at Day 100 Post Autologous Stem Cell Transplantation in Multiple Myeloma



    Saturday, December 5, 2020, 7:00 AM-3:30 PM
    1592



    Role of clonoSEQ®, a Next-Generation Sequencing (NGS) Assay and PET/CT As a Measure of Minimal Residual Disease Negativity Among Patients with Multiple Myeloma



    Saturday, December 5, 2020, 7:00 AM-3:30 PM



    2237



    Making Clinical Decisions to Change Therapy Using Measurable Residual Disease Improves the Outcome in Multiple Myeloma



    Sunday, December 6, 2020, 7:00 AM-3:30 PM



    3426Cost-Effectiveness of Implementing Clonoseq NGS-MRD Testing Using the Emory MRD Decision Protocol in Multiple Myeloma



    Monday, December 7, 2020, 7:00 AM-3:30 PM



    3156



    Minimal Residual Disease in Multiple Myeloma: Targeted Mass Spectrometry in Blood Vs Next Generation Sequencing in Bone Marrow



    Monday, December 7, 2020, 7:00 AM-3:30 PM



    About the clonoSEQ Assay

    The clonoSEQ Assay is the first and only FDA-cleared assay for MRD in chronic lymphocytic leukemia (CLL), multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (ALL). Minimal residual disease (MRD) refers to the small number of cancer cells that can stay in the body during and after treatment. clonoSEQ was initially granted De Novo designation and marketing authorization by the FDA for the detection and monitoring of MRD in patients with MM and B-ALL using DNA from bone marrow samples. In August 2020, clonoSEQ received additional clearance from the FDA to detect and monitor MRD in blood or bone marrow from patients with CLL. 

    The clonoSEQ Assay leverages Adaptive's proprietary immune medicine platform to identify and quantify specific DNA sequences found in malignant cells, allowing clinicians to assess and monitor MRD during and after treatment. The assay provides standardized, accurate and sensitive measurement of MRD that allows physicians to predict patient outcomes, assess response to therapy over time, monitor patients during remission and predict potential relapse. Clinical practice guidelines in hematological malignancies recognize that MRD status is a reliable indicator of clinical outcomes and response to therapy, and clinical outcomes have been shown to be strongly associated with MRD levels measured by the clonoSEQ Assay in patients diagnosed with CLL, MM and ALL. 

    The clonoSEQ Assay is a single-site test performed at Adaptive Biotechnologies. In addition to its FDA-cleared uses, clonoSEQ is also available as a CLIA-validated laboratory developed test (LDT) service for use in other lymphoid cancers and sample types.  For important information about the FDA-cleared uses of clonoSEQ, including the full intended use, limitations, and detailed performance characteristics, please visit www.clonoSEQ.com/technical-summary.

    About immunoSEQ Assay

    Adaptive's immunoSEQ Assay helps researchers make discoveries in areas such as oncology, autoimmune disorders, infectious diseases and basic immunology. The immunoSEQ Assay can identify millions of T- and B-cell receptors from a single sample in exquisite detail. Offered as a Service or Kit, the immunoSEQ Assay is used to ask and answer translational research questions and discover new prognostic and diagnostic signals in clinical trials. The immunoSEQ Assay provides quantitative, reproducible sequencing results along with access to powerful, easy-to-use analysis tools. The immunoSEQ Assay is for research use only and is not for use in diagnostic procedures.

    About Adaptive

    Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature's most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics and drug discovery. We have two commercial products and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient.

    For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.

    Forward Looking Statements

    This press release contains forward-looking statements that are based on management's beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations.

    In some cases, you can identify forward-looking statements by the words "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "continue," "ongoing" or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors are described under "Risk Factors," "Management's Discussion and Analysis of Financial Condition and Results of Operations" and elsewhere in the documents we file with the Securities and Exchange Commission from time to time. We caution you that forward-looking statements are based on a combination of facts and factors currently known by us and our projections of the future, about which we cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent our views as of the date hereof. We undertake no obligation to update any forward-looking statements for any reason, except as required by law.

    MEDIA CONTACT:

    Beth Keshishian

    917-912-7195

    media@adaptivebiotech.com 

    ADAPTIVE INVESTORS:

    Karina Calzadilla

    201-396-1687

    Carrie Mendivil, Gilmartin Group

    investors@adaptivebiotech.com



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