1. STATEN ISLAND, N.Y., Sept. 2, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that the Company is set to join the Russell Microcap® Index when the market opens on September 20, 2021, according to a preliminary list of additions posted on September 1, 2021.  

    Membership in the Russell Microcap Index, which remains in place for one year, means automatic inclusion in the appropriate growth and value style indexes. FTSE Russell determines membership for its Russell indexes primarily by objective, market-capitalization rankings, and style attributes.

    "Inclusion in…

    STATEN ISLAND, N.Y., Sept. 2, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that the Company is set to join the Russell Microcap® Index when the market opens on September 20, 2021, according to a preliminary list of additions posted on September 1, 2021.  

    Membership in the Russell Microcap Index, which remains in place for one year, means automatic inclusion in the appropriate growth and value style indexes. FTSE Russell determines membership for its Russell indexes primarily by objective, market-capitalization rankings, and style attributes.

    "Inclusion in the Russell Microcap Index reflects the ongoing achievement of our previously stated drug development objectives for our pipeline of DNA polymerase IIIC inhibitors, and the fact that, if approved, we would bring to market the first of a new class of antibiotics in over 30 years," said David P. Luci, President and CEO of Acurx. "Inclusion in the Index benefits our Company and stockholders by elevating our visibility within the global investment community. We look forward to continuing our progress towards completing the clinical development program for ibezapolstat, our lead antibiotic candidate targeting the treatment of C. difficile Infection and delivering on several key milestone catalysts through 2021 and 2022," concluded Luci.

    Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. Approximately $10.6 trillion in assets are benchmarked against Russell's US indexes. Russell indexes are part of FTSE Russell, a leading global index provider.

    About FTSE Russell

    FTSE Russell is a global index leader that provides innovative benchmarking, analytics, and data solutions for investors worldwide. FTSE Russell calculates thousands of indexes that measure and benchmark markets and asset classes in more than 70 countries, covering 98% of the investable market globally.

    FTSE Russell index expertise and products are used extensively by institutional and retail investors globally. Approximately $17.9 trillion is currently benchmarked to FTSE Russell indexes. For over 30 years, leading asset owners, asset managers, ETF providers and investment banks have chosen FTSE Russell indexes to benchmark their investment performance and create ETFs, structured products, and index-based derivatives.  A core set of universal principles guides FTSE Russell index design and management: a transparent rules-based methodology is informed by independent committees of leading market participants. FTSE Russell is focused on applying the highest industry standards in index design and governance and embraces the IOSCO Principles.

    FTSE Russell is also focused on index innovation and customer partnerships as it seeks to enhance the breadth, depth and reach of its offering. FTSE Russell is wholly owned by London Stock Exchange Group. For more information on the Russell Microcap® Index and the Russell indexes reconstitution, please visit www.ftserussell.com.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D pipeline includes antibiotic product candidates that target Gram-positive bacteria, including Clostridioides difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus (VRE) and drug-resistant Streptococcus pneumoniae (DRSP).  To learn more about Acurx Pharmaceuticals and its product pipeline, please visit www.acurxpharma.com

    Any statements in this press release about our future expectations, plans and prospects, including statements regarding our strategy, future operations, prospects, plans and objectives, and other statements containing the words "believes," "anticipates," "plans," "expects," and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether ibezapolstat will benefit from the QIDP designation; whether ibezapolstat will advance through the clinical trial process on a timely basis; whether the results of the clinical trials of ibezapolstat will warrant the submission of applications for marketing approval, and if so, whether ibezapolstat will receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies where approval is sought; whether, if ibezapolstat obtains approval, it will be successfully distributed and marketed; and other factors. In addition, the forward-looking statements included in this press release represent our views as of August 30, 2021.   We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward- looking statements at some point in the future, we specifically disclaim any obligation to do so.

    Investor Contact:

    Acurx Pharmaceuticals, Inc.

    David P. Luci, President & CEO

    Tel:  917-533-1469

    Email:  davidluci@acurxpharma.com

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  2. STATEN ISLAND, N.Y., Aug. 31, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that David P. Luci, President & CEO, will present at the H.C. Wainwright 23rd Annual Global Investment Conference.

    Investors may listen to the presentation online beginning on September 13 at 7:00 A.M. (ET) via the link below.

    Event:

    H.C. Wainwright 23rd Annual Global Investment Conference

    Date:

    September 13-15, 2021

    Session Start Date


    and Time:

    7 a.m. ET on September 13, 2021

    Webcast:

    https://journey.ct.events/view/75943fdc-2093-4e66-a80a-c6d6e6f9ed6a

    Archived:

    90 days

    About

    STATEN ISLAND, N.Y., Aug. 31, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that David P. Luci, President & CEO, will present at the H.C. Wainwright 23rd Annual Global Investment Conference.

    Investors may listen to the presentation online beginning on September 13 at 7:00 A.M. (ET) via the link below.

    Event:

    H.C. Wainwright 23rd Annual Global Investment Conference

    Date:

    September 13-15, 2021

    Session Start Date



    and Time:

    7 a.m. ET on September 13, 2021

    Webcast:

    https://journey.ct.events/view/75943fdc-2093-4e66-a80a-c6d6e6f9ed6a

    Archived:

    90 days

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D pipeline includes antibiotic product candidates that target Gram-positive bacteria, including Clostridioides difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus (VRE) and drug-resistant Streptococcus pneumoniae (DRSP).

