Drug Pipeline Database & Screener

Over 2000 drug entries from about 500 biotech companies in Phase 2, 3 or NDA development.

Company SCREENER also available to filter through financial and clinical data. Financial filters include market cap, short ratio, price to book and relative volume, while you can also run a filter according to the development stage of the drug (e.g. Phase 2, PDUFA date).

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Showing 570 companies

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Company Price Change Market Cap Outstanding Shares Short Ratio Updated

Stage

Any... Phase 1a Phase 1 Phase 1b Phase 1/2 Phase 2a Phase 2 Phase 2b Phase 2/3 Phase 3 NDA Filing sNDA Filing BLA Filing PDUFA PDUFA priority review Approved CRL

Indication

Any... 22q11.2 Deletion Syndrome AADC deficiency Abdominal symptom claims (ASC) Achalasia Achondroplasia Achromatopsia Acid sphingomyelinase deficiency (ASMD) Acinetobacter baumannii infections Acne Acquired thrombotic thrombocytopenic purpura (aTTP) Acromegaly Actinic keratosis Acute bacterial skin and skin structure infections (ABSSSI) Acute Coronary Syndrome Acute hepatic porphyrias Acute lymphoblastic leukemia (ALL) Acute myeloid leukemia (AML) Acute myocardial infarction (AMI) Acute otitis externa Acute Promyelocytic Leukemia acute pyelonephritis Acute Respiratory Distress Syndrome Acute-on-Chronic Liver Failure (ACLF) Adenosine deaminase severe combined immunodeficiency (ADA-SCID) Adenovirus ADHD Adrenoleukodystrophy (ALD) Adult Growth Hormone Deficiency (AGHD) Age-related macular degeneration (AMD) Agitation Alcohol Use Disorder Alcohol-induced liver decompensation (AILD) Alcoholic Hepatitis Alcoholic steatohepatitis (ASH) Alopecia areata Alpha-1 Antitrypsin deficiency (AATD) Alport Syndrome Alstrom Syndrome Alzheimer’s disease Ammonia Amyloidosis Amyotrophic Lateral Sclerosis (ALS) Anal cancer Anal fissures Anaphylaxis ANCA-associated vasculitis (AAV) Androgenetic alopecia (AGA) Androgenic Alopecia Anemia Angelman syndrome Angina Angiosarcoma Animal related Ankylosing spondylitis Anthrax Arginase I deficiency Asthma Atopic dermatitis Atopic keratoconjunctivitis Atrial fibrillation (AF) ATTR (transthyretin amyloidosis) atypical Hemolytic Uremic Syndrome (aHUS) Autism Autism Spectrum Disorder (ASD) Auto-immune Hemolytic Anemia (AIHA) Autoimmune pulmonary alveolar proteinosis (PAP) autosomal dominant retinitis pigmentosa (adRP) Autosomal Recessive Congenital Ichthyosis Autosomal Recessive Stargardt Disease Axial Spondyloarthritis Axillary hyperhidrosis B-Cell Lymphoma Back pain Bacteremia Bardet-Biedl Syndrome Barth Basal cell carcinoma Batten Disease Behcet's Disease Benign Prostatic Hyperplasia (BPH) Beta-Thalassemia Biliary atresia Biliary Tract Cancer Biosimilar Bipolar depression Bladder cancer Bladder pain syndrome/interstitial cystitis (BPS/IC) Blastic plasmacytoid dendritic cell neoplasm (BPDCN) Bleeding Blepharoptosis Blindness Bowel related Brain cancer Brain injury Breast cancer Bronchiectasis Bulimia Bullous Pemphigoid Bunionectomy C. difficile Infection C3 glomerulopathy (C3G) Cachexia Candida Auris Candidemia Carcinoid Syndrome Carcinoma In-Situ (CIS) Cardiomyopathy Cardiovascular disease Cartilage/Knee Catecholamine-resistant hypotension (CRH) CDKL5 disorder Celiac disease Celluite Cervical cancer Cervical dysplasia Cervical dystonia Charcot-Marie-Tooth disease (CMT) Chemotherapy induced nausea and vomiting (CINV) Chemotherapy-induced neutropenia (CIN) Chikungunya vaccine Chikungunya Virus Infection Cholangiocarcinoma Choroideremia Chronic cough Chronic Dysphonia Chronic idiopathic constipation (CIC) Chronic Kidney Disease-Associated Pruritus Chronic Lymphocytic Leukemia (CLL) Chronic myelogenous leukemia Chronic myelomonocytic leukemia (CMML) Chronic obstructive pulmonary disease (COPD) Chronic Prostatitis Chronic spontaneous urticaria Chronic Urticaria Cocaine related Cold agglutinin disease Colon cancer Colorectal cancer Community-acquired bacterial pneumonia (CABP) Complement-dependent Nephropathies (CDN) Complex regional pain syndrome (CRPS) Complicated intra-abdominal infections (cIAI) Complicated urinary tract infections (cUTI) Condyloma Congenital Adrenal Hyperplasia (CAH) Congenital hyperinsulinism Congenital Myasthenic Syndromes (CMS) Conjunctivitis Connective tissue growth factor (CTGF) Constipation Contact lens Contraception Contrast-induced Nephropathy Coronary artery disease (CAD) Coronary microvascular dysfunction (CMD) Cow’s milk protein allergy (CMPA) Crigler-Najjar Critical limb ischemia (CLI) Crohn’s Disease Cushings syndrome Cutaneous fibrosis Cutaneous squamous cell carcinoma Cutaneous T-cell lymphoma (CTCL) Cystic fibrosis Cystinosis Cystinuria Cytomegalovirus (CMV) Danon disease Degenerative cervical myelopathy (DCM) Dementia Dengue Depression Dermal scarring Dermatomyositis Developmental and Epileptic Encephalopathies (DEE) Diabetes Diabetic cardiomyopathy (DbCM) Diabetic Foot Ulcers Diabetic macular edema (DME) Diabetic nephropathy Diabetic neuropathy Diabetic Retinopathy Diarrhea Diffuse Intrinsic Pontine Glioma (DIPG) Diffuse Large B-Cell Lymphoma (DLBCL) Dravet Syndrome Dry eye disease Duchenne Muscular Dystrophy Dyslipidemia Ebola Eczema Egg Allergy End Stage Renal Disease on Dialysis Endometrial cancer Endometriosis Eosinophilic esophagitis Eosinophilic Gastritis Eosinophilic Granulomatosis with Polyangiitis (EGPA) Epidermolysis Bullosa Epilepsy Epithelioid Sarcoma Epstein-Barr virus (EBV-PTLD) Erectile dysfunction Erythropoietic protoporphyria (EPP) Esophageal cancer Esophagogastric adenocarcinoma Essential hypertension Essential thrombocythemia Essential tremor Exocrine pancreatic insufficiency (EPI) Fabry disease Facioscapulohumeral muscular dystrophy (FSHD) Factor Xa Familial Adenomatous Polyposis (FAP) Familial amyloid polyneuropathy (FAP) Familial amyloidotic cardiomyopathy (FAC) Familial chylomicronemia syndrome (FCS) Familial partial lipodystrophy (FPL) Fanconi Anemia (FA) Fascioliasis Fatty Acid Oxidation Disorders (FAOD) Female Sexual Arousal Disorder (FSAD) Female sexual dysfunction (FSD) Fibrodysplasia ossificans progressiva (FOP) Fibromyalgia Focal segmental glomerulosclerosis (FSGS) Follicular Lymphoma Forehead lines Fragile X syndrome Frailty Friedreich's Ataxia (FA) Friedreich’s ataxia (FA) Frozen Shoulder syndrome Galactosemia Gastric cancer Gastroenteritis Gastroesophageal reflux disease (GERD) Gastrointestinal stromal tumors (GIST) Gastroparesis Gaucher disease Generalized anxiety disorder (GAD) Generalized pustular psoriasis Genital warts Geographic atrophy (GA) Gestational Trophoblastic Neoplasia (GTN) Giant cell arteritis (GCA) Glabellar lines Glaucoma Glioblastoma Multiforme (GBM) Glioma Glomerulopathies Glucocorticoid-induced osteoporosis (GIOP) Glut1 DS Glycogen Storage Disease GM1 gangliosidosis GM2 gangliosidosis GNE Myopathy Gonorrhea Gorlin syndrome Gout Graft versus host disease (GvHD) Granulomatosis with polyangiitis (GPA) Growth hormone deficiency GSD1 Gynecomastia H. pylori Hair-related Head and Neck Cancer Headache Hearing loss Heart failure Heat stroke Hematopoietic stem cell transplant-related thrombotic microangiopathy (HSCT-TMA) Hemochromatosis Hemophilia Hemophilia A Hemophilia B Hemorrhoids Hemostasis Hepatic encephalopathy Hepatic porphyrias Hepatitis B Hepatitis C (HCV) Hepatitis delta virus (HDV) Hepatocellular carcinoma (HCC) Hepatorenal syndrome (HRS) Hereditary Angioedema (HAE) Hernia Herpes Heterozygous Familial Hypercholesterolemia (HeFH) Hidradenitis Suppurativa High Triglycerides Hip-related HIV Hodgkin lymphoma Homozygous familial hypercholesterolemia (HoFH) Hospital-Acquired Bacterial Pneumonia Hot flashes Human lipomas Human Papilloma Virus (HPV) Huntingtons disease Hutchinson-Gilford Progeria Syndrome (HGPS) Hyperammonemia Hypercholesterolemia Hypereosinophilic syndrome (HES) Hyperkalemia Hyperlipidemias Hyperoxaluria Hyperphosphatemia Hyperprolactinemia Hypertension Hypertriglyceridaemia Hypertriglyceridemia Hypertrophic cardiomyopathy (HCM) Hyperuricemia Hypoactive sexual desire disorder (HSDD) Hypoglycemia Hypogonadism Hypoparathyroidism Hypotension Hypothyroidism Idiopathic Hypersomnia Idiopathic Polypoidal Choroidal Vasculopathy Idiopathic pulmonary fibrosis (IPF) IgA nephropathy IgG4-Related Disease Immune Thrombocytopenic Purpura (ITP) Incisional complications Indolent Systemic Mastocytosis Infantile spasms (IS) Infections - various Inflammatory bowel disease (IBD) Influenza Inherited Metabolic Disorders (IMD) Insomnia Intermittent claudication (IC) Invasive aspergillosis Invasive candidiasis Irritable bowel syndrome (IBS) IVF Jaundice Jet Lag Disorder Kaposi’s sarcoma Kidney disease Knee arthroplasty Lactose intolerance Lambert-Easton Myasthenic Syndrome (LEMS) Lassa virus Leber's Congenital Amaurosis (LCA) Leber’s hereditary optic neuropathy (LHON) Leiomyosarcoma (LMS) Lennox-Gastaut syndrome Leukemia Leukocyte Adhesion Deficiency-I (LAD-I) Levodopa-Induced Dyskinesia Lipodystrophy Liposarcoma Liver cancer Liver Cirrhosis Liver disease Liver fibrosis Low Cardiac Output Syndrome Lung cancer Lung transplant rejection Lupus Lymphedema Lymphoma Macular Edema Malaria Malignant hyperthermia Malignant pleural disease Mantle cell lymphoma (MCL) Marginal zone lymphoma Medullary thyroid cancer Melanoma Ménière's disease Meningitis Menkes disease Merkel cell carcinoma MERS virus (Middle East Respiratory Syndrome) Mesothelioma Metachromatic leukodystrophy (MLD) Methylmalonic Acidemia (MMA) Microsatellite Instability-High Cancer Microscopic polyangiitis (MPA) Migraine Mitochondrial Myopathy Mmyxoid/round cell liposarcoma (MRCLS) Molluscum Contagiosum Molybdenum cofactor deficiency (MoCD) MPS 7 MPS I MPS II MPS III MPS IIIA MPS IIIB MPS IVA Mucocutaneous candidiasis Multiple myeloma Multiple Osteochondroma (MO) Multiple Sclerosis (MS) Multiple system atrophy (MSA) Myasthenia Gravis (MG) Mycosis Fungoides Mydriasis Myelodysplastic syndromes (MDS) Myelofibrosis Myocardial ischemia Myopia Narcolepsy Nasal polyps Nasopharyngeal cancer Nasopharyngeal carcinoma (NPC) Neuroblastoma Neuroendocrine tumors Neurogenic Orthostatic Hypotension (nOH) Neuromyelitis Optica Spectrum Disorder (NMOSD) Neuropathic pain Neutropenia Nicotine Addiction Niemann-Pick Disease Non-cystic fibrosis bronchiectasis (non-CF BE) Non-Hodgkin Lymphoma (NHL) Non-infectious uveitis Non-small cell lung cancer (NSCLC) Nonalcoholic fatty liver disease (NAFLD) Nonalcoholic steatohepatitis (NASH) Nonproliferative Diabetic Retinopathy Nontuberculous mycobacteria (NTM) Norovirus Obesity Obsessive compulsive disorder (OCD) Obstructive Sleep Apnea (OSA) Ocular Inflammation Oculopharyngeal Muscular Dystrophy Oncology Opioid dependence Opioid overdose Opioid-induced constipation (OIC) Oral Mucositis Ornithine Transcarbamylase (OTC) Deficiency Osteoarthritis Osteoporosis Other Otitis media Ovarian cancer Overactive Bladder (OAB) Pain Painful Lumbosacral Radiculopathy (PLSR) Pancreatic cancer Papulopustular Rosacea Parkinson’s disease Paroxysmal Nocturnal Hemoglobinuria (PNH) Paroxysmal supraventricular tachycardia (PSVT) Peanut Allergy Pemphigus vulgaris (PV) Pericarditis Peripheral artery disease Peripheral Neuropathic Pain (PNP) Phenylketonuria (PKU) Pheochromocytoma Phosphoglucomutase 1 (PGM1) deficiency Pigmented Villonodular Synovitis (PVNS) PKAN Plantar fasciitis Plaque psoriasis Plasma Plasminogen Deficiency Platelets Pneumonia Polycythemia Vera Pompe Disease Portal Hypertension Post-Bariatric Hypoglycemia (PBH) Post-herpetic neuralgia (PHN) Post-traumatic stress disorder (PTSD) Posterior Uveitis Postpartum depression (PPD) Prader-Willi Syndrome (PWS) Pre-term labor Preeclampsia Presbyopia Primary axillary hyperhidrosis Primary biliary cholangitis (PBC) Primary hyperoxaluria (PH) Primary Immune Deficiency Disease (PIDD) Primary immunodeficiency (PI) Primary ovarian insufficiency (POI) Primary palmar hyperhidrosis Primary sclerosing cholangitis (PSC) Progeria Progressive familial intrahepatic cholestasis (PFIC) Progressive keratoconus Progressive supranuclear palsy (PSP) Proliferative vitreoretinopathy (PVR) Prophylaxis Prostate cancer Proteus Syndrome Prurigo nodularis Pruritus Pseudomonas aeruginosa Psoriasis Psoriatic arthritis Psychosis Pulmonary arterial hypertension (PAH) Pulmonary Hypertension Pulmonary sarcoidosis Pyoderma Gangraenosum (PG) Pyoderma Gangrenosum Pyruvate kinase deficiency Rare Bile Acid Synthesis Disorders Renal cancer Renal cell cancer (RCC) Respiratory syncytial virus (RSV) Retinal diseases Rett syndrome Rheumatoid Arthritis Richter's Transformation Rosacea RPE65-Deficiency S. aureus Sanfilippo syndrome Sarcomas Schizophrenia Sciatica Scleroderma Seborrheic keratosis (SK) Secondary hyperparathyroidism (SHPT) Secondary hypogonadism Seizures Severe aplastic anemia (SAA) Severe burns Sexual health (female) Sexual health (male) Sezary syndrome Shingles Short bowel syndrome Sialorrhea Sickle disease Sinus related Sinusitis Sjögren-Larsson Syndrome (SLS) Small cell lung cancer (SCLC) Small Fibre Neuropathy Small lymphocytic lymphoma (SLL) Smallpox Smith-Magenis Syndrome Smoking cessation Social Anxiety Disorder (SAD) Soild tumors Solid tumors Spasticity Spinal muscular atrophy (SMA) Spinal muscular atrophy (SMA) Type 1 Spinal muscular atrophy (SMA) Type 2 Spinal muscular atrophy (SMA) Type 3 Spinal-related Spinocerebellar Ataxia sporadic Inclusion Body Myositis (sIBM) Squamous Cell Carcinoma of the Head and Neck (SCCHN) Squamous cell lung cancer SRSE Staphylococcus aureus Status Epilepticus Stress related Stress urinary incontinence (SUI) Stroke Systemic mastocytosis (SM) Systemic Sclerosis T-cell lymphoma Tardive dyskinesia Testosterone related Thrombocytopenia Thrombotic microangiopathy (TMA) Thyroid cancer Thyroid Eye Disease (TED) Tinnitus Tourette syndrome Transfusion-dependent thalassemia (TDT) Transplant Transthyretin cardiomyopathy Trigeminal Neuralgia Tuberous Sclerosis Complex Tumor-induced osteomalacia (TIO) Type 1 diabetes Type 2 diabetes Ulcerative Colitis Urea Cycle Disorder Urinary tract infections Urothelial cancer Usher Syndrome Uterine Fibroids Vascular Ehlers-Danlos Syndrome Vasculitis Vasomotor symptoms (VMS) Veno-occlusive Disease (VOD) Venous Leg Ulcers Venous Thromboembolism (VTE) Vertigo Vitiligo Vulvovaginal candidiasis (VVC) Waldenström’s macroglobulinemia Walnut Allergy Warm autoimmune hemolytic anemia (WAIHA) Warts Wet age-related macular degeneration (AMD) WHIM syndrome Wilson disease Wiskott-Aldrich Syndrome (WAS) Women's health (pain/contraception) Wounds Wrinkles X-linked chronic granulomatous disease (X-CGD) X-Linked Hypophosphatemia (XLH) X-Linked Myotubular Myopathy X-linked Retinitis Pigmentosa (XLRP) X-linked retinoschisis (XLRS) X-linked Severe Combined Immunodeficiency (XSCID) Xerostomia Zika

Market Cap

Any Mega ($200bln and more) Large ($10bln to $200bln) Mid ($2bln to $10bln) Small ($300mln to $2bln) Micro ($50mln to $300mln) Nano (under $50mln) +Large (over $10bln) +Mid (over $2bln) +Small (over $300mln) +Micro (over $50mln) -Large (under $200bln) -Mid (under $10bln) -Small (under $2bln) -Micro (under $300mln)

Price

Any Under $1 Under $2 Under $3 Under $4 Under $5 Under $7 Under $10 Under $15 Under $20 Under $30 Under $40 Under $50 Over $1 Over $2 Over $3 Over $4 Over $5 Over $7 Over $10 Over $15 Over $20 Over $30 Over $40 Over $50 Over $60 Over $70 Over $80 Over $90 Over $100 $1 to $5 $1 to $10 $1 to $20 $5 to $10 $5 to $20 $5 to $50 $10 to $20 $10 to $50 $20 to $50 $50 to $100

Short ratio

Any Low (<5 days) High (>20 days) Under 5 days Under 10 days Under 15 days Under 20 days Under 25 days Under 30 days Over 5 days Over 10 days Over 15 days Over 20 days Over 25 days Over 30 days

Relative Volume

Any Over 10 Over 5 Over 3 Over 2 Over 1.5 Over 1 Over 0.75 Over 0.5 Over 0.25 Under 2 Under 1.5 Under 1 Under 0.75 Under 0.5 Under 0.25 Under 0.1

Price to book

Any Low (<3) High (>50) Under 1 Under 2 Under 3 Under 4 Under 5 Under 6 Under 7 Under 8 Under 9 Under 10 Over 1 Over 2 Over 3 Over 4 Over 5 Over 6 Over 7 Over 8 Over 9 Over 10 Over 20 Over 30 Over 40 Over 50

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Company

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EST EPCD

Updated

ABBV AbbVie Inc.