    To learn more about Acurx Pharmaceuticals and its product pipeline, please visit www.acurxpharma.com

    Any statements in this press release about our future expectations, plans and prospects, including statements regarding our strategy, future operations, prospects, plans and objectives, and other statements containing the words "believes," "anticipates," "plans," "expects," and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether ibezapolstat will benefit from the QIDP designation; whether ibezapolstat will advance through the clinical trial process on a timely basis; whether the results of the clinical trials of ibezapolstat will warrant the submission of applications for marketing approval, and if so, whether ibezapolstat will receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies where approval is sought; whether, if ibezapolstat obtains approval, it will be successfully distributed and marketed; and other factors. In addition, the forward-looking statements included in this press release represent our views as of August 30, 2021.   We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward- looking statements at some point in the future, we specifically disclaim any obligation to do so.

    Investor Contact:

    Acurx Pharmaceuticals, Inc.

    David P. Luci, President & CEO

    Tel:  917-533-1469

    Email:  davidluci@acurxpharma.com

     

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    SOURCE Acurx Pharmaceuticals, Inc.

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  3. STATEN ISLAND, N.Y., Aug. 16, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today certain financial and operational results for the quarter ended June 30, 2021. 

    Highlights of, and certain events subsequent to the second quarter of 2021 include:

    • Health Holland has awarded a grant of approximately $500,000 USD to Leiden University Medical Center to further study the mechanism of action of DNA pol IIIC inhibitors in scientific collaboration with Acurx; and
    • Acurx filed a provisional patent application with the U.S. Patent and Trademark Office for use of ibezapolstat…

    STATEN ISLAND, N.Y., Aug. 16, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today certain financial and operational results for the quarter ended June 30, 2021. 

    Highlights of, and certain events subsequent to the second quarter of 2021 include:

    • Health Holland has awarded a grant of approximately $500,000 USD to Leiden University Medical Center to further study the mechanism of action of DNA pol IIIC inhibitors in scientific collaboration with Acurx; and
    • Acurx filed a provisional patent application with the U.S. Patent and Trademark Office for use of ibezapolstat to treat C. difficile Infection (CDI) while reducing recurrence of infection and improving the health of the gut microbiome.

    "Successful closing of our IPO is a significant corporate milestone and provides the resources required to complete the Company's Phase 2b clinical trial of ibezapolstat in patients with CDI, and to advance development of ACX-375C, our second antibiotic candidate program," stated David P. Luci, President and Chief Executive Officer of Acurx. 

    Second Quarter 2021 Financial Results

    Research and development expenses were $0.1 million for the three months ended June 30, 2021 compared to $0.4 million for the three months ended June 30, 2020. The decrease is primarily due to completion of the Phase 2a trial in 2020.  For the six months ended June 30, 2021, research and development expenses were $0.2 million compared to $1.1 million for the six months ended June 30, 2020.  The decrease is due to a decrease in Phase 2a trial related costs which was completed in the second half of 2020 and a decrease in consulting costs.

    Selling, general and administrative expenses were $3.9 million for the three months ended June 30, 2021 compared to $0.5 million for the three months ended June 30, 2020.  The increase was primarily due to an increase in stock-based director fees and stock-based compensation, and an increase in professional fees.

    For the six months ended June 30, 2021, selling, general and administrative expenses were $5.4 million compared to $1.1 million for the six months ended June 30, 2020. The increase in selling, general and administrative expenses is primarily attributable to an increase in stock-based compensation, professional fees and stock-based director fees.

    The Company reported a net loss of $4.0 million or $(0.57) per diluted share for the three months ended June 30, 2021 compared to a net loss of $0.9 million or $(0.15) per diluted share for the three months ended June 30, 2020 and a net loss of $5.5 million or $(0.79) per diluted share for the six months ended June 30, 2021 compared to a net loss of $2.2 million or $(0.37) per diluted share for the six months ended June 30, 2020, for the reasons previously mentioned.

    As of June 30, 2021, the Company had a cash balance  of $17.1 million.

    Conference Call

    As previously announced, David P. Luci, President and Chief Executive Officer, and Robert G. Shawah, Chief Financial Officer, will host a conference call to discuss the results and provide a business update as follows:

    Date:

    Tuesday, August 17, 2021

    Time:

    8:30 a.m. ET

    Toll free (U.S. and International):

    877-790-1503

    Conference ID:

    13721752

    About Ibezapolstat

    Ibezapolstat is a novel, orally-administered antibacterial compound being developed as a targeted, narrow spectrum oral antibiotic for the treatment of patients with C. difficile Infection (CDI). It is the first of a novel class of DNA polymerase IIIC inhibitors under development by Acurx to treat bacterial infections.

    In June 2018, ibezapolstat was designated by the U.S. Food and Drug Administration (FDA) as a Qualified Infectious Disease Product (QIDP) for the treatment of patients with CDI and will be eligible to benefit from the incentives for the development of new antibiotics established under the Generating New Antibiotic Incentives Now (GAIN) Act. In January 2019, FDA granted "Fast Track" designation to ibezapolstat for the treatment of patients with CDI. 

    The Company successfully completed Phase 1 and Phase 2a clinical trials of ibezapolstat and in the second half of 2021 it expects to begin enrollment of its Phase 2b vancomycin-controlled efficacy study in a 1:1 randomized trial of a total of 64 patients with CDI. 

    The CDC has designated C. difficile as an urgent threat highlighting the need for new antibiotics to treat CDI.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D preclinical pipeline includes antibiotic candidates that target other Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Penicillin-Resistant Streptococcus pneumoniae (PRSP).  