$70.19

-0.08  -0.11%

1.5 billion

$103.8 billion

2.45

729.3 thousand

9.3 million

0.08

-$13.27

$70.15

$70.27

07/16/2019

Tap to view 40 drug drugs

Drug	Indication	Stage	News
Risankizumab	Ulcerative colitis	Phase 3	Phase 3 trial to be initiated 1H 2018.
Depatuxizumab mafodotin ABT-414	Glioblastoma (rGBM)	Phase 3	Phase 3 trial did not meet primary endpoint at interim analysis - May 17, 2019.
Veliparib	Squamous non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC)	Phase 3	Phase 3 trial did not meet primary endpoints - April 19, 2017.
Ibrutinib	Relapsed or refractory MCL mantle cell lymphoma	Approved	Approved November 13, 2013.
Imbruvica	Cancer - Chronic Lymphocytic Leukemia Who Have Received at Least One Prior Therapy	Approved	Approved February 12, 2014.
Imbruvica	Deletion 17p	Approved	Approved July 19, 2014.
VIEKIRA PAK	HCV - genotype 1	Approved	Approved December 19, 2014.
IMBRUVICA	Waldenström’s Macroglobulinemia	Approved	Approved January 29, 2015 - PCYC
ABBV-8E12	Progressive supranuclear palsy (PSP)	Phase 2	Phase 2 initiation announced January 25, 2017.
ABBV-8E12	Alzheimer's disease	Phase 2	Phase 2 initiation announced January 25, 2017.
Venclexta (MURANO)	Relapsed or refractory Chronic Lymphocytic Leukemia (CLL)	Approved	Approval announced June 11, 2018.
Venetoclax	Relapsed or refractory multiple myeloma	Phase 3	Partial clinical hold lifted June 24, 2019.
Venclexta	First-line Diffuse large B-cell lymphoma (DLBCL)	Phase 3	Phase 3 trial planned.
Venclexta	Follicular lymphoma (FL)	Phase 3	Phase 3 trial planned.
Risankizumab	Crohn’s Disease	Phase 3	Phase 3 trial to commence 2H 2017.
Risankizumab	Psoriasis	Approved	FDA approval announced April 23, 2019.
Imbruvica	Second-line Chronic graft-versus-host disease (GVHD)	Approved	Approval announced August 2, 2017.
ABT-494	Psoriatic Arthritis	Phase 3	Phase 3 trial to commenced 2017.
Risankizumab	Psoriatic Arthritis	Phase 2b	Phase 3 trial planned for 2018.
ABT-494	Crohn’s Disease	Phase 3	Phase 3 trial initiated late 2017.
Rova-T (TRINITY)	Third-line Small Cell Lung Cancer	Phase 2	Phase 2 pivotal data released March 22, 2018. ORR of 16% + overall survival 5.6 months noted. Abstract 8507.
ABT-494	Atopic Dermatitis	Phase 3	Phase 2b data released September 7, 2017 - primary endpoint met. Phase 3 trial to be initiated 1H 2018.
Imbruvica	Marginal zone lymphoma	Approved	sNDA filing announced September 26, 2017. Priority Review. Approved January 19, 2017.
Glecaprevir/Pibrentasvir (G/P)	Hepatitis C virus (HCV)	Approved	Approval announced August 3, 2017.
Elagolix	Uterine Fibroids	NDA Filing	NDA filing due mid-2019.
Elagolix	Endometriosis	Approved	FDA approval announced July 24, 2018.
ABT-494 upadacitinib	Rheumatoid arthritis	PDUFA priority review	PDUFA date under priority review estimated at August 19, 2019.
Rova-T (TAHOE)	Second-line Small Cell Lung Cancer	Phase 3	Phase 3 enrolment to be stopped due to shorted overall survival following recommendation from Independent Data Monitoring Committee (IDMC) December 5, 2018.
Rova-T (MERU)	First-line Small Cell Lung Cancer	Phase 3	Phase 3 data due 2020.
Imbruvica and Gazyva - iLLUMINATE	Chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL)	Approved	FDA approval announced January 28, 2019.
IMBRUVICA (ibrutinib)	Waldenström’s Macroglobulinemia	Approved	FDA approval announced August 27, 2018.
IMBRUVICA (ibrutinib)	Diffuse large B-cell lymphoma (DLBCL)	Phase 3	Phase 3 trial did not meet primary endpoint - noted July 11, 2018.
Venclexta	First line unfit AML	Approved	FDA approval announced November 21, 2018.
Upadacitinib - U-ACHIEVE	Ulcerative colitis	Phase 2/3	Phase 2b data released October 22, 2018 - primary endpoint met. Phase 3 trial initiation announced October 2018.
Venetoclax and obinutuzumab	Chronic Lymphocytic Leukemia	Phase 3	FDA approval announced May 15, 2019.
Ibrutinib (Imbruvica)	Pancreatic cancer	Phase 3	Phase 3 primary endpoint not met (PFS/OS).
Venclexta plus Gazyva	Chronic lymphocytic leukemia (CLL)	Phase 3	Phase 3 data presented at ASCO June 4, 2019. HR 0.35. CRR 49.5%. ORR 84.7% vs. 71.3%.
Venclexta MIRROS	Acute myeloid leukemia (AML)	Phase 3	Phase 3 data due 2019.
Venclexta BELLINI	Multiple myeloma	Phase 3	Phase 3 primary endpoint met.
Venetoclax and obinutuzumab	Chronic lymphocytic leukemia	sNDA Filing	sNDA filing announced June 4, 2019.

ABEO Abeona Therapeutics Inc.

$4.15

-0.07  -1.66%

49.2 million

$204 million

114.8 thousand

645.7 thousand

0.18

$1.73

$4.25

$4.22

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
ABO-101	Sanfilippo syndrome type B (MPS IIIB)	Phase 1/2	Phase 1/2 interim data due 2H 2019.
EB-101	Recessive dystrophic epidermolysis bullosa (RDEB)	Phase 1/2	Phase 3 trial to be initiated mid-2019.
ABO-102	Sanfilippo syndrome type A (MPS IIIA)	Phase 1/2	Phase 1/2 safety and tolerability data to be presented at WORLDSymposium February 6, 2019.
ABO-202	CLN1 disease (Infantile Batten disease)	Phase 1/2	Phase 1/2 trial planned. Timing to be announced later in 2019.

ABIO ARCA biopharma Inc.

$6.87

-0.09  -1.32%

1.5 million

$10 million

534

542.7 thousand

0

$1.36

$6.90

$6.96

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
Gencaro	Chronic Heart Failure	Phase 3	Phase 3 trial to be initiated 4Q 2019 under SPA subject to securing additional financing. Potential interim analysis 3Q 2021 with data due 2Q 2022.

ABUS Arbutus Biopharma Corporation

$2.26

-0.08  -3.42%

58 million

$131.1 million

107.7 thousand

543.6 thousand

0.2

$2.51

$2.35

$2.34

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
ARB-1467, tenofovir, and pegylated interferon	Hepatitis B (HBV)	Phase 2	Phase 2 trial ongoing but no plans to continue further development.
ARB-1467	Hepatitis B (HBV)	Phase 2	Phase 2 Cohort 4 data released September 25, 2017 with detailed data due at AASLD in October 2017.
AB-452	Hepatitis B	Phase 1	Phase 1 trial initiation delayed - noted October 9, 2018. Decision regarding clinical development due early 2020.
AB-506	Hepatitis B (HBV)	Phase 1	Phase 1 data due July 2019.
AB-729	Hepatitis B (HBV)	Phase 1	Phase 1a/b trial to be initiated to be initiated shortly - June 21, 2019.

ACAD ACADIA Pharmaceuticals Inc.

$26.48

-0.23  -0.88%

144.2 million

$3.8 billion

47.7 thousand

989.7 thousand

0.05

$9.13

$26.61

$26.72

07/16/2019

Tap to view 7 drug drugs

Drug	Indication	Stage	News
Pimavanserin - CLARITY-2	Adjunctive Treatment in Patients With Major Depressive Disorder	Phase 3	Phase 3 trial initiation announced April 25, 2019.
Pimavanserin - Advance	Adjunctive treatment in patients with negative symptoms of schizophrenia	Phase 2	Phase 2 data due year-end 2019.
Pimavanserin - Enhance	Adjunctive treatment of schizophrenia	Phase 3	Phase 3 data due mid-2019.
Pimavanserin - SERENE	Alzheimer’s disease agitation	Phase 2	Announced October 4, 2017 that trial will be discontinued.
Pimavanserin	Parkinson’s disease psychosis (PDP)	Approved	Approved April 29 2016. Additional dose approval announced June 29, 2018.
Pimavanserin - Harmony	Alzheimer’s disease psychosis	Phase 3	Phase 3 interim data 2H 2019 with final data due 2020.
Trofinetide	Rett Syndrome	Phase 3	Phase 3 trial to be initiated 4Q 2019.

ACER Acer Therapeutics Inc.

$3.25

-0.04  -1.36%

10.1 million

$32.8 million

33.7 thousand

336.8 thousand

0.1

$0.87

$3.32

$3.30

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
EDSIVO	Vascular Ehlers-Danlos Syndrome	CRL	CRL issued June 25, 2019.
Tovaxin (Tcelna)	Secondary Progressive MS (SPMS)	Phase 2b	Phase 2b trial did not meet primary endpoint - October 28, 2016.
ACER-001	Urea cycle disorder (UCD)	Phase 2	Pivotal bridging trial to be initiated 4Q 2019 with NDA filing 1Q 2020.

ACHN Achillion Pharmaceuticals Inc.

$2.46

-0.01  -0.40%

138.7 million

$341.3 million

39.1 thousand

1.1 million

0.04

$1.37

$2.47

$2.47

07/16/2019

Tap to view 6 drug drugs

Drug	Indication	Stage	News
ACH-4471	C3 glomerulopathy (C3G)	Phase 2	End of Phase 2 meeting 4Q 2019.
JNJ-4178	Hepatitis C (HCV)	Phase 2a	Janssen noted September 11, 2017 that no further development planned.
ACH-4471	Paroxysmal nocturnal hemoglobinuria (PNH)	Phase 2	Phase 2 final data presented at EHA June 15, 2019.
JNJ-4178 - OMEGA-1	Hepatitis C (HCV)	Phase 2b	Janssen noted September 11, 2017 that no further development planned.
ACH-4471	C3 glomerulopathy (C3G)	Phase 2	End of Phase 2 meeting 4Q 2019.
ACH-5228	Healthy volunteers	Phase 1	Phase 1 multiple ascending dose trial to be completed 2019.

ACHV Achieve Life Sciences Inc.

$1.82

-0.03  -1.64%

7.8 million

$14.2 million

8.6 thousand

239.2 thousand

0.04

$1.40

$1.84

$1.85

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
Cytisine	Smoking cessation	Phase 2b	Phase 2b data met primary endpoint in 3/4 arms - June 11, 2019. Data to be presented at SRNT-E Conference, September 12-14, 2019.

ACIU AC Immune SA

$5.59

+0.08  +1.45%

67.6 million

$377.7 million

6.8 thousand

123.7 thousand

0.05

$1.54

$5.52

$5.51

07/16/2019

Tap to view 7 drug drugs

Drug	Indication	Stage	News
Crenezumab - CREAD 2	Alzheimer’s disease	Phase 3	Phase 3 trial terminated following interim analysis indicating primary endpoint would not be met.
RG6100 (Anti-Tau RO7105705)	Alzheimer’s disease	Phase 2	Phase 2 data due 3Q 2020.
ACI-24 (anti-Abeta vaccine)	Alzheimer's disease-like characteristics in individuals with Down syndrome	Phase 1/2	Phase 1/2 interim data due 2019.
Crenezumab - CREAD 1	Alzheimer’s disease	Phase 3	Phase 3 trial terminated following interim analysis indicating primary endpoint would not be met.
ACI-24	Alzheimer’s disease	Phase 2	Phase 2 trial initiation announced August 20, 2018.
MTAU9937A	Alzheimer’s disease	Phase 2	Phase 2 trial initiation announced February 20, 2019.
ACI-35	Alzheimer’s disease	Phase 1b	Phase 2 trial planned for 1H 2019.

ACOR Acorda Therapeutics Inc.

$6.50

-0.06  -0.91%

48.1 million

$312.8 million

66.6 thousand

943.5 thousand

0.07

$0.55

$6.55

$6.56

07/16/2019

Tap to view 6 drug drugs

Drug	Indication	Stage	News
Ampyra	Improve walking in patients with multiple sclerosis		Decision on Inter Partes Review (IPR) released March 10, 2017 - patents upheld.
CVT-427	Migraine	Phase 1	Phase 1 complete. Noted November 2017 that it will not advance into a Phase 2 study by the end of 2017, as previously expected. Evaluating next steps.
Tozadenant	Parkinson’s disease (PD)	Phase 3	Noted November 15, 2017 seven cases of sepsis, five of which were fatal. Company noted November 20, 2017 that program will be discontinued.
Dalfampridine	Post stroke deficits	Phase 3	Phase 3 data released November 21, 2016 - failed to show efficacy, development to be discontinued.
INBRIJA (CVT-301)	OFF episodes of Parkinson’s disease (PD)	Approved	FDA Approval announced December 22, 2018.
BTT1023	Primary Sclerosing Cholangitis	Phase 2	Phase 2 interim data were slated for 3Q 2018 - no update given to date from company.