    To learn more about Acurx Pharmaceuticals and its product pipeline, please visit www.acurxpharma.com

    Forward-Looking Statements 

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the potential of Ibezapolstat, Acurx's future expectations, plans and prospects, including without limitation, Acurx's expectations regarding its growth, strategy, progress and timing of its clinical trials, the potential of its antibiotics, and its intellectual property protection. The use of words such as "may," "might," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "potential," or "continue," and other similar expressions are intended to identify such forward-looking statements. All such forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include the possibility that data from clinical trials will be inconsistent with the data observed in subsequent clinical trials, whether ibezapolstat will benefit from the QIDP designation, whether ibezapolstat will advance through the clinical trial process on a timely basis, whether the results of the clinical trials of ibezapolstat will warrant the submission of applications for marketing approval, and if so, whether ibezapolstat will receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies where approval is sought, whether, if ibezapolstat obtains approval, it will be successfully distributed and marketed, competition from third parties that are developing products for similar uses, Acurx's ability to obtain, maintain and protect its intellectual property, Acurx's dependence on third parties for development and manufacture of product candidates including to supply any clinical trials, Acurx's ability to manage expenses and to obtain additional funding when needed to support its business activities and establish and maintain strategic business alliances and new business initiatives, and the impacts of public health pandemics such as COVID-19 on business operations including its clinical trials. Additional detailed information concerning a number of the important factors that could cause actual results to differ materially from the forward-looking information contained in this release is readily available in Acurx's publicly filed Registration Statement on Form S-1 and will also be included in quarterly, annual and other reports. Acurx disclaims any obligation to update developments of these risk factors or to announce publicly any revision to any of the forward-looking statements contained in this release, or to make corrections to reflect future events or developments.

    Investor Contact:

    Acurx Pharmaceuticals, Inc.

    David P. Luci, President & CEO

    Tel:  917-533-1469

    Email:  davidluci@acurxpharma.com

    FINANCIAL TABLES FOLLOW

    ACURX PHARMACEUTICALS, INC.

    CONDENSED INTERIM BALANCE SHEETS







    June 30, 



    December 31, 





    2021



    2020

    ASSETS



    (unaudited)







    CURRENT ASSETS













    Cash



    $

    17,095,596



    $

    3,175,411

    Prepaid Expenses





    344,549





    48,609

    TOTAL ASSETS



    $

    17,440,145



    $

    3,224,020















    LIABILITIES AND MEMBERS' AND SHAREHOLDERS' EQUITY













    CURRENT LIABILITIES













    Accounts Payable and Accrued Expenses



    $

    1,918,639



    $

    455,931

    Paycheck Protection Program Loan









    16,625

    TOTAL CURRENT LIABILITIES





    1,918,639





    472,556















    NON CURRENT LIABILITIES













    Paycheck Protection Program Loan









    49,878

    TOTAL LIABILITIES





    1,918,639





    522,434















    COMMITMENTS AND CONTINGENCIES



























    MEMBERS' AND SHAREHOLDERS' EQUITY













    Members' Equity, Class A









    16,402,198

    Members' Equity, Class B









    100,000

    Common Stock; $.001 par value, 200,000,000 shares authorized, 9,916,208 shares issued and outstanding at June 30, 2021





    9,916





    Additional Paid-in Capital





    34,790,591





    Accumulated Deficit





    (19,279,001)





    (13,800,612)

    TOTAL MEMBERS' AND SHAREHOLDERS' EQUITY





    15,521,506





    2,701,586















    TOTAL LIABILITIES AND MEMBERS' AND SHAREHOLDERS' EQUITY



    $

    17,440,145



    $

    3,224,020

     

    ACURX PHARMACEUTICALS, INC.

    CONDENSED INTERIM STATEMENTS OF OPERATIONS







    Three Months Ended



    Six Months Ended





    June 30, 



    June 30, 





    2021



    2020



    2021



    2020





    (unaudited)



    (unaudited)



    (unaudited)



    (unaudited)

    OPERATING EXPENSES

























    Research and Development



    $

    95,074



    $

    400,738



    $

    186,981



    $

    1,085,469

    General and Administrative





    3,975,488





    512,622





    5,357,911





    1,106,992

    TOTAL OPERATING EXPENSES





    4,070,562





    913,360





    5,544,892





    2,192,461

    Gain on forgiveness of Paycheck Protection Program Loan





    66,503









    66,503





    NET LOSS



    $

    (4,004,059)



    $

    (913,360)



    $

    (5,478,389)



    $

    (2,192,461)

    LOSS PER SHARE

























    Basic and diluted net loss per common share/units



    $

    (0.57)



    $

    (0.15)



    $

    (0.79)



    $

    (0.37)

    Weighted average pro forma shares outstanding basic and diluted





    6,968,341





    5,975,971





    6,908,396





    5,919,792

     

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  4. STATEN ISLAND, N.Y., Aug. 12, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that David P. Luci, President & CEO, will present at the Emerging Growth Conference as follows:

    Date:

    Wednesday, August 18, 2021

    Time:

    11:15 a.m. Eastern Time

    Webcast: 

    https://goto.webcasts.com/starthere.jsp?ei=1486517&tp_key=3bd9735fe4&sti=acxp

    This live, interactive online event will provide current stockholders and the investment community the opportunity to interact with David P. Luci.  As time permits, Mr. Luci may be able to respond to questions from participants.

    The presentations…

    STATEN ISLAND, N.Y., Aug. 12, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that David P. Luci, President & CEO, will present at the Emerging Growth Conference as follows:

    Date:

    Wednesday, August 18, 2021

    Time:

    11:15 a.m. Eastern Time

    Webcast: 

    https://goto.webcasts.com/starthere.jsp?ei=1486517&tp_key=3bd9735fe4&sti=acxp

    This live, interactive online event will provide current stockholders and the investment community the opportunity to interact with David P. Luci.  As time permits, Mr. Luci may be able to respond to questions from participants.