ACRS Aclaris Therapeutics Inc.

$2.19

-0.04  -1.79%

41.3 million

$90.4 million

15 thousand

793.8 thousand

0.02

$0.50

$2.21

$2.23

07/16/2019

Tap to view 9 drug drugs

Drug	Indication	Stage	News
ATI-502 (ATI-50002-AA-201) - dose ranging	Alopecia areata	Phase 2	Phase 2 data did not meet primary endpoint - June 26, 2019.
ATI-502 (VITI-201 Topical)	Vitiligo	Phase 2	Phase 2 open label 6-month data due mid-2019.
ATI-501 (AUAT-201 Oral)	Alopecia areata	Phase 2	Phase 2 data due 2H 2019.
ESKATA (hydrogen peroxide)	Seborrheic keratosis (SK)	Approved	Approval announced December 15, 2017.
A-101 THWART-1 and THWART-2	Common warts (verruca vulgaris)	Phase 3	Phase 3 data due 2H 2019.
ATI-502 AA-202 Topical - PK/safety	Alopecia areata	Phase 2	Phase 2 interim data released June 28, 2018.
ATI-502 (ATI-50002-AGA-201) - open label	Androgenetic alopecia (AGA) - Hair loss	Phase 2	Phase 2 6-month data noted increase in hair count of 8.6 hairs/cm2. 12 month data due YE 2019.
ATI-502 (AD-201 Topical)	Atopic dermatitis (AD)	Phase 2	Phase 2 data due mid-2019.
ATI-450	Rheumatoid arthritis (RA)	Phase 1/2	Phase 1/2 trial to be initiated 2H 2019.

ACRX AcelRx Pharmaceuticals Inc.

$2.78

-0.06  -1.99%

78.9 million

$219.7 million

299.9 thousand

1.6 million

0.19

-$27.84

$2.82

$2.84

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
ARX-04 (SAP302)	Patients who presented to emergency departments with moderate-to-severe acute pain associated with trauma or injury	Phase 3	Phase 3 data released August 15 2016
DSUVIA (ARX-04)	Moderate-to-severe acute pain following a surgical procedure	Approved	FDA Approval announced November 2, 2018.
Zalviso	Post-operative pain following open abdominal surgery and hip or knee replacement surgery	Phase 3	CRL Jul 26 2014. NDA resubmission timing to be known in 2H 2019.

ACST Acasti Pharma Inc.

$1.42

-0.01  -0.70%

79.1 million

$110.9 million

31.8 thousand

795 thousand

0.04

$10.35

$1.44

$1.43

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
CaPre (TRILOGY 1 and 2)	Hypertriglyceridemia	Phase 3	Phase 3 top-line data due in December 2019 (1) and January 2020 (2).

ADAP Adaptimmune Therapeutics plc

$3.52

+0.02  +0.57%

104.7 million

$368.6 million

3.2 thousand

301.5 thousand

0.01

$1.68

$3.47

$3.50

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
MAGE-A4 (ADP-A2M4)	Soild tumors	Phase 1	Phase 1 update due 2H 2019.
AFP (ADP-A2AFP)	Hepatocellular carcinoma	Phase 1	Phase 1 update due 1H 2020.
MAGE-A10 (ADP-A2M10)	Non-Small Cell Lung Cancer (NSCLC)	Phase 1	Phase 1 data May 6, 2019 noted 4/7 stable disease. No partial responses. Update due 2H 2019.
MAGE-A4 (SPEARHEAD‑1)	Synovial sarcoma or myxoid/round cell liposarcoma (MRCLS)	Phase 2	Phase 2 trial to be initiated later in 2019.
MAGE-A4 (ADP-A2M4CD8 - SURPASS)	Soild tumors	Phase 1	Phase 1 trial to be initiated in 2019 with data due in 2020.

ADIL Adial Pharmaceuticals Inc

$1.99

+0.01  +0.51%

10.2 million

$20.3 million

508

65.3 thousand

0.01

$1.73

$1.99

$1.98

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
AD04	Alcohol use disorder	Phase 3	Phase 3 data due in 2020. Data from second Phase 3 trial for U.S. required endpoint due 2022.

ADMA ADMA Biologics Inc

$4.07

+0.03  +0.82%

59.3 million

$241.6 million

57 thousand

1.1 million

0.05

$23.96

$4.00

$4.04

07/16/2019

Tap to view 2 drug drugs

Drug	Indication	Stage	News
RI-002	Primary Immune Deficiency Diseases	Approved	FDA Approval announced April 1, 2019.
BIVIGAM	Primary humoral immunodeficiency	CRL	Response to Complete Response Letter submitted January 7, 2019.

ADMP Adamis Pharmaceuticals Corporation

$1.32

-0.14  -9.59%

47.6 million

$62.9 million

409.3 thousand

381.5 thousand

1.07

$1.57

$1.38

$1.46

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
Epinephrine Pre-filled Syringe (PFS)	Emergency treatment of anaphylaxis.	Approved	CRL issued March 27 2015. CRL issued again June 6, 2016. Approval announced June 15, 2017 following third submission.
APC-1000	Asthma/COPD	Phase 2	Phase 3 development on hold - noted May 9, 2019.
Symjepi - low dose	Anaphylaxis	Approved	FDA Approval announced September 27, 2018.
Higher Dose Naloxone Injection	Opioid overdose	PDUFA	PDUFA date October 31, 2019.
APC-8000 (sublingual tadalafil)	Erectile dysfunction	NDA Filing	Refusal to file letter received February 26, 2019.

ADMS Adamas Pharmaceuticals Inc.

$6.02

+0.08  +1.35%

27.5 million

$165.7 million

16.2 thousand

395.2 thousand

0.04

$2.60

$5.94

$5.94

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
ADS-4101	Partial onset seizures in patents with epilepsy	Phase 1b	Further development deferred - noted May 9, 2019.
GOCOVRI (amantadine)	Multiple sclerosis (MS)	Phase 3	Phase 3 data due 4Q 2019.
Namzaric	Moderate to severe dementia of the Alzheimer's type.	Approved	Approved December, 24 2014.
ADS-5102	Levodopa-Induced Dyskinesia	Approved	Approval announced August 24, 2017.
GOCOVRI (amantadine)	Dyskinesia patients with Parkinson's disease	Phase 3	Phase 3 open-label data released April 19, 2018.

ADPT Adaptive Biotechnologies Corporation

$38.80

+0.66  +1.73%

123.2 million

$4.8 billion

27.4 thousand

0

$16.58

$38.04

$38.14

07/16/2019

Drug	Indication	Stage	News

ADRO Aduro Biotech Inc.

$1.53

+0.01  +0.60%

80 million

$122.4 million

19.5 thousand

497.1 thousand

0.04

$1.06

$1.53

$1.52

07/16/2019

Tap to view 10 drug drugs

Drug	Indication	Stage	News
ADU-S100	Solid tumors or lymphomas	Phase 1b	Initial data at SITC November 2018 noted 2/40 PRs and 11 with SD.
CRS-207 and GVAX Pancreas - ECLIPSE trial	Pancreatic cancer	Phase 2b	Phase 2b primary endpoint not met - May 2016
CRS-207 and GVAX Pancreas and nivolumab - STELLAR trial	Pancreatic cancer	Phase 2b	Partial clinical hold announced October 24, 2016. Hold released November 21, 2016.
CRS-207 with pembrolizumab	Mesothelioma - cancer	Phase 2	Noted December 12, 2017 that development to be discontinued.
pLADD	Colorectal Cancer	Phase 1	Phase 1 ongoing.
pLADD	Colorectal Cancer	Phase 1	Phase 1 ongoing.
ADU-214 with Nivolumab	Non-Small Cell Lung Cancer	Phase 1/2	Phase 1b initiation announced June 7, 2018.
ADU-S100 and Spartalizumab	Solid tumors or lymphomas	Phase 1b	Phase 1b presentation at ASCO June 2, 2019 noted 1 CR and 2/8 PRs among TNBC patients. 2/25 PRs among melanoma patients.
ADU-S100 and ipilimumab	Melanoma	Phase 1	Phase 1 commencement of dosing announced February 11, 2019.
BION-1301	IgA Nephropathy	Phase 1	Phase 1 initial data in healthy volunteers expected in 1H 2020 and IgAN patients in 2H 2020.

ADVM Adverum Biotechnologies Inc.

$16.09

+0.63  +4.08%

63.8 million

$1 billion

149.6 thousand

974.1 thousand

0.15

$5.45

$15.55

$15.46

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
ADVM-043	Alpha-1 Antitrypsin (A1AT) Deficiency	Phase 1/2	Development to be discontinued - noted November 1, 2018.
AVA-101	Wet age-related macular degeneration (Wet-AMD)	Phase 2a	Phase 2a negative data released June 2015 (met primary endpoint but increase in retinal thickness). As a result Phase 2b development will not proceed.
ADVM-022	Wet age-related macular degeneration (Wet-AMD)	Phase 1	Phase 1 24-Week data from first cohort to be presented September 12, 2019.

ADXS Advaxis Inc.

$1.46

-0.11  -7.01%

8 million

$11.7 million

74.9 thousand

237.6 thousand

0.32

$0.27

$1.55

$1.57

07/16/2019

Tap to view 7 drug drugs

Drug	Indication	Stage	News
Axalimogene filolisbac + durvalumab	Recurrent or refractory HPV-associated cervical cancer and head & neck cancer	Phase 1/2	Enrollment to be terminated - noted November 2, 2018.
ADXS-PSA and Keytruda - KEYNOTE-046	Castrate-resistant prostate cancer	Phase 1/2	Phase 1 monotherapy, overall survival was 8.5 months, combo with Keytruda 23 months.
Axalimogene filolisbac - AIM2CERV Trial	High-risk, locally advanced cervical cancer	Phase 3	Phase 3 trial closed - noted June 27, 2019.
ADXS-HER2	HER2-driven malignancies - cancer	Phase 1b	Decided not to proceed to the expansion phase of the trial - noted in 10K December 21, 2017.
Axalimogene filolisbac	Anal cancer (FAWCETT)	Phase 2	Noted in 10-K December 21, 2017 that it will not initiate the Stage 2 portion of the trial in order to focus its resources on other clinical priorities.
ADXS-NEO	Non-small cell lung cancer (NSCLC)	Phase 1	Phase 1 safety and immunogenicity data presented at AACR March 2019
ADXS-HOT 503	Non-small cell lung cancer (NSCLC)	Phase 1/2	Phase 1/2 preliminary data due 2H 2019.

AERI Aerie Pharmaceuticals Inc.

$24.80

-0.45  -1.78%

45.9 million

$1.1 billion

69.5 thousand

672.1 thousand

0.1

$5.93

$25.05

$25.25

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
Roclatan	Glaucoma	Approved	FDA Approval announced March 12, 2019.
Rhopressa	Glaucoma	Approved	PDUFA date February 28, 2018. Approved ahead of schedule - December 18, 2017.
AR-13503	Neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME)	Phase 1/2	Phase 1/2 trial to be initiated 2Q 2019.
AR-1105	Macular edema due to RVO (retinal vein occlusion)	Phase 2	Phase 2 trial initiated March 2019.

AEZS Aeterna Zentaris Inc.

$2.67

-0.01  -0.37%

16.4 million

$43.9 million

11.1 thousand

135.2 thousand

0.08

$34.08

$2.72

$2.68

07/16/2019

Tap to view 2 drug drugs

Drug	Indication	Stage	News
Macimorelin Acetate - Macrilen	Adult Growth Deficiency	Approved	CRL issued November 2014. Approval announced following resubmission December 20, 2017.
Zoptrex	Endometrial cancer	Phase 3	Phase 3 trial did not meet primary endpoint - May 1, 2017.

AFMD Affimed N.V.

$3.14

-0.01  -0.32%

62.4 million

$196 million

30.6 thousand

996.4 thousand

0.03

$4.08

$3.14

$3.15

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
AFM13 with Keytruda	Hodgkin Lymphoma - Cancer	Phase 1b	Phase 1b updated data at ICML June 22, 2019 noted ORR of 88% at highest dose, CR rates of 42%-46%.
AFM13	Hodgkin Lymphoma - Cancer	Phase 2	Phase 2a ongoing.
AFM13	CD30-positive lymphoma	Phase 1/2	Phase 1b/2a updated data at ICML June 19, 2019 noted 50% ORR.
AFM11	Non-Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL)	Phase 1	Phase 1 program terminated - noted May 22, 2019.
AFM13	Relapsed/refractory peripheral T cell lymphoma (PTCL); transformed mycosis fungoides (TMF)	Phase 2	Phase 2 trial to be initiated 2H 2019.

AGEN Agenus Inc.

$2.50

-0.04  -1.57%

134.3 million

$335.6 million

136.2 thousand

1.1 million

0.13

-$2.87

$2.53

$2.54

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
AGEN2034 and AGEN1884	Solid tumors	Phase 1/2	Phase 1/2 data due 2019.
AGEN1884 (anti-CTLA-4)	Solid cancers	Phase 1	Phase 1 data due 2019.
Shingrix	Shingles	Approved	Approval announced October 20, 2017.
AGEN2034 (anti-PD-1)	Cervical cancer	Phase 1/2	Phase 1 data presented at ESMO October 2018 noted clinical benefit of 3/7 cervical cancer patients.
AGEN1181 - 2nd gen CTLA	Advanced cancer	Phase 1	Phase 1 data due 2019.

AGIO Agios Pharmaceuticals Inc.

$46.20

+0.03  +0.06%

58.7 million

$2.7 billion

43.9 thousand

577.6 thousand

0.08

$4.38

$45.88

$46.17

07/16/2019

Tap to view 16 drug drugs

Drug	Indication	Stage	News
AG-348 - Mitapivat	Thalassemia	Phase 2	Phase 2 data due 2H 2019.
Ivosidenib	IDH1m Relapsed/Refractory AML - cancer	Approved	FDA Approval announced July 20, 2018.
AG-348 (ACTIVATE)	Pyruvate kinase deficiency	Phase 3	Phase 3 enrolment to be completed 2019.
AG-120 and VIDAZA - AGILE	Frontline Acute myeloid leukemia (AML) harboring an IDH1 mutation - cancer	Phase 3	Phase 3 enrolment to be completed 2020.
Enasidenib (AG-221) - IDHENTIFY	Refractory Acute myeloid leukemia (AML) - cancer	Phase 3	Global Phase 3 study for AG-221 initiated October 2015. Continues to enroll as of January 2018.
IDHIFA (enasidenib) - AG-221	Advanced hematologic malignancies with an IDH2 mutation	Approved	Approval announced August 1, 2017.
AG-120 Ivosidenib	IDH1 mutant positive cholangiocarcinoma - cancer	Phase 3	Phase 3 data released May 15, 2019 met primary endpoint. Data to be presented at ESMO September 27-October 1, 2019.
AG-120 Ivosidenib	R/R Acute Myeloid Leukemia (AML)	Phase 1	Phase 1 data at ASCO June 2018 noted CR rate was 24%.
Enasidenib or ivosidenib with VIDAZA	Frontline AML with IDH1 or IDH2 mutation	Phase 1/2	Phase 1 updated data February 25, 2019 noted ORR of 78%, 57% CR rate, and 12-month Survival Rate of 82%.
Ivosidenib or enasidenib	Frontline AML with IDH1 or IDH2 mutation	Phase 1	Phase 1 updated data at ASH December 2018. CR+CRi/CRp 80%.
AG-270	Solid tumors	Phase 1	Phase 1 dose escalation data due 2H 2019.
Vorasidenib (AG-881)	Glioma	Phase 3	Phase 3 trial to be initiated YE 2019.
Ivosidenib	Frontline AML with IDH1 mutation	Approved	FDA Approval announced May 2, 2019.
Ivosidenib and Vorasidenib (AG-881)	IDHm low-grade glioma	Phase 1	Phase 1 data presented at ASCO June 3, 2019, 2:15pm.
Ivosidenib	IDH1 mutant newly diagnosed AML ineligible for standard therapies	Phase 1	Phase 1 updated data at ASCO June 3, 2019. 30% CR rate.
Ivosidenib and azacitidine ( Vidaza)	Newly diagnosed AML with an IDH1 mutation	Phase 1	Phase 1 updated data at ASCO June 3, 2019. 61% CR rate.

AGLE Aeglea BioTherapeutics Inc.

$6.85

+0.07  +1.03%

28.8 million

$197.6 million

2.1 thousand

158.6 thousand

0.01

$1.70

$6.79

$6.78

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
AEB1102	Acute myeloid leukemia (AML) or Myelodysplastic syndromes (MDS)	Phase 1	Phase 1 initiation announced July 2016. Enrollment to be completed in 2017.
Pegzilarginase (AEB1102)	Arginase I deficiency	Phase 1/2	Phase 3 trial initiation announced June 3, 2019 with data due 1Q 2021. Phase 1/2 further data due September 2019.
AEB1102	Solid tumors	Phase 1	Phase 1 dose escalation data presented at AACR April 15, 2018.
Pegzilarginase (AEB1102)	Solid tumors	Phase 1	Phase 1 data presented at ESMO October 2018 noted 1/28 PRs and 8/23 SD.
Pegzilarginase (AEB1102) + KEYTRUDA	Small cell lung cancer (SCLC)	Phase 2	Phase 1/2 top-line data due 1H 2020.

AGN Allergan plc

$165.95

-0.13  -0.08%

327.8 million

$54.4 billion

0.8

441.6 thousand

4.5 million

0.1

$0.88

$165.89

$166.08

07/16/2019

Tap to view 32 drug drugs

Drug	Indication	Stage	News
Botox	Forehead lines	Approved	Approval (third indication) announced October 3, 2017.
RTGel in combination with BOTOX	Overactive Bladder (OAB)	Phase 2	Phase 2 trial to be completed 2H 2019.
JUVÉDERM VOLLURE	Correction of moderate to severe facial wrinkles and folds	Approved	Approval announced March 20, 2017.
Brazikumab	Crohn's disease	Phase 3	Phase 3 data due 2020.
Bimatoprost	Androgenic Alopecia	Phase 3	Phase 3 enrollment to be completed 2H 2018.
Botox	Depression	Phase 2	Phase 2 top-line data released April 5, 2017 - primary endpoint missed. Phase 3 planned.
RORγt agonist	Psoriasis	Phase 2b	Phase 2b trial ongoing.
Cariprazine	Maintenance Treatment of Schizophrenia	Approved	Approval announced November 13, 2017.
ABP 798	RITUXAN biosimilar - non-Hodgkin lymphoma	Phase 3	Phase 3 data released January 24, 2019 - primary endpoint met.
ATOGEPANT	Chronic migraine	Phase 3	Phase 3 data due in 2020.
RAPASTINEL	Major depressive disorder (MDD)	Phase 3	Phase 3 trials did not meet primary endpoints - March 6, 2019.
RELAMORELIN	Diabetic Gastroparesis	Phase 3	Phase 3 top-line data due 2020.
ESMYA (ulipristal acetate)	Uterine Fibroids	CRL	CRL issued August 21, 2018.
ABICIPAR	Diabetic macular edema (DME)	Phase 3	Phase 3 trial to be initiated 2019.
Cenicriviroc (CVC)	Nonalcoholic steatohepatitis (NASH)	Phase 3	Phase 3 data due 2020.
ABICIPAR	Age-related macular degeneration (AMD)	BLA Filing	BLA filing due 2H 2019.
AVYCAZ (ceftazidime and avibactam)	Complicated Urinary Tract Infections (cUTI)	Approved	sNDA acceptance announced October 11, 2016. Approval announced January 30, 2017.
Oxymetazoline HCl cream 1.0%	Facial Erythema (Redness) Associated with Rosacea	Approved	Approved January 19, 2017.
Linaclotide 72 mcg dose for use in the treatment of adults	Chronic idiopathic constipation (CIC)	Approved	sNDA approval announced January 26, 2017.
MVASITM (bevacizumab-awwb)	Biosimilar candidate to Avastin (bevacizumab)	Approved	Approved September 14, 2017.
Sarecycline	Severe acne vulgaris	Approved	FDA Approval announced October 2, 2018.
Cariprazine	Bipolar I Depression	PDUFA	FDA Approval announced May 28, 2019.
UBROGEPANT	Migraine	PDUFA	NDA acceptance announced March 11, 2019. PDUFA 4Q 2019. No exact date provided.
Brazikumab	Ulcerative colitis	Phase 2/3	Phase 2/3 data due 2020.
Brimo DDS	Geographic atrophy	Phase 3	Phase 3 trial to be initiated 2H 2018.
Bimatoprost	Open-angle glaucoma or ocular hypertension	NDA Filing	NDA filing due estimate 3Q 2019.
AVYCAZ (ceftazidime and avibactam)	Complicated Urinary Tract Infections (cUTI) - pediatric	Approved	FDA Approval announced March 18, 2019.
Botox	Lower limb spasticity	PDUFA	PDUFA date 4Q 2019.
Botox	Upper limb spasticity	Approved	FDA Approval announced June 21, 2019.
AGN-241751	Major Depressive Disorder (MDD)	Phase 2	Phase 2 top-line data due 2H 2019.
Presbysol	Presbyopia	Phase 3	Phase 3 top-line data due 2020.
RAPASTINEL	Depression	Phase 2	Phase 2 monotherapy interim analysis 2H 2019.

AGRX Agile Therapeutics Inc.

$1.28

-0.06  -4.25%

43.7 million

$56.1 million

28.5 thousand

208.8 thousand

0.14

$2.29

$1.35

$1.34

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
Twirla	Contraceptive patch	PDUFA	CRLs issued 2013 and 2017. New PDUFA date November 16, 2019. Advisory Committee Meeting October 30, 2019.