    The presentations will be webcast live at the aforementioned time, and archived for 30 days thereafter, via the Company's website at www.acurxpharmaceuticals.com, under the Investors section.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D preclinical pipeline includes antibiotic candidates that target other Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Penicillin-Resistant Streptococcus pneumoniae (PRSP).   

    To learn more about Acurx Pharmaceuticals and its product pipeline, please visit www.acurxpharma.com

    Investor Contact:

    Acurx Pharmaceuticals, Inc.

    David P. Luci, President & CEO

    Tel:  917-533-1469

    Email:  davidluci@acurxpharma.com

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  5. WASHINGTON, Aug. 5, 2021 /PRNewswire/ -- The Antimicrobials Working Group (AWG) announced today the addition of Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) (Acurx) to its coalition of companies with the mission to combat drug resistant infections and spur life-saving innovations. This new addition brings AWG's membership to 13 antimicrobial drug companies.

    Acurx is a clinical stage biopharmaceutical company developing a new class of antibiotics for infections caused by bacteria listed as priority pathogens by the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), and Food and Drug Administration (FDA). Their lead product candidate, ibezapolstat, is a first-in-class of a new class of DNA pol IIIC inhibitors which is in Phase 2 clinical development to treat C. difficile Infection (CDI). Ibezapolstat is the first antibiotic candidate intended to work by blocking the DNA Pol IIIC enzyme, the enzyme necessary for replication of the DNA of the C. difficile bacterial cell.

    "We are delighted to have Acurx join AWG and add their voice to our mission to improve the antimicrobial drug and device environment to provide doctors and patients with innovative treatment options for difficult to treat infectious diseases," said Ted Schroeder, Chief Executive Officer of Nabriva Therapeutics and Chairman of AWG. "Through the collective power of our membership, AWG will continue to engage with key legislators and stakeholders to drive public policy that will stabilize the fragile antimicrobial ecosystem, enable appropriate patient access to novel products, and spur much-needed research and development to help combat the growing threat of antimicrobial resistance. We look forward to working with Acurx to accomplish these goals."

    Bob DeLuccia, Executive Chairman of Acurx, stated: "Antibiotic-resistant Gram-positive infections are substantial societal, public health, and economic burdens worldwide.   Methicillin-Resistant Staphylococcus aureus (MRSA) alone accounts for more than half of the infections in US-hospitalized patients, more than any other category of pathogens, including the most problematic serious Gram-negative infections combined. He further stated: "Acurx is pleased to join the AWG and support its efforts to improve the regulatory, investment and commercial environment for successful antimicrobial drug development and commercialization, thereby ensuring preparedness for the next pandemic, antimicrobial resistance, for the benefit of patients worldwide."

    All pharmaceutical and biotechnology companies developing new antimicrobial therapeutics and diagnostic devices are eligible for consideration of membership in AWG. If you are interested in learning more about becoming a member of AWG, please contact us here.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme. Its R&D pipeline includes antibiotic product candidates that target Gram-positive bacteria, including Clostridioides difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE) and drug-resistant Streptococcus pneumoniae (PRSP). 

    For more information, please visit: www.acurxpharma.com.

    About The Antimicrobials Working Group

    AWG was founded in 2012 with the vision of utilizing collective power to improve the regulatory, investment, and commercial environment for emerging infectious disease companies. Today, AWG is comprised of thirteen antimicrobials companies: Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP), Cidara Therapeutics Inc. (NASDAQ: CDTX), , Crestone, Inc., Entasis Therapeutics Inc., Iterum Therapeutics Ltd. (NASDAQ: ITRM), Melinta Therapeutics Inc. (NASDAQ: MLNT), Nabriva Therapeutics US Inc. (NASDAQ: NBRV), Paratek Pharmaceuticals Inc. (NASDAQ: PRTK), Qpex Biopharma, Inc., SCYNEXIS Inc. (NASDAQ: SCYX), Summit Therapeutics plc (NASDAQ: SMMT) (AIM: SUMM), UTILITY therapeutics Ltd., and Venatorx Pharmaceuticals, Inc.

    For more information, visit: www.antimicrobialsworkinggroup.org

    About The Conafay Group

    The Conafay Group, led by Stephen R. Conafay, Principal, is a life-sciences government relations firm based in Washington D.C. that serves as Washington counsel and coalition manager for AWG.

    For more information, visit: www.conafaygroup.com

     

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  6. STATEN ISLAND, N.Y., Aug. 2, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (Nasdaq ACXP) ("Acurx" or the "Company") a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that Health Holland has awarded a grant of approximately $500,000 USD to Leiden University Medical Center (LUMC) and, through a three-party Consortium Agreement, Acurx Pharmaceuticals.  This grant will fund an innovative research project entitled: Bad bugs, new drugs: structural elucidation of polymerase C* from multidrug resistant organisms to guide optimization of a new class of therapeutics.  

    Dr.Wiep Klaas Smits, Associate Professor, LUMC Department of Medical Microbiology will be…

    STATEN ISLAND, N.Y., Aug. 2, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (Nasdaq ACXP) ("Acurx" or the "Company") a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that Health Holland has awarded a grant of approximately $500,000 USD to Leiden University Medical Center (LUMC) and, through a three-party Consortium Agreement, Acurx Pharmaceuticals.  This grant will fund an innovative research project entitled: Bad bugs, new drugs: structural elucidation of polymerase C* from multidrug resistant organisms to guide optimization of a new class of therapeutics.  