AGTC Applied Genetic Technologies Corporation

$3.75

-0.05  -1.32%

18.2 million

$68.1 million

1.6 thousand

42 thousand

0.04

$0.77

$3.80

$3.80

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
AAV Gene Therapy	CNGB3 Achromatopsia	Phase 1/2	Phase 1/2 six-month data for the dose escalation portion due 4Q 2019.
rAAV-hRS1	X-linked retinoschisis (XLRS)	Phase 1/2	Phase 1/2 interim data released December 12, 2018. No signs of clinical activity.
AAV-based gene therapy	X-linked Retinitis Pigmentosa (XLRP)	Phase 1/2	Phase 1/2 dose escalation data due 3Q 2019. Expansion data due 4Q 2019.

AIMT Aimmune Therapeutics Inc.

$18.98

-0.01  -0.05%

62.5 million

$1.2 billion

117.1 thousand

527.2 thousand

0.22

$4.63

$18.98

$18.99

07/16/2019

Tap to view 7 drug drugs

Drug	Indication	Stage	News
AR101 ARTEMIS	Peanut Allergy	Phase 3	Phase 3 trial met primary endpoint - March 25, 2019.
AR101 RAMSES	Peanut Allergy	Phase 3	Phase 3 data released November 8, 2018 noted no serious adverse events
AR101	Peanut Allergy	PDUFA	PDUFA date late-January 2020. Advisory Committee meeting September 13, 2019.
AR 201	Egg Allergy	Phase 2	Phase 2 trial to be initiated mid-2019.
AR 301	Walnut Allergy	Phase 2	Phase 2 trial to be initiated 2H 2019.
AR101 with adjunctive dupilumab	Peanut Allergy	Phase 2	Phase 2 trial initiation announced October 15, 2018.
AR101 POSEIDON	Peanut Allergy	Phase 3	Phase 3 initiation announced December 19, 2018.

AKBA Akebia Therapeutics Inc.

$4.21

-0.06  -1.41%

117.9 million

$496.2 million

51.5 thousand

1.2 million

0.04

$0.88

$4.29

$4.27

07/16/2019

Tap to view 6 drug drugs

Drug	Indication	Stage	News
Vadadustat - TRILO2GY	Three-times-weekly dosing regimen for vadadustat	Phase 3	Phase 3 trial to be initiated in 2019.
Vadadustat - FO2RWARD	Renal anemia	Phase 2	Phase 2 trial data due 2019.
Auryxia	Hyperphosphatemia	Approved	Approved Sept 5, 2014.
Vadadustat - INNO2VATE	Anemia related to chronic kidney disease who are undergoing dialysis (DD-CKD)	Phase 3	Phase 3 data due 2Q 2020.
Vadadustat - PRO2TECT	Non-dialysis patients with anemia related to CKD (NDD-CKD)	Phase 3	Phase 3 data due mid-2020.
Auryxia	Iron deficiency anemia in non-dialysis dependent CKD patients	Approved	sNDA FDA Approval announced November 7, 2017.

AKCA Akcea Therapeutics Inc.

$23.44

-0.04  -0.17%

92.8 million

$2.2 billion

13.5 thousand

209.8 thousand

0.06

$5.59

$23.52

$23.48

07/16/2019

Tap to view 9 drug drugs

Drug	Indication	Stage	News
AKCEA-ANGPTL3-LRx	Rare hyperlipidemias	Phase 2	Phase 2b data due 1H 2020.
AKCEA-ANGPTL3-LRx	Non-alcoholic fatty liver disease (NAFLD), Hypertriglyceridemia and Type 2 Diabetes Mellitus	Phase 2	Phase 2b data due 1H 2020.
AKCEA-APOCIII-LRx	Hyperlipoproteinemia and established cardiovascular disease	Phase 2b	Phase 2b data due 1H 2020.
AKCEA-APO(a)-LRx	Hyperlipoproteinemia(a) and established cardiovascular disease	Phase 2b	Phase 2 data presented at AHA November 2018 - endpoints met.
Inotersen (IONIS-TTRRx)	NEURO-TTR - familial amyloid polyneuropathy (FAP).	Approved	FDA Approval announced October 5, 2018,
Volanesorsen - APPROACH	Familial chylomicronemia syndrome (FCS)	CRL	CRL issued August 27, 2018.
Volanesorsen	Partial lipodystrophy rapidly	Phase 3	Phase 3 initiated November 2015
Volanesorsen	Familial partial lipodystrophy (FPL)	Phase 3	Phase 3 data due mid-2019.
AKCEA-TTR-LRx	hATTR Amyloidosis	Phase 1/2	Phase 1/2 data and Phase 3 trial initiation due 2H 2019.

AKRO Akero Therapeutics Inc.

$20.60

-0.15  -0.71%

27 million

$557.2 million

13.8 thousand

0

$7.99

$20.80

$20.75

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
AKR-001	Nonalcoholic steatohepatitis (NASH)	Phase 2a	Phase 2a data due 1H 2020.

AKTX Akari Therapeutics Plc

$1.87

  +0.00%

16.5 million

$30.9 million

1.9 thousand

149.6 thousand

0.01

$26.71

$1.88

$1.87

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
Coversin - CAPSTONE	Paroxysmal nocturnal hemoglobinuria (PNH)	Phase 3	Phase 3 staged readouts - no definitive timeline set by company. 2019?
Coversin	Atopic keratoconjunctivitis	Phase 1/2	Phase 1/2 Part B data due 4Q 2019.
Coversin	Bullous Pemphigoid	Phase 2	Phase 2 further data due 4Q 2019.
Coversin	Hematopoietic stem cell transplant-related thrombotic microangiopathy (HSCT-TMA)	Phase 2	Pivotal HSCT-TMA trial to be initiated 4Q 2019.

ALBO Albireo Pharma Inc.

$29.09

+0.25  +0.86%

12 million

$350.2 million

4.1 thousand

75 thousand

0.05

$3.15

$28.90

$28.84

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
Odevixibat (A4250) - PEDFIC- 1	Liver disease	Phase 3	Phase 3 top-line data due mid-2020.
Elobixibat	Nonalcoholic steatohepatitis (NASH)	Phase 2	Phase 2 data due mid-2020.
Odevixibat (A4250)	Biliary atresia	Phase 3	Phase 3 trial planned for 2020.

ALDR Alder BioPharmaceuticals Inc.

$11.11

-0.27  -2.37%

83.5 million

$927.7 million

30 thousand

948.6 thousand

0.03

$5.91

$11.35

$11.38

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
Eptinezumab ALD403	Frequent episodic migraine	PDUFA	PDUFA date February 21, 2020.
ALD403	Chronic Migraine	Phase 2b	Phase 2b data released March 2016 met primary and secondary endpoints. 24 week data released July 2016.
ALD403 - PROMISE 1	Frequent episodic migraine	Phase 3	Phase 3 PROMISE 1 top-line data released June 27, 2017, Primary and key secondary endpoints met but competitive concerns raised.
Eptinezumab	Acute migraine	Phase 3	Phase 3 trial to be initiated 2H 2019.

ALDX Aldeyra Therapeutics Inc.

$5.66

-0.02  -0.35%

27.5 million

$155.6 million

5.4 thousand

270.8 thousand

0.02

$1.99

$5.70

$5.68

07/16/2019

Tap to view 6 drug drugs

Drug	Indication	Stage	News
ADX-102 - topical ocular reproxalap - RENEW	Dry eye syndrome	Phase 3	Phase 3 initiation announced April 2, 2019.
Reproxalap (ADX-102)	Allergic conjunctivitis	Phase 3	Phase 3 data March 25, 2019 - primary endpoint met.
ADX-102 reproxalap	Noninfectious anterior uveitis	Phase 3	Phase 3 data did not meet endpoints - June 25, 2019.
Reproxalap (ADX-102)	Sjögren-Larsson Syndrome (SLS)	Phase 3	Phase 3 initial data due in 2H 2019.
ADX-1612 (ganetespib)	Mesothelioma	Phase 2	Phase 2 trial to be initiated 2H 2019.
ADX-2191	Proliferative vitreoretinopathy (PVR)	Phase 3	Phase 3 trial to be initiated 2H 2019 with initial data due 2020.

ALEC Alector Inc.

$18.97

-0.03  -0.16%

68.9 million

$1.3 billion

17.6 thousand

123.4 thousand

0.14

$4.92

$18.66

$19.00

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
AL001	Frontotemporal Dementia	Phase 1	Phase 1b trial to be initiated 1H 2019.
AL002	Alzheimer’s disease	Phase 1	Phase 1 initiation of dosing announced May 6, 2019.
AL003	Alzheimer’s disease	Phase 1	Phase 1 trial initiation announced April 3, 2019.

ALIM Alimera Sciences Inc.

$0.88

+0.01  +1.15%

71 million

$62.5 million

6.1 thousand

70.3 thousand

0.09

-$2.10

$0.86

$0.87

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
Iluvien	Diabetic macular edema	Approved	CRL Nov 2011. Second CRL Oct 17 2013. Approved Sept 26 2014

ALKS Alkermes plc

$23.44

+0.1  +0.43%

156.9 million

$3.7 billion

209.5 thousand

1.3 million

0.16

$3.34

$23.37

$23.34

07/16/2019

Tap to view 13 drug drugs

Drug	Indication	Stage	News
Aripiprazole Lauroxil NanoCrystal Dispersion (ALNCD)	Schizophrenia	Approved	FDA approval announced July 2, 2018.
ALKS 3831 - ENLIGHTEN-Early	Schizophrenia - young adults	Phase 3	Phase 3 data due early 2020.
ALKS 3831 - ENLIGHTEN-2	Schizophrenia, bipolar	NDA Filing	Noted July 15, 2019 that NDA filing due 4Q 2019 will include Bipolar I indication
BYDUREON	Type 2 diabetes	Approved	CRL received March 15, 2010.
Aristada	Schizophrenia	Approved	Approved October 5 2015. sNDA filed for 2-month option with approval announced June 6, 2017.
Diroximel fumarate (BIIB098)	Multiple sclerosis (MS)	PDUFA	NDA filing announced December 17, 2018. NDA acceptance announced February 25, 2019. PDUFA estimate December 24, 2019.
ALKS 6428	Opioid dependence	Phase 3	Phase 3 trial did not meet endpoint - February 2017. Second trial is ongoing.
ALKS 5461	Major depressive disorder	CRL	CRL announced February 1, 2019.
ALKS 3831 - ENLIGHTEN-1	Schizophrenia	Phase 3	Phase 3 preliminary data released June 30, 2017. Primary endpoint met - adverse events included weight gain.
ALKS 4230 ARTISTRY-1	Solid tumors	Phase 1	Phase 1/2 commences expansion phase of trial - June 12, 2019.
Aristada and Invega Sustenna	Schizophrenia	Phase 3	Phase 3 data released April 9, 2019 - primary endpoint met.
ALKS 4230 + Keytruda - ARTISTRY-2	Solid tumors	Phase 1	Phase 1 initiation announced February 26, 2019.
Diroximel fumarate (BIIB098) - Head-to-head trial versus Tecfidera -	Relapsing Remitting Multiple Sclerosis (RRMS)	Phase 3	Phase 3 top-line data due mid-2019.

ALLK Allakos Inc.

$35.16

-0.8  -2.21%

43.1 million

$1.5 billion

9 thousand

329.8 thousand

0.03

$9.04

$36.03

$35.96

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
AK002	Severe Allergic Conjunctivitis	Phase 1	Phase 1 data May 7, 2019 noted a 78% median improvement in ocular symptoms
AK002	Indolent Systemic Mastocytosis	Phase 1	Phase 1 data released February 19, 2019.
AK002	Chronic Urticaria	Phase 2	Phase 2 additional data released February 11, 2019. 9% UAS7 complete responder rate.
AK002	Eosinophilic Gastritis	Phase 2	Phase 2 top-line data due mid-2019.

ALLO Allogene Therapeutics Inc.

$27.12

+0.07  +0.28%

121.5 million

$3.3 billion

6.4 thousand

515.1 thousand

0.01

$4.84

$27.08

$27.05

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
UCART19 (PALL)	Acute lymphoblastic leukemia (ALL)	Phase 1	Phase 1 update at ASH December 3, 2018 noted 86% CR/CRi.
UCART19 - CALM	Refractory B-cell Acute Lymphoblastic Leukaemia	Phase 1	Phase 1 update 2019.
ALLO-715	Multiple myeloma	Phase 1/2	Phase 1/2 trial to be initiated in 2H 2019.
ALLO-501 - ALPHA	Non-Hodgkin lymphoma (NHL)	Phase 1	Phase 1 initial data due 1H 2020.

ALNA Allena Pharmaceuticals Inc.

$4.91

-0.07  -1.31%

20.8 million

$102.1 million

2.9 thousand

159.2 thousand

0.02

$2.64

$5.02

$4.97

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
Reloxaliase ALLN-177 (URIROX-1)	Enteric Hyperoxaluria	Phase 3	Data from first Phase 3 trial due 2H 2019.
Reloxaliase ALLN-177 (Study 206)	Primary hyperoxaluria	Phase 2	Phase 2 top-line data due 2H 2019.
Reloxaliase ALLN-177 (URIROX-2)	Enteric Hyperoxaluria	Phase 3	Phase 3 trial initiated 4Q 2018.

ALNY Alnylam Pharmaceuticals Inc.

$73.26

+0.47  +0.65%

106.5 million

$7.8 billion

71.2 thousand

1 million

0.07

$5.04

$72.79

$72.79

07/16/2019

Tap to view 16 drug drugs

Drug	Indication	Stage	News
Fitusiran	Hemophilia A and B	Phase 2	Noted September 7, 2017 that Fitusiran program suspended dosing due to fatal thrombotic event. Announced December 15, 2017 that clinical hold has been released. Dosing to resume later December.
Givosiran	Acute hepatic porphyrias	NDA Filing	Rolling NDA completion announced June 5, 2019.
Inclisiran - ORION-9	Hypercholesterolemia	Phase 3	Phase 3 data 3Q 2019.
ALN-HBV02 (VIR-2218))	Chronic hepatitis B virus (HBV)	Phase 1/2	Phase 1/2 data due late-2019.
Lumasiran (ALN-GO1) ILLUMINATE-A	Primary Hyperoxaluria Type 1 (PH1)	Phase 3	Phase 3 data due late-2019.
Patisiran	Familial Amyloidotic Polyneuropathy (FAP) in Patients with ATTR	Approved	FDA Approval announced August 10, 2018.
ALN-CC5 (cemdisiran)	IgA nephropathy	Phase 2	Phase 2 trial to be initiated.
Fitusiran (ATLAS)	Hemophilia	Phase 3	Phase 3 first read-out expected 2H 2019
ALN-TTRsc02 - HELIOS-A	ATTR amyloidosis	Phase 3	Phase 3 trial enrolling - noted December 6, 2018.
Inclisiran - ORION-10	Cardiovascular disease (ASCVD)	Phase 3	Phase 3 sata due 3Q 2019.
Inclisiran - ORION 11	Cardiovascular disease (ASCVD)	Phase 3	Phase 3 data due 3Q 2019.
ALN-AAT02	alpha-1 anti-trypsin deficiency-associated liver disease	Phase 1/2	Phase 1/2 data due late-2019.
Lumasiran (ALN-GO1) ILLUMINATE-B	Primary Hyperoxaluria Type 1	Phase 3	Phase 3 top-line data due mid-2020.
Patisiran APOLLO-B	Wild-type ATTR amyloidosis patients with cardiomyopathy	Phase 3	Phase 3 trial to be initiated mid-2019.
Lumasiran (ALN-GO1) ILLUMINATE-C	Impaired renal function	Phase 3	Phase 3 trial to be initiated mid-2019.
ALN-AGT	Hypertension	Phase 1	Phase 1 dosing has commenced - noted May 31, 2019. Initial data due late-2019.

ALPN Alpine Immune Sciences Inc.

$4.21

  +0.00%

18.6 million

$78.2 million

4

8.8 thousand

0

$1.38

$0.00

$4.21

07/16/2019

Tap to view 2 drug drugs

Drug	Indication	Stage	News
N91115	Cystic Fibrosis - one copy of the F508del mutation and a second mutation that results in a gating defect in the CFTR protein	Phase 2	Phase 2 data released February 24, 2017 - primary endpoint not met.
ALPN-101	Healthy volunteers	Phase 1	Phase 1 safety trial initiation announced February 11, 2019.

ALRN Aileron Therapeutics Inc.

$0.58

-0.02  -3.52%

26.7 million

$15.5 million

63.2 thousand

248.3 thousand

0.25

$1.21

$0.57

$0.60

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
ALRN-6924	Peripheral T-cell lymphoma (PTCL)	Phase 2a	Noted that development to be discontinued - no pivotal trial.
ALRN-6924 and Cytarabine (Ara-C)	Acute myeloid leukemia (AML); Myelodysplastic syndrome (MDS)	Phase 1b	Phase 1/1b data due 4Q 2019.
ALRN-6924 and IBRANCE (palbociclib)	Solid tumors	Phase 2a	Phase 2a preliminary data due at ESMO Sept 27-Oct 1, 2019 with final data due 2H 2020.
ALRN-6924 and Paclitaxel	Breast cancer	Phase 1	Phase 1 has been initiated.
ALRN-6924	Small Cell Lung Cancer (SCLC)	Phase 1/2	Phase 1b/2 trial to commence September 2019 with data due 1Q 2020.

ALT Altimmune Inc.

$2.45

-0.02  -0.94%

13.5 million

$32.9 million

18.6 thousand

326.6 thousand

0.06

$0.56

$2.46

$2.47

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
HepTCell	Hepatitis B	Phase 1	Phase 2 trial planned for 2020.
NasoVAX	Flu vaccine	Phase 2	Phase 2 additional data released March 19, 2019 noted all patients remained seroprotected.
NASOSHIELD	Anthrax	Phase 1	Phase 1 data showed limited response.

ALXN Alexion Pharmaceuticals Inc.

$123.68

+0.64  +0.52%

224.2 million

$27.7 billion

98 thousand

1.4 million

0.07

$2.86

$123.59

$123.04

07/16/2019

Tap to view 9 drug drugs

Drug	Indication	Stage	News
CAEL‐101	AL amyloidosis	Phase 2/3	Phase 2b/3 trial to be initiated early 2020.
Eculizumab	Relapsing Neuromyelitis Optica Spectrum Disorder (NMOSD)	Approved	FDA Approval announced June 27, 2019.
ALXN1210	atypical Hemolytic Uremic Syndrome (aHUS)	PDUFA priority review	PDUFA data under priority review October 19, 2019.
ULTOMIRIS (ravulizumab-cwvz)	Paroxysmal nocturnal hemoglobinuria (PNH)	Approved	FDA approval announced December 21, 2018.
Eculizumab	Refractory generalized myasthenia gravis (gMG)	Approved	Approval announced October 23, 2017.
ALXN1840 (WTX101)	Wilson disease	Phase 3	Phase 3 enrolment to be completed early 2020.
ULTOMIRIS (ravulizumab-cwvz)	Generalized myasthenia gravis (gMG)	Phase 3	Phase 3 trial initiated 1Q 2019.
ALXN1830	Warm autoimmune hemolytic anemia (WAIHA)	Phase 1/2	Phase 1b/2a trial to be completed in 2019.
ULTOMIRIS (ravulizumab-cwvz) subcutaneous	Paroxysmal nocturnal hemoglobinuria (PNH) and atypical Hemolytic Uremic Syndrome (aHUS)	Phase 3	Phase 3 PK data due early 2020.

AMAG AMAG Pharmaceuticals Inc.

$9.10

-0.13  -1.41%

33.8 million

$307.3 million

35 thousand

952.8 thousand

0.04

$0.50

$9.16

$9.23

07/16/2019

Tap to view 6 drug drugs

Drug	Indication	Stage	News
AMAG-423 / Digoxin immune fab (DIF)	Severe preeclampsia in pregnant women	Phase 2/3	Phase 2/3 top-line data due mid-2020.
Vyleesi (Bremelanotide)	Female sexual dysfunction (FSD)	Approved	FDA approval announced June 21, 2019.
Feraheme	Adults with iron deficiency anemia (IDA)	Approved	Approval for sNDA filing announced February 5, 2018.
Makena - auto injector	Reduce the risk of preterm birth in women with a singleton pregnancy	Approved	Approval announced February 14, 2018.
Makena	Preterm birth	Phase 3	Phase 3b trial did not meet co-primary endpoints - March 8, 2019.
Ciraparantag	Anticoagulated reversal agent / Healthy volunteers	Phase 2	Phase 3a trial to be initiated 2H 2019.

AMGN Amgen Inc.