    Dr.Wiep Klaas Smits, Associate Professor, LUMC Department of Medical Microbiology will be the lead researcher in collaboration with Dr. Meindert Lamers, Associate Professor, LUMC Department of Cell and Chemical Biology.

    Dr. Smits stated: "This collaborative grant opportunity will be a novel scientific accomplishment contributing to Acurx programs by enhancing knowledge of the structure of pol IIIC from different pathogenic, multidrug-resistant organisms. Additionally, we will study the binding of Acurx drug candidates in complex with pol IIIC enzymes to establish a detailed in vitro characterization of polymerase and inhibiting activity."  He further stated: "This work will lead to important insights into differences between replicative polymerases of critical drug-resistant Gram-positive pathogens and pave the way for rational design of novel inhibitors based on structure-activity relationships in the future."

    Acurx is commencing a Ph2b clinical trial in patients with CDI during the second half of this year after having recently completed a Ph2a clinical trial which demonstrated that 10 of 10 patients with CDI (100%) met the study's primary and secondary efficacy endpoints of Clinical Cure at end of treatment and Sustained Clinical Cure with no recurrence of CDI at the 28-day follow-up visit.  These results have validated the therapeutic effect of DNA pol IIIC as a bacterial target.

    Robert J. DeLuccia, Executive Chairman of Acurx, stated "We believe this state-of-the-art structural biology research, which includes crystallography and cryo-electron microscopy, can be translated into chemical synthesis strategies to develop an innovative portfolio of novel inhibitors of DNA polymerases of target organisms with our GPSS™ (Gram-positive Selective Spectrum) antibiotic candidates".  He further stated: "This could lead to identification of selective inhibitors for serious Gram-positive pathogens, particularly MRSA, VRE and PRSP, offering more opportunities to enhance our development pipeline and to expand the treatment options with new classes of antibiotics for multi-drug resistant bacterial infections."

    *"pol C" is alternative nomenclature for "pol IIIC"

    About the Research Project, Leiden University Medical Center, the Research Consortium

    Antimicrobial resistant microorganisms are a major threat to global health and pose a significant economic burden. Increasing resistance to multiple agents and resistance to so called last-resort antibiotics underscore the necessity to develop therapeutics that have a novel mode of action. DNA replication is a process that can be successfully targeted by small molecules. Ibezapolstat, an inhibitor of the replicative DNA polymerase pol IIIC from Gram-positive bacteria identified by screening library of dGTP analogues, has shown promising results for the treatment of Clostridioides difficile Infection in a recent Phase 2a clinical trial, but the molecular basis of selective inhibition is not fully characterized as no structural information is available on pol IIIC proteins from pathogens. This research project will determine the structure of pol IIIC from the multidrug-resistant organisms methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococci (VRE) and/or penicillin resistant Streptococcus pneumoniae (PRSP) in the absence and presence of lead compounds. These results will reveal the structural space of inhibitor-binding and guide the rational design of inhibitors with optimal pharmacological properties and organism-specificity that will be demonstrated by in vitro polymerase inhibition assays and in vivo minimal inhibitory concentration determination.

    Leiden University was the first university to be established in the Netherlands. Its motto is praesidium libertatis – bastion of freedom.  The University wishes to create an increasingly attractive and challenging working climate for top academics and young researchers that is guided by quality and excellence. Leiden University Medical Center (LUMC) research aims to meet the highest international standards of quality and academic integrity. LUMC promotes excellent research through greater collaboration, both disciplinary and interdisciplinary; stronger positioning and greater scope for top talent; and better supervision and more support for young researchers.

    The Research Consortium participants are the Dutch Top Sector Life Sciences and Health ('Topconsortium voor Kennis en Innovatie' or 'TKI' Life Sciences and Health) and is represented by Stichting Life Sciences Health – TKI (aka, Health~Holland) and is tasked by the Dutch government to promote and stimulate new public-private partnerships (PPPs) to undertake R&D projects in the life sciences. To promote such partnerships, the Minister of Economic Affairs and Climate Policy has allocated certain funds to Stichting LSH-TKI, to grant allowances to projects under the TKI-programme Life Sciences & Health. Stichting LSH-TKI has designated the Board of Directors of LUMC as delegated grantor for the PPP allowance allocated to the LUMC.

    Together with Acurx Pharmaceuticals the PPP will initiate the research project entitled "Bad bugs, new drugs: elucidation of the structure of DNA polymerase C of multidrug resistant bacteria in complex with novel classes of antimicrobials." The collaboration project is co-funded by the PPS Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships.

    About Clostridioides difficile Infection (CDI).

    According to the 2017 Update (published February 2018) of the Clinical Practice Guidelines for C. difficile Infection by the Infectious Diseases Society of America (IDSA) and Society or Healthcare Epidemiology of America (SHEA), CDI remains a significant medical problem in hospitals, in long-term care facilities and in the community. C. difficile is one of the most common causes of health care-associated infections in U.S. hospitals (Lessa, et al, 2015, New England Journal of Medicine).  Recent estimates suggest C. difficile approaches 500,000 infections annually in the U.S. and is associated with approximately 20,000 deaths annually. (Guh, 2020, New England Journal of Medicine). Based on internal estimates, the recurrence rate of two of the three antibiotics currently used to treat CDI is between 20% and 40% among approximately 150,000 patients treated. We believe the annual incidence of CDI in the U.S. approaches 600,000 infections and a mortality rate of approximately 9.3%.

    The U.S. Center for Diseases Control 2019 Update on Antimicrobial Resistance. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf . CDC reported that more than 2.8 million antibiotic-resistant infections occur in the U.S. each year and more than 35,000 people die as a result, nearly twice as many annual deaths than previously reported by CDC in 2013. These deaths are attributed to antimicrobial-resistant pathogens including Enterococcus (including vancomycin-resistant strains or VRE), Staphylococcus (including methicillin-resistant strains or MRSA), and Streptococcus (including antibiotic-resistant strains), which are the bacterial targets of the Company's antibiotic pipeline with its GPSS™ (Gram-Positive Selective Spectrum) in preclinical development and also potentially eligible for QIDP and FDA-Fast-Track-Designation for priority review.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme. Its R&D pipeline includes antibiotic product candidates that target Gram-positive bacteria, including Clostridioides difficile, Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Penicillin-Resistant Streptococcus pneumoniae (PRSP).  For more information, please visit: www.acurxpharma.com.

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the potential of Ibezapolstat, Acurx's future expectations, plans and prospects, including without limitation, Acurx's expectations regarding its growth, strategy, progress and timing of its clinical trials, the potential of its antibiotics, and its intellectual property protection. The use of words such as "may," "might," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "potential," or "continue," and other similar expressions are intended to identify such forward-looking statements. All such forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include the possibility that data from clinical trials will be inconsistent with the data observed in subsequent clinical trials, whether ibezapolstat will benefit from the QIDP designation, whether ibezapolstat will advance through the clinical trial process on a timely basis, whether the results of the clinical trials of ibezapolstat will warrant the submission of applications for marketing approval, and if so, whether ibezapolstat will receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies where approval is sought, whether, if ibezapolstat obtains approval, it will be successfully distributed and marketed, competition from third parties that are developing products for similar uses, Acurx's ability to obtain, maintain and protect its intellectual property, Acurx's dependence on third parties for development and manufacture of product candidates including to supply any clinical trials, Acurx's ability to manage expenses and to obtain additional funding when needed to support its business activities and establish and maintain strategic business alliances and new business initiatives, and the impacts of public health pandemics such as COVID-19 on business operations including its clinical trials.  Additional detailed information concerning a number of the important factors that could cause actual results to differ materially from the forward-looking information contained in this release is readily available in Acurx's publicly filed Registration Statement on Form S-1 and will also be included in quarterly, annual and other reports. Acurx disclaims any obligation to update developments of these risk factors or to announce publicly any revision to any of the forward-looking statements contained in this release, or to make corrections to reflect future events or developments.

    Investor Contact:

    Acurx Pharmaceuticals, Inc.

    David P. Luci, President & CEO

    Tel:  917-533-1469;

    Email:  davidluci@acurxpharma.com

    Cision View original content:https://www.prnewswire.com/news-releases/health-holland-awards-innovative-research-grant-for-dna-pol-iiic-inhibitors-to-leiden-university-medical-center-and-acurx-pharmaceuticals-301345042.html

    SOURCE Acurx Pharmaceuticals, Inc.

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  7. STATEN ISLAND, N.Y., July 28, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that the Company will release its 2021 second quarter financial results on Tuesday, August 17, 2021, at 8:30 am ET before the U.S. financial markets open.

    David P. Luci, President and Chief Executive Officer, and Robert G. Shawah, Chief Financial Officer, will host a conference call to discuss the results and provide a business update as follows:

    Date: Tuesday, August 17, 2021
    Time: 8:30 a.m. ET
    Toll free (U.S. and International): 877-790-1503
    Conference ID: 13721752

    About Ibezapolstat

    STATEN ISLAND, N.Y., July 28, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) ("Acurx" or the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that the Company will release its 2021 second quarter financial results on Tuesday, August 17, 2021, at 8:30 am ET before the U.S. financial markets open.

    David P. Luci, President and Chief Executive Officer, and Robert G. Shawah, Chief Financial Officer, will host a conference call to discuss the results and provide a business update as follows:

    Date: Tuesday, August 17, 2021

    Time: 8:30 a.m. ET

    Toll free (U.S. and International): 877-790-1503

    Conference ID: 13721752

    About Ibezapolstat

    Ibezapolstat is a novel, orally-administered antibacterial compound being developed as a targeted, narrow spectrum oral antibiotic for the treatment of patients with C. difficile Infection (CDI). It is the first of a novel class of DNA polymerase IIIC inhibitors under development by Acurx to treat bacterial infections.

    In June 2018, ibezapolstat was designated by the U.S. Food and Drug Administration (FDA) as a Qualified Infectious Disease Product (QIDP) for the treatment of patients with CDI and will be eligible to benefit from the incentives for the development of new antibiotics established under the Generating New Antibiotic Incentives Now (GAIN) Act. In January 2019, FDA granted "Fast Track" designation to ibezapolstat for the treatment of patients with CDI.

    The Company successfully completed Phase 1 and Phase 2a clinical trials of ibezapolstat and in the second half of 2021 Acurx expects to begin enrollment of its Phase 2b vancomycin-controlled efficacy study in a 1:1 randomized trial of a total of 64 patients with CDI.

    The CDC has designated C. difficile as an urgent threat highlighting the need for new antibiotics to treat CDI.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D preclinical pipeline includes antibiotic candidates that target other Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Penicillin-Resistant Streptococcus pneumoniae (PRSP).

    To learn more about Acurx Pharmaceuticals and its product pipeline, please visit www.acurxpharma.com.

    Investor Contact:

    Acurx Pharmaceuticals, Inc.