$176.74

+0.62  +0.35%

609.9 million

$107.8 billion

191 thousand

2.8 million

0.07

$9.95

$176.34

$176.12

07/16/2019

Tap to view 28 drug drugs

Drug	Indication	Stage	News
Tezepelumab - NAVIGATOR	Asthma	Phase 3	Phase 3 data due 2020.
Prolia (denosumab)	Glucocorticoid-induced osteoporosis (GIOP)	Approved	Approval announced May 21, 2018.
KYPROLIS (ASPIRE)	Relapsed Multiple Myeloma	Approved	sNDA approval announced June 11, 2018.
Vectibix (Panitumumab)	Wild-Type RAS Metastatic Colorectal Cancer	Approved	sBLA approval announced June 29, 2017.
MVASITM (bevacizumab-awwb)	Biosimilar candidate to Avastin (bevacizumab)	PDUFA	Approved September 14, 2017.
Corlanor	Chronic Heart Failure	Approved	Approved April 15, 2015.
Erenumab	Migraine	Approved	Approval announced May 17, 2018.
CNP 520	Alzheimer’s Disease	Phase 3	Phase 3 ongoing. Expected completion 2024.
Repatha	Cardiovascular disease	Approved	Approval announced December 1, 2017.
XGEVA	Multiple Myeloma	Approved	sBLA approval announced January 5, 2017.
KYPROLIS (ARROW)	Multiple Myeloma	Approved	FDA approval announced October 1, 2018.
KYPROLIS (ENDEAVOR)	Relapsed Multiple Myeloma	Approved	sNDA approved January 17, 2018.
BLINCYTO	Ph+ R/R ALL	Approved	PDUFA date under priority review August 14, 2017. Approval announced July 11, 2017.
ABP 798	RITUXAN biosimilar - non-Hodgkin lymphoma	Phase 3	Phase 3 data released January 24, 2019 - primary endpoint met.
ABP 980 (Kanjinti; trastuzumab-anns)	Herceptin biosimilar	CRL	FDA approval announced June 13, 2019.
ABP 710	REMICADE biosimilar - rheumatoid arthritis	PDUFA	BLA filing announced December 17, 2018. Estimated PDUFA date December 16, 2019.
Parsabiv	Secondary hyperparathyroidism (SHPT)	Approved	Approved February 7, 2017.
EVENITY (Romosozumab)	Osteoporosis	Approved	FDA Approval announced April 9, 2019.
Omecamtiv mecarbil GALACTIC-HF	Acute heart failure	Phase 3	Phase 3 completion of enrolment announced July 15, 2019 with second interim analysis due 1H 2020.
Omecamtiv mecarbil METEORIC-HF	Acute heart failure	Phase 3	Second Phase 3 trial initiation announced February 21, 2019.
AMG 420	Relapsed. Refractory (R/R) Multiple Myeloma (MM)	Phase 1	Phase 1 data ASCO June 2, 2019. Overall response rate 70% (7/10) in high dose, 13/42 response across all cohorts.
AMG 330	Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)	Phase 1	Phase 1 data at ASH December 1, 2018 noted 12.5% ORR.
Nplate (Romiplostim)	Immune Thrombocytopenia (Pediatric)	Approved	FDA approval announced December 14, 2018.
Nplate (Romiplostim)	Immune thrombocytopenia (ITP)	PDUFA	sNDA filing announced December 19, 2018. Estimated PDUFA date October 18, 2019.
KYPROLIS (CANDOR)	Multiple Myeloma	Phase 3	Phase 3 data due 2019.
AMG 594	Healthy volunteers	Phase 1	Phase 1 trial initiation announced February 20, 2019.
AMG 510	Solid tumors	Phase 1	Phase 1 data at ASCO June 3, 2019. 50% ORR in lung cancer patients. 90% SD.
CNP520	Alzheimer’s Disease	Phase 2/3	Phase 2/3 trial discontinued due to lack of efficacy.

AMPE Ampio Pharmaceuticals Inc.

$0.40

  +-0.64%

141.7 million

$57.1 million

8.82

62.9 thousand

1.3 million

0.05

$12.09

$0.41

$0.41

07/16/2019

Tap to view 2 drug drugs

Drug	Indication	Stage	News
Ampion	Osteoarthritis of the Knee	Phase 3	Phase 3 trial to be initiated under SPA - noted June 14, 2019.
Optina	Diabetic Macula Edema	Phase 2b	Phase 2b data released May 2015 did not meet endpoints

AMPH Amphastar Pharmaceuticals Inc.

$20.32

+0.13  +0.64%

47.1 million

$956.4 million

20.6 thousand

187.6 thousand

0.11

$2.85

$20.18

$20.19

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
Albuterol DPI	Asthma	Phase 2b
Naloxone Intranasal	Opioid overdose	CRL	CRL announced February 21, 2017.
Primatene Mist (epinephrine inhalation aerosol)	Asthma	CRL	CRL issued December 27, 2016.

AMRN Amarin Corporation plc

$21.61

-0.26  -1.19%

330.7 million

$7.1 billion

558.2 thousand

6.6 million

0.08

$60.03

$21.87

$21.87

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
Vascepa	High Triglycerides With Mixed Dyslipidemia	PDUFA priority review	PDUFA date under priority review September 28, 2019.

AMRX Amneal Pharmaceuticals Inc. Class A

$3.48

-0.03  -0.85%

298.8 million

$1 billion

4.65

488.9 thousand

1.7 million

0.29

$2.20

$3.52

$3.51

07/16/2019

Tap to view 1 drug drugs

Drug	Indication	Stage	News
IPX203	Parkinson's disease	Phase 3	Phase 3 data due 1H 2020.

ANAB AnaptysBio Inc.

$54.84

-0.82  -1.47%

27 million

$1.5 billion

9.8 thousand

303.4 thousand

0.03

$3.17

$55.73

$55.66

07/16/2019

Tap to view 5 drug drugs

Drug	Indication	Stage	News
ANB020 - etokimab	Moderate-to-severe adult atopic dermatitis	Phase 2b	Phase 2b data due 2H 2019.
ANB020 - etokimab	Severe adult eosinophilic asthma	Phase 2a	Phase 2b trial to be initiated 2019.
ANB019	Palmo-plantar pustular psoriasis	Phase 2	Phase 2 data due 1H 2020.
ANB019	Generalized pustular psoriasis	Phase 2	Phase 2 data due mid-2019.
ANB020 - etokimab	Nasal polyps	Phase 2	Phase 2 data due 2H 2019.

ANCN Anchiano Therapeutics Ltd.

$4.30

  +0.00%

6.8 million

$29.3 million

4.2 thousand

0

-$26.88

$0.00

$4.30

07/16/2019

Tap to view 2 drug drugs

Drug	Indication	Stage	News
Inodiftagene - Codex	Non-muscle invasive bladder cancer (NMIBC)	Phase 2	Phase 2 pivotal initial data due 4Q 2019.
Inodiftagene with BCG - Leo	Non-muscle invasive bladder cancer (NMIBC)	Phase 3	Phase 3 planned for 2019.

ANIK Anika Therapeutics Inc.

$40.53

+0.19  +0.47%

14.2 million

$575.8 million

11.9 thousand

171.3 thousand

0.07

$2.14

$40.21

$40.34

07/16/2019

Tap to view 3 drug drugs

Drug	Indication	Stage	News
Cingal	Osteoarthritis	Phase 3	Phase 3 trial did not meet primary endpoint - June 19, 2018. Noted February 21, 2019 that further Phase 3 trial is required.
Monovisc	Osteoarthritis	Approved	Approved Feb 2014
HYALOFAST	Cartilage defects of the knee	Phase 3	Phase 3 enrollment to be completed by the end of 2018.

ANIX Anixa Biosciences Inc.

$4.16

-0.01  -0.24%

20.1 million

$83.6 million

205

48.3 thousand

0

$12.61

$4.16

$4.17

07/16/2019

Drug	Indication	Stage	News

APLS Apellis Pharmaceuticals Inc.

$26.31

+0.07  +0.28%

63.2 million

$1.7 billion

85.2 thousand

424.5 thousand

0.2

$7.41

$26.18

$26.24

07/16/2019

Tap to view 6 drug drugs

Drug	Indication	Stage	News
Discovery (APL2-201)	Complement-dependent Nephropathies (CDN)	Phase 2	Phase 2 data due 2019.
APL-2 subcutaneous	Auto-immune Hemolytic Anemia (AIHA) and Cold agglutinin disease (CAD)	Phase 2	Phase 2 data released June 15, 2019
APL-2 PHAROAH	Paroxysmal Nocturnal Hemoglobinuria (PNH)	Phase 1b	Phase 1b trial ongoing.
APL-2 OAKS	Geographic atrophy (GA) associated with age-related macular degeneration (AMD)	Phase 3	Phase 3 enrolment to be completed 1Q 2020.
APL-2 subcutaneous PEGASUS	Paroxysmal Nocturnal Hemoglobinuria (PNH)	Phase 3	Phase 3 data due December 2019.
APL-2 PADDOCK	Paroxysmal Nocturnal Hemoglobinuria	Phase 1	Phase 1b update due at ASH December 2, 2018 noted normalization of mean hemoglobin to 12.2 g/dL by day 85, an increase of 4.2 g/dL from baseline.

APLT Applied Therapeutics Inc.

$8.36

-1.06  -11.25%

17.1 million

$142.6 million

1.1 thousand

61.8 thousand

0.02

-$5.10

$9.26

$9.42

07/16/2019

Tap to view 2 drug drugs

Drug	Indication	Stage	News
AT-001	Diabetic cardiomyopathy (DbCM)	Phase 2/3	Phase 2/3 trial to be initiated late-2019.
AT-007	Galactosemia	Phase 1	Phase 1 trial initiation announced June 24, 2019.

APTO Aptose Biosciences Inc.

$2.92

+0.05  +1.74%

55.4 million

$161.9 million

82.8 thousand

419.7 thousand

0.2

$10.31

$2.96

$2.87

07/16/2019

Tap to view 2 drug drugs

Drug	Indication	Stage	News
APTO-253	Acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)	Phase 1b	Phase 1b clinical hold released June 29, 2018. First patient of re-initiation announced November 26, 2018. Primary completion 1H 2020.
CG-806	Chronic lymphocytic leukemia (CLL/SLL) or non-Hodgkin lymphomas (NHL)	Phase 1	Phase 1 safety/response data due late-2019.

APTX Aptinyx Inc.

$3.77

-0.04  -0.92%

33.7 million

$127.1 million

11.9 thousand

264.4 thousand

0.04

$0.94

$3.80

$3.81

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
NYX-458	Parkinson’s Disease Cognitive Impairment (healthy volunteers)	Phase 1	Phase 2 trial to be initiated 2H 2019.
NYX-2925	Fibromyalgia	Phase 2	Phase 2 data released June 10, 2019 - primary endpoint met.
NYX-2925	Neuropathic Pain Associated with Diabetic Peripheral Neuropathy	Phase 2	Phase 2 data released January 16, 2019 - primary endpoint not met. Additional Phase 2 trial to be initiated 2H 2019.
NYX-783	Post-traumatic stress disorder (PTSD)	Phase 2	Phase 2 trial initiation announced February 19, 2019 with data due 1H 2020.

APVO Aptevo Therapeutics Inc.

$0.85

-0.02  -1.95%

45.1 million

$38.5 million

267.8 thousand

516.6 thousand

0.52

$0.98

$0.87

$0.87

07/16/2019

Tap to view 4 drug drugs

Drug	Indication	Stage	News
APVO414	Castration-resistant prostate cancer	Phase 1	Development terminated - noted November 14, 2018.
Otlertuzumab	Relapsed or refractory peripheral T-cell lymphoma	Phase 2	Development terminated - noted November 14, 2018.
APVO436	Acute myeloid leukemia (AML)	Phase 1	Phase 1 preliminary data due 3Q 2019.
APVO210	Healthy volunteers	Phase 1	Phase 1 trial initiation announced March 20, 2019 with initial single ascending doses (SAD) data due 3Q and safety data 4Q 2019.

AQST Aquestive Therapeutics Inc.

$4.20

+0.05  +1.20%

25 million

$104.9 million

24.8 thousand

137 thousand

0.18

-$17.50

$4.26

$4.15

07/16/2019

Tap to view 6 drug drugs

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Drug	Indication	Stage	News
Exservan (riluzole) Oral Film	Amyotrophic Lateral Sclerosis	PDUFA	PDUFA date November 30, 2019.
Sympazan	Lennox-Gastaut Syndrome	Approved	Tentative approval issued August 31, 2018. Full approval issued November 2, 2018.
Libervant - AQST-203	Epileptic seizures	NDA Filing	Rolling NDA filing has commenced - noted June 4, 2019. To be completed 4Q 2019.