    David P. Luci, President & CEO

    Tel: 917-533-1469

    Email: davidluci@acurxpharma.com

    Cision View original content:https://www.prnewswire.com/news-releases/acurx-pharmaceuticals-to-discuss-2021-second-quarter-financial-results-on-august-17-2021-conference-call-and-provide-business-update-301342371.html

    SOURCE Acurx Pharmaceuticals, Inc.

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  8. STATEN ISLAND, N.Y., July 7, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (Nasdaq ACXP) ("Acurx" or the "Company") a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that it has filed a provisional patent application in the United States Patent and Trademark Office (USPTO). The filing of this patent application relates to ibezapolstat and its use to treat C. difficile Infection while reducing the recurrence of the infection, as well as improving the health of the gut microbiome. This is the latest in the series of patent applications that Acrux has filed to protect its proprietary technologies in the field of antimicrobials. Acurx is commencing a Phase…

    STATEN ISLAND, N.Y., July 7, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (Nasdaq ACXP) ("Acurx" or the "Company") a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today that it has filed a provisional patent application in the United States Patent and Trademark Office (USPTO). The filing of this patent application relates to ibezapolstat and its use to treat C. difficile Infection while reducing the recurrence of the infection, as well as improving the health of the gut microbiome. This is the latest in the series of patent applications that Acrux has filed to protect its proprietary technologies in the field of antimicrobials. Acurx is commencing a Phase 2b clinical trial in patients with CDI (Clostridioides difficile Infection) during the second half of this year after having recently completed a Ph2a clinical trial which demonstrated that 10 of 10 patients with CDI (100%) met the study's primary and secondary efficacy endpoints of Clinical Cure at end of treatment and Sustained Clinical Cure with no recurrence of CDI at the 28-day follow-up visit.

    Acurx continues to pursue protection for its technologies in the United States and internationally. Acurx aims to protect the technology, inventions, know-how, and improvements that are important to the development of its business using the most effective intellectual property instruments.

    Robert J. DeLuccia, Executive Chairman of Acurx, stated "We believe that ibezapolstat's Gram-Positive Selective Spectrum (GPSS™), kills C. difficile, but not other Firmicutes necessary for maintaining a healthy microbiome, and it spares the important Actinobacteria phylum needed for maintaining a healthy microbiome." He further stated: "This concept of a dual-effect treatment which includes bactericidal activity against C. difficile bacteria while at the same time providing a restorative effect on the microbiome has the potential to position ibezapolstat as an important first-line therapy for CDI."

    David P. Luci, President & CEO of Acurx, stated: "We believe ibezapolstat's dual effect to effectively treat patients with CDI while simultaneously and dramatically reducing the likelihood of recurrence by restoring the microbiome would be a significant therapeutic advance. This dual effect would substantially reduce CDI recurrences and if this trend continues in later-stage clinical trials, and ibezapolstat is ultimately approved, it could have a dramatically positive impact on patient outcomes and on reducing downstream healthcare costs." 

    About Clostridioides difficile Infection (CDI). According to the 2017 Update (published February 2018) of the Clinical Practice Guidelines for C. difficile Infection by the Infectious Diseases Society of America (IDSA) and Society or Healthcare Epidemiology of America (SHEA), CDI remains a significant medical problem in hospitals, in long-term care facilities and in the community. C. difficile is one of the most common causes of health care-associated infections in U.S. hospitals (Lessa, et al, 2015, New England Journal of Medicine). Recent estimates suggest C. difficile approaches 500,000 infections annually in the U.S. and is associated with approximately 20,000 deaths annually. (Guh, 2020, New England Journal of Medicine). Based on internal estimates, the recurrence rate of two of the three antibiotics currently used to treat CDI is between 20% and 40% among approximately 150,000 patients treated. We believe the annual incidence of CDI in the U.S. approaches 600,000 infections and a mortality rate of approximately 9.3%.

    About the Microbiome in Clostridioides difficile Infection (CDI)

    C. difficile can sometimes be a normal component of the healthy gut microbiome, but when the microbiome is thrown out of balance, the C. difficile can thrive and cause an infection. After colonization with C. difficile, the organism produces and releases the main virulence factors, the two large clostridial toxins A (TcdA) and B (TcdB). (Kachrimanidou, Microorganisms 2020, 8, 200; doi:10.3390/microorganisms8020200.) TcdA and TcdB are exotoxins that bind to human intestinal epithelial cells and are responsible for inflammation, fluid and mucous secretion, as well as damage to the intestinal mucosa.

    About the Ibezapolstat Phase 2 Clinical Trial.

    The multicenter, open-label single-arm segment of this study is to be followed by a double-blind, randomized, active-controlled segment comprise the Phase 2 clinical trial designed to evaluate ibezapolstat in the treatment of CDI. Segment 2a of this trial was an open-label cohort of up to 20 subjects from study centers in the United States. In this cohort, all 10 patients with diarrhea caused by C. difficile were treated with ibezapolstat 450 mg orally, twice daily for 10 days. All patients were followed for recurrence for 28± 2 days. Per protocol, after 10 patients of the projected 20 Phase 2a patients completed treatment, the Trial Oversight Committee assessed the safety and tolerability and made recommendation regarding study continuation.  Based on the recommendation of Acurx's Scientific Advisory Board (SAB), we terminated enrollment in Phase 2a early and are now advancing to Phase 2b. The SAB unanimously supported the early termination of the Phase 2a trial after 10 patients were enrolled in the trial instead of 20 patients as originally planned. The early termination was further based on the evidence of meeting the treatment goals of eliminating the infection (100%), with no recurrences of infection, and with an acceptable adverse event profile. In Segment 2b, approximately 64 additional patients with CDI will be enrolled and randomized in a 1:1 ratio to either ibezapolstat 450 mg every 12 hours or vancomycin 125 mg orally every 6 hours for 10 days and followed for 28 ± 2 days following the end of treatment for recurrence of CDI. The two treatments will be identical in appearance, dosing times, and number of capsules administered to maintain the blind.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D pipeline includes early stage antibiotic candidates that target other Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Penicillin-Resistant Streptococcus pneumoniae (PRSP). For more information, please visit: www.acurxpharma.com.

    This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the potential of Ibezapolstat, Acurx's future expectations, plans and prospects, including without limitation, Acurx's expectations regarding its growth, strategy, progress and timing of its clinical trials, the potential of its antibiotics, and its intellectual property protection. The use of words such as "may," "might," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "project," "intend," "future," "potential," or "continue," and other similar expressions are intended to identify such forward-looking statements. All such forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include the possibility that data from clinical trials will be inconsistent with the data observed in subsequent clinical trials, whether ibezapolstat will benefit from the QIDP designation, whether ibezapolstat will advance through the clinical trial process on a timely basis, whether the results of the clinical trials of ibezapolstat will warrant the submission of applications for marketing approval, and if so, whether ibezapolstat will receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies where approval is sought, whether, if ibezapolstat obtains approval, it will be successfully distributed and marketed, competition from third parties that are developing products for similar uses, Acurx's ability to obtain, maintain and protect its intellectual property, Acurx's dependence on third parties for development and manufacture of product candidates including to supply any clinical trials, Acurx's ability to manage expenses and to obtain additional funding when needed to support its business activities and establish and maintain strategic business alliances and new business initiatives, and the impacts of public health pandemics such as COVID-19 on business operations including its clinical trials. Additional detailed information concerning a number of the important factors that could cause actual results to differ materially from the forward-looking information contained in this release is readily available in Acurx's publicly filed Registration Statement on Form S-1 and will also be included in quarterly, annual and other reports. Acurx disclaims any obligation to update developments of these risk factors or to announce publicly any revision to any of the forward-looking statements contained in this release, or to make corrections to reflect future events or developments.

    Investor Contact:

    Acurx Pharmaceuticals, Inc.

    David P. Luci, Co-Founder & Managing Partner 917-533-1469

    davidluci@acurxpharma.com

    Cision View original content:https://www.prnewswire.com/news-releases/acurx-announces-filing-of-provisional-patent-application-for-ibezapolstat-to-treat-cdi-while-reducing-recurrence-of-infection-and-improving-the-health-of-the-gut-microbiome-301326841.html

    SOURCE Acurx Pharmaceuticals, Inc.

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  9. STATEN ISLAND, N.Y., June 29, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) (the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today the closing of its previously announced underwritten initial public offering of 2,875,000 newly-issued shares of common stock, including the full exercise by the underwriters of their option to purchase 375,000 additional shares of common stock, at a price to the public of $6.00 per share. The shares are listed for trading on the Nasdaq Capital Market under the ticker symbol "ACXP." The net proceeds to the Company from the offering, after deducting the underwriter discounts and commissions and…

    STATEN ISLAND, N.Y., June 29, 2021 /PRNewswire/ -- Acurx Pharmaceuticals, Inc. (NASDAQ:ACXP) (the "Company"), a clinical stage biopharmaceutical company developing a new class of antibiotics for difficult-to-treat bacterial infections, announced today the closing of its previously announced underwritten initial public offering of 2,875,000 newly-issued shares of common stock, including the full exercise by the underwriters of their option to purchase 375,000 additional shares of common stock, at a price to the public of $6.00 per share. The shares are listed for trading on the Nasdaq Capital Market under the ticker symbol "ACXP." The net proceeds to the Company from the offering, after deducting the underwriter discounts and commissions and estimated offering expenses, were approximately $14.8 million.

    Alexander Capital L.P. acted as lead book-running manager for the offering. Network 1 Financial Securities, Inc. acted as co-manager.

    A registration statement on Form S-1 relating to these securities was declared effective by the Securities and Exchange Commission ("SEC") on June 24, 2021. A final prospectus relating to the offering was filed with the SEC and is available on the SEC's website at http://www.sec.gov. Copies of the final prospectus may be obtained from: Alexander Capital, L.P., 17 State Street, New York, New York 10014, (212) 687-5650, info@alexandercapitallp.com.

    This press release does not constitute an offer to sell or the solicitation of an offer to buy any securities of the Company being offered, and shall not constitute an offer, solicitation or sale of any security in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

    About Acurx Pharmaceuticals, Inc.

    Acurx Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing new antibiotics for difficult to treat infections. The Company's approach is to develop antibiotic candidates that target the DNA polymerase IIIC enzyme and its R&D pipeline includes early stage antibiotic candidates that target other Gram-positive bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Penicillin-Resistant Streptococcus pneumoniae (PRSP).  For more information, please visit: www.acurxpharma.com.

    Investor Contact:

    David P. Luci, President and Chief Executive Officer

    Acurx Pharmaceuticals, Inc.

    Phone: (917) 533-1469

    davidluci@acurxpharma.com

    Cision View original content:https://www.prnewswire.com/news-releases/acurx-pharmaceuticals-inc-announces-closing-of-initial-public-offering-of-common-stock-and-full-exercise-of-underwriters-option-to-purchase-additional-shares-301322424.html

    SOURCE Acurx Pharmaceuticals, LLC

